Search Results (1,381)

Two new species assigned to the genus Myanmarina of the family Myanmarinidae are described and figured from male specimens preserved in Upper Cretaceous ambers from the Hukawng Valley of northern Myanmar. Myanmarina simplex sp. nov. can be distinguished by a small head, 13-segmented antennae, the first flagellomere equal to the second one in length and protibiae with a bifurcated spur. Myanmarina grandis sp. nov. is established based on a large head, 11-segmented antennae, the first flagellomere shorter than the second one and all tibiae with a spur and dorso-apical tooth. In addition, the key to known species of Myanmarina was updated. Full article

Reports of carbon monoxide (CO) pharmacology have spurred intense interest in developing its fluorescent probes with much success. However, one unfortunate event in this area is the wide-spread use of chemically reactive metal/BH₃-CO complexes as “CO-releasing molecules” or CORMs that do not produce CO or produce CO in an idiosyncratic fashion. Consequently, a large number of reported fluorescent “CO probes” only respond to the CORM used, but not to CO. Though most of these issues have been clarified in the literature, there is a surprising recent publication on a Cu(II)-based fluorescent “CO probe,” Nap-BC-Cu(II), relying on undefined chemical principles. We reassessed the ability for Nap-BC-Cu(II) to detect CO and found no evidence for Nap-BC-Cu(II) to selectively detect CO at even non-physiologically relevant high concentrations (high micromolar) of CO. Marginal effects were observed only when CO was continuously bubbled through the “probe” solution for 15 min. Further, Nap-BC-Cu(II) was found to be sensitive to ascorbic acid and cysteine. Overall, this probe did not respond to CO in a pathophysiologically relevant context. Our findings do not support the notion of Nap-BC-Cu(II) being a CO probe for studying CO biology. We hope this will be the last of this saga of “CO probes” that do not afford selective detection of CO, largely due to the confusions caused by using chemically reactive CORMs. Full article

Food security remains a critical challenge in Nigeria. As a result, this research examines the impact of fertilizer use, economic expansion, population growth, and methane emissions on food security in Nigeria from 1970 to 2022. The methodologies used include the Autoregressive Distributed Lag (ARDL) model, Wald Test, and the Spectral Granger Causality test. The ARDL results demonstrate that in the long run, fertilizer use spurs food security, although not significantly, while population growth reduces food security insignificantly. On the other hand, economic expansion and agricultural methane emissions are positively associated with food security, likely reflecting scale effects of agricultural production rather than a direct beneficial role of emissions. In the short run, fertilizer use and methane emissions drive food security. The Wald Test also confirms the short-run findings. Furthermore, the Spectral Granger Causality test showed that fertilizer use and economic expansion Granger-cause food security in the long, medium, and short term. Population growth, however, Granger-causes food security only in the long term, while methane emissions Granger-cause food security in the medium and long term. Based on these results, policies are recommended, and their further implications are discussed. Full article

Bacteriophages, or phages, are viruses that specifically infect and lyse bacterial cells. Since their discovery 110 years ago, they have held a unique place in microbiology, medicine, and agriculture as both scientific tools and potential therapeutic agents. The concept of employing phages to combat bacterial infections, known as phage therapy, predates the antibiotic era and has undergone cycles of enthusiasm, neglect, and revival. Initially explored in the early 20th century, phage therapy offered a targeted biological approach to bacterial disease control. However, the widespread adoption of antibiotics led to a significant reduction in phage research, which only regained momentum in recent decades owing to the global rise of antibiotic-resistant bacteria and increasing demand for environmentally sustainable disease management strategies. This review traces the complete timeline of this history, highlighting key milestones in phage discovery, molecular microbiology, the antibiotic era, and the resulting critical events that spurred the modern phage renaissance in plant disease management. Finally, the significance of cutting-edge integration of synthetic biology, advanced phage delivery systems, and artificial intelligence (AI), which could drive the development of next-generation biopesticides, is also discussed. Full article

Efficacy beliefs influence individuals’ thinking and academic outcomes. Indeed, a growing body of literature has identified self-efficacy (SE) as a predictor of a range of favourable outcomes and a buffer against the likelihood of less desirable ones. The evidence linking high levels of SE to positive outcomes has spurred interest in understanding how such beliefs are developed and sustained, particularly via the theorised sources of efficacy information: mastery experience, vicarious experience, social persuasion and physiological state. However, while most research on the sources of mathematics SE is quantitative, no prior review has systematically examined the qualitative literature. This review analyses eight qualitative or mixed-methods studies on these sources in primary and secondary students. It demonstrates that qualitative data illuminate how SE-relevant information is individually interpreted and how even a single encouraging comment can have a lasting influence. The source-specific findings indicate that the development of mathematics SE is less about isolated experiences and more about how those experiences are socially mediated, interpreted, and emotionally supported—most notably through teachers’ practices and relational environments. In addition, five broader cross-source insights are discussed following a critical examination of how future research can build on the strengths of existing qualitative studies. Full article

The optimal branch bending angle for Pyrus sinkiangensis Yü (Korla fragrant pear) remains undefined. In this study, the optimal angle was determined by integrating the phenological, nutritional, hormonal, and fruit-quality responses across a 15-day bloom window. Four branch angles (40°, 60°, 80°, and 100°) were applied to 8-year-old trees in spring 2022, and flowering dynamics, bud carbon/nitrogen status, leaf morphology/mineral content, fruiting-shoot architecture, endogenous hormones, and fruit quality were comprehensively evaluated. The 80° angle maximized the fruit set (11.77%) and bud soluble sugar content (8.84 mg/g DW), significantly outperforming the other angles (p < 0.05). The flowering rate peaked at 100° (7.89%) but was statistically comparable to that at 60° and 80° (p > 0.05); calyx removal was greatest at 60° (73.33%), with no significant difference from that at 80° (71%, p > 0.05). These reproductive benefits aligned with enhanced leaf source capacity—80° pulling resulted in the greatest leaf area (59.51 cm²), the greatest amount of chlorophyll (3.11 mg/g DW), and elevated N/Mg/Cu concentrations. Branch architecture was optimized at 80°, with the percentage of medium fruiting spurs reaching 41.1% and the xylem:phloem dry-weight ratio peaking at 1.78, indicating the development of efficient assimilate transport pathways. Hormonally, 80° triggered a distinct cascade: a transient GA₄/GA₇ surge (50.6 and 1.34 ng/g DW) on 28 April, followed by sustained IAA elevation (2.05 ng/g DW) and zeatin stabilization (0.27–0.29 ng/g DW) during ovary development. Consequently, the fruit quality was comprehensively improved at 80°—the single-fruit weight (110.7 g), soluble sugar content (10.08 mg/g DW), and sugar/acid ratio (17.08) were greatest, whereas the stone-cell content was lowest (0.49 mg/g DW). Principal component analysis of 57 traits confirmed 80° as the system-wide optimum (D = 0.718). These results demonstrate that an 80° bending angle synchronizes carbohydrate supply, hormone signaling, and fruit quality in Korla fragrant pear, providing a low-cost, nonchemical benchmark for precision canopy management in high-density orchards. An 80° branch-bending angle optimizes carbon-hormone synergy via a transient GA₄/GA₇ surge and sustained IAA-zeatin signaling, maximizing fruit set and quality in high-density Korla fragrant pear orchards. Full article

The threat of antimicrobial resistance (AMR) and the need for sustainable disinfectants have spurred interest in natural antimicrobials such as essential oils (EOs). However, their application is limited by volatility, poor water solubility, and cytotoxicity. Herein, we present the development of bio-based core–shell sub-micro-/nanocapsules (NCs) with encapsulated oregano (OO), thyme (TO), eucalyptus (EuO), and tea tree (TTO) oils to enhance antimicrobial (AM) performance and reduce cytotoxicity. NCs were synthesized via a nanoencapsulation method using chemically modified zein or poly(methyl vinyl ether-co-maleic anhydride) (GZA) as shell polymers, with selected EOs encapsulated in their core (encapsulation efficacy > 98%). Chemical modification of zein with vanillin (VA) and GZA with either dodecyl amine (DDA) or 3-(glycidyloxypropyl)trimethoxysilane (EPTMS) resulted in improvement in particle size distributions, polydispersity indices (PDIs) of synthesized NCs, and in the stability of the NC-dispersions in water. Antibacterial testing against Staphylococcus aureus and cytotoxicity assays showed that encapsulation significantly reduced toxicity while preserving their antibacterial activity. Among the formulations, GZA-based NCs modified with EPTMS provided the best balance between safety and efficacy. Despite this, life cycle assessment revealed that zein-based NCs were more environmentally sustainable due to lower energy use and material impact. Overall, the approach offers a promising strategy for developing sustainable, effective, and safe EO-based antibacterial agents for AM applications. Full article

Background: Plant architecture, particularly branching patterns, plays a crucial role in plant growth, photosynthetic performance, and yield. Spur-type apple, characterized by compact growth, early fruiting, high productivity, and manageable canopy structure, represent valuable germplasm for establishing dwarf and high-density apple orchards. While hybrid breeding of spur-type varieties offers significant potential for genetic advancement, severe segregation of traits in hybrid progeny and the difficulty of combining multiple favorable traits still significantly limit breeding efficiency. Moreover, the genetic basis and molecular mechanisms of the spur-type trait remain poorly understood at the genomic level, hindering the development of precise molecular breeding approaches. Methods: To address this, we used the spur-type line ‘0301-13-14’ and the non-spur-type line ‘0301-50-32’ from hybrid progenies of the spur-type cultivars ‘Miyazaki Spur Fuji’ and ‘Starkrimson’ to elucidate the regulatory mechanisms underlying apple branch formation and spur-type trait development by characterizing their branching traits, performing whole-genome resequencing analysis, and identifying candidate genes using bioinformatics analyses. Results: Anatomical observations revealed that the spur-type line ‘0301-13-14’ possessed smaller cells with a more compact spatial arrangement compared to the non-spur-type line ‘0301-50-32’. Whole-genome resequencing generated 5,003,968 high-quality single-nucleotide polymorphisms (SNPs) and 577,886 high-quality insertions/deletions (InDels). We further identified 29,157 candidate genes harboring predicted deleterious mutations (classified as high or moderate impact). Gene Ontology (GO) enrichment analysis indicated that genes associated with the spur-type trait were mainly enriched in molecular function and biological process categories. Specifically, variant genes related to molecular function were enriched in transferase and catalytic activities, while those in biological process were mainly involved in phosphorylation and phosphorus metabolism. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis showed that candidate genes were significantly enriched in environmental information processing and metabolic pathways. Conclusions: These results will provide a genomic foundation for identifying genes controlling spur-type branching traits and facilitate the genetic improvement of spur-type apple. Full article

This paper presents the results of a numerical study on the influence of the tooth root fillet manufacturing method on the bending strength of spur gears with straight teeth. A mathematical model describing the gear tooth geometry was developed, in which the transition curve at the tooth root was directly related to the applied machining process—either rack-type gear shaping or pinion-type gear shaping. Based on this model, a numerical procedure for calculating the bending stresses at the tooth root was formulated and verified using the finite element method (FEM). The results demonstrated high consistency between the proposed approach and FEM analysis, confirming the accuracy of the developed mathematical model and numerical methodology. The study also examined the effect of the tool fillet radius on the stress distribution in the root region. It was found that increasing the tool radius leads to a reduction in bending stresses, while the differences between the two machining methods gradually diminish. The proposed methodology offers a reliable numerical framework for assessing the strength of spur gears and can be effectively used in the design of lightweight, high-performance gear transmissions for aerospace and automotive applications. Full article

Considering the rapid iteration of you-only-look-once (YOLO)-series algorithms, this paper aims to provide a data-driven performance spectrum and selection guide for the latest YOLO series algorithm (YOLOv8 to YOLOv13) in printed circuit board (PCB) automatic optical inspection (AOI) through systematic benchmarking. A comprehensive evaluation of the six state-of-the-art YOLO series algorithms is conducted on a standardized dataset containing six typical PCB defects: missing hole, mouse bite, open circuit, short circuit, spur, and spurious copper. An innovative dual-cycle comparative experiment (100 rounds and 500 rounds) is designed, and a systematic assessment is performed across multiple dimensions, including accuracy, efficiency, and inference speed. The experimental results have revealed significant variations in algorithm performance with training cycles: under short-term training (100 rounds), YOLOv13 achieves leading detection performance (mAP50 = 0.924, mAP50-95 = 0.484) with the fewest parameters (2.45 million); after full training (500 rounds), YOLOv10 achieves the highest overall accuracy (mAP50 = 0.946, mAP50-95 = 0.526); additionally, YOLOv11 shows the optimal speed-accuracy balance after long-term training, while YOLOv12 excels in short-term training; moreover, “open circuit” and “spur” are evaluated as the most challenging defect categories to detect. The findings given in this paper indicate the absence of a universally applicable “all-in-one” algorithm and propose a clear algorithm selection roadmap: YOLOv10 is recommended for offline analysis scenarios prioritizing extreme accuracy; YOLOv13 is the top choice for applications requiring rapid iteration with tight training time constraints; and YOLOv11 is the best option for high-throughput online inspection PCB production lines. Full article

With the continuous proliferation of radio frequency devices, electromagnetic environments in various regions are becoming increasingly complex. Effective monitoring of the electromagnetic environment and identification of interference sources have thus become critical tasks for maintaining order in the electromagnetic spectrum. In recent years, rapid advances in UAV technology have spurred exploration of UAV-based electromagnetic spectrum monitoring as a novel approach. However, the limited payload capacity and endurance of UAVs constrain their monitoring capabilities. To address these challenges, we propose HMUDRL, a distributed heterogeneous multi-agent deep reinforcement learning algorithm. By leveraging cooperative operation between cluster-head UAVs (CH) and cluster-monitoring UAVs (CM) within a heterogeneous UAV swarm, HMUDRL enables high-precision detection and wide-area localization of UHF radiation source. Furthermore, we integrate a minimum-gap localization algorithm that exploits the spatial distribution of multiple CM to accurately pinpoint anomalous radiation sources. Simulation results validate the effectiveness of HMUDRL: in the later stages of training, the success rate of localizing target radiation sources converges to 96.1%, representing an average improvement of 1.8% over baseline algorithms; localization accuracy, measured by root mean square error (RMSE), is enhanced by approximately 87.3% compared to baselines; and communication overhead is reduced by more than 80% relative to homogeneous architectures. These results demonstrate that HMUDRL effectively addresses the challenges of data transmission control and sensing-localization performance faced by UAVs in UHF spectrum monitoring. Full article

Systemic sclerosis (SSc) is a disease in which malfunctioning immune cells lead to the formation of autoantibodies that damage blood vessels and body tissues. Fibrosis then develops in the affected organs. Its complex pathogenesis involves multiple immune and stromal cell types, soluble mediators, and dysregulated tissue repair, resulting in heterogeneous clinical manifestations and poor prognosis. Current disease-modifying therapies provide only modest benefits, often slowing but rarely reversing disease progression, and are associated with considerable adverse effects. These limitations have spurred the development of cell-based therapeutic strategies aimed at restoring immune tolerance and promoting tissue repair. In this review, we summarize recent advances in hematopoietic stem cell transplantation, mesenchymal stem cell therapy, and adoptive regulatory T cell transfer and highlight the emerging role of chimeric antigen receptor (CAR)-T cell therapy as a transformative approach for SSc. Collectively, these evolving strategies hold the potential to improve survival, achieve durable remissions, and significantly enhance quality of life for patients with SSc. Full article

Background: The main cause of chronic nasal obstruction in ENT practice is represented by the deviated nasal septum. Septoplasty remains the gold standard treatment, performed using either conventional or endoscopic techniques. Methods: A narrative review of the literature was conducted using PubMed and Google Scholar for studies published between May 1999 and October 2024. Eligible studies included adult patients (≥16 years) undergoing conventional or endoscopic septoplasty, with at least one reported outcome measure: NOSE, VAS, or SNOT-22 scores; operative time; or complication rates. Results: Across multiple clinical studies, both conventional and endoscopic septoplasty provided significant improvements in nasal airflow and symptom relief. Endoscopic septoplasty was consistently associated with superior intraoperative visualization, more precise correction of posterior deformities and isolated septal spurs, and lower rates of intraoperative and postoperative complications. Complication rates were low overall for both approaches. Conclusions: Current evidence supports both conventional and endoscopic septoplasty as effective treatments for nasal obstruction due to septal deviation. However, endoscopic septoplasty offers distinct advantages in terms of visualization, operative efficiency, and safety, making it an increasingly preferred technique. Full article

Rural e-commerce has spurred profound changes in rural production and living patterns. Taking the policy of E-commerce Entering Rural Areas as a quasi-natural experiment, based on the data from fixed observation points in rural China, this paper examines how rural e-commerce development affects rural households’ green production practices. The results show that (1) while rural e-commerce has generally led to a 5% increase in farmers’ chemical fertilizer use, its promoting effect on farmers’ chemical fertilizer input has been gradually weakening over time. (2) Crop planting types moderate the relationship between rural e-commerce and farmers’ fertilizer input behaviors. For farmers mainly planting food crops, rural e-commerce increases their chemical fertilizer use by 6.87%, while for those mainly planting cash crops, rural e-commerce reduces their chemical fertilizer use by 4.25%. (3) Mechanism analysis reveals that service outlet construction and e-commerce training for farmers are the main channels through which rural e-commerce drives farmers to increase fertilizer input, while brand cultivation is a channel through which rural e-commerce inhibits farmers’ fertilizer input, and this influence channel only exists among farmers mainly planting cash crops. Full article

Erinacine A, a cyathane diterpenoid derived from the medicinal and edible fungus Hericium erinaceus, is increasingly recognized for its potent neurotrophic and neuroprotective properties. It demonstrates significant therapeutic promise for neurodegenerative disorders, such as Alzheimer’s and Parkinson’s disease, primarily by stimulating the synthesis of nerve growth factor (NGF). However, the clinical applicability of erinacine A is currently restricted by its low yield from natural sources and high production costs. This challenge has spurred significant research focused on optimizing its production. This review provides a comprehensive overview of the current advancements in the fermentation-based preparation of erinacine A, including both liquid and solid-state cultivation techniques. Furthermore, we summarize its diverse biological activities, spanning neuroprotection, anticancer, and anti-inflammatory effects, and detail the recent discoveries elucidating its complex biosynthetic pathway. This consolidated overview offers insights into strategies for enhancing its production and supports its ongoing development as a therapeutic agent. Full article