This paper investigates the role of simplex perfectives in the Russian aspectual system, which are known to display a number of characteristics that seem to escape a proper theoretical treatment. It is proposed that simplex perfective roots (like re&...
Experimentation is a strong methodology that improves and optimizes processes. Nevertheless, in many cases, real-life dynamics of production demands and other restrictions inhibit the use of these methodologies because their use implies stopping prod...
We prove that the Nelder–Mead simplex method converges in the sense that the simplex vertices converge to a common limit point with a probability of one. The result may explain the practical usefulness of the Nelder–Mead method.
Spatial information is increasingly becoming a vital factor in the field of hyperspectral endmember extraction, since it takes into consideration the spatial correlation of pixels, which generally involves jointing spectral information for preprocess...
Peribacillus simplex is a Gram-positive, spore-forming bacterium derived from a vast range of different origins. Notably, it is part of the plant-growth-promoting rhizobacterial community of many crops. Although members of the Bacillaceae family have...
Selection of the most efficient algorithm for a given set of linear programming problems has been a significant and, at the same time, challenging process for linear programming solvers. The most widely used linear programming algorithms are the prim...
Six new cyclic peroxides (1–6) were isolated from the Korean sponge Plakortis simplex, along with two new alkylpyridinium alkaloids (7 and 8). The structures of these compounds were completely determined by a combination of NMR analysis and chemica...
Bacillus simplex is an environmental microorganism found in soil. Herein, we present the case of a 69-year-old Greek male patient who attended the Emergency Department at our hospital. The patient complained of lower right extremity swelling and pain...
This study assessed the seroprevalence of anti-Anisakis simplex antibodies in Norwegian patients with inflammatory bowel disease (IBD), specifically ulcerative colitis (UC) and Crohn’s disease (CD), compared with healthy controls. Associations...
Herpes simplex virus (HSV) is the leading cause of proctitis in HIV-infected individuals. However, no cases of rectal masses secondary to HSV infection have been reported to date. Herein, we present the case of a 45-year-old man with HIV infection wh...
Herpes simplex viruses (HSV) are ubiquitously distributed with a seroprevalence ranging up to 95% in the adult population. Refractory viral infections with herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) represent a major global health issue....
An enthusiastic artificial-free linear programming method based on a sequence of jumps and the simplex method is proposed in this paper. It performs in three phases. Starting with phase 1, it guarantees the existence of a feasible point by relaxing a...
It was known in antiquity that the sum of the three angles of a triangle equals
16α-Hydroxyprednisolone, an anti-inflammatory drug, could be potentially obtained from hydrocortisone bioconversion by combining a 1,2-dehydrogenation reaction performed by Arthrobacter simplexATCC31652 with a 16α-hydroxylation reaction b...
The green algae Dunaliella salina offers great potential for the food industry due to its high β-carotene content. To guarantee the economic profitability of cultivation, growth conditions must be improved. Therefore, the effects of pH and salin...
The cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-dependent Cl− channel, is closely associated with multiple pathogen infections, such as SARS-CoV-2. However, whether the function of the CFTR is involved in herpes simplex v...
Spontaneous self-assemblies of biomolecules can generate geometrical patterns. Our findings provide an insight into the mechanism of self-assembled ring pattern generation by human serum albumin (HSA). The self-assembly is a process guided by kinetic...
Successful infection of herpes simplex virus is dependent upon chromatin modulation by the cellular coactivator host cell factor-1 (HCF-1). This review focuses on the multiple chromatin modulation components associated with HCF-1 and the chromatin-re...
Background: Herpes simplex keratitis (HSK) is a disease characterized by the recurrent infection of the cornea, mainly due to infection caused by herpes simplex virus type 1. The suppression of recurrence can suppress progressive corneal scarring, ul...
State transition algorithm (STA) is a metaheuristic method for global optimization. However, due to the insufficient utilization of historical information, it still suffers from slow convergence speed and low solution accuracy on specific problems in...
Diseases caused by human herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) affect millions of people worldwide and range from fatal encephalitis in neonates and herpes keratitis to orofacial and genital herpes, among other manifestations. The viru...
Background and objectives: Recurrent herpes simplex keratitis (HSK) is the most common cause of corneal blindness in the developed world. A relationship between host gene polymorphisms and the recurrence of herpes simplex virus (HSV) infection has pr...
Herpes simplex encephalitis (HSE), predominantly caused by herpes simplex virus type 1 (HSV-1), is the most common sporadic viral encephalitis worldwide and remains life threatening despite antiviral therapy. Although herpes simplex virus (HSV) infec...
Anisakis simplex third-stage larvae are the main source of hidden allergens in marine fish products. Some Anisakis allergens are thermostable and, even highly processed, could cause hypersensitivity reactions. However, Anisakis proteome has not been...
Antibiotic-loaded bone cements (ALBCs) are used to prevent and treat periprosthetic joint infections (PJI). This study compares the in vitro release and antibacterial effectiveness of gentamicin from Palacos® R+G and tobramycin from Simplex®...
Ivermectin (IVM), an antiparasitic drug, has a positive effect against Anisakis simplex s.s. infection and has been used for the treatment and prevention of anisakiasis in humans. However, the molecular mechanism of action of IVM on A. simplex s.s. r...
Most traditional endmember extraction algorithms focus on spectral information, which limits the effectiveness of endmembers. This paper develops a spatial potential energy weighted maximum simplex algorithm (SPEW) for hyperspectral endmember extract...
Herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) are two of the most prevalent human viruses worldwide. They are known to cause a variety of diseases including genital herpes, meningitis, encephalitis, cold sores and herpes...
In order to increase a nonlinear system’s state estimate precision, an iterated orthogonal simplex cubature Kalman filter (IOSCKF) is presented in this study for target tracking. The Gaussian-weighted integral is decomposed into a spherical int...
We investigate and compare two versions of the Nelder–Mead simplex algorithm for function minimization. Two types of convergence are studied: the convergence of function values at the simplex vertices and convergence of the simplex sequence. Fo...
The third-stage larvae (L3) of Anisakis simplex are the most important source of hidden allergens in seafood products. However, there exist no commercial methods for detecting Anisakis proteins in food. Furthermore, only a few methods have been valid...
With the increased worldwide burden of cancer, including aggressive and resistant cancers, oncolytic virotherapy has emerged as a viable therapeutic option. Oncolytic herpes simplex virus (oHSV) can be genetically engineered to target cancer cells wh...
Anisakis simplex sensu stricto (s.s.) L3 larvae are one of the major etiological factors of human anisakiasis, which is one of the most important foodborne parasitic diseases. Nevertheless, to date, Anisakis secretome proteins, with important functio...
Herpes simplex virus (HSV) infections are highly widespread among humans, producing symptoms ranging from ulcerative lesions to severe diseases such as blindness and life-threatening encephalitis. At present, there are no vaccines available, and some...
In the development of simplex mixed-effects models, random effects in these mixed-effects models are generally distributed in normal distribution. The normality assumption may be violated in an analysis of skewed and multimodal longitudinal data. In...
Herpes simplex keratitis (HSK) is classically described as an immunopathological disease driven by recurrent herpes simplex virus type 1 (HSV-1) infection and chronic inflammation. So far, immune-mediated tissue damage has not fully explained the mol...
Soil salinization is currently one of the main abiotic stresses that restrict plant growth. Plant endophytic bacteria can alleviate abiotic stress. The aim of the current study was to isolate, characterize, and assess the plant growth-promoting and s...
Conventional spherical simplex-radial cubature Kalman filter (SSRCKF) for maneuvering target tracking may decline in accuracy and even diverge when a target makes abrupt state changes. To overcome this problem, a novel algorithm named strong tracking...
This article develops a boundary-adaptive nonparametric methodology for estimating the geometric conditional quantiles of a multivariate response when the conditioning covariate is supported on the simplex—an important case, as it is the natura...
Excessive nitrogen fertilizer application in baby maize production can contribute to nutrient losses and environmental degradation, highlighting the need for sustainable nutrient management strategies. This study aimed to isolate, characterize, and e...
The paper addresses the problem of using machine learning in practical robot applications, like dynamic path planning with obstacle avoidance, so as to achieve the performance level of machine learning model scorers in terms of speed and reliability,...
Microbial α-amylases are widely used in industrial biotechnology due to their catalytic efficiency, stability, and cost-effective production. Identifying sources of newly isolated bacterial strains with desirable biochemical properties remains...
The existence of intra-class spectral variability caused by differential scene components and illumination conditions limits the improvement of endmember extraction accuracy, as most endmember extraction algorithms directly find pixels in the hypersp...
Background: Fibonacci patterns and tubular forms both arose early in the phylogeny of multicellular organisms. Tubular forms offer the advantage of a regulated internal milieu, and Fibonacci forms may offer packing efficiencies. The underlying mechan...
When the response variable is defined on the (0,1) interval, the beta and simplex regression models are commonly used by researchers. However, there is no software support for these models to make their implementation easy for researchers. In this st...
Herpes simplex virus (HSV), a human pathogenic virus, has evolved several strategies to evade the production and function of interferons (IFNs) and cytokines generated by the innate immune system to restrict the virus. Equilibrium exists between the...
Herpes simplex virus (HSV) keratitis is one of the leading causes of blindness worldwide. Additionally, up to 90% of the population in some countries is seropositive for HSV. HSV can cause a wide spectrum of ocular disease ranging from blepharitis to...
Current therapy against herpes simplex viruses (HSV) relies on the use of a few nucleoside antivirals such as acyclovir, famciclovir and valacyclovir. However, the current drugs are ineffective against latent and drug-resistant HSV infections. A seri...
Three new cycloartenol triterpene saponins, named shengmaxinsides A-C, have been isolated from the ethyl acetate soluble fraction of an ethanol extract of Cimicifuga simplex Wormsk roots. Their structures were established by chemical tests and detail...
Background: Herpes simplex encephalitis (HSE) is a rare but life-threatening infection of the central nervous system associated with high mortality and severe neurological sequelae. The diagnosis may be particularly challenging in patients presenting...
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