Search Results (151)

Extragalactic background light (EBL), formed by the light radiated and re-radiated by stars, galaxies, and active galactic nuclei throughout the evolution of the Universe, brings the imprint of the history of the rate of the formation of emitting astrophysical objects and the Universe’s expansion. It makes EBL one of the fundamental quantities in cosmology. The optical depth for high-energy emission from the distant active galactic nuclei provides a constraint for the EBL density that is clear from the foreground galactic and other emissions, and, therefore, for the cosmological parameters. In this work, we investigate the high-redshift active galaxy 4C +55.17 (z = 0.902), whose unusually hard and stable high-energy spectrum makes it a valuable probe of EBL-induced absorption effects. Using observations extending from GeV to TeV energies, we reconstruct the optical depth associated with gamma-ray propagation and compare the inferred attenuation with predictions from existing EBL models. The results favor relatively low EBL intensities in the optical and infrared bands, consistent with low-level EBL models and suggesting reduced star formation activity and dust contributions over cosmic evolution. We further explore the cosmological implications of the reconstructed optical depth and derive constraints on the Hubble constant in the range $H_0\approx$ 64–74 km s⁻¹ Mpc⁻¹, with an average value of $H_0=69\pm 4$ km s⁻¹ Mpc⁻¹. These findings demonstrate the potential of hard-spectrum, high-redshift gamma-ray sources such as 4C +55.17 as cosmological probes for studying EBL evolution and addressing current tensions in cosmological parameter measurements. Full article

This paper develops an analytical treatment of vibro-acoustic wave propagation in a cylindrical waveguide containing two clamped elastic membranes and a central flexible-shell segment. The acoustic field obeys the time-harmonic Helmholtz equation, the shell motion is described by Donnell–Mushtari thin-shell theory under axisymmetric loading, and the membrane response is governed by classical membrane theory and incorporated through a tailored Galerkin scheme. The resulting coupled fluid–structure boundary-value problem is solved by the Mode-Matching Method: the acoustic potentials are expanded in orthogonal radial eigenfunctions within each subregion, and continuity of pressure, normal velocity, and structural displacement are enforced at every interface. The mirror symmetry of the configuration is exploited by an exact decomposition into symmetric and anti-symmetric sub-problems, each of which reduces to a truncated linear algebraic system of dimension $4N+4$ for the unknown modal amplitudes. Acoustic power-balance identities provide a quantitative consistency check on the numerical implementation and diagnose convergence with respect to the truncation order; structural damping is accommodated through complex-modulus substitutions for the shell and the membrane tension without altering the algebraic structure of the system. The numerical results demonstrate that the dual-membrane configuration delivers transmission-loss values exceeding $25\mathrm{dB}$ across the low-frequency band relevant to HVAC and automotive applications, with a representative plateau near $13\mathrm{dB}$ at the reference geometry, through resonance-driven modal coupling between the acoustic field and the compliant interfaces. Parametric studies identify the excitation frequency, the inner-membrane radius, the shell radius, and the chamber length as effective design parameters for tuning the attenuation. The formulation furnishes a unified and computationally efficient analytical tool for predicting and optimising noise attenuation in flexibly coupled cylindrical duct systems. Full article

Background/Objectives: Valgus deformities of the knee and ankle are frequently diagnosed during adolescence. Hemiepiphysiodesis (HED) using the tension-plate technique has become the standard approach for guided growth in both joints. Notably, valgus deformities may simultaneously affect both joints. While substantial data supports monoarticular guided growth, evidence for ipsilateral biarticular growth modulation remains limited. The aim of this case series was to evaluate the feasibility, safety and short-term radiographic outcome of simultaneous ipsilateral biarticular HED for concomitant valgus deformities in the knee and ankle (CKAVD). Methods: This retrospective monocentric observational study included 21 legs from 21 consecutive children treated with simultaneous ipsilateral biarticular HED for CKAVD between 2013 and 2022. The initiation and termination of growth modulation were based on clinical (intermalleolar distance, pain in both joints) and radiological parameters. Standing whole-leg coronal plain radiographs were evaluated at the start of modulation and after complete hardware removal, assessing the anatomical femorotibial angle (aFTA), anatomical lateral distal femoral angle (aLDFA), medial proximal tibial angle (MPTA), and lateral distal tibial angle (LDTA). Results: The mean age at implantation was 11.5 years (SD 1.08); females (n = 7) were younger than males (n = 14, p < 0.05). The mean duration of growth modulation was 14.3 months (SD 4.3). The intermalleolar distance improved by an average of 10 cm (SD 4.4). The aFTA improved by an average of 6.9 degrees (SD 2.6), the aLDFA by 6.7 degrees (SD 2.7), the MPTA by 7.2 degrees (SD 2.3), and the LDTA by 7.1 degrees (SD 3.0). Two-stage hardware removal was required in 6 legs (29%). In one case, a relapse of knee valgus occurred. Conclusions: Comprehensive evaluation of all major joints seems to be crucial during the diagnostic workup for coronal plane deformities of the lower extremity. For children with ipsilateral symptomatic CKAVD, simultaneous biarticular HED may be considered as a feasible treatment approach, demonstrating promising short-term outcomes and a low observed complication rate. Full article

According to the National Cancer Institute, approximately 3.9 billion people worldwide suffer from non-communicable oral diseases, with head and neck cancer patients experiencing exacerbated oral mucositis primarily from radiotherapy. This condition manifests as painful, debilitating mucosal lesions, necessitating effective antimicrobial interventions. This study developed and characterized stable mouthwash formulations containing green-synthesized silver nanoparticles (AgNPs) derived from Baccharis trimera (carqueja) extract for the management of oral mucositis, evaluating their physicochemical stability, antimicrobial efficacy, and biosafety. AgNPs formation was confirmed by color change to brown and a surface plasmon resonance band at 407 nm (UV-Vis), with dynamic light scattering revealing a monomodal hydrodynamic diameter of ~25 nm and stable dispersion; scanning electron microscopy showed spherical particles of 25–35 nm. Four formulations (22–85 ppm AgNPs) in a commercial vehicle exhibited excellent stability over 60 days at 5 °C and 25 °C, maintaining near-neutral pH (~7), low surface tension (<5 mN/m), and unchanged spectral profiles, with no phase separation under centrifugation or thermal stress (up to 70 °C). Antimicrobial assays via broth microdilution demonstrated broad-spectrum activity for the 85 ppm formulation: MICs of 125 µg/mL (S. epidermidis, E. faecalis), 62.5 µg/mL (E. coli, P. aeruginosa), and 250 µg/mL (S. aureus), with MBC of 125 µg/mL (bactericidal) against P. aeruginosa; no activity against C. albicans (MIC > 500 µg/mL). Against human oral microbiota (n = 4 volunteers), it reduced bacterial growth by 14–156% relative to controls (e.g., −5% to 156% inhibition). Cytogenotoxicity tests (A. cepa) confirmed non-toxicity (mitotic index 79–93% of control, low cellular alteration index). These findings establish the carqueja-mediated instant green AgNPs mouthwash as a stable, potent antimicrobial agent, poised to mitigate mucositis-related infections and enhance the quality of life of cancer patients. Full article

Background: Over the past 25 years, advances in knee surgery have been driven by an improved understanding of fracture morphology and associated injuries, as well as by significant technological progress. The introduction of novel classification systems has led to the refinement of treatment strategies, particularly with respect to the selection of surgical approaches. Furthermore, advances in biomechanical understanding have facilitated the development of new osteosyntheses designed to promote earlier rehabilitation while simultaneously reducing complication rates. Research Question: Which key milestones over the last 25 years have significantly influenced treatment strategies for knee joint fractures, with a perspective on unresolved issues? Results: Recent advances in fracture management, osteosynthesis, imaging techniques, and biomechanical research have substantially improved clinical outcomes, including a reduction in infection rates and improved postoperative results. The implementation of new classification systems has enabled more precise preoperative planning, allowing surgeons to define approaches that ensure adequate visualization of the articular surface while facilitating optimal positioning of the osteosynthesis. In terms of osteosynthesis, the introduction of locking plate technology has become widely established and supported by biomechanical evidence and has largely replaced traditional methods such as tension-band wiring of the patella. Despite these advances, fracture management in geriatric patients remains a considerable challenge, as compromised bone quality frequently limits the ability to achieve sufficiently load-stable osteosynthesis. Direct visualization of the articular surface is essential for adequate assessment and reduction of the affected articular segment. However, there is currently no consensus on which surgical approach or possible extension is most appropriate while simultaneously ensuring a low complication rate. Full article

While macroscopic stress significantly impacts the performance of metallic components, the underlying atom–electron coupling mechanisms governed by distinct crystal symmetries remain insufficiently understood. To address this gap, this work systematically investigates the structural and electronic evolution of representative metallic materials under applied stress. Experimentally, X-ray diffraction (XRD) revealed complex macroscopic residual stress distributions in cold rolled titanium alloy and silicon steel. Motivated by these engineering observations, first-principles density functional theory (DFT) calculations were conducted to uncover the underlying physical mechanisms. Specifically, the responses of face-centered cubic (FCC) aluminum and copper, body-centered cubic (BCC) iron, and hexagonal close-packed (HCP) titanium crystals were investigated under tension and compression using the RPBE functional. Stress-dependent elastic properties, density of states (DOS), band structures, and phonon spectra were calculated. Results show that tension softens all metals (Al becomes mechanically unstable), whereas compression stiffens their lattices. Electronically, tensile loading sharpens DOS peaks near the Fermi level and shifts conduction bands closer to it, whereas compression smooths DOS peaks and shifts bands away. Phonon analysis indicates Cu and Ti remain dynamically stable, while Al and Fe exhibit phonon mode softening under high tension. These stress-induced changes highlight crucial atom–electron coupling mechanisms, providing a theoretical basis for tailoring metallic performance via stress engineering. Full article

Ground subsidence and shaft lining deformation caused by compressed dewatered bottom aquifers in deep unconsolidated strata mining areas are critical engineering challenges, making the study of the seepage–soil deformation coupling mechanism during groundwater injection remediation vital. This study built a visual cylindrical model (1025 mm × 150 mm); formulated well-graded analogous materials based on the D₂₀ principle to simulate sandy gravel layers; embedded FBG sensors at 200/400/600 mm depths, combined with a dial indicator on the model top; and conducted two water injection–dewatering cycles. Results indicate: water injection generates excess pore water pressure, placing the entire model in a tensile stress state with top rebound; post-injection vertical stress redistributes (tension above the injection point, compression below, and an interlaced transitional band), validating the necessity of full-section injection; during the second injection–dewatering cycle, tensile strain at the upper monitoring point reaches 597.77 με, while compressive strain at lower depths reaches −253.90 με, internal deformation stabilizes within 6.5–10.0 days, injection improves the in situ stress state by reducing effective stress, and the deformation of the field strata remains in a stabilization period, with the stabilization time decreasing as the depth of the strata increases. This study clarifies the temporal evolution and representative spatial variation in internal strain at monitored depths during injection, providing theoretical and design references for optimizing water injection schemes to mitigate coal mine shaft damage. Full article

The β grain size in titanium alloys during industrial forging is critical for balancing toughness, cost-effectiveness, and processability. To address the industrial challenge of high cost and difficulty in refining β grains to the tens of micrometers scale, this study investigates the feasibility of achieving a superior strength–ductility balance in TC18 alloy with near-industrial coarse β grains (296~857 μm) under room temperature tension. A pronounced inverse correlation is observed between β grain size and both strength and ductility. The yield strength–grain size relationship follows the Hall–Petch effect, while the anomalous increase in ductility for fine-grained specimens is attributed to three factors. First, smaller grains provide a higher grain boundary density, promoting stress redistribution and mitigating stress concentrations. Second, more uniform stress distribution induces thinner, denser kink bands that enhance plasticity. Third, strain-induced martensite evolves from discrete nanoscale particles to discontinuous lines and ultimately coalesces into continuous planar bands along the (112)β and (110)β planes. This phase transformation, which initiates below a critical grain size of ~500 μm, further alleviates stress concentrations towards slip bands and contributes to dynamic work hardening. The findings demonstrate that coordinated deformation mechanisms enable excellent mechanical performance even in coarse-grained microstructures, providing a practical pathway for optimizing industrial-grade titanium alloys. Full article

This study examines the mechanical response of medium-manganese TRIP steels under different stress states, focusing on deformation-induced austenite-to-martensite transformation and ageing phenomena. Two steels with distinctly different ferrite–austenite morphologies and retained austenite (RA) fractions were analysed: a globular microstructure with 18% RA and a lamellar microstructure with 14% RA, produced by single (SA) and double annealing (DA), respectively. Continuous and interrupted tests were performed under in-plane shear, uniaxial tension, and plane strain stress states. Strain fields were analysed using high-resolution digital image correlation, while RA fractions were quantified as a function of strain by ex situ X-ray diffraction. The results demonstrate a pronounced stress-state dependence. SA samples exhibit discontinuous yielding, with uniaxial tests showing clear Lüders band formation. Both steels exhibit dynamic strain ageing manifested by Portevin–Le Chatelier (PLC) serrations and associated strain bands, which are most pronounced under uniaxial tension, weaker in plane strain, and barely detectable in in-plane shear. Static strain ageing is also evidenced by a strengthened yield response upon unloading–reloading in all samples. The SA globular microstructure exhibits higher PLC band inclination angles than the lamellar DA microstructure, consistent with its more pronounced anisotropy. The propagation velocity in uniaxial tensile samples decreases with increasing strain following the work-hardening response. For both steels, the austenite-to-martensite transformation rate is highest in uniaxial tension, slightly reduced in plane strain, and strongly suppressed under in-plane shear. A Beese–Mohr/Johnson–Mehl–Avrami–Kolmogorov formulation incorporating stress triaxiality and Lode angle captures these trends for both steels. For the stress states considered, the DA condition exhibits a consistently higher transformation rate than the SA condition, accompanied by a higher work-hardening rate. These findings highlight the coupled role of stress state and microstructural morphology in governing localisation behaviour and strain-induced transformation in medium-manganese steels. Full article

Optic neuritis (ON) has been recognized since antiquity, but its modern clinical identity emerged only in the late 19th century and was definitively shaped by the Optic Neuritis Treatment Trial (ONTT). The ONTT established the natural history, visual prognosis, association with multiple sclerosis (MS), and therapeutic response to corticosteroids, building the foundation for contemporary ON management. Subsequent discoveries—most notably aquaporin-4 IgG-associated ON (AQP4-ON), myelin oligodendrocyte glycoprotein antibody-associated ON (MOG-ON), and double-negative ON—have fundamentally transformed this paradigm, shifting ON from a seemingly uniform demyelinating syndrome to a group of biologically distinct disorders. These subtypes differ in immunopathology, clinical course, MRI features, retinal injury patterns, CSF profiles, and long-term outcomes, making early and accurate differentiation essential. MRI provides key distinctions in lesion length, orbital tissue inflammation, bilateral involvement, and chiasmal or optic tract extension. Optical coherence tomography (OCT) offers complementary structural biomarkers, including severe early ganglion cell loss in AQP4-ON, relative preservation in MOG-ON, and variable patterns in double-negative ON. CSF analysis further refines diagnosis, with oligoclonal bands strongly supporting MS-ON. Together, these modalities enable precise early stratification and timely initiation of targeted immunotherapy, which is critical for preventing irreversible visual disability. Despite major advances, significant unmet needs persist. Access to high-resolution MRI, OCT, cell-based antibody assays, and evidence-based treatments remains limited in many regions, contributing to global disparities in outcomes. The understanding of the pathogenesis of double-negative optic neuritis, the identification of reliable biomarkers of relapse and visual recovery, and the determination of standardized cut-off values for multimodal diagnostic tools—including MRI, OCT, CSF analysis, and serological assays—remain unresolved challenges. Future research must expand biomarker discovery, refine imaging criteria, and ensure equitable global access to cutting-edge diagnostic platforms and therapeutic innovations. Four decades after the ONTT, ON remains a dynamic field of investigation, with ongoing advances holding the potential to transform care for patients worldwide. Together, these advances expose a fundamental tension between historically MS-centered diagnostic frameworks and the emerging biological heterogeneity of ON, a tension that underpins the structure and critical perspective of the present review. Full article

Jones fractures are Zone 2 fractures of the fifth metatarsal. Biomechanical comparisons of fixation strategies for Jones fractures remain limited by the lack of standardized, head-to-head evaluations across major fixation methods. The purpose of this study was to perform a standardized biomechanical comparison of six fixation configurations representing the three primary surgical techniques for Jones fractures and to examine the mechanical factors underlying differences in early construct stability. A synthetic fifth metatarsal model with a simulated Zone 2 fracture was stabilized using lateral plate fixation with different screw configurations, Kirschner wire fixation with or without tension-band wiring, or intramedullary headless screw fixation. All constructs were tested under displacement-controlled cantilever bending, and the force required to reach 1 mm of fracture site displacement was obtained and construct stiffness was calculated. Plate-based fixation demonstrated the highest resistance to bending deformation, followed by intramedullary screw fixation, whereas Kirschner wire-based constructs exhibited the lowest stability. These differences were explained by variations in load-sharing pathways and effective working length among fixation constructs. The addition of tension-band wiring did not result in a measurable improvement in stability compared with Kirschner wire fixation alone, consistent with the dependence of tension-band mechanisms on active muscle loading not represented in the experimental model. These findings provide a unified biomechanical comparison of commonly used fixation constructs for Jones fractures and clarify the mechanical basis for differences in early construct stability. Full article

Background and Objectives: Coronal plane deformities of the knee, particularly genu valgum and varum, represent common indications for guided growth in pediatric orthopedics. This study evaluates the clinical and radiographic outcomes of temporary hemiepiphysiodesis using tension-band plates in skeletally immature patients and identifies factors associated with successful correction. Materials and Methods: A retrospective review was conducted on patients treated with tension-band plate hemiepiphysiodesis for knee valgus or varus deformities between 2012 and 2023. Inclusion required open physes, pre- and postoperative full-length radiographs, and follow-up until implant removal or skeletal maturity. Mechanical axis parameters (mLDFA, mMPTA) were compared pre- and postoperatively, and correction rates were calculated. Idiopathic cases were analyzed separately from those with neurological or osteological disorders. Results: Sixty-six limbs were included (51 valgus, 15 varus). In the idiopathic subgroup, significant correction was achieved, with mLDFA improving by +5.19° and mMPTA by −1.88°, corresponding to annual correction rates of 4.75°/year and −1.74°/year, respectively (p < 0.001). Regression analysis showed no significant predictive value of age or treatment duration for total correction. Patients with pathological physes demonstrated inconsistent outcomes, often requiring additional procedures. No major complications occurred. Conclusions: Temporary hemiepiphysiodesis using tension-band plates is a safe, minimally invasive, and highly effective method for correcting idiopathic valgus deformities in growing children, with correction rates comparable to the existing literature. Outcomes in patients with neurological or osteological comorbidities remain less predictable, underscoring the need for individualized planning and close follow-up. Full article

Understanding the deformation–failure process of sandstone is essential for energy extraction and stability assessment. Here, laboratory mechanical tests and discrete element simulations are combined to resolve how grain size controls deformation, cracking, and failure. Under uniaxial compression, fine-grained sandstone shows the highest strength (60.85–65.37 MPa) yet undergoes an abrupt brittle transition to axial splitting at a small peak axial strain of 0.41–0.42%; coarse-grained sandstone exhibits lower strength (26.94–28.67 MPa) but fails at peak axial strains of 0.44–0.53%, on average about 17% higher than those of FGS, indicating enhanced ductility; medium-grained sandstone lies in between in both strength (41.15–43.79 MPa) and peak axial strain (0.42–0.45%). With confining pressure, fine- and medium-grained sandstones display pronounced process evolution toward ductility, whereas coarse-grained sandstone shows limited pressure sensitivity. DEM results link microcrack evolution with the macroscopic response: under uniaxial loading, fine-grained sandstone is dominated by intergranular tensile cracking, while coarse-grained sandstone includes more intragranular cracks. Increasing confinement controls the cracking process, shifting fine- and medium-grained rocks from intergranular tension to mixed intragranular tension–shear, thereby enhancing ductility; in contrast, coarse-grained sandstone at high confinement localizes shear bands and remains relatively brittle. Normalized microcrack aperture distributions and fragment identification capture a continuous damage accumulation process from micro to macro scales. These process-based insights clarify the controllability of failure modes via grain size and confinement and offer optimization-oriented guidance for design parameters that mitigate splitting and promote stable deformation in deep sandstone reservoirs and underground excavations. Full article

Structural heterogeneity plays a crucial role in enhancing the mechanical properties of metallic glasses (MGs) by impeding the propagation of shear bands (SBs). Metallic glass matrix composites (MGCs) consisting of reinforcements are of great interest as they enhance the mechanical performance of brittle MGs. However, managing the dispersity of hetero-phases within the glassy matrix presents technical challenges due to surface tension and thermal property incompatibility. Binodal phase separation is an effective approach for fabricating MGCs with uniformly dispersed glassy droplets or particles. The species of matrix and characteristics of particle reinforcements significantly influence mechanical properties. This study theoretically examines how the fraction, size, and variety of particle reinforcements influence performance using finite element models based on free volume theory. The synergistic mechanisms for performance tuning involve stress fields generated by particle reinforcements that modify the nucleation and propagation of SBs in the matrix. Additionally, the size effect of particles depends on their interaction with SBs. This comprehensive understanding could substantially enhance the design and optimization for MGCs. Full article

This study introduces a comprehensive three-dimensional micromechanical framework to capture the nonlinear mechanical behavior of diverse composite materials, including coupled elastic degradation, inelastic strain evolution, and phenomenological failure in their constituents. The primary objective is to integrate a generalized elastic degradation–inelasticity (EDI) model into the parametric high-fidelity generalized method of cells (PHFGMC) micromechanical approach, enabling accurate prediction of nonlinear responses and failure mechanisms in multi-phase composites. To achieve this, a unified three-dimensional orthotropic EDI modeling formulation is developed and implemented in the PHFGMC. Grounded in continuum mechanics, the EDI employs scalar field variables to quantify material damage and defines an energy potential function. Thermodynamic forces are specified along three principal directions, decomposed into tensile and compressive components, with shear failure accounted for across the respective planes. Inelastic strain evolution is modeled using incremental anisotropic plasticity theory, coupling damage and inelasticity to maintain generality and flexibility for diverse phase behaviors. The proposed model offers a general, unified framework for modeling damage and inelasticity, which can be calibrated to operate in either coupled or decoupled modes. The PHFGMC micromechanics framework then derives the overall (macroscopic) nonlinear and damage responses of the multi-phase composite. A failure criterion can be applied for ultimate strength evaluation, and a crack-band type theory can be used for post-ultimate degradation. The method is applicable to different types of composites, including polymer matrix composites (PMCs) and ceramic matrix composites (CMCs). Applications demonstrate predictions of monotonic and cyclic loading responses for PMCs and CMCs, incorporating inelasticity and coupled damage mechanisms (such as crack closure and tension–compression asymmetry). The proposed framework is validated through comparisons with experimental and numerical results from the literature. Full article