Search Results (133)

The accurate and effective prediction of PM2.5 concentrations is crucial for mitigating air pollution, improving environmental quality, and safeguarding public health. To address the challenge of strong temporal correlations in PM2.5 concentration forecasting, this paper proposes a novel hybrid model that integrates the Particle Optimization Algorithm (POA) and Variational Mode Decomposition (VMD) with the Long Short-Term Memory (LSTM) network. First, POA is employed to optimize VMD by adaptively determining the optimal parameter combination [k, α], enabling the decomposition of the original PM2.5 time series into subcomponents while reducing data noise. Subsequently, an LSTM model is constructed to predict each subcomponent individually, and the predictions are aggregated to derive hourly PM2.5 concentration forecasts. Empirical analysis using datasets from Beijing, Tianjin, and Tangshan demonstrates the following key findings: (1) LSTM outperforms traditional machine learning models in time series forecasting. (2) The proposed model exhibits superior effectiveness and robustness, achieving optimal performance metrics (e.g., MAE: 0.7183, RMSE: 0.8807, MAPE: 4.01%, R²: 99.78%) in comparative experiments, as exemplified by the Beijing dataset. (3) The integration of POA with serial decomposition techniques effectively handles highly volatile and nonlinear data. This model provides a novel and reliable tool for PM2.5 concentration prediction, offering significant benefits for governmental decision-making and public awareness. Full article

Background: Influenza A viruses (IAV) cause seasonal flu and occasional pandemics. In addition, the potential for the emergence of new strains presents unknown challenges for public health. Face masks and other personal protective equipment (PPE) can act as barriers that prevent the spread of these viruses. Metal ions embedded into PPE have been demonstrated to inactivate respiratory viruses, but the underlying mechanism of inactivation and potential for resistance is presently not well understood. Methods: In this study, we used hemagglutination assays to quantify the effect of zinc ions on IAV sialic acid receptor binding. We varied the zinc concentration, incubation time, incubation temperature, and passaged IAV in the presence of zinc ions to investigate if resistance to zinc ions could evolve. Results: We found that zinc ions impact the ability of IAV particles to hemagglutinate and observed inhibition within 1 min of exposure. Maximum inhibition was achieved within 1 h and sustained for at least 24 h in a concentration-dependent manner. Inhibition was also temperature-dependent, and optimal above room temperature. Serial passaging of IAV in the presence of zinc ions did not result in resistance. Conclusions: e conclude that zinc ions prevent IAV hemagglutination in a concentration and temperature-dependent manner for at least 24 h. Overall, these findings are in line with previous observations indicating that zinc-embedded materials can inactivate the IAV hemagglutinin and SARS-CoV-2 spike proteins, and they support work toward developing robust, passive, self-cleaning antiviral barriers in PPE. Full article

Bacterial persisters are dormant cells that survive antibiotic treatment, serving as a reservoir for the emergence of resistant mutations. The evolution of antibiotic resistance poses a significant challenge to public health. In this study, we investigated the development of resistance in Pseudomonas aeruginosa persister cells by exposing the reference strain PA14 to meropenem and tracked the emergence of resistance mutations over serial passages. Whole-genome sequencing of the populations or individual resistant strains revealed evolutionary trajectories. In the initial passages, low-level meropenem-resistant mutants harbored various mutations, accompanied by increasing population survival. Then, mutations in the oprD gene appeared, followed by mutation in the mexR gene in most of the cells, leading to high-level meropenem resistance and collateral resistance to ciprofloxacin. Our study provides insights into the evolutionary pathways of P. aeruginosa under lethal antibiotic pressure, highlighting the dynamic interplay between persister cells and the emergence of resistance mutations. Full article

Background/Objectives: A 2-year-old male presented to the emergency department (ED) with vomiting and abdominal discomfort following ingestion of multiple magnets from a sibling’s bracelet. This case highlights the risks associated with magnet ingestion and the need for coordinated multidisciplinary care and public health intervention. Methods: Radiographs revealed magnets in the oropharynx, stomach, and small bowel. Emergency physicians coordinated care with otolaryngology, gastroenterology, and general surgery. Results: Laryngoscopy successfully removed two magnets from the uvula, and endoscopy retrieved 30 magnets from the stomach. General surgery performed a diagnostic laparoscopy, identifying residual magnets in the colon. Gastroenterology attempted a colonoscopy but was unable to retrieve magnets due to formed stool, leading to bowel preparation and serial imaging. The patient eventually passed 12 magnets per rectum without surgical intervention. Conclusions: This case emphasizes the importance of multidisciplinary collaboration in managing magnet ingestion, a preventable cause of serious gastrointestinal injury. Recent studies highlight the increasing incidence and severity of such cases due to accessibility and inadequate regulation. These findings underscore the need for public awareness and adherence to management protocols to mitigate morbidity and mortality in pediatric patients. Full article

Bacterial infections, particularly those caused by multidrug-resistant strains, remain a significant global public health challenge. The growing resistance to traditional antibiotics highlights the urgent need for novel antibacterial strategies. Herein, we successfully synthesized three types of nitrogen-doped carbon dots (tBuCz-CDs, HAH-CDs, and EC-CDs) via hydrothermal method using tert-butyl carbazate, hydroxyacetic acid hydrazide, and ethyl carbazate as precursors. tBuCz-CDs, HAH-CDs, and EC-CDs exhibited potent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA), with minimum inhibitory concentrations (MICs) of 100, 100, and 150 µg/mL, respectively. Their antibacterial effect on MRSA was comparable to that of the widely used antibiotic vancomycin hydrochloride, as shown by the zone of inhibition assay. Furthermore, the carbon dots exhibited low cytotoxicity and hemolytic activity showing their excellent biocompatibility both in vitro and in vivo. They also significantly promoted wound healing compared to untreated controls. Notably, the serial passaging of MRSA exposed to these carbon dots did not result in the bacterial resistance. Mechanistic studies revealed that the carbon dots exerted antibacterial effects through multiple mechanisms, including the disruption of bacterial membranes, inhibition and eradication of biofilm formation, generation of reactive oxygen species, and DNA damage. This work highlights the potential of nitrogen-doped CDs as a promising material for combating drug-resistant bacterial infections and underscores their potential for further biomedical development. Full article

Background: The global space economy has grown remarkably, witnessing a 10-fold increase in active satellites during the last 15 years. This growth was accompanied by both the increase in geopolitical tensions feeding huge investments (the New Space Race), on the one hand, and the transformation, shifting from a domain historically dominated by government-led programs to one partially energized by commercial players and innovative business models (“New Space”), on the other hand. Objective: To assess the space economy’s current state and future prospects by considering its economic and social dimensions. Methods: Over 120 scholarly articles and “grey” literature positions (e.g., industry reports) were reviewed. The review was structured by a modified Structure–Conduct–Performance framework originally developed by industrial organization (IO) scholars. Findings: Outer space creates extremely harsh conditions for placing and operating objects in orbits, which results in high launching costs, steep reliability standards, capital intensity, and risks that are unmatched in most terrestrial industries. One of the main motivations to venture into this harsh domain was, and still is, the desire to dominate or the fear of being subjugated by others. This “original sin”, born of geopolitical rivalries, continues to cast a shadow over the space economy, channeling the majority of public space budgets into military-related programs. Moreover, many space technologies have a dual-use feature. Not surprisingly, governments are still the major source of demand, dominating midstream in the space value chain. This triad—harsh physics, great power rivalry, and a state-centric midstream—produces a specificity of the sector. In the recent two decades, new entrants (called “New Space”) have begun altering market structure, resulting in new conduct patterns focused on pursuits towards serial production, reusability, and lowering costs. Performance outcomes are mixed. While some efficiency gains are unprecedented, some doubts about market power and negative externalities arise. The assessment of the space economy’s performance is a challenge, as such, due to the blurred boundary between political objectives (supplying public goods, mitigating negative externalities) and economic optimization. Such trade-offs are becoming even more complicated considering the potential conflict between national and global perspectives. The paper offers a preliminary, descriptive study of the space economy through the lens of the modified S-C-P framework, laying basic foundations for the future, possibly more rigorous research of the increasingly important space economy. Full article

The United Kingdom has long been a frontrunner in green finance, establishing programs like the Green Finance Institute to promote corporate engagement in sustainable initiatives. The Green Finance Strategy, enacted in 2019, aligns UK financial procedures with international standards, including the EU taxonomy for sustainable Activities. The study examined how sustainable finance enhances the corporate reputation of the firms listed on the London Stock Exchange. A purposive sampling yielded 17 years of data from 143 non-financial companies from the Thomson Reuters Eikon DataStream between 2007 and 2023. In dealing with the issue of endogeneity and auto-serial correlation, the Generalized Methods of Movement (GMM) was employed to provide reliable and unbiased estimation results. The study revealed a positive impact of green bond issues, environmental expenditures, and policies for emission reduction on corporate reputation. The moderating relationship between green bond issues, environmental expenditures, and board diversity revealed a positive and significant relationship with corporate reputation. Managers should ensure that their endorsed activities gain public recognition and align with sustainability goals, particularly by emphasizing the issuance of green bonds in their financing strategy. They should also collaborate with environmental experts and stakeholders to ensure that the outcomes of funded projects are evaluated in line with international ESG standards. Full article

The influenza A viruses (IAV) are the principal pathogens for annual (seasonal) influenza, which cause world-wide outbreaks in poultry and pose a persistent threat to public health. The Hemagglutinin protein (HA) of IAV promotes virus infection by binding the host membrane receptor and mediating virus–host membrane fusion. Immunoprecipitation–mass spectrometry (IP-MS) provides global insights into IAV HA–host protein interactions. However, various experimental conditions might affect the identification of interactions. Here, we performed a serial IP-MS to compare interactors of IAV HA in accidental host human, chicken and reservoir host duck cells. We found that the positive ratio of interactors identified by the IP-MS was improved when the transfected HA plasmid had a similar expression level to HA proteins found in IAV virus infection. Comparing interactors in human, chicken and duck cells, we found that HA–interacting host factors might play a role in the susceptibility of accidental hosts (human and chicken) to IAV infection compared to reservoir hosts (duck). We then focused on the function of two heat shock proteins (HSPA5 and HSPA8), which interacted with IAV HA proteins in all three species (human, chicken and duck). We found that both HSPA5 and HSPA8 promoted the IAV replication by enhancing the viral attachment and internalization. These findings extend our knowledge about the mechanisms of IAV entry to host cells and provide target genes to create chickens resistant to avian influenza. Full article

In this essay, we propose that the prevalence of cheating by accounting students and serial cheating by accounting practitioners at Big-4 accounting firms are related. Our model of this problem suggests that students who cheat in school become practitioners who cheat in practice, and practitioners, in turn, model dishonest behavior for students. We propose that this vicious cycle of dishonesty poses a threat to the public’s trust in the accounting profession, and this crisis calls for drastic measures, both in academia and in practice, akin to measures like the Sarbanes–Oxley Act of 2002. As an honorable profession, dishonesty cannot be tolerated. Brief overviews of the prevalence of cheating, both by students and by Big-4 accounting practitioners are presented. Suggestions are included for a three-prong approach by accounting stakeholders to reduce this egregious ethical problem—a problem that, we suggest, is causing a new crisis in confidence for the accounting profession. Full article

Quantifying the infectious titre of preparations containing rabbit haemorrhagic disease virus (RHDV) is an essential virological technique during RHDV research. The infectious titre of an RHDV preparation is determined using a bioassay to identify the endpoint dilution at which 50% of rabbits become infected (RID₅₀). Previous publications have briefly described the method for estimating the infectious titre of RHDV preparations by challenging rabbits with 10-fold serial dilutions. However, these descriptions lack the critical considerations for a standardised method to estimate RID₅₀. These details are presented here, along with a comparison between the Reed–Muench, Dragstedt–Behrens, Spearman–Kärber, and probit regression methods for calculating the RID₅₀. All the statistical approaches demonstrated a high level of agreement in calculating the RID₅₀. To help assess the precision of the estimated infectious titre, the improved Spearman–Kärber and probit regression methods provide the 95% confidence intervals. The method outlined improves the accuracy of results when undertaking studies of pathogenicity, host resistance, and the production of vaccines against RHDV. Full article

Mobbing, also referred to as workplace bullying, has significant impacts on employee behavior within organizational contexts, negatively affecting organizational performance. Consequently, promoting workplace well-being and individual performance emerges as a critical factor in mitigating the adverse effects associated with this phenomenon. This study aims to fill a gap in the research because it integrates a sequential mediation model, which elucidates the underlying mechanisms through which mobbing influences organizational outcomes. The research involved 388 workers from the public and private sectors, aged between 21 and 59 years, selected through non-probabilistic convenience sampling. Despite its limitations, this method was chosen to ensure an adequate representation of employees experiencing workplace mobbing across different sectors. Data collection was carried out using the Luxembourg Workplace Mobbing Scale, the Job Performance Questionnaire, the Organizational Performance Questionnaire, and the Workplace Welfare Scale. The findings revealed that high levels of mobbing are significantly associated with a reduction in organizational performance. Furthermore, workplace well-being and individual performance were identified as serial mediators in this relationship, indicating that more harmonious work environments enhance individual efficacy, thereby contributing to improved organizational performance. These results highlight the importance of strategic interventions focused on promoting well-being in the workplace to promote healthier and more productive organizational cultures. Full article

Background/objectives: recent studies have suggested that components typical of the Mediterranean diet (MedDiet) are associated with depression and anxiety prevention. In this sense, the main objective of this study was to analyse the associations between adherence to the MedDiet and depression and anxiety symptoms and to examine whether this relationship is mediated by lean mass and the muscle strength index (MSI). Methods: a cross-sectional study (based on data obtained from the Nuts4Brain-Z study) was conducted from 2023–2024, involving 428 university students, aged 18–30 years, from a Spanish public university. Depression was assessed using the Beck Depression Inventory (BDI-II), and anxiety was assessed via the General Anxiety Disorder-7 (GAD-7) tool. Adherence to the MedDiet was assessed using the MEDAS questionnaire. Lean mass was assessed via bioimpedance, and MSI was measured via a dynamometer. ANCOVA models were used to test the mean differences in depression and anxiety scores using MEDAS categories (low adherence < 9 points vs high adherence ≥ 9 points). Serial multiple mediation models, adjusted for the main confounders, were used to explore the role of lean mass and MSI in the relationships between adherence to the MedDiet and depression and anxiety symptoms. Results: university students with high adherence to the MedDiet exhibited lower scores for depression and anxiety symptoms (p < 0.05) than did students with low adherence to the MedDiet. The mediation analysis preliminarily revealed that both lean mass and MSI acted as mediators of the relationships between adherence to the MedDiet and depression and anxiety. Conclusion:adherence to the MedDiet in university students per se does not appear to have a direct effect on depression and anxiety symptoms because these associations are partially (for depression) or entirely (for anxiety) explained by lean mass and MSI. Full article

Brucellosis is a common zoonotic disease affecting livestock and humans globally. The disease is endemic in Ethiopian livestock. This study was conducted to estimate Brucella seropositivity and identify its risk factors in livestock, and practices that may expose pastoralists to the disease. Data were collected from 2133 animals across 149 households (HHs) in Dubti and Amibara districts, Afar region, Ethiopia. Blood samples from livestock and household data were collected, and interviews were conducted on husbandry and dairy consumption practices. Sera were serially tested using the Rose Bengal test and indirect enzyme-linked immunosorbent assay. The overall seropositivity to anti-Brucella antibodies was 8% (95% CI, 6.6–9.2). The antibodies were found in 12.4%, 6.5%, 6%, and 3% of the goats, cattle, camels, and sheep, respectively. Among the HHs, 59.7% had at least one seropositive animal. A mixed-effects logistic regression analysis revealed species and the acquisition of new animals (in cattle and camels), and age and district (in sheep, goats, and cattle) as significant risk factors. Goats, cattle, and camels had significantly higher odds of Brucella seropositivity than sheep (p < 0.05). Seropositivity was significantly higher (p < 0.05) in adults than in young animals, in acquired than in homebred (cattle and camels), and in those with reproductive disorders than those without. Pastoralists lacked knowledge of brucellosis and its modes of transmission, while practices exposing humans and livestock to brucellosis were common. The findings underscore the need for public awareness campaigns and implementation of brucellosis control measures in pastoral systems. Full article

Background: The “copycat effect” is a psychological phenomenon in which a person’s actions influence the behavior of others, leading to imitations of behaviors, events, or ideas. It is often observed in contexts such as crimes, suicides, or violent behaviors, where media coverage of an event can trigger similar reactions in other people. Usually, many studies associate the copycat phenomenon with homicide or serial crimes. Little attention is paid to the phenomenon of emulation in suicide and, therefore, to the copycat phenomenon in this context. Methods: In our study, a systematic review of the literature was carried out using keywords related to copycat and suicide. Subsequently, each study was read and analyzed. Results: The results were compared with each other and demonstrated how it is essential to mitigate the resonance of suicidal events, especially through the media and social networks. In particular, this risk of emulation is greater among young people who are exposed to a continuous external source of information through news from the web in an incessant and constant way. This risk increases most immediately after the publicity of the suicidal event in a limited period of time. Conclusions: Unfortunately, little attention is given to the analysis of the copycat phenomenon, which causes an underestimation of the data related to suicide emulation, especially from the preventive perspective of a phenomenon that is still widespread. Full article

Background: This study aims to illuminate the role of perceived crisis responsibility in shaping vaccination intention. By using the case of Hong Kong during the COVID-19 pandemic, we examined whether and how the allocation of crisis responsibility to the government predicts the public’s intention to take vaccines, particularly by investigating its underlying mechanism. Method and Results: Based on a population-representative sample of Hong Kong adults (N = 3188), our results indicated that (1) the attribution of crisis responsibility directly led to lower vaccination intention, and (2) it also had indirect influences on vaccination intention through trust and anger; specifically, the crisis attribution resulted in less willingness to take vaccines via a decreased trust in government health agencies. We also found a serial mediation pathway in which anger aroused by the crisis attribution could decrease trust, which, in turn, yielded lower vaccination intentions. Conclusion: The findings of this study offer theoretical insights into the role of attribution of crisis responsibility in affecting vaccination decisions during a public health emergency. Further, these findings provide directions for crisis managers and public health authorities to develop communication strategies to motivate vaccine uptake and formulate an approach to tackle the pandemic crisis. Full article