Search Results (529)

The integration of glass fibre-reinforced polymer (GFRP) and steel reinforcement in hybrid RC beams offers durability benefits, yet the specific influence of GFRP surface treatments on bond mechanics remains critical. This study experimentally investigates the performance of hybrid GFRP-steel-reinforced beams under three-point bending, comparing sand-coated and ribbed GFRP bars, while maintaining a constant total reinforcement ratio of 1.4% to isolate interface mechanics. Due to the exploratory nature of the study and the specific specimen matrix, the results are interpreted as observed experimental trends rather than statistically generalised performance metrics. The results indicate that ribbed GFRP bars provide enhance mechanical interlocking; in this specific experimental program, the ribbed GFRP hybrid beam exhibits an observed load capacity approximately 11% greater than the sand-coated specimen in this study and surpassing comparable steel-only beams. Additionally, ribbed configurations demonstrated an observed 15% higher toughness. In contrast, sand-coated hybrid beams exhibited signs of premature bond degradation, quantitatively captured by strain gauge monitoring; sand-coated bars plateaued at 14,000 µε, reaching only 79% of their theoretical rupture capacity. This strain limitation indicates failure by internal slippage rather than material rupture, further evidenced by a 50% reduction in crack propagation compared to ribbed beams. While energy-based ductility indices suggest a marginal 6% advantage for sand-coated bars, both hybrid systems exhibited relatively low energy-based ductility indices (μ < 2), reflecting the linear-elastic nature of GFRP reinforcement. These findings suggest that the mechanical interlock of ribbed surface treatments is more resilient under the combined stress states typical of hybrid configurations, providing a foundational baseline for the development of future numerical models and reliability-based design frameworks for hybrid GFRP-steel-RC systems. Full article

Groundwater fluctuations in bedrock affect the mechanical behavior of rock masses hosting geo-energy recovery systems utilizing borehole heat exchangers. To investigate the combined influencing mechanism of changes in groundwater saturation and fracture dip angle on mechanical properties of typical fractured rock masses, triaxial compressive tests were conducted using specimens containing fissures at different angles (15° and 75°) under three conditions: conventional dry, water-immersed, and immersed-dried. The results reveal a combined influencing mechanism of groundwater saturation and fracture dip angle on mechanical properties of typical fractured rock mass. Since specimens with gentle fissure angles tend to fail through fracturing of the intact rock, while those with steeper fissure angles are more prone to failure via slippage along fissure planes, the stress–strain response exhibits greater variability among samples with gentle fissures, attributable to the material heterogeneity of the rock matrix; an increase in water saturation reduces the strength of steeper fissures more pronouncedly due to the relatively homogeneous properties of these fissures, and gravitational water present along fissure planes reduces effective stress and weakens interfacial bonding. Therefore, rock masses with steeper fissures are more susceptible to water-induced weakening and pose a higher risk of shear slippage by fissure reactivation. The findings have a practical value in offering theoretical support for assessing stability risks in geo-energy structures in shallow bedrocks. Full article

Lung cancer remains the leading cause of cancer-related mortality worldwide and is characterized by high aggressiveness and therapeutic resistance, partly driven by mitotic dysregulation. Key mitotic regulators, including kinases such as PLK1, AURKA, AURKB, and MPS1 and kinesins such as CENPE and Eg5, are frequently overexpressed in NSCLC and SCLC, contributing to chromosomal instability, aneuploidy, and highly proliferative tumor phenotypes. Although multiple inhibitors targeting these proteins have been developed, their clinical efficacy as monotherapies has been limited. This is largely due to insufficient target dependency, adaptive resistance mechanisms, mitotic slippage, activation of compensatory pathways, and dose-limiting toxicity. This review integrates current knowledge on the physiological roles of major mitotic regulators, their dysregulation in lung tumorigenesis, and the biological and pharmacological barriers that underlie the limited success of antimitotic drugs. We further highlight preclinical and clinical evidence supporting rational combination strategies designed to enhance the antitumor activity of mitotic inhibitors while minimizing toxicity. Together, these insights underscore the need for refined therapeutic approaches that better exploit vulnerabilities in mitotic control to improve outcomes for patients with lung cancer. Full article

A sucker rod pump is an artificial lift system widely used in oil wells to extract crude oil from deep underground. Due to the clearance between the barrel and the pump plunger, a phenomenon termed slippage occurs in which the annulus column of oil returns to the pump chamber due to the plunger motion and the pressure difference at the two ends of the plunger. Although it is important to maintain the clearance for lubrication between the plunger and the pump barrel in order to prevent excessive wear and tear along with galling, excessive clearance can also be a primary factor in the reduction of oil well production and must be managed. In this research, after briefly reviewing the Couette and Poiseuille flows within the annulus region, the relaxation time for the transients, and the eccentricity effects, we focus on the derivation of important system parameters such the effective mass, stiffness, and damping ratio based on the measurements of the sucker rod displacement and the pressures or loads. Analysis of experimental measurement data can provide better understanding of the sucker rod pump system parameters, helping to quantify and manage the so-called slippage issues. Full article

The steady operation of underground gas storage (UGS) is significant for securing national energy. However, long-term cyclic injection-production operation causes the dynamic changes in formation stress, potentially leading to fault reactivation and slippage. This could affect the seal performance of the fault zone and cause disastrous consequences. In this paper, a mechanical analysis model for fault slip is constructed to study the dynamic seal performance in response to long-term injection-production cycles. An intelligent approach is proposed to predicate the fault slip value based on machine learning algorithms. It can realize long-term prediction of fault slip value under a new condition of injection-production operation. The study shows that (1) formation pressure tends to accumulate near the fault zone due to the low permeability, and the interface of the reservoir layer, cap layer, and fault zone is the seal weak position of UGS; (2) the response of fault slip is driven by the injection-production rate and the reservoir pressure. There is a significant coupling relationship between the fault slip value and the accumulated injection gas volume; (3) the intelligent prediction approach can capture the nonlinear dynamic characteristics of slip tendency accurately, and it exhibits good prediction performance and generalization ability under the new operating condition. This study effectively assesses the dynamic risk for fault slip of depleted hydrocarbon reservoir UGS during the long-term injection-production procedure. It provides an effective technical approach for fault slip tendency analysis and injection-production process optimization, which is important for the sustainable operation of UGS reducing the risk of seal failure and supporting gas storage security. Full article

Agricultural soil fertility is a key determinant of crop productivity and long-term sustainability. However, intensive farming practices often require repeated passes of heavy machinery, which can lead to soil compaction. This study examines the interplay between tractor traffic, tire inflation pressure, and their effects on soil physical properties and fertility indicators. Tire pressure management emerges as a crucial mitigation strategy: high inflation pressures concentrate the load and exacerbate subsoil compaction, whereas reduced pressures (within safe limits) enlarge the tire–soil contact area, distributing the vehicle’s weight more evenly. This in turn improves traction, lowers ground pressure, and reduces energy losses. As a result, both the depth and severity of soil compaction are reduced. Further advances may be achieved through innovative tires manufactured with eco-sustainable materials and tread patterns specifically designed to enhance traction and minimize slippage-related energy loss. In this context, CREA conducted comparative field tests on two tractor tire models from the same manufacturer: a conventional design and an evolved version featuring an innovative tread and larger footprint. The trials assessed the impact of each tire on soil compaction, traction performance, and energy efficiency. Tests were performed on a silty-clay agricultural soil naturally settled for a year, using a dynamometric vehicle to apply different controlled traction force levels, combined with two inflation pressure settings. To highlight performance differences between the two models, the tractor was rear-ballasted, and the study focused on the rear axle, which carried most of the traction stress. Results indicated that, under the specific test conditions, at high inflation pressure both tires performed similarly (with the innovative model slightly reducing fuel use and the conventional yielding marginally higher maximum tractive force), whereas at low pressure the innovative tire clearly outperformed the traditional model in traction efficiency and caused less soil compaction. The extent of the benefits associated with using the innovative tire model across various soil conditions, moisture levels, and in the absence of rear ballasting will be evaluated in further tests based on traction force control using the proposed testing system. Full article

Growing electricity demand and decarbonisation requirements pose significant challenges for coal-dependent transition economies. This study examines whether nuclear deployment can support low-carbon economic transformation using Poland’s national nuclear programme as a case study. We conduct a structured document analysis that integrates a systematic search and screening of peer-reviewed literature with an analysis of national policy and planning materials and a synthesis of publicly available project documentation for the Lubiatowo-Kopalino nuclear power plant, the Pątnów project, and the planned small modular reactor (SMR) deployments. Impacts on employment, infrastructure, technical education, technology transfer, and local supply chain participation are assessed and mapped to the sustainable development goals and the EU climate policy criteria. The analysis indicates that, if accompanied by early workforce development and supplier prequalification, nuclear investments can stimulate industrial upgrading, strengthen energy security, and deliver regional co-benefits beyond electricity generation. At the same time, scheduling slippage, governance uncertainty, and gaps in domestic capabilities in nuclear-specific components can limit these benefits. The article concludes with recommendations for national and local authorities on stakeholder engagement, local content strategy, and risk management that can be transferred to Central European economies with similar starting conditions. Full article

Octa(3,3,3-trifluoropropyl) polyhedral oligomeric silsesquioxane (8F-POSS) was synthesized via a vertex-capping method and incorporated into natural rubber (NR) and deproteinized natural rubber (DPNR) to fabricate inorganic–organic vulcanizates. Curing characteristics, crosslink density, and the filler–rubber interaction parameter (α) were evaluated. We found that 8F-POSS retarded vulcanization kinetics but eventually enhanced network integrity. Two-dimensional infrared (2D-IR) spectroscopy indicated a hydrogen-bond shielding effect between siloxane cages and protein hydroxyl groups in NR. This interaction governed morphology development: proteins in NR acted as compatibilizers to improve initial POSS dispersion, though at high loadings they compromised reinforcement efficiency (α fell from 18.12 to 9.04). In contrast, DPNR vulcanizates showed stronger direct filler–rubber interactions, with higher α values (25.66–35.58) and a more constrained physical network. Despite a denser physical network, the 8F-POSS cages increased fractional free volume and promoted interfacial frictional slippage, leading to a synergistic “reinforcement–dissipation” effect. As a consequence, 8F-POSS/DPNR vulcanizates exhibited an enhanced damping performance (e.g., a loss factor of 1.26) alongside a depressed Tg, reduced equilibrium swelling in oil from 324% to 147%, high hydrophobicity (water contact angle above 120°), and distinctive multi-stage thermal stability. These findings demonstrate a strategy to manipulate the protein network in NR using nanoscale hybrid fillers for the design of high-performance vulcanizates. Full article

Autosomal short tandem repeat (STR) markers remain the cornerstone of modern forensic genetics, providing exceptional power for individualization, kinship verification, and reconstruction of complex investigative cases. Over the last decade, the field has undergone a major technological transition from length-based capillary electrophoresis (CE) toward sequence-level characterization using massively parallel sequencing (MPS), enabling detection of internal sequence variants (isoalleles) and flanking-region polymorphisms that substantially increase discriminatory power in many forensic contexts. Although MPS is increasingly adopted in forensic laboratories, implementation remains dependent on infrastructure, cost considerations, validation requirements, and jurisdiction-specific legal frameworks. This review synthesizes the molecular mechanisms underlying STR variability, including replication slippage and mutation processes, and critically evaluates the transition to sequencing-based analysis. Particular attention is given to analytical challenges such as stochastic effects in ultra-low-template DNA and PCR inhibition in degraded samples. Special emphasis is placed on identification of skeletal remains from mass graves and historical contexts, where hierarchical analytical strategies—from mini-STR approaches to MPS-based workflows—enable recovery of highly fragmented DNA. The review also examines the evolution of probabilistic genotyping (PG), highlighting the importance of algorithmic transparency and reproducible analytical frameworks for judicial applications. By integrating technological advances with practical forensic challenges, this review outlines a comprehensive framework for implementing high-resolution STR analysis in contemporary genomic casework. As a narrative synthesis, the conclusions reflect currently available published evidence and acknowledge variability in validation status, implementation practices, and regional forensic infrastructures. Full article

Pipeline integrity is crucial for ensuring the safe and efficient transportation of hydrocarbons. One of the essential methods for maintaining pipeline integrity is periodic inspection using Pipeline Inspection Gauges (PIGs). These PIGs traverse extensive pipeline networks, collecting critical data related to inertial navigation and inspection technologies, such as geometric, ultrasonic, or magnetic flux inspection. Following an inspection, data is downloaded for post-processing to identify and accurately locate pipeline anomalies. Accurate positioning of indications is crucial for effective repair or maintenance of the identified pipeline section. Thus, ongoing efforts aim to improve the precision of indication positioning. This study introduces an innovative method and model for deriving pipeline trajectory characteristics to enhance positioning accuracy. The method is based on distance sampling of odometers, improving the PIG displacement measurement by implementing multiple odometries. Using the method described in this work can compensate for odometer slip, since the distance measurement error was reduced from 15.67% to 1.38%. The model simulates (three and four) odometer trajectories in curvature and calculates the curvature along the pipeline based on odometer data. The curvature model is evaluated with real data obtained from a test circuit, demonstrating that the proposed method and model technique can yield trajectory characteristics such as curvature detection; we can differentiate linear sections from bend sections in the test circuit. However, the curvature measurement error remains considerable due to odometer slippage. Therefore, future work proposes using additional odometers to improve measurement accuracy. Full article

In the complex operational environment of coal mine shafts, trajectory tracking control of crawler hydraulic drill-anchor robots is susceptible to track slippage and internal–external uncertain disturbances, leading to low tracking accuracy. This issue hinders the implementation of efficient and precise coal mine roadway support operations. To address these challenges, enhance the automation level of coal mine roadway support, and improve operational safety and reliability, research on high-precision trajectory tracking control for crawler hydraulic drill-anchor robots is imperative. Therefore, this paper takes crawler hydraulic drill-anchor robots as the research object and focuses on the trajectory tracking control of such robots. First, a kinematic model incorporating track slippage was established for the crawler hydraulic drill-anchor robot. Second, a cascade predictive control strategy is proposed. The upper-layer trajectory tracking control adopts an adaptive model predictive controller, which adjusts controller weights according to tracking error variations and provides reference rotational speeds for the lower-layer predictive controller. Simulation results of linear and sinusoidal trajectory tracking show that the proposed strategy can effectively compensate for the effects of track slippage and improve trajectory tracking accuracy. Finally, a friction-compensated predictive control method was designed to regulate the rotational speeds of the left and right track drive wheels, and the proposed method achieves optimal control performance with a minimum MEAE of 0.12292 rpm, SDAE of 0.44366 rpm, ITAE of 4.9168, MEACI of 3.0607 mA, SDACI of 1.2497 mA, and ITACI of 122.4283. This performance is significantly superior to that of the conventional PID, ADRC, and MPC methods, thereby realizing high-precision track speed control. Full article

This study addresses the common challenges of complex soil behavior and the difficulties in achieving precise control during the construction of large open caissons. A centrifugal model test was conducted to investigate open caisson–fine sandy soil interaction, and the findings were further verified through field testing. Results indicated that during the sinking process, the open caisson–soil interface exhibited slip failure characteristics, while the soil at the cutting edge of the open caisson showed a tendency for inward shear slippage. The horizontal earth pressure along the open caisson sidewall was found to correspond to static earth pressure in the upper section and gradually approached active earth pressure in the lower section. The maximum earth pressure occurred at approximately three-quarters of the embedded depth of the open caisson wall. Furthermore, the friction angle at the soil-open caisson interface was approximately 0.63 times that of the soil friction angle. Based on the observed distribution patterns of earth pressure and skin friction, theoretical calculation formulas were developed. Their accuracy was confirmed through field tests, providing valuable references for the design and construction of large open caisson projects. Full article

Prosthetic hands have seen significant improvements in recent years, enabling increasingly more natural interactions between patients with upper limb loss and their environment. Nonetheless, progress is continuously being made to enhance user acceptance, which remains a major drawback in such systems. The efficiency of the actuation mechanism is a critical parameter when designing these devices. Maximising actuation approach efficiency enables the use of smaller and lighter motors, thus decreasing the overall weight of the solution. Simultaneously, increased efficiency contributes to more precise motor control. Within this context, the present work introduces a novel actuation concept. Conventional tendon–pulley mechanisms are often susceptible to tendon slippage; therefore, a hobbed tendon–pulley approach was investigated to maintain cable tension more consistently and efficiently. This approach aims to provide smoother operation, improved reliability, and a reduced risk of mechanical failure due to tendon slippage. Simultaneously, the capability of holding and maintaining a set force is of utmost importance in these systems, and the force-feedback system is usually a major concern. The present work also focuses on comparing current and pressure-based control methodologies for the developed prosthesis. The current-based approach had the significant advantage of not requiring external sensors to be assembled on the prosthesis and not relying on the point of application of force being inside the sensor’s active area. During these tests, the prosthesis successfully grasped various objects of different sizes, shapes, stiffnesses, and weights using a current-based approach, without observable tendon slippage. Full article

Background/Objectives: Short Interspersed Nuclear Elements (SINEs) constitute major components of mammalian genomes, but the structural diversity and evolutionary dynamics of their characteristic 3′ poly(A) tails have not been fully characterized. Methods: Based on the custom-developed SINEtail-scan pipeline, 1,018,332 SINEs with tail in the pig reference genome (Sus scrofa 11.1) were identified and systematically classified, revealing the diversity of tail sequence structures. According to nucleotide composition and microsatellite repeat patterns, the tail sequences were divided into 16 different structural types. Results: A-rich sequences predominated (66.3%), while non-A-rich tails exhibited characteristic architectures including AT-format, AC-format, and AG-format repeats. Temporal analysis spanning 85 million years demonstrated progressive tail modification, with A-rich proportions declining from 84.2% in recent insertions to 31.9% in ancient elements, accompanied by accumulation of complex non-A-rich structures. Comparative genomic analysis across 10 pig genome assemblies identified 308 SINE tail insertions within protein-coding sequences, of which 45 (14.6%) exhibited inter-individual structural polymorphism. Detailed investigation of a polymorphic insertion in the VWA8 gene revealed a 16-bp tail variant causing a frameshift mutation and C-terminal protein structure divergence. Conclusions: These findings establish SINE tail sequences as dynamic evolutionary substrates undergoing continuous modification through slippage-mediated mechanisms, with implications for genome evolution, population genetics, and gene function modulation in mammals. Full article

Glioblastoma (GBM) is the most aggressive primary brain tumor, marked by molecular heterogeneity and poor clinical prognosis. Lysyl oxidase-like 3 (LOXL3) is frequently upregulated in GBM, but its mechanistic contribution remains insufficiently defined. Here, we investigated the functional role of LOXL3 in GBM using CRISPR-Cas9-mediated LOXL3 knockdown in two genetically distinct GBM cell lines: U87MG (wild-type TP53) and U251 (mutant TP53). Reduced LOXL3 expression markedly reduced α-tubulin acetylation, particularly in U87MG cells, and downregulated genes involved in cell cycle progression and proliferation. Both cell lines exhibited mitotic defects, including delayed cell cycle progression and spindle abnormalities; however, cell fate diverged according to TP53 status. U87MG cells, sustained spindle checkpoint activation triggered a p53-dependent spindle checkpoint response culminating in apoptosis, while U251 cells underwent mitotic slippage and senescence. Transcriptomic analyses confirmed differential regulation of apoptosis versus senescence pathways in accordance with TP53 functionality. Additionally, reduced LOXL3 expression markedly impaired adhesion and migration in U87MG cells, whereas U251 cells were minimally affected, consistent with more pronounced microtubule destabilization. Collectively, these findings identify that LOXL3 is a key regulator of microtubule homeostasis, mitotic fidelity, adhesion, and invasive behavior in GBM. Targeting LOXL3 may therefore provide a therapeutic opportunity for genotype-informed intervention in GBM. Full article