Search Results (90)

This article develops a systematic reinterpretation of Amartya Sen’s capability approach as a human-centered renewal of the theory of justice grounded in Adam Smith’s moral philosophy. The central claim is that the epistemological foundation of Sen’s theory does not primarily depends on Kantian normativism mediated by Rawls’s theory of justice as fairness, but rather on The Theory of Moral Sentiments, particularly it depends on the concepts of “sympathy”, “impartial spectator”, and justice interpreted as “a social practice”. Through a genealogical reconstruction that brings Aristotle, Adam Smith, and Amartya Sen into dialog, the paper argues that the capability approach can be interpreted as an alternative tradition to Enlightenment theories of justice, because oriented toward human person flourishing and the public evaluation of real freedoms. By overcoming the limits of classical liberal egalitarianism and transcendental institutionalism, the article shows that Sen’s formalization of extended sympathy within social choice theory enables a comparative, pluralistic, and non-dogmatic conception of justice, capable of assessing real social states without recourse to transcendental foundations. In line with the thematic focus of the Special Issue Adam Smith’s Philosophy and Modern Moral Economics, the paper highlights the implications of this interpretation for contemporary moral economics, economic justice, human development, and the role of markets in pluralistic democratic societies. Full article

The paper contends that post-Christianity in the West is a condition whose genealogy can be traced to fifteenth-century humanism and the subsequent events of the Reformation and the Enlightenment. The essence of this condition lies in the emergence of the state, an outcome from centuries of debate concerning the domain of the spiritual versus secular authority over man and his world. This discourse ultimately undermined the authority of the ecclesiastical order and, consequently, Christianity in the West. And as the Christian foundation of the West gradually eroded, it was replaced by the secular, i.e., the state. This withering of Christianity has allowed the political, the emblematic feature of the state, to occupy the place previously held by the divine. The triumph of the secular realm has brought to saliency the centrality of the secular religion, i.e., the state, which strives to achieve broad, and often contradictory, social justice and equality goals, all in pursuit of its perceived noble aim of attaining happiness in this life. Full article

In recent years, there has been an unprecedented upsurge in opioid prescriptions for pain management. Consequently, the widespread availability of these medicines has led to an increase in misuse and abuse. This has led to a greater number of overdose-related deaths. The high prevalence of drug misuse was born of multiple and complex societal factors. However, from a medical perspective, critical contributors to the dire consequences of the crisis have been the need for chronic pain relief, as well as mental health issues within communities. Chronic pain coupled with psychological distress exacerbates patients’ predicaments and thus further fuels the crisis. Anxiety and depression have bidirectional and complex relationships with pain. The somatic symptoms associated with anxiety potentially worsen pain, whilst pain emanating from a chronic condition worsens anxiety. The same relational dynamic applies to depression and pain. Thus, these psychopathological states may be major contributors to the opioid abuse epidemic. Thus, psychosocial management as a first-line treatment instead of starting with drug treatments seems an enlightened approach to this problem. Cognitive behavioral therapy (CBT) has been proven to be effective in managing specific symptoms associated with chronic pain. Similarly, patient education has been shown to be a viable alternative to drugs for certain aspects of chronic pain treatment. We consider that the opioid crisis could be addressed with a greater reliance and emphasis on non-pharmacological approaches to managing chronic pain patients. This mini-review examines non-pharmaceutical and monitoring-based interventions to reduce opioid misuse risk among adults prescribed opioids for chronic non-cancer pain. Studies were identified through PubMed/MEDLINE, Scopus, and Google Scholar using terms related to chronic pain, prescription opioid misuse, opioid use disorder, cognitive behavioral therapy, patient education, prescription drug monitoring programs, digital health, telehealth, and non-pharmacological interventions. Studies were included if they focused on adults with chronic pain who were prescribed opioids or at risk of misuse, and evaluated interventions aimed at reducing unsafe opioid use, misuse risk, or opioid-related harm. Evidence was synthesized narratively to identify key intervention approaches, limitations, and clinical implications. Full article

During the critical period of agricultural green transformation, clarifying the evolutionary logic of farmers’ green production behavior under a multi-stakeholder framework provides significant insights for implementing “Dual Carbon” goals, establishing long-term mechanisms for high-quality agricultural development, and resolving deep-seated contradictions in agricultural non-point source pollution. Based on the social co-governance and public participation framework, this paper constructs a tripartite evolutionary game model involving government departments, farmer groups, and the general public, grounded in cost–benefit analysis, social governance friction, and evolutionary game theory. Through simulation, the study explores the equilibrium states and the specific impacts of varying parameter values on stable points. The findings reveal that: (1) The “interest price scissors” (benefit disparity) between green and conventional production is the key determinant of farmers’ strategic equilibrium. Once this structural contradiction is resolved, green production becomes the optimal strategy. (2) Farmers are highly sensitive to marginal cost–benefit fluctuations, leading to a sequential behavioral cascade: farmers retreat first, followed by the government, and finally the public. (3) Public participation cost is the pivotal variable for activating the co-governance mechanism, and the application of digital governance tools determines the time required to reach equilibrium. (4) A “Success Paradox” exists in government regulation; incentive mechanisms must be adjusted promptly after initial success. (5) Integrated policy combinations outperform single instruments; breaking the “locked-in” state requires a policy shock of sufficient intensity. This research offers a theoretical basis and policy enlightenment for optimizing the social co-governance landscape and promoting sustainable agricultural modernization. Full article

Zhuangzi, a seminal figure in ancient Chinese philosophy, offers profound insights into emotional well-being through his Qi-emotion theory. This paper examines Zhuangzi’s approach to emotional well-being by exploring the interplay between Qi (vital energy), atmosphere, and emotions. By drawing comparative perspectives from Neo-Phenomenology’s concept of atmosphere and the Chinese classical concept of Qi-feeling, the study challenges traditional views that emotions are solely internal phenomena. Instead, it proposes that emotions are field-like, arising from dynamic interactions between individuals and their environments. Through an in-depth analysis of Zhuangzi’s philosophy, particularly his methods of self-cultivation such as “fasting the mind” (xin zhai 心齋) and non-action (wu wei 無爲), this paper illustrates how aligning oneself with the Dao (the Way 道) and harmonizing Qi can lead to emotional balance and spiritual freedom. The study integrates Eastern and Western philosophical traditions, highlighting the significance of enlightened mind, embodiment, and atmospheric resonance in achieving emotional well-being. The findings suggest that Zhuangzi’s Qi-emotion theory provides valuable insights for contemporary philosophical practice and therapy by emphasizing the unity of mind, body, and environment. By fostering harmony with the natural world and transcending personal attachments, individuals can attain a state of inner peace and holistic well-being. Full article

Relation extraction serves as an essential task for knowledge acquisition and management, defined as determining the relation between two annotated entities from a piece of text. Over recent years, zero-shot learning has been introduced to train relation extraction models due to the expensive cost of incessantly annotating emerging relations. Current methods endeavor to transfer knowledge of seen relations into predictions of unseen relations by conducting relation extraction through different tasks. Nonetheless, the divergence in task formulations prevents relation extraction models from acquiring informative semantic representations, resulting in inferior performance. In this paper, we strive to exploit the relational knowledge contained in pre-trained language models, which may generate enlightening information for the representation of unseen relations from seen relations. To this end, we investigate a Prompt-Contrastive learning perspective for Relation Extraction under a zero-shot setting, namely PCRE. To be specific, based on leveraging semantic knowledge from pre-trained language models with prompt tuning, we augment each instance with different prompt templates to construct two views for an instance-level contrastive objective. Additionally, we devise an instance-description contrastive objective to elicit relational knowledge from relation descriptions. With joint optimization, the relation extraction model can learn how to separate relations. The experimental results show our PCRE method outperforms state-of-the-art baselines in zero-shot relation extraction. The further extensive analysis verifies that our proposal is robust in different datasets, the number of seen relations, and the number of training instances. Full article

Technocracy refers to any political–social–economic system that is governed and managed using purportedly objective scientific and technical principles, and in which ultimate power and authority rests with technical and scientific experts. The concept had its initial origins in the early decades of the Industrial Revolution (with antecedents stretching back to the rationalism of ancient Greece and, later, the Enlightenment in the West). Henri Saint-Simon in early 19th century France was the earliest exponent of a technocratic system which involved overall political and economic government by industrialists. Technocracy was formally coined as a term in the early 20th century in the United States in the context of a specific intellectual movement under the same name which laid out a more detailed system of economic and social management by industrialists and scientists that supposedly would guarantee maximum efficiency in production, consumption and distribution without the self-defeating tendencies of political systems of the time, either democratic or authoritarian. Technocracy is currently used to refer to any policy or governmental arrangement that purportedly emphasizes technical criteria above non-technical values in policy, planning and public decision-making, and which gives significant authority to experts. Singapore is often referred to as a leading example of such an approach. Various controversies have arisen around technocracy, especially its potential incompatibility with democracy and social values that are not easily translated into technical terms. There is also debate about how feasible a genuine technocracy actually is in practice. Full article

In the last half century, the approach that identifies the influence of the Enlightenment in the academic and public activities of the ecclesiastical intellectuals has taken root in the history of ideas, including in Central and Eastern Europe. One of the aims of this trend is to identify the reform ideas that emerged among the leaders of Christian churches and non-Christian religious communities to modernize pastoral practice. As one of the most important results, the changes that took place in the second half of the 18th century are no longer seen as the inevitable consequence of external forces, primarily from the state, but also as the derivative of internal aspirations in dialog with the ‘Zeitgeist’. Previous scholarly work, however, rarely examined the theoretical considerations behind the reform of religious practice, which can in fact be explained by changes in the image of the church among the ecclesiastical intelligentsia. The study aims to illustrate these changes in the ecclesiastical image by means of three contemporary texts, focused on the episcopal oath and the reform of the clergy. Full article

The article is focused on the recent exegetical trend of “contextual” readings of the Bible, or context-sensitive exegesis in global Biblical scholarship. It is written by three authors from different ethnic and cultural contexts (German, Korean, Ethiopian) in order to emphasize the diversity to be considered. In the first part, the aims, history and relevant factors of contextual reading are described. The second part makes clear that also the traditional historical-critical exegesis is strongly contextual, drawing on Enlightenment thought and Western views of life. Therefore, any claims of “objectivity” or universality are problematic. In the third and fourth section of the article, two different contexts from global Christianity or the Majority World are introduced. first the African, especially Ethiopian context under the label of “vulnerability”, and then an Asian, precisely South Korean context with regard to the understanding of spirits and demons. The Ethiopian author describes how vulnerability has generally shaped the African cultural experience and specifically common language in Ethiopia, including religious attitudes which are characterized by a general openness for the divine. She also shows, that in such a culture, with the danger of naivete and acceptance of many problematic interpretations critical discernment is needed, as has already been stated by an Ethiopian philosopher of the 17th century. The part on Korean interpretation discusses the various views on spirits and demons in Korean Bible translations and the influence of Confucian thought and Shamanism on readings of the Bible. Using the example of the Gerasene demoniac, the author shows readers aware of shamanic ritual including pigs and intended to pacify the restless souls can impact the reading of this particular Biblical text even among modern Koreans. A brief concluding section draws some conclusions. Both examples demonstrate the diversity of contexts and their resonances with the Biblical texts when they are read in these different contexts. It is also obvious that there is not a single clear-cut dualism between Western and “postcolonial” readings. Neither the historical readings nor the contextual are “right” as such. Rather, there should be an open dialogue, on equal footing, that considers the context and also allows for critical interaction in order to prevent abuse of biblical texts, not only in colonial relations, but also within a given context by traditionalists, political powers, and spiritual authorities, so that the liberating power of the gospel can come into effect, for the benefit its readers. Full article

Acute respiratory distress syndrome (ARDS) is an inflammatory pulmonary condition that remains at alarming rates of fatality, with neutrophils playing a vital role in its pathogenesis. Beyond their classical antimicrobial functions, neutrophils contribute to pulmonary injury via the release of reactive oxygen species, proteolytic enzymes, and neutrophil extracellular traps (NETs). To identify targets for treatment, it was found that epigenetic mechanisms, including histone modifications, hypomethylation, hypermethylation, and non-coding RNAs, regulate neutrophil phenotypic plasticity, survival, and inflammatory potential. It has been identified that neutrophils in ARDS patients exhibit abnormal methylation patterns and are associated with altered gene expression and prolonged neutrophil activation, thereby contributing to sustained inflammation. Histone citrullination, particularly via PAD4, facilitates NETosis, while histone acetylation status modulates chromatin accessibility and inflammatory gene expression. MicroRNAs have also been shown to regulate neutrophil activity, with miR-223 and miR-146a potentially being biomarkers and therapeutic targets. Neutrophil heterogeneity, as evidenced by distinct subsets such as low-density neutrophils (LDNs), varies across ARDS etiologies, including COVID-19. Single-cell RNA sequencing analyses, including the use of trajectory analysis, have revealed transcriptionally distinct neutrophil clusters with differential activation states. These studies support the use of epigenetic inhibitors, including PAD4, HDAC, and DNMT modulators, in therapeutic intervention. While the field has been enlightened with new findings, challenges in translational application remain an issue due to species differences, lack of stratification tools, and heterogeneity in ARDS presentation. This review describes how targeting neutrophil epigenetic regulators could help regulate hyperinflammation, making epigenetic modulation a promising area for precision therapeutics in ARDS. Full article

This review essay proposes that the influence of individualism, the tendency to prefer individual freedoms over collective obligations, in American society impacted the manner in which the US population responded to the recent global COVID-19 pandemic. During the pandemic, societal rifts were exposed that questioned the infringement on personal freedoms by governmental authority in the effort to protect public health. The essay traces the development of individualism from the Enlightenment through the emergence of the United States, during which individualism entwined with American identity. A review of social science research in the fields sociology, psychology, and anthropology demonstrates the ways in which individualism, in varying degrees from self-centered to collectivist tendencies, can be observed to affect social interaction and perception. With that background, it is possible to use individualism as a lens to investigate cultural responses to affliction. Societal responses to leprosy, syphilis, and COVID-19 are examined, and it is argued that the influence of degrees of individualism greatly impacted the social responses, and the extent to which individual freedoms were lost was notably varied in each case. Full article

Insoluble dietary fibers (IDFs) represent one of the most promising candidates for novel food formulations, since they can be produced from a wide range of food by-products and wastes, have health benefits, and often enhance the rheology and stability of foods. Recently, the most innovative engineering and processing aspects of these attractive ingredients have received considerable attention. The present work is aimed at enlightening the technological state of the art regarding IDFs (much less investigated than soluble fibers, as discussed in this review). The review begins with a brief but crucial discussion on the definition of this type of dietary fiber by highlighting the raw materials, functional properties, physiological activity, and stabilization capacity in food products. The analysis of the rheological methods dedicated to the technical investigations of these ingredients and recent advancements are discussed. Finally, food processing technologies used in the formulation of foods containing insoluble IDFs, such as homogenization techniques, are discussed. Full article

Diphtheria is a severely infectious and deadly bacterial disease with Corynebacterium diphtheriae as the causative agent. Since the COVID-19 pandemic, contagious diseases such as diphtheria have re-emerged due to disruptions in routine childhood immunization programs worldwide. Nigeria is witnessing a significant increase in diphtheria outbreaks likely due to an inadequate health care system and insufficient public enlightenment campaign. This paper presents a mathematical epidemic diphtheria model in Nigeria, which includes a public enlightenment campaign to assess its positive impact on the prevalence of the disease. The mathematical analysis of the model reveals two equilibrium points: the diphtheria infection-free equilibrium and the endemic equilibrium. These equilibrium points are shown to be stable globally asymptotically if ${\mathcal{R}}_c<1$ and ${\mathcal{R}}_c>1$, respectively. The model was fit using the confirmed diphtheria cases data of Kano State from January to December 2023. Sensitivity analysis indicates that the transmission rate and recovery rate of asymptomatic peopleare crucial parameters to be considered in developing effective strategies for diphtheria control and prevention. This analysis also reveals that the implementation of a high-level public enlightenment campaign and its high efficacy effectively reduce the prevalence of diphtheria. Finally, numerical simulations show that combining the public enlightenment campaign and isolating infected individuals is the best strategy to contain the spread of diphtheria. Full article

The Huayan Grotto in Anyue County is one of the most typical caves of the grottoes of Sichuan 四川 and Chongqing 重慶. Being well known for its grand scale and the beautiful style of its sculptures, the cave was designed and carved by the Liu-Zhao sect 柳趙教派 in eastern Sichuan during the Southern Song Dynasty. The Liu-Zhao sect is a local religious group that relies on grottoes and statues to state concepts, propagate ideas, and spread doctrines. The sect is good at integrating a variety of Buddhist thoughts to form its own unique theoretical and practical system. The large-scale statue-making activities under the auspices of the Liu-Zhao sect 柳趙教派 are a classic example of the localization of Buddhism in Southwest China. The ideological system of the Liu-Zhao sect is centered on Huayan, and Huayan Grotto is the very concentration of its special philosophy. This paper considers that the cave constitutes a holy place, with a theme of thoughts of Huayan, which was built based on important doctrines of two masters. Through the combination and arrangement of diversified images, the cave is so far the most complex, complete, and systematic visualized representation of the Huayan’s theory and practice. Inside the cave are carved full-length portraits of Li Tongxuan 李通玄, the Elder of Huayan, and Guifeng Zongmi 圭峰宗密, the fifth patriarch of the Huayan sect. There are also statues and inscriptions that illustrate Li’s thoughts, such as the Ten Assemblies in Ten Locations 十處十會and the Sudhana’s Pilgrimage 善財遍參based on Li’s exegetical writings on the Avataṃsaka Sūtra; the Three Saints of the Huayan School (Huayan sansheng 華嚴三聖) carved on the basis of Li’s pioneering idea about the trinity of three saints; and the mind-only verse 惟心偈, emphasizing mind as the foundation of Avataṃsaka practice. Zongmi’s Avataṃsaka thoughts were mainly expounded through a series of commentaries on the Sutra of Perfect Enlightenment 大方廣圓覺修多羅了義經, to which the impressive Twelve Bodhisattvas of Perfect Enlightenment are directly related. In addition to the theoretical system, the cave offers two means for Avataṃsaka practice. Highly qualified Avataṃsaka practitioners practice by viewing the Trinity of Three Saints and the Buddha’s Light, and then they go through five phases of fruition to attain Buddhahood, which is the Avataṃsaka practice dominated by Li Tongxuan’s thoughts. Less qualified practitioners practice through repentance liturgies and sitting in meditation at the Ritual Site of Perfect Enlightenment, which is the practice of Perfect Enlightenment advocated by Zongmi 宗密. Full article

This paper challenges the conventional view that pre-Qin Confucianism represents kingly virtue politics that lacks institutional duty. By interpreting Xunzi’s notion of yi 義, particularly gong-yi 公義, as a form of public obligation, I show that Xunzi exposes yi to state institutions to oblige people to serve public ends. While institutional duty is often associated with post-Enlightenment political philosophy, this paper argues that Xunzi’s philosophy offers a comparable framework of public–private exchange. Xunzi’s gong-yi may be a public-servicing sense of duty that combines moral and civic dimensions, compelling individuals to cooperate for the collective good. Unlike social contract theories that trade private rights with public duties, Xunzi’s system relies on moral compulsion and normative reciprocity. This system posits a sensible exchange between individual duties from inner compulsion for the public good. By contrasting gong 公 (the public) with si 私 (the private), Xunzi envisions the public as an entity that is serviced through public duties and a place for human flourishing. Positioning the role of gong-yi in Xunzi’s broader institutional project crystalizes this nascent concept of a “public” and its relationships with civic duties. Full article