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22 pages, 742 KB  
Article
Bounded Graph Conditioning for LiDAR 3D Object Detection Under Sensor Degradation
by Xiuping Li, Xiyan Sun, Jingjing Li, Yuanfa Ji and Wentao Fu
Sensors 2026, 26(9), 2667; https://doi.org/10.3390/s26092667 - 25 Apr 2026
Viewed by 619
Abstract
Light Detection and Ranging (LiDAR) three-dimensional (3D) object detection degrades under point sparsity, outliers, coordinate noise, and calibration drift, yet detector evaluation remains largely limited to clean benchmarks. This study focuses on sensing robustness rather than detector redesign. We introduce Bounded Graph Conditioning [...] Read more.
Light Detection and Ranging (LiDAR) three-dimensional (3D) object detection degrades under point sparsity, outliers, coordinate noise, and calibration drift, yet detector evaluation remains largely limited to clean benchmarks. This study focuses on sensing robustness rather than detector redesign. We introduce Bounded Graph Conditioning (BGC)—a deterministic pre-voxelization front-end that applies k-nearest-neighbor (kNN) neighborhood averaging with bounded residual correction upstream of an unchanged detector backbone. BGC is evaluated together with a reproducible sensor-degradation stress protocol and a risk-constrained operating-boundary analysis. Experiments on KITTI with PointPillars, SECOND, and Voxel R-CNN show that BGC most clearly improves retained detection quality and feasible operating coverage under strong noise and strong outlier stress; gains under other degradation types are smaller and backbone-dependent. In the primary score-level box-disjoint calibration/test evaluation on SECOND, maximum feasible coverage at a target risk bound of 0.2 improves from 0.0754 to 0.1374 under strong noise (σ=0.10 m) and from 0.1323 to 0.1591 under strong outliers (p=0.10); a cross-backbone check on Voxel R-CNN confirms the same direction (0.18600.2864). Comparison with traditional filtering (SOR and ROR) reveals complementary strengths across fault types. A range-adaptive BGC variant that adjusts parameters per distance bin further improves performance under mixed unknown faults, spherical-coordinate noise, and on a dataset-matched nuScenes validation (adaptive BGC mAP/NDS: 0.2687/0.4493 vs. baseline 0.2471/0.3846 under strong noise). Severe translation drift collapses all configurations to full rejection, exposing an explicit sensing boundary beyond the reach of local conditioning. These results support BGC as a practical sensor-side robustness enhancement under the studied degradation protocol, with conditional rather than universal applicability across backbones and fault types. Full article
(This article belongs to the Section Radar Sensors)
15 pages, 2271 KB  
Technical Note
Resource-Constrained 3D Volume Estimation of Lunar Regolith Particles from 2D Imagery for In Situ Dust Characterization in a Lunar Payload
by Filip Wylęgała and Tadeusz Uhl
Remote Sens. 2025, 17(20), 3450; https://doi.org/10.3390/rs17203450 - 16 Oct 2025
Viewed by 1386
Abstract
Future lunar exploration will depend on a clearer understanding of regolith behavior, as underscored by adhesion issues observed during Apollo. The Lunaris Payload, a compact instrument developed in Poland, targets in situ assessment of lunar regolith adhesion to engineering materials using a resource-constrained [...] Read more.
Future lunar exploration will depend on a clearer understanding of regolith behavior, as underscored by adhesion issues observed during Apollo. The Lunaris Payload, a compact instrument developed in Poland, targets in situ assessment of lunar regolith adhesion to engineering materials using a resource-constrained optical approach. Here we introduce and validate six lightweight 2D-to-3D geometric models for estimating particle volume from planar images, benchmarked against the high-resolution micro-computed tomography (micro-CT) ground truth. The tested methods include spherical, cylindrical, fixed-aspect-ratio ellipsoid, adaptive ellipsoid, and Feret-based models and an empirically scaled voxel proxy. Using micro-CT scans of adhered simulant particles, we evaluate accuracy across >8000 particles segmented from 2D projections. Ellipsoid-based models consistently outperform the alternatives, with absolute percentage errors of 30–35%, while fixed-aspect-ratio variants offer strong accuracy–complexity trade-offs suitable for mass- and power-limited payloads. To our knowledge, this is the first comprehensive benchmarking of six 2D-to-3D volume models against micro-CT for bulk-adhered lunar regolith analogs. The results provide a validated, efficient framework for in situ dust characterization and reliable particle mass estimation, advancing Lunaris’ capability to quantify regolith adhesion and supporting broader goals in dust mitigation, ISRU, or habitat construction. Full article
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15 pages, 3734 KB  
Article
Ionospheric Anomaly Identification: Based on GNSS-TEC Data Fusion Supported by Three-Dimensional Spherical Voxel Visualization
by Boqi Peng, Biyan Chen, Busheng Xie and Lixin Wu
Atmosphere 2025, 16(4), 428; https://doi.org/10.3390/atmos16040428 - 6 Apr 2025
Viewed by 1668
Abstract
Ionospheric tomography, an effective method for reconstructing 3-D electron density, is traditionally pictured by 3-D IED (ionospheric electron density) slices to express ionospheric disturbances, which may overlook the critical information in 3-D spherical manifold space. Here, we develop a novel visualization framework that [...] Read more.
Ionospheric tomography, an effective method for reconstructing 3-D electron density, is traditionally pictured by 3-D IED (ionospheric electron density) slices to express ionospheric disturbances, which may overlook the critical information in 3-D spherical manifold space. Here, we develop a novel visualization framework that integrates tomography reconstruction with a spherical latitude–longitude grid system, enabling the comprehensive characterization of 3-D IED dynamic evolution in 3-D manifold spherical space. Through this method, we visualized two cases: the Hualien earthquake on 2 April 2024 and the geomagnetic storm on 24 April 2023. The results demonstrate the evolution of the electron density during earthquake and geomagnetic storms in the real 3-D space, showing that seismic events induce bottom-up IED negative anomalies localized near epicenters, while geomagnetic storms trigger top-down depletion processes, with IED propagating from higher altitudes in the real 3-D manifold space. Compared to the conventional slice, our visualization model can visualize the characteristics, with the coverage area being observed to increase with the altitude within the same geospatial coordinates. This framework can advance the identification of ionosphere anomalies by enabling the precise differentiation of anomaly sources. This work bridges gaps in geospatial modeling by harmonizing ionospheric tomography with Earth system grids, offering a feasible solution for analyzing multi-scale ionospheric phenomena. Full article
(This article belongs to the Special Issue Ionospheric Sounding for Identification of Pre-seismic Activity)
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20 pages, 15726 KB  
Article
Point Cloud Wall Projection for Realistic Road Data Augmentation
by Kana Kim, Sangjun Lee, Vijay Kakani, Xingyou Li and Hakil Kim
Sensors 2024, 24(24), 8144; https://doi.org/10.3390/s24248144 - 20 Dec 2024
Cited by 2 | Viewed by 2315
Abstract
Several approaches have been developed to generate synthetic object points using real LiDAR point cloud data for advanced driver-assistance system (ADAS) applications. The synthetic object points generated from a scene (both the near and distant objects) are essential for several ADAS tasks. However, [...] Read more.
Several approaches have been developed to generate synthetic object points using real LiDAR point cloud data for advanced driver-assistance system (ADAS) applications. The synthetic object points generated from a scene (both the near and distant objects) are essential for several ADAS tasks. However, generating points from distant objects using sparse LiDAR data with precision is still a challenging task. Although there are a few state-of-the-art techniques to generate points from synthetic objects using LiDAR point clouds, limitations such as the need for intense compute power still persist in most cases. This paper suggests a new framework to address these limitations in the existing literature. The proposed framework contains three major modules, namely position determination, object generation, and synthetic annotation. The proposed framework uses a spherical point-tracing method that augments 3D LiDAR distant objects using point cloud object projection with point-wall generation. Also, the pose determination module facilitates scenarios such as platooning carried out by the synthetic object points. Furthermore, the proposed framework improves the ability to describe distant points from synthetic object points using multiple LiDAR systems. The performance of the proposed framework is evaluated on various 3D detection models such as PointPillars, PV-RCNN, and Voxel R-CNN for the KITTI dataset. The results indicate an increase in mAP (mean average precision) by 1.97%1.3%, and 0.46% from the original dataset values of 82.23%86.72%, and 87.05%, respectively. Full article
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21 pages, 15517 KB  
Article
3D Reconstruction of Building Blocks Based on Extraction of Exterior Wall Lines Using Point Cloud Density Generated from Spherical Camera Images
by Qazale Askari, Hossein Arefi and Mehdi Maboudi
Remote Sens. 2024, 16(23), 4377; https://doi.org/10.3390/rs16234377 - 23 Nov 2024
Cited by 1 | Viewed by 2193
Abstract
The 3D modeling of urban buildings has become a common research area in various disciplines such as photogrammetry and computer vision, with different applications such as intelligent city management, navigation of self-driving cars and architecture, just to name a few. The objective of [...] Read more.
The 3D modeling of urban buildings has become a common research area in various disciplines such as photogrammetry and computer vision, with different applications such as intelligent city management, navigation of self-driving cars and architecture, just to name a few. The objective of this study is to produce a 3D model of the external facade of the buildings with the required precision, accuracy and level of detail according to the user’s requirements, while minimizing time and cost. This research focuses on the production of 3D models for blocks of residential buildings in Tehran, Iran. The Insta 360 One X2 spherical camera is selected to capture the data due to its low cost and 360 × 180° field of view. The camera specifications have facilitated more efficient data collection in terms of both time and cost. The proposed modeling method is based on extracting lines of external walls through the utilization of the point cloud density concept. Initially, photogrammetric point clouds are generated in with a reconstruction precision of 0.24 m from spherical camera images. In the next step, the 3D point cloud is projected into a 2D point cloud by setting the height component to zero. The 2D point cloud is then rotated based on the direction angle determined by the Hough transform so that the perpendicular walls are parallel to the axes of the coordinate system. Next, a 2D point cloud density analysis is performed by voxelizing the point cloud and counting the number of points in each voxel in both the horizontal and vertical directions. By determining the peaks in the density plot, the lines of the external vertical and horizontal walls are extracted. To extract the diagonal external walls, the density analysis is performed in the direction of the first principal component. Finally, by determining the height of each wall in the point cloud, a 3D model is created at the level of detail one. The resulting model has a precision of 0.32 m compared to real sizes, and the 2D plan has a precision of 0.31 m compared to the ground truth map. The use of the spherical camera and point cloud density analysis makes this method efficient and cost-effective, making it a promising approach for future urban modeling projects. Full article
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23 pages, 7868 KB  
Article
Target Fitting Method for Spherical Point Clouds Based on Projection Filtering and K-Means Clustered Voxelization
by Zhe Wang, Jiacheng Hu, Yushu Shi, Jinhui Cai and Lei Pi
Sensors 2024, 24(17), 5762; https://doi.org/10.3390/s24175762 - 4 Sep 2024
Cited by 5 | Viewed by 2643
Abstract
Industrial computed tomography (CT) is widely used in the measurement field owing to its advantages such as non-contact and high precision. To obtain accurate size parameters, fitting parameters can be obtained rapidly by processing volume data in the form of point clouds. However, [...] Read more.
Industrial computed tomography (CT) is widely used in the measurement field owing to its advantages such as non-contact and high precision. To obtain accurate size parameters, fitting parameters can be obtained rapidly by processing volume data in the form of point clouds. However, due to factors such as artifacts in the CT reconstruction process, many abnormal interference points exist in the point clouds obtained after segmentation. The classic least squares algorithm is easily affected by these points, resulting in significant deviation of the solution of linear equations from the normal value and poor robustness, while the random sample consensus (RANSAC) approach has insufficient fitting accuracy within a limited timeframe and the number of iterations. To address these shortcomings, we propose a spherical point cloud fitting algorithm based on projection filtering and K-Means clustering (PK-RANSAC), which strategically integrates and enhances these two methods to achieve excellent accuracy and robustness. The proposed method first uses RANSAC for rough parameter estimation, then corrects the deviation of the spherical center coordinates through two-dimensional projection, and finally obtains the spherical center point set by sampling and performing K-Means clustering. The largest cluster is weighted to obtain accurate fitting parameters. We conducted a comparative experiment using a three-dimensional ball-plate standard. The sphere center fitting deviation of PK-RANSAC was 1.91 μm, which is significantly better than RANSAC’s value of 25.41 μm. The experimental results demonstrate that PK-RANSAC has higher accuracy and stronger robustness for fitting geometric parameters. Full article
(This article belongs to the Section Sensing and Imaging)
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14 pages, 3053 KB  
Article
Comparison of Transcranial Magnetic Stimulation Dosimetry between Structured and Unstructured Grids Using Different Solvers
by Francesca Camera, Caterina Merla and Valerio De Santis
Bioengineering 2024, 11(7), 712; https://doi.org/10.3390/bioengineering11070712 - 13 Jul 2024
Cited by 3 | Viewed by 2506
Abstract
In recent years, the interest in transcranial magnetic stimulation (TMS) has surged, necessitating deeper understanding, development, and use of low-frequency (LF) numerical dosimetry for TMS studies. While various ad hoc dosimetric models exist, commercial software tools like SimNIBS v4.0 and Sim4Life v7.2.4 are [...] Read more.
In recent years, the interest in transcranial magnetic stimulation (TMS) has surged, necessitating deeper understanding, development, and use of low-frequency (LF) numerical dosimetry for TMS studies. While various ad hoc dosimetric models exist, commercial software tools like SimNIBS v4.0 and Sim4Life v7.2.4 are preferred for their user-friendliness and versatility. SimNIBS utilizes unstructured tetrahedral mesh models, while Sim4Life employs voxel-based models on a structured grid, both evaluating induced electric fields using the finite element method (FEM) with different numerical solvers. Past studies primarily focused on uniform exposures and voxelized models, lacking realism. Our study compares these LF solvers across simplified and realistic anatomical models to assess their accuracy in evaluating induced electric fields. We examined three scenarios: a single-shell sphere, a sphere with an orthogonal slab, and a MRI-derived head model. The comparison revealed small discrepancies in induced electric fields, mainly in regions of low field intensity. Overall, the differences were contained (below 2% for spherical models and below 12% for the head model), showcasing the potential of computational tools in advancing exposure assessment required for TMS protocols in different bio-medical applications. Full article
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33 pages, 10723 KB  
Article
IONOLAB-Fusion: Fusion of Radio Occultation into Computerized Ionospheric Tomography
by Sinem Deniz Yenen and Feza Arikan
Atmosphere 2024, 15(6), 675; https://doi.org/10.3390/atmos15060675 - 31 May 2024
Cited by 3 | Viewed by 2073
Abstract
In this study, a 4-D, computerized ionospheric tomography algorithm, IONOLAB-Fusion, is developed to reconstruct electron density using both actual and virtual vertical and horizontal paths for all ionospheric states. The user-friendly algorithm only requires the coordinates of the region of interest and range [...] Read more.
In this study, a 4-D, computerized ionospheric tomography algorithm, IONOLAB-Fusion, is developed to reconstruct electron density using both actual and virtual vertical and horizontal paths for all ionospheric states. The user-friendly algorithm only requires the coordinates of the region of interest and range with the desired spatio-temporal resolutions. The model ionosphere is formed using spherical voxels in a lexicographical order so that a 4-D ionosphere can be mapped to a 2-D matrix. The model matrix is formed automatically using a background ionospheric model with an optimized retrospective or near-real time manner. The singular value decomposition is applied to extract a subset of significant singular values and corresponding signal subspace basis vectors. The measurement vector is filled automatically with the optimized number of ground-based and space-based paths. The reconstruction is obtained in closed form in the least squares sense. When the performance of IONOLAB-Fusion across Europe was compared with ionosonde profiles, a 26.51% and 32.33% improvement was observed over the background ionospheric model for quiet and disturbed days, respectively. When compared with GIM-TEC, the agreement of IONOLAB-Fusion was 37.89% and 31.58% better than those achieved with the background model for quiet and disturbed days, respectively. Full article
(This article belongs to the Section Upper Atmosphere)
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14 pages, 2842 KB  
Article
Enhancing Whole-Brain Magnetic Field Homogeneity for 3D-Magnetic Resonance Spectroscopic Imaging with a Novel Unified Coil: A Preliminary Study
by Archana Vadiraj Malagi, Xinqi Li, Na Zhang, Yucen Liu, Yuheng Huang, Fardad Michael Serry, Ziyang Long, Chia-Chi Yang, Yujie Shan, Yubin Cai, Jeremy Zepeda, Nader Binesh, Debiao Li, Hsin-Jung Yang and Hui Han
Cancers 2024, 16(6), 1233; https://doi.org/10.3390/cancers16061233 - 21 Mar 2024
Cited by 2 | Viewed by 2625
Abstract
The spectral quality of magnetic resonance spectroscopic imaging (MRSI) can be affected by strong magnetic field inhomogeneities, posing a challenge for 3D-MRSI’s widespread clinical use with standard scanner-equipped 2nd-order shim coils. To overcome this, we designed an empirical unified shim–RF head coil (32-ch [...] Read more.
The spectral quality of magnetic resonance spectroscopic imaging (MRSI) can be affected by strong magnetic field inhomogeneities, posing a challenge for 3D-MRSI’s widespread clinical use with standard scanner-equipped 2nd-order shim coils. To overcome this, we designed an empirical unified shim–RF head coil (32-ch RF receive and 51-ch shim) for 3D-MRSI improvement. We compared its shimming performance and 3D-MRSI brain coverages against the standard scanner shim (2nd-order spherical harmonic (SH) shim coils) and integrated parallel reception, excitation, and shimming (iPRES) 32-ch AC/DC head coil. We also simulated a theoretical 3rd-, 4th-, and 5th-order SH shim as a benchmark to assess the UNIfied shim–RF coil (UNIC) improvements. In this preliminary study, the whole-brain coverage was simulated by using B0 field maps of twenty-four healthy human subjects (n = 24). Our results demonstrated that UNIC substantially improves brain field homogeneity, reducing whole-brain frequency standard deviations by 27% compared to the standard 2nd-order scanner shim and 17% compared to the iPRES shim. Moreover, UNIC enhances whole-brain coverage of 3D-MRSI by up to 34% compared to the standard 2nd-order scanner shim and up to 13% compared to the iPRES shim. UNIC markedly increases coverage in the prefrontal cortex by 147% and 47% and in the medial temporal lobe and temporal pole by 29% and 13%, respectively, at voxel resolutions of 1.4 cc and 0.09 cc for 3D-MRSI. Furthermore, UNIC effectively reduces variations in shim quality and brain coverage among different subjects compared to scanner shim and iPRES shim. Anticipated advancements in higher-order shimming (beyond 6th order) are expected via optimized designs using dimensionality reduction methods. Full article
(This article belongs to the Special Issue Advanced Imaging in Brain Tumor Patient Management)
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34 pages, 4150 KB  
Article
Impact of Deltoid Computer Tomography Image Data on the Accuracy of Machine Learning Predictions of Clinical Outcomes after Anatomic and Reverse Total Shoulder Arthroplasty
by Hamidreza Rajabzadeh-Oghaz, Vikas Kumar, David B. Berry, Anshu Singh, Bradley S. Schoch, William R. Aibinder, Bruno Gobbato, Sandrine Polakovic, Josie Elwell and Christopher P. Roche
J. Clin. Med. 2024, 13(5), 1273; https://doi.org/10.3390/jcm13051273 - 23 Feb 2024
Cited by 13 | Viewed by 4068
Abstract
Background: Despite the importance of the deltoid to shoulder biomechanics, very few studies have quantified the three-dimensional shape, size, or quality of the deltoid muscle, and no studies have correlated these measurements to clinical outcomes after anatomic (aTSA) and/or reverse (rTSA) total shoulder [...] Read more.
Background: Despite the importance of the deltoid to shoulder biomechanics, very few studies have quantified the three-dimensional shape, size, or quality of the deltoid muscle, and no studies have correlated these measurements to clinical outcomes after anatomic (aTSA) and/or reverse (rTSA) total shoulder arthroplasty in any statistically/scientifically relevant manner. Methods: Preoperative computer tomography (CT) images from 1057 patients (585 female, 469 male; 799 primary rTSA and 258 primary aTSA) of a single platform shoulder arthroplasty prosthesis (Equinoxe; Exactech, Inc., Gainesville, FL) were analyzed in this study. A machine learning (ML) framework was used to segment the deltoid muscle for 1057 patients and quantify 15 different muscle characteristics, including volumetric (size, shape, etc.) and intensity-based Hounsfield (HU) measurements. These deltoid measurements were correlated to postoperative clinical outcomes and utilized as inputs to train/test ML algorithms used to predict postoperative outcomes at multiple postoperative timepoints (1 year, 2–3 years, and 3–5 years) for aTSA and rTSA. Results: Numerous deltoid muscle measurements were demonstrated to significantly vary with age, gender, prosthesis type, and CT image kernel; notably, normalized deltoid volume and deltoid fatty infiltration were demonstrated to be relevant to preoperative and postoperative clinical outcomes after aTSA and rTSA. Incorporating deltoid image data into the ML models improved clinical outcome prediction accuracy relative to ML algorithms without image data, particularly for the prediction of abduction and forward elevation after aTSA and rTSA. Analyzing ML feature importance facilitated rank-ordering of the deltoid image measurements relevant to aTSA and rTSA clinical outcomes. Specifically, we identified that deltoid shape flatness, normalized deltoid volume, deltoid voxel skewness, and deltoid shape sphericity were the most predictive image-based features used to predict clinical outcomes after aTSA and rTSA. Many of these deltoid measurements were found to be more predictive of aTSA and rTSA postoperative outcomes than patient demographic data, comorbidity data, and diagnosis data. Conclusions: While future work is required to further refine the ML models, which include additional shoulder muscles, like the rotator cuff, our results show promise that the developed ML framework can be used to evolve traditional CT-based preoperative planning software into an evidence-based ML clinical decision support tool. Full article
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22 pages, 6683 KB  
Article
Synthetic Forest Stands and Point Clouds for Model Selection and Feature Space Comparison
by Michelle S. Bester, Aaron E. Maxwell, Isaac Nealey, Michael R. Gallagher, Nicholas S. Skowronski and Brenden E. McNeil
Remote Sens. 2023, 15(18), 4407; https://doi.org/10.3390/rs15184407 - 7 Sep 2023
Cited by 3 | Viewed by 3932
Abstract
The challenges inherent in field validation data, and real-world light detection and ranging (lidar) collections make it difficult to assess the best algorithms for using lidar to characterize forest stand volume. Here, we demonstrate the use of synthetic forest stands and simulated terrestrial [...] Read more.
The challenges inherent in field validation data, and real-world light detection and ranging (lidar) collections make it difficult to assess the best algorithms for using lidar to characterize forest stand volume. Here, we demonstrate the use of synthetic forest stands and simulated terrestrial laser scanning (TLS) for the purpose of evaluating which machine learning algorithms, scanning configurations, and feature spaces can best characterize forest stand volume. The random forest (RF) and support vector machine (SVM) algorithms generally outperformed k-nearest neighbor (kNN) for estimating plot-level vegetation volume regardless of the input feature space or number of scans. Also, the measures designed to characterize occlusion using spherical voxels generally provided higher predictive performance than measures that characterized the vertical distribution of returns using summary statistics by height bins. Given the difficulty of collecting a large number of scans to train models, and of collecting accurate and consistent field validation data, we argue that synthetic data offer an important means to parameterize models and determine appropriate sampling strategies. Full article
(This article belongs to the Section Forest Remote Sensing)
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14 pages, 3184 KB  
Article
Fiber Orientation Estimation from X-ray Dark Field Images of Fiber Reinforced Polymers Using Constrained Spherical Deconvolution
by Ben Huyge, Jonathan Sanctorum, Ben Jeurissen, Jan De Beenhouwer and Jan Sijbers
Polymers 2023, 15(13), 2887; https://doi.org/10.3390/polym15132887 - 29 Jun 2023
Cited by 2 | Viewed by 2598
Abstract
The properties of fiber reinforced polymers are strongly related to the length and orientation of the fibers within the polymer matrix, the latter of which can be studied using X-ray computed tomography (XCT). Unfortunately, resolving individual fibers is challenging because they are small [...] Read more.
The properties of fiber reinforced polymers are strongly related to the length and orientation of the fibers within the polymer matrix, the latter of which can be studied using X-ray computed tomography (XCT). Unfortunately, resolving individual fibers is challenging because they are small compared to the XCT voxel resolution and because of the low attenuation contrast between the fibers and the surrounding resin. To alleviate both problems, anisotropic dark field tomography via grating based interferometry (GBI) has been proposed. Here, the fiber orientations are extracted by applying a Funk-Radon transform (FRT) to the local scatter function. However, the FRT suffers from a low angular resolution, which complicates estimating fiber orientations for small fiber crossing angles. We propose constrained spherical deconvolution (CSD) as an alternative to the FRT to resolve fiber orientations. Instead of GBI, edge illumination phase contrast imaging is used because estimating fiber orientations with this technique has not yet been explored. Dark field images are generated by a Monte Carlo simulation framework. It is shown that the FRT cannot estimate the fiber orientation accurately for crossing angles smaller than 70, while CSD performs well down to a crossing angle of 50. In general, CSD outperforms the FRT in estimating fiber orientations. Full article
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12 pages, 1511 KB  
Article
Single-Compartment Dose Prescriptions for Ablative 90Y-Radioembolization Segmentectomy
by Srinivas Cheenu Kappadath and Benjamin P. Lopez
Life 2023, 13(6), 1238; https://doi.org/10.3390/life13061238 - 24 May 2023
Cited by 4 | Viewed by 2155
Abstract
Background: Yttrium-90 (90Y) radioembolization is increasingly being utilized with curative intent. While single-compartment doses with respect to the perfused volume for the complete pathologic necrosis (CPN) of tumors have been reported, the actual doses delivered to the tumor and at-risk margins [...] Read more.
Background: Yttrium-90 (90Y) radioembolization is increasingly being utilized with curative intent. While single-compartment doses with respect to the perfused volume for the complete pathologic necrosis (CPN) of tumors have been reported, the actual doses delivered to the tumor and at-risk margins that leads to CPN have hitherto not been estimated. We present an ablative dosimetry model that calculates the dose distribution for tumors and at-risk margins based on numerical mm-scale dose modeling and the available clinical CPN evidence and report on the necessary dose metrics needed to achieve CPN following 90Y-radioembolization. Methods: Three-dimensional (3D) activity distributions (MBq/voxel) simulating spherical tumors were modeled with a 121 × 121 × 121 mm3 soft tissue volume (1 mm3 voxels). Then, 3D dose distributions (Gy/voxel) were estimated by convolving 3D activity distributions with a 90Y 3D dose kernel (Gy/MBq) sized 61 × 61 × 61 mm3 (1 mm3 voxels). Based on the published data on single-compartment segmental doses for the resected liver samples of HCC tumors showing CPN after radiation segmentectomy, the nominal voxel-based mean tumor dose (DmeanCPN), point dose at tumor rim (DrimCPN), and point dose 2 mm beyond the tumor boundary (D2mmCPN), which are necessary to achieve CPN, were calculated. The single-compartment dose prescriptions to required achieve CPN were then analytically modeled for more general cases of tumors with diameters dt = 2, 3, 4, 5, 6, and 7 cm and with tumor-to-normal-liver uptake ratios T:N = 1:1, 2:1, 3:1, 4:1, and 5:1. Results: The nominal case defined to estimate the doses needed for CPN, based on the previously published clinical data, was a single hyperperfused tumor with a diameter of 2.5 cm and T:N = 3:1, treated with a single-compartment segmental dose of 400 Gy. The voxel-level doses necessary to achieve CPN were 1053 Gy for the mean tumor dose, 860 Gy for the point dose at the tumor boundary, and 561 Gy for the point dose at 2 mm beyond the tumor edge. The single-compartment segmental doses necessary to satisfy the criteria for CPN in terms of the mean tumor dose, point dose at the tumor boundary, and the point dose at 2 mm beyond the tumor edge were tabulated for a range of tumor diameters and tumor-to-normal-liver uptake ratios. Conclusions: The analytical functions that describe the relevant dose metrics for CPN and, more importantly, the single-compartment dose prescriptions for the perfused volume needed to achieve CPN are reported for a large range of conditions in terms of tumor diameters (1–7 cm) and T:N uptake ratios (2:1–5:1). Full article
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17 pages, 2929 KB  
Article
Fast Adaptive Temperature-Based Re-Optimization Strategies for On-Line Hot Spot Suppression during Locoregional Hyperthermia
by H. Petra Kok and Johannes Crezee
Cancers 2022, 14(1), 133; https://doi.org/10.3390/cancers14010133 - 28 Dec 2021
Cited by 5 | Viewed by 2182
Abstract
Background: Experience-based adjustments in phase-amplitude settings are applied to suppress treatment limiting hot spots that occur during locoregional hyperthermia for pelvic tumors. Treatment planning could help to further optimize treatments. The aim of this research was to develop temperature-based re-optimization strategies and compare [...] Read more.
Background: Experience-based adjustments in phase-amplitude settings are applied to suppress treatment limiting hot spots that occur during locoregional hyperthermia for pelvic tumors. Treatment planning could help to further optimize treatments. The aim of this research was to develop temperature-based re-optimization strategies and compare the predicted effectiveness with clinically applied protocol/experience-based steering. Methods: This study evaluated 22 hot spot suppressions in 16 cervical cancer patients (mean age 67 ± 13 year). As a first step, all potential hot spot locations were represented by a spherical region, with a user-specified diameter. For fast and robust calculations, the hot spot temperature was represented by a user-specified percentage of the voxels with the largest heating potential (HPP). Re-optimization maximized tumor T90, with constraints to suppress the hot spot and avoid any significant increase in other regions. Potential hot spot region diameter and HPP were varied and objective functions with and without penalty terms to prevent and minimize temperature increase at other potential hot spot locations were evaluated. Predicted effectiveness was compared with clinically applied steering results. Results: All strategies showed effective hot spot suppression, without affecting tumor temperatures, similar to clinical steering. To avoid the risk of inducing new hot spots, HPP should not exceed 10%. Adding a penalty term to the objective function to minimize the temperature increase at other potential hot spot locations was most effective. Re-optimization times were typically ~10 s. Conclusion: Fast on-line re-optimization to suppress treatment limiting hot spots seems feasible to match effectiveness of ~30 years clinical experience and will be further evaluated in a clinical setting. Full article
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15 pages, 2430 KB  
Article
Feasibility of Monitoring Tumor Response by Tracking Nanoparticle-Labelled T Cells Using X-ray Fluorescence Imaging—A Numerical Study
by Henrik Kahl, Theresa Staufer, Christian Körnig, Oliver Schmutzler, Kai Rothkamm and Florian Grüner
Int. J. Mol. Sci. 2021, 22(16), 8736; https://doi.org/10.3390/ijms22168736 - 14 Aug 2021
Cited by 14 | Viewed by 3696
Abstract
Immunotherapy has been a breakthrough in cancer treatment, yet only a subgroup of patients responds to these novel drugs. Parameters such as cytotoxic T-cell infiltration into the tumor have been proposed for the early evaluation and prediction of therapeutic response, demanded for non-invasive, [...] Read more.
Immunotherapy has been a breakthrough in cancer treatment, yet only a subgroup of patients responds to these novel drugs. Parameters such as cytotoxic T-cell infiltration into the tumor have been proposed for the early evaluation and prediction of therapeutic response, demanded for non-invasive, sensitive and longitudinal imaging. We have evaluated the feasibility of X-ray fluorescence imaging (XFI) to track immune cells and thus monitor the immune response. For that, we have performed Monte Carlo simulations using a mouse voxel model. Spherical targets, enriched with gold or palladium fluorescence agents, were positioned within the model and imaged using a monochromatic photon beam of 53 or 85 keV. Based on our simulation results, XFI may detect as few as 730 to 2400 T cells labelled with 195 pg gold each when imaging subcutaneous tumors in mice, with a spatial resolution of 1 mm. However, the detection threshold is influenced by the depth of the tumor as surrounding tissue increases scattering and absorption, especially when utilizing palladium imaging agents with low-energy characteristic fluorescence photons. Further evaluation and conduction of in vivo animal experiments will be required to validate and advance these promising results. Full article
(This article belongs to the Special Issue Multifunctional Nanomaterials: Synthesis, Properties and Applications)
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