Search Results (1,024)

The joint probability distribution of observable variables from a system is constrained by the underlying causal structure. In the presence of hidden variables, untestable independencies that involve hidden variables lead to testable causally-imposed inequality constraints for observable variables, whose violation can reject the compatibility of a causal structure with data. One type of causally informative inequalities is entropic inequalities, which appear in the space of entropic terms associated with the distribution of observable variables. We derive a new type of minimum information (minInf) entropic inequalities that substantially increases causal inference power. These new entropic inequalities appear when considering the constraints that the causal structure imposes on entropic terms determined by information minimization within families of distributions that preserve sets of marginals shared with the original distribution. We introduce a new family of minInf data processing inequalities and a procedure to recursively combine different types of data processing inequalities to create tighter testable entropic inequalities. We extensively illustrate the applicability of this procedure in the instrumental causal scenario, integrating the new inequalities with standard instrumental entropic inequalities constructed with multivariate instrumental sets. We also provide additional examples with other types of entropic inequalities, such as the Information Causality and Groups-Decomposition inequalities. Full article

Background/Objectives: Facilities for persons with Alzheimer disease need to be adapted for them in terms of architecture and interior and exterior design, where the introduction of an artistic dimension is recommended. This raises the question of exploring the aesthetic preferences of the people concerned in order to optimise the design. We assessed whether individuals with Alzheimer’s disease can make aesthetic judgements, and if so, their nature and how stable they were over time. Methods: We compared the aesthetic preferences of 23 persons with Alzheimer’s disease matched to 23 controls. Preferences were collected using a Q-PEG questionnaire, which presents photographs of various artworks: paintings, sculptures, functional objects, and representation of living things: human, animal, and landscape, in various styles: figurative, stylized, abstract. This tool was created specifically by our team for this research; this is the first exploratory publication to use it. Results: We confirm the feasibility of collecting aesthetic judgements from individuals living with Alzheimer’s disease using the Q-PEG tool. The aesthetic judgements of both participant groups proved to be stable over time. Furthermore, the aesthetic judgements of individuals with Alzheimer’s disease did not differ from those of the controls, regardless of the style or type of artwork. These preferences are independent of the various cognitive functions assessed. Hypotheses about the Alzheimer-resistant nature of the cognitive register of aesthetic preferences are discussed. Conclusions: As they can express their artistic preferences, individuals living with Alzheimer’s disease should be consulted. These results provide insights for the design of facilities and therapeutic gardens based on evidence-based design (EBD) criteria. The integration of an artistic dimension in line with these preferences and in compliance with the general recommendations makes it possible to create adapted, specific spaces that are appreciated by all. Full article

Intensive ornamental planting is increasingly prevalent in urban green spaces, yet its effects on soil microbial community assembly and interaction networks remain poorly understood. Here, we examined shifts in soil properties, microbial diversity, community composition, and interaction networks across successive planting cycles. Bacterial alpha-diversity remained relatively stable, whereas fungal communities showed pronounced sensitivity to early planting stages. Beta-diversity analyses revealed that bacterial community composition was jointly influenced by planting stage and site type, while fungal communities were primarily structured by site characteristics. Co-occurrence network analysis revealed contrasting reassembly trajectories between microbial groups. Bacterial networks exhibited increasing complexity and modularity, indicating enhanced interaction intensity and competitive structuring under intensive management. In contrast, fungal networks displayed reduced connectivity but maintained or recovered modular organization, suggesting structural buffering. Notably, keystone taxa remained taxonomically conserved, indicating that network reorganization was driven by interaction rewiring rather than species turnover. We propose a dual-speed reassembly framework in which bacteria function as fast-responding components with dynamic interaction networks, whereas fungi act as slow-buffering, structurally persistent elements. This decoupling of short-term functional responsiveness and long-term stability provides new insights into how intensive management reshapes soil microbiomes in botanical garden ecosystems. Full article

Blue-green infrastructure in high-density communities has been found to be vital to the well-being of urban residents, particularly in 15 min walkable communities. However, residents’ environmental preferences for blue-green infrastructure in high-density urban areas have received little attention. This study uses a walking interview method with 90 participants to explore residents’ motivations, activities and preferences in both community and riverside green spaces. The study area centers on the Licun River and surrounding communities within a 15 min walking distance of the river in Qingdao, China, a high-density city promoting 15 min walkable communities. The findings showed that relaxation was the main reason for visiting both types of spaces. Riverside green spaces supported a wider variety of activities but notable differences in preferences for particular spaces, particularly across gender and age groups. Within community green spaces, artificial elements had a stronger impact on preferences, whereas in riverside green spaces, natural elements were more influential. Blue-green infrastructure planning in high-density cities should then consider diverse user needs by accounting for demographic differences and adapting design elements to various spatial contexts. Since a 15 min walk is not feasible for all residents, enhancing the safety, walkability and inclusivity of blue-green infrastructure is essential for everyday use. Full article

Nucleoside diphosphate kinase (NDPK) is a ubiquitous enzyme that maintains cellular nucleotide balance by catalyzing the transfer of phosphate groups between nucleoside diphosphates and triphosphates. Although the evolutionary conservation of NDPK is well established, several aspects of its diversification and functional adaptation remain unclear. The central question of this work is how NDPK evolved across plant species, focusing on the Solanaceae family and how its evolutionary history relates to the diversification of its cellular functions. Phylogenetic and molecular dating analyses showed that the division between NDPK groups 1 and 2 predates the divergence of plants and animals, whereas plant-specific NDPK types (I–IV) originated early in streptophyte evolution. Solanaceae species retain a conserved set of NDPK genes, including a type III isoform with features consistent with mitochondrial targeting. Functional assays in isolated potato tuber mitochondria revealed high NDPK activity in the intermembrane space, sustaining ADP supply to oxidative phosphorylation. Activation of mitochondrial NDPK induced a phosphorylative respiratory state, which partially dissipated the mitochondrial membrane potential and significantly reduced reactive oxygen species (ROS) production. GDP and UDP were preferentially phosphorylated, conferring a stronger antioxidant effect than other nucleotides. Consistently, the mitochondrial isoform StNDPK3 was upregulated during tuber development. Together, our results demonstrate that NDPKs are evolutionarily conserved yet functionally diversified enzymes in plants and identify mitochondrial NDPK as a key modulator of mitochondrial redox homeostasis. By linking nucleotide metabolism to Δψ_m control and ROS suppression, this study highlights a previously underappreciated antioxidant mechanism that integrates mitochondrial energy metabolism with developmental and stress-related processes in plants. Full article

Background: This study compared two xenogeneic bone graft materials, A-Oss (bovine-derived) and The Graft (porcine-derived), using a rabbit calvarial defect model and a canine mandibular dehiscence-type defect model. Methods: Healing was evaluated at 6 and 12 weeks in rabbits and at 24 weeks in mongrel dogs. Micro-computed tomography quantified mineralized tissue fill (defect closure) in rabbits and, in dogs, the compartments classified as new bone and residual graft, together with vertical and horizontal volumetric maintenance. Hematoxylin and eosin (H&E) sections provided complementary qualitative observations. Results: In rabbits, defect closure did not differ between materials at 6 weeks (67.1 ± 12.7% vs. 70.2 ± 15.1%, p = 0.090) or 12 weeks (78.6 ± 5.9% vs. 72.3 ± 0.9%, p = 0.124). In dogs, new bone was similar between groups (43.5 ± 3.2% vs. 45.9 ± 1.1%, p = 0.208), whereas residual graft showed a numerical trend toward higher values with A-Oss (20.2 ± 3.5% vs. 13.3 ± 4.5%, p = 0.069). Vertical volume maintenance also trended higher with A-Oss (91.1 ± 1.6% vs. 87.8 ± 1.3%, p = 0.056), while horizontal maintenance was comparable (94.5 ± 1.8% vs. 91.4 ± 2.8%, p = 0.241). Histology in both models showed graft particles within the defect/augmented regions with surrounding eosinophilic matrix and intervening tissue spaces. Conclusions: Overall, both materials produced similar healing profiles across models, with small between-material differences most apparent in the canine dehiscence setting. Full article

Globally, the combined pollution of fine particulate matter (PM_2.5) and ground-level ozone (O₃) poses severe challenges to public health and sustainable urban development. Recent data indicate that the annual average PM_2.5 concentration in the vast majority of cities worldwide fails to meet World Health Organization safety standards, with air pollution causing millions of premature deaths annually. As a nature-based solution, the purification efficacy of vegetation remains poorly quantified due to unclear coupling mechanisms with local meteorological conditions. This study systematically reviewed and synthesized 229 empirical studies published between 2000 and 2025 from Web of Science and China National Knowledge Infrastructure (CNKI), aiming to clarify the quantitative relationships and regulatory mechanisms of plant–meteorological synergistic purification of PM_2.5–O₃. Following double-blind independent screening (κ = 0.85) and data extraction, a quantitative minimal feasible synthesis approach was adopted due to high data heterogeneity. The results indicated the following. (1) The median canopy purification efficiency of urban vegetation for PM_2.5 was 18.2% (IQR: 12.5–30.1%, n = 17), with a median dry deposition velocity (Vd–PM) of 0.05 cm s⁻¹ (0.02–30 cm s⁻¹, n = 15). The median dry deposition velocity (Vd–O₃) for O₃ was 0.55 cm s⁻¹ (0.12–1.82 cm s⁻¹, n = 8), with non-stomatal deposition contributing approximately 35%. (2) Meteorological factors exhibit nonlinear regulation: relative humidity (RH) > 70% significantly enhances PM_2.5 adsorption, wind speeds of 1.5–3.0 m s⁻¹ are optimal for PM_2.5 deposition, and temperatures > 30 °C generally inhibit plant uptake of both pollutants (n = 7). (3) Functional traits strongly correlate with purification efficacy: species with high leaf roughness (R² = 0.8), high stomatal conductance, and low BVOC emissions (e.g., Ginkgo biloba, Platycladus orientalis) exhibit optimal synergistic purification potential. Species with high BVOC emissions (Populus przewalskii, Eucalyptus robusta) can increase daily net O₃ pollution equivalents by up to 86 g and must be strictly avoided. Based on quantitative evidence, a green space planning decision matrix indexed by climate zone and pollution type was developed, specifying vegetation configuration patterns, functional group selection, and key design parameters (canopy closure, green belt width, etc.) for different scenarios. This study provides an actionable scientific basis for precision planning and climate-adaptive management of urban green infrastructure. Full article

Metal-chalcogenide compounds with perovskite-type compositions have drawn increasing attention for their optical properties for solar energy conversion. Herein, a new α-type polymorph of the ternary sulfide SrHfS₃ is described, crystallizing in the NH₄CdCl₃ structure type. The yellow-colored plate-shaped crystals were synthesized at 1173 K using an elemental tin flux in an evacuated sealed tube. Its crystal structure was characterized at room temperature using single crystal X-ray diffraction to form in the orthorhombic Pnma space group, with the refined cell parameters of a = 8.5041(4) Å, b = 3.8004(2) Å, c = 13.8935(6) Å, and V = 449.02(4) ų. The structure comprises five independent crystallographic sites, having one Sr, one Hf, and three S sites. The structure can be described as containing one-dimensional chains of distorted HfS₆ octahedra extending down the b-axis to form ${\displaystyle \genfrac{}{}{0pt}{}{1}{\infty }}[$HfS₃]²⁻ strips of edge-sharing octahedra. The Sr atoms act as charge-balancing space fillers in the structure. High-purity bulk samples of α-SrHfS₃ could be prepared for measurement of its bandgap by optical diffuse-reflectance spectroscopy, showing a direct bandgap of 2.1(1) eV. Results of electronic structure calculations are consistent with this bandgap and type. The conduction and valence band edges stem from the respective empty Hf d-orbitals and the filled S p-orbital states. In summary, crystal growth of the α-type polymorph of SrHfS₃ has been demonstrated using a Sn flux approach, which can facilitate future broader synthetic explorations at lower temperatures. Full article

Urban pedestrianization has become a widely adopted strategy to promote sustainable mobility, improve urban livability, and enhance the quality of public space. Despite its potential benefits, pedestrianization interventions often generate heterogeneous perceptions among different user groups, which may influence their long-term acceptance. This study analyzes citizen perceptions of an urban pedestrianization intervention implemented in the city of Loja, Ecuador, considering residents, business owners or employees, and pedestrians or visitors. A structured survey was conducted, and the collected data were analyzed using exploratory analytical techniques, including rescaled single-item indices, user segmentation, and Spearman correlation analysis to identify patterns and relationships among variables. The results reveal significant associations between socio-demographic characteristics, user type, and acceptance of permanent pedestrianization, as well as differentiated patterns of urban experience. These findings provide empirical evidence to support decision-making in urban mobility policies and contribute to the academic discussion on pedestrianization in intermediate Latin American cities. Full article

Objective: Emphysema is an important chronic obstructive pulmonary disease (COPD) phenotype characterized by the destruction of air spaces distal to the terminal bronchiole. Aiming to detect potential emphysema biomarkers and to assess the systemic effects of emphysema in blood plasma, we conducted a small cross-sectional shotgun proteomics study. Methods: This study included N = 40 participants divided into four subgroups (N = 10 per group): patients with emphysema and COPD (CE), patients with COPD but without emphysema (CN), healthy smokers (HS) and healthy never-smokers (HN). The participants were sampled non-probabilistically to be similar in terms of age, sex and comorbidities. Participants’ blood plasma was analyzed using liquid chromatography–mass spectrometry. Bioinformatic analysis included detection of differentially expressed proteins (DEPs) and overrepresentation analysis (ORA). Results: Across all groups, a total of 994 proteins were identified, with NADP-dependent malic enzyme (NADP-ME; encoded by ME1) being the only DEP in the CE vs. CN contrast. Proteins such as BMP1, ADAMTSL-2, -4 and IGFBP4, -5, 6 were identified to be upregulated in CE vs. HN. Fibulin-1, -3 and several immunoglobulin components were identified to be downregulated in the CE vs. HN contrast. ORA revealed several enriched processes, including serine-type endopeptidase activity, insulin-like growth factor I and II binding, and signaling receptor binding. Conclusion: We propose NADP-ME, an important enzyme of intermediary metabolism and redox homeostasis, as a potential biomarker candidate of emphysema. Notably, NADP-ME is also implicated in anoikis resistance. Additionally, changes in the expression levels of BMP1, ADAMTSL-2 and -4, and fibulin suggest potential major systemic effects of extracellular matrix perturbation. As all data was derived from LC-MS analysis, these findings need to be further evaluated with complementary methods. Full article

Background and Objectives: When a single missing tooth must be replaced, the best solution is the placement of an implant. In adults, most of the time the space for implant is totally or partially closed due to the shift in the adjacent teeth. The objective of the study was to describe the clinical parameters, treatment choices, and outcomes associated with orthodontic space opening for single-tooth implants in various treatment solutions, as well as to determine their influence on the variation in the dimension of the edentulous space. Materials and Methods: An observational prospective cohort study was designed in which patients with a single missing tooth were selected to be included in the study. After the clinical examination two groups were formed: patients who opted for fixed orthodontic treatment (metallic or sapphire) to open space for implant and patients who opted for alignment to achieve this (with Invisalign or Spark). All subjects received orthodontic treatment. A dental chart was created for each patient which included demographics, clinical data, orthopantomography (OPG), profile cephalograms, and photographs. The potential implant prosthetic space was measured during orthodontic treatment to observe the space dimension evolution in time. Results: In total, 97 patients were included in the study, 60 women and 37 men, with ages between 14 and 60 years. Edentulous spaces dimensions were opened from 1–4 mm to 5–6 mm (39.18% patients), 6–8 mm (48.45%), and >8 mm (12.37%). Both types of orthodontic treatments were effective in opening the potential prosthetic space for implant. Conclusions: Large prosthetic spaces and older edentulism tend to require longer treatments. Older patients had experienced edentulism for a longer period, indicating a correlation between age and the duration of tooth loss. Metal fixed orthodontic appliances were used in exceedingly long treatments, while aligners/sapphire brackets were used in short–medium durations. For the study group, fixed appliances and aligners proved to be effective in opening the space for future implants. Full article

The prosperity of the Maritime Spice Route in China during the Song–Yuan dynasties (960–1368) propelled Quanzhou into a global hub for maritime trade and cultural integration. A large number of Muslims settled in Quanzhou via maritime routes, living and multiplying over generations—their journey fully documenting the localization trajectory of the immigrant group. To explore the relationship between the evolution of their traditional residence types and immigration localization, this study takes 185 “one bright hall and two dark rooms” traditional residences of the Ding’s Hui ethnic group in Chendai as an example, constructing a “4 × 6” matrix framework via the spatiotemporal biaxial coordinate classification method, with an integrated application of statistics, field surveying and mapping, Space Syntax, and genealogical document analysis. Results reveal that 15 of the 24 theoretical residence types are effectively preserved, forming a “prototype + combined type” evolutionary chain. Residence-type acceptance presents distinct traits, Class A as the foundational form, Class D as the mainstream, and Classes B and C as transitional types, a pattern reflecting the comprehensive influence of construction land conditions, living patterns, and local construction concepts on residence-type selection. Significant disparities in average connectivity between the central courtyard and various core public spaces embody the multi-branch small-family cohabitation mode and verify the localization development trajectory of residential space. The evolution of this residence-type system is confirmed to feature three core characteristics—nonlinearity, integrated and diversified fusion, and spatial constraint—and proposes preservation strategies for double-standard dimensional, multicultural and identifiability qualities, which provide a scientific reference for the protection and renewal of architectural heritage in Hui ethnic communities and similar immigrant settlements on China’s southeast coast. Full article

Background: Gait re-education is one of the key elements of comprehensive rehabilitation after total hip replacement. Recent technological advancements allow patients to benefit from increasingly sophisticated training solutions based on biofeedback. The aim of this study was to assess the impact of a treadmill training protocol with a digital biofeedback component on the gait parameters of patients after an uncomplicated total hip replacement and on their functional status. Methods: The study included 137 patients after total hip replacement. In the control group, traditional walking training with biofeedback in the form of a mirror was used. In the study group, the Biodex Gait Trainer 3 treadmill was used for this purpose, which also served as a diagnostic tool for both groups. The following parameters were assessed: distance, average walking speed, average step cycle, step length, coefficient of variability and time on each foot. Additionally, the study included the Timed Up & Go (TUG) test and the use of orthopedic supplies. Results were considered statistically significant at p < 0.05. Results: Significant statistical differences were found between the groups in terms of distance, average walking speed, and step length. Additionally, significantly shorter TUG times were observed and a higher rate of discontinuation of orthopedic supplies in the study group. However, the therapy method did not have a significant effect on the average step cycle, coefficient of variability or time on each foot. These parameters showed comparable improvement in both groups. Conclusions: Treadmill training with visual biofeedback has a positive effect on certain gait parameters. The greatest benefits from this type of training can be gained by patients with deficits in stability and mobility in space. Full article

Land transition in China has led to the emergence of highly heterogeneous neighborhoods. This process challenges the social sustainability of public green spaces. This research investigates the driving mechanisms of place attachment within green space across diverse community typologies in Beijing. This study constructed a structural equation model (SEM) based on 626 valid questionnaires, using the Stimulus–Organism–Response (S-O-R) framework. The overall SEM results indicate that place identity significantly contributes to civic behavior (β = 0.439, p < 0.001). However, a persistent ‘value-action’ gap remains, with 65.81% of residents demonstrating high identity yet low participation. Furthermore, the multi-group analysis (MGA) reveals that place attachment logic diverges significantly across groups. Regarding user identity, public events promote visitors’ place identity, but this effect remains insignificant among residents (β = −0.064, p > 0.05). Regarding generational differences, the macro-spatial environment is significantly associated with place dependence for young people (β = 0.330, p < 0.001) but is insignificant for the elderly. Community heterogeneity reveals distinct failure modes. In commodity housing communities, a disconnect exists where daily usage fails to foster dependence (β = 0.026, p > 0.05). Conversely, urban–rural resettlement communities display an identity deficit where public events fail to translate into place identity (β = 0.131, p > 0.05). The study proposes differentiated renewal pathways tailored to three community types. For commercial housing communities, it advocates precise interventions that prioritize social engagement. Meanwhile, for urban–rural resettlement communities, the focus shifts to accessibility and culturally rooted activities to help reconnect displaced populations. Full article

A novel catalyst, Tm₂FeSbO₇, was synthesized by employing the solid-phase high-temperature sintering method, and, for the first time, it was utilized to create a Z-type heterojunction with BiYO₃. A direct Z-scheme Tm₂FeSbO₇/BiYO₃ heterojunction photocatalyst (TBHP) was successfully produced by employing the ball-milling technique. X-ray diffraction analysis results indicated that Tm₂FeSbO₇ crystallized in a cubic pyrochlorestructure which owned the Fd-3m space group, with a unit cell parameter of 10.1769 Å, whereas BiYO₃ displayed a fluorite structure in the Fm-3m space group, with a unit cell parameter of 5.4222 Å. The Mossbauer spectrum of Tm₂FeSbO₇ showed that Fe³⁺ ions might locate at octahedral sites. The measured bandgap widths for the TBHP, Tm₂FeSbO_7, and BiYO₃ were 2.14 eV, 2.21 eV, and 2.30 eV, respectively. Multiple experimental results demonstrated that the TBHP exhibited a higher valence band ionization potential, a narrower band gap width, and a higher removal efficiency of the sulfamethoxazole (SMX) compared with the Dy₂TmSbO₇/BiHoO₃ heterojunction photocatalyst. Under visible-light irradiation (VISLI) of 115 min, the TBHP showcased exceptional photocatalytic elimination performance; therefore, the elimination rate of the SMX and the total organic carbon (TOC) mineralization rate reached 99.51% and 98.10%, respectively. In contrast to single-component Tm₂FeSbO₇, BiYO_3, or conventional nitrogen-doped titanium dioxide (N-TiO₂) catalyst, the TBHP exhibited removal efficiency enhancement for degrading the SMX by 1.17 times, 1.31 times, or 4.06 times. Simultaneously, the matching mineralization rate for removing the TOC density by employing the TBHP was 1.20 times, 1.34 times, or 4.73 times higher than that by employing Tm₂FeSbO₇, BiYO₃, or conventional N-TiO₂. Above experimental results indicated that the mineralization efficiency for removing TOC density by employing the TBHP was higher than that by employing Tm₂FeSbO₇, BiYO₃, or N-TiO₂. Radicals trapping experiments and the electron paramagnetic resonance spectroscopy results revealed that hydroxyl radicals, superoxide anions, and photoinduced holes were the primary active species during the catalytic elimination course of the SMX by employing the TBHP under VISLI. The results demonstrated that the direct Z-scheme TBHP, which was developed in this study, exhibited the maximal removal efficiency for degrading the SMX in contrast to Tm₂FeSbO₇, BiYO₃, or N-TiO₂. Additionally, the possible elimination routes and elimination mechanisms of the SMX were proposed. Therefore, an important scientific foundation for developing high-performance heterojunction catalysts was established. Full article