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Search Results (1,749)

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15 pages, 1607 KB  
Article
Functional Reduced-Fat Mozzarella Cheese from “Essential Oil-Fed” Milk and Inulin Fortification
by Claudia Antonino, Giuseppe Natrella, Pietro Caliandro, Lucrezia Forte, Antonella Pasqualone and Michele Faccia
Foods 2026, 15(9), 1565; https://doi.org/10.3390/foods15091565 - 1 May 2026
Abstract
The demand for functional dairy products is increasing, in response to the adverse correlation between high saturated fat consumption and cardiovascular health problems. The present study investigated the physicochemical and sensory features of a prototype of functional reduced-fat Mozzarella cheese fortified with inulin [...] Read more.
The demand for functional dairy products is increasing, in response to the adverse correlation between high saturated fat consumption and cardiovascular health problems. The present study investigated the physicochemical and sensory features of a prototype of functional reduced-fat Mozzarella cheese fortified with inulin made from milk obtained by integrating the cattle diet with laurel essential oil (LEO). Two samples were compared over a 10-day storage period: a whole-milk Mozzarella cheese (MC), and a reduced-fat Mozzarella cheese fortified with 10% (w/v) of inulin (MI). The results show that incorporating inulin during the stretching phase required more time (2.55 min longer) to obtain the final product. However, in addition to a 5% fat decrease, the MI cheese achieved an inulin content of 3.31%, satisfying the European Regulation No 1924/2006, for the “Source of Fiber” claim. On the other hand, from a nutritional perspective, the dietary LEO integration significantly modulated the lipid fraction of the sample, resulting in a 40% increase in monounsaturated fatty acids (MUFAs) and a marked enrichment in polyunsaturated fatty acids (PUFAs). Considering the texture attributes, the incorporation of inulin during the stretching phase led to the formation of a micro-gel that acted as a functional filler, resulting in significantly higher hardness (33.41 N for MI and 16.10 N for MC), throughout the 10-day storage period. Temporal Check-All-That-Apply (TCATA) analysis confirmed that while the MI sample introduced vegetable and cooked milk notes, MI maintained major textural integrity throughout the shelf-life. These findings demonstrate that the synergy between inulin fortification and dietary laurel essential oil supplementation represents a highly effective strategy for producing reduced-fat pasta filata cheeses. This dual approach not only preserves sensory and textural integrity but also yields a high-value functional product characterized by an optimized fatty acid profile and a significant fiber intake. Full article
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20 pages, 3216 KB  
Article
Combined Effects of Kaolin Particle Film and Training System on Sunburn Mitigation and Wine Aroma
by Fernando Sánchez-Suárez, Francisco Javier Mesas-Carrascosa and Rafael A. Peinado
Horticulturae 2026, 12(5), 554; https://doi.org/10.3390/horticulturae12050554 - 1 May 2026
Abstract
Climate warming in Mediterranean vineyards accelerates grape ripening and increases the incidence of sunburn and berry shriveling, leading to imbalances in grape composition and wine quality. This study evaluated the combined effects of a non-positioned training system (asymmetric sprawl) and foliar application of [...] Read more.
Climate warming in Mediterranean vineyards accelerates grape ripening and increases the incidence of sunburn and berry shriveling, leading to imbalances in grape composition and wine quality. This study evaluated the combined effects of a non-positioned training system (asymmetric sprawl) and foliar application of kaolin particle film on vine microclimate, agronomic performance and wine aroma profile in a Syrah cv. vineyard under warm conditions. Vine canopy temperature was monitored by UAV thermography at veraison and harvest, while grape damage, yield components and vegetative balance were assessed at harvest. Wines obtained from each treatment were analysed for chemical composition, volatile compounds and sensory attributes. Kaolin application significantly reduced canopy temperature, particularly under water-limited conditions at veraison (up to 1.9 °C), and the combination with sprawl training decreased the proportion of sunburnt and shrivelled clusters. These microclimatic modifications were associated with higher ethanol content, improved colour intensity and increased total polyphenol index in wines. The combined strategy also enhanced the concentration of key aroma compounds, especially terpenes and fruity esters, resulting in higher values of citrus, floral and fruity aromatic series. Sensory evaluation confirmed a better overall appreciation of wines produced from vines managed with both practices. Overall, the integration of canopy architecture modification and reflective particle film represents an effective strategy to mitigate heat stress effects in warm viticultural regions, improving grape physiological performance and contributing to the preservation of wine aromatic quality under climate change scenarios. Full article
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40 pages, 3961 KB  
Systematic Review
Trends, Challenges, and Opportunities of Cañihua (Chenopodium pallidicaule) for Functional Food Development and Sustainable Agriculture: A Bibliometric and Systematic Approach
by Alberto Estalla, Jennifer Alvarez, Karina Eduardo, Milagros Coaguila-Gonza, Gabriela Barreto-Tarrillo, Juan D. Rios-Mera and Erick Saldaña
Agriculture 2026, 16(9), 992; https://doi.org/10.3390/agriculture16090992 - 30 Apr 2026
Abstract
Cañihua (Chenopodium pallidicaule) is an underutilized Andean pseudocereal of strategic interest for sustainable agriculture in high-altitude, climate-constrained environments, where its tolerance to frost, drought, and saline soils positions it as a potential climate-resilient crop. Despite its high nutritional value and potential [...] Read more.
Cañihua (Chenopodium pallidicaule) is an underutilized Andean pseudocereal of strategic interest for sustainable agriculture in high-altitude, climate-constrained environments, where its tolerance to frost, drought, and saline soils positions it as a potential climate-resilient crop. Despite its high nutritional value and potential for functional food applications, its research landscape remains fragmented and unevenly developed across agronomic, nutritional, and technological dimensions. This study aimed to systematically and bibliometrically analyze the scientific literature on cañihua published between 1995 and 2025. A total of 104 documents indexed in the Scopus database were evaluated following the PRISMA 2020 approach, including analyses of publication trends, geographic distribution, collaboration networks, and thematic structures, together with a qualitative critical appraisal of the included evidence. Results indicate a marked increase in scientific output since 2006, with research predominantly concentrated in food science and technology and limited development in agronomy, clinical nutrition, and socio-economic domains. Thematic analysis reveals a strong focus on bioactive compounds, nutritional composition, and processing technologies, while clinical, socio-economic, and large-scale agricultural studies remain limited. Processing strategies such as germination, malting, and fermentation enhance nutrient bioavailability, reduce antinutritional factors, and improve sensory properties, supporting the incorporation of cañihua into functional and gluten-free foods at levels of up to 25%. Significant gaps persist in clinical validation, agronomic standardization, production scalability, genetic improvement, and integration across research domains. Overall, cañihua shows strong potential to contribute to sustainable Andean agriculture, food security, and functional food innovation, although further interdisciplinary and translational research linking agricultural production with nutritional and technological outcomes is required to realize its full applied potential. Full article
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23 pages, 456 KB  
Review
Recent Progress in the Applications of Levilactobacillus brevis in Food Fermentation: A Review
by Muhammad Salman Farid, Muhammad Imran Hussain, Saba Akhtar, Aniqa Abbas, Mahwish Tanveer, Sania Khalid, Izabela Dmytrów and Łukasz Łopusiewicz
Fermentation 2026, 12(5), 225; https://doi.org/10.3390/fermentation12050225 - 30 Apr 2026
Abstract
The rising global demand for functional, “clean-label” fermented foods has driven intense interest in versatile microbial starter cultures. Levilactobacillus brevis is an obligately heterofermentative lactic acid bacterium that is highly valued for its robust environmental adaptability and exceptional capacity to synthesize bioactive metabolites, [...] Read more.
The rising global demand for functional, “clean-label” fermented foods has driven intense interest in versatile microbial starter cultures. Levilactobacillus brevis is an obligately heterofermentative lactic acid bacterium that is highly valued for its robust environmental adaptability and exceptional capacity to synthesize bioactive metabolites, notably γ-aminobutyric acid (GABA) and exopolysaccharides (EPS). This review comprehensively evaluates the recent progress in L. brevis applications across major food fermentations. In dairy systems, L. brevis is most effective in co-cultures, where partner starters compensate for limited proteolysis and acidification, enabling improved texture, aroma profiles, and GABA enrichment. In fermented meats, selected strains contribute to nitrite reduction, flavor formation, and bioprotection, supporting nitrite-reduced strategies while maintaining sensory quality. In fish and seafood fermentations, L. brevis shows promise for controlling spoilage indicators and biogenic amines (notably histamine) in high-salt environments, although strain compatibility in mixed cultures is product-dependent. In plant-based matrices, outcomes are strongly constrained by acidity and nitrogen limitation; however, optimized fermentation can enhance phenolic bioaccessibility, generate high GABA levels, and enable emerging precision-biofortification approaches. Despite these functional advantages, its industrial application is frequently constrained by strain-specific technological limitations, and its use often necessitates synergistic co-culture systems, particularly in challenging matrices. Ultimately, this review highlights current research gaps and proposes future directions, including multi-omics integration and targeted strain evolution, to overcome sensory trade-offs and fully harness the biotechnological potential of L. brevis in next-generation functional foods and agricultural byproduct valorization. Full article
(This article belongs to the Special Issue The Roles of Lactic Acid Bacteria in Food Fermentation)
14 pages, 1165 KB  
Article
An ERP Study of Modality-Specific Effects on Emotional Word Processing
by Yue Huang, Xiaogen Liao and Chuanbin Ni
Brain Sci. 2026, 16(5), 488; https://doi.org/10.3390/brainsci16050488 - 30 Apr 2026
Abstract
Background/Objectives: Sensory experiences and emotional information contribute to conceptual knowledge. Compared to exteroceptive modality (e.g., visual, auditory), interoceptive modality predominates in the representation of emotional concepts. However, few studies have examined the interoceptive modality-specific effects on emotional word processing. Additionally, questions remain about [...] Read more.
Background/Objectives: Sensory experiences and emotional information contribute to conceptual knowledge. Compared to exteroceptive modality (e.g., visual, auditory), interoceptive modality predominates in the representation of emotional concepts. However, few studies have examined the interoceptive modality-specific effects on emotional word processing. Additionally, questions remain about when emotional valence interacts with sensory experiences during the processing of emotional words, and to what extent these words are grounded in different sensory experiences. Methods: To address these gaps, the present ERP study investigated how sensory information (interoception and vision) influences emotional word processing in a lexical decision task. Results: Behavioral results showed significant differences between interoceptive and visual words, as well as between positive and negative valence. A trend toward an interaction between sensory modality and emotional valence was also observed. ERP results indicated that negative words elicited a more positive-going P2 than positive words. Significantly smaller N400 amplitudes were observed for interoceptive words than visual words in the positive condition. Negative visual words evoked enhanced LPC amplitudes compared with both negative interoceptive words and positive visual words. Conclusions: The present findings suggest a dynamic pattern of valence effects in emotional word processing, characterized by a negativity bias and a positivity bias at different stages. Furthermore, our findings highlight that interoception promotes the semantic retrieval and integration of emotional words. This study provides empirical support for the modality-specific hypothesis within the framework of interoceptive embodied cognition and offers novel implications for future research on emotional word processing. Full article
(This article belongs to the Section Neurolinguistics)
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27 pages, 1670 KB  
Article
The Influence of Soundscapes and Visual Landscape Evaluation in Taoist Temples on Spatial Worship Experience
by Yue Shan, Dongxu Zhang, Wenjie Ma, Ying Xiong, Xinyi Chen, Yifan Wu and Zixia Wang
Buildings 2026, 16(9), 1783; https://doi.org/10.3390/buildings16091783 - 29 Apr 2026
Abstract
This study investigates the soundscape of Taoist temples and its influence on visitors’ worship experiences, integrating auditory perception, visual landscape evaluation, and emotional and experiential responses into a comprehensive analytical framework. Based on questionnaire surveys conducted in multiple Taoist temples, the study examines [...] Read more.
This study investigates the soundscape of Taoist temples and its influence on visitors’ worship experiences, integrating auditory perception, visual landscape evaluation, and emotional and experiential responses into a comprehensive analytical framework. Based on questionnaire surveys conducted in multiple Taoist temples, the study examines how different sound sources affect soundscape evaluation and how this evaluation shapes perceptual and experiential outcomes. The results indicate that Taoist ritual sounds (e.g., ritual music and chanting) play a significant positive role in shaping visitors’ soundscape evaluation, whereas artificial sounds related to general human activities show a negative effect. Soundscape evaluation is found to significantly influence visual landscape evaluation and emotional perception, and further contributes to visitors’ overall temple experience. Visual landscape evaluation is found to partially mediate the relationship between soundscape evaluation and emotional perception, while emotional perception further mediates the relationship between soundscape evaluation and temple experience. A comparison across sensory dimensions suggests that soundscape evaluation exerts a relatively stronger influence on temple experience than visual landscape evaluation, highlighting the important role of auditory experience in religious and cultural environments. The study also identifies a synergistic interaction between auditory and visual evaluation, indicating that multisensory integration can enhance the overall experiential quality of Taoist temples. Overall, this research provides empirical insights into the role of soundscapes in religious spaces and offers practical implications for the design, management, and optimization of multisensory environments in Taoist temples. Full article
(This article belongs to the Section Architectural Design, Urban Science, and Real Estate)
23 pages, 1498 KB  
Article
Physico-Chemical, Textural, Antioxidant and Sensory Characterization of White Chocolate Enriched with Barley Powder
by Otilia Cristina Murariu, Florin Daniel Lipsa, Irina Gabriela Cara and Gianluca Caruso
Foods 2026, 15(9), 1548; https://doi.org/10.3390/foods15091548 - 29 Apr 2026
Abstract
The enrichment of chocolate with healthy beneficial ingredients represents an effective strategy to create functional food with high nutritional and bioactive potential. Comparisons were made between eight treatments derived by the factorial combination of 2 types of butter (milk and cocoa) and 4 [...] Read more.
The enrichment of chocolate with healthy beneficial ingredients represents an effective strategy to create functional food with high nutritional and bioactive potential. Comparisons were made between eight treatments derived by the factorial combination of 2 types of butter (milk and cocoa) and 4 concentrations of green barley powder addition (1%, 3%; 5%; and 7%), plus 2 untreated controls (milk butter and cocoa butter with no green barley powder addition), in terms of chemical, colorimetric, physical, antioxidant, mineral and sensory characteristics of white chocolate. Increasing addition of green barley to both milk and cocoa butter led to the decrease in dry matter, soluble solids, pH and fat in the produced chocolate, with the untreated controls always showing the highest values. Opposite trends were recorded for proteins, fiber, ash and mineral substances. The ‘L’, ‘a’ and ‘b’ color components gradually decreased from the untreated control to the highest concentration of barley powder addition both to milk and cocoa butter. The increasing integration of barley powder either into milk or cocoa butter resulted in the gradual decrease in F max compression and F max cutting of the chocolate manufactured, compared to the untreated control. The addition of barley powder to milk and cocoa butter elicited a gradual increase in all the antioxidants analyzed, i.e., vitamin C, carotenes, lycopene and xanthophylls, and of chlorophyll a and b, compared to the untreated control. Vegetal flavor attributes were enhanced by the increasing addition of green barley powder. The latter incorporation into milk and cocoa butter sheds light on the interesting topic of conceiving and applying the manufacture of innovative functional chocolate with high content of fiber, nutrients and antioxidants. Full article
(This article belongs to the Section Grain)
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22 pages, 8021 KB  
Systematic Review
AI-Driven Digital Twins in Mining Operations: A Comprehensive Review
by Shouki A. Ebad, Aws I. Abueid, Marwa Amara and Rabie Ahmed
Technologies 2026, 14(5), 269; https://doi.org/10.3390/technologies14050269 - 29 Apr 2026
Abstract
The mining industry is going through a big digital change because of the use of new technologies that are meant to make work safer, more productive, and more environmentally friendly. AI-driven digital twins (AI-DTs) are one of these new ideas. They combine real-time [...] Read more.
The mining industry is going through a big digital change because of the use of new technologies that are meant to make work safer, more productive, and more environmentally friendly. AI-driven digital twins (AI-DTs) are one of these new ideas. They combine real-time data collection with smart analytics to make it possible for decisions to be made in a predictive, adaptive, and autonomous way. This paper provides a thorough systematic literature review (SLR) of AI-DT applications in mining operations, encompassing studies published from 2015 to 2025. According to the PRISMA method, 68 primary studies were chosen and looked at from many angles, such as publication trends, demographic analysis, research methods, data sources, mining domains, and the AI techniques that were used. The findings reveal an increasing scholarly interest in AI-DTs, characterized by a significant prevalence of machine learning and deep learning methodologies, alongside a preference for real-world sensory data to augment model accuracy. Most applications deal with physical assets, processing plants, and operational systems. Subsurface environments, on the other hand, are still not well understood. The review also points out some major problems with data integration, scalability, interoperability, and the fact that there has not been much large-scale industrial validation. Based on these findings, the paper points out important areas of research that need more work and suggests ways to move forward with the development and use of AI-DTs in mining. In conclusion, this study gives researchers and practitioners a clear plan for how to use AI-DTs to make mining operations more efficient, resilient, and long-lasting. Full article
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19 pages, 1177 KB  
Review
Fruit Quality Regulation in Passion Fruit (Passiflora edulis): Biological Mechanisms, Omics Evidence, and Opportunities for Biological Intervention
by Jose Leonardo Santos-Jiménez and Maite Freitas Silva Vaslin
Agriculture 2026, 16(9), 958; https://doi.org/10.3390/agriculture16090958 - 27 Apr 2026
Viewed by 269
Abstract
Passion fruit (Passiflora edulis) quality is defined by integrated sensory and nutritional traits, including sugar–acid balance, volatile organic compounds (VOCs), pigment-related attributes, and bioactive compounds such as ascorbic acid and phenolics. These traits emerge from coordinated regulation of carbon allocation, mineral [...] Read more.
Passion fruit (Passiflora edulis) quality is defined by integrated sensory and nutritional traits, including sugar–acid balance, volatile organic compounds (VOCs), pigment-related attributes, and bioactive compounds such as ascorbic acid and phenolics. These traits emerge from coordinated regulation of carbon allocation, mineral nutrition, ripening metabolism, and stress- and defense-related signaling pathways, which are strongly modulated by environmental conditions. Sustainable biological inputs are increasingly explored as tools to influence these regulatory networks; however, evidence linking such interventions to reproducible fruit quality outcomes in Passiflora remains fragmented. This review first synthesizes current knowledge on the physiological, biochemical, and molecular mechanisms underlying passion fruit quality formation and maintenance, and then discusses how biofertilizers; microbial inoculants (including plant growth-promoting rhizobacteria—PGPR and arbuscular mycorrhizal fungi—AMF); fungal-derived elicitors such as chitosan and chitooligosaccharides; and complementary postharvest biological strategies may modulate these processes. Emphasis is placed on traits beyond yield, including sugar–acid balance, aroma and VOC profiles, color, nutritional quality, texture, and shelf life. By integrating genomics, transcriptomics, metabolomics, proteomics, and microbiome-based evidence, we examine how environmental modulation and key signaling pathways intersect with metabolic networks underlying fruit quality. Available studies indicate that responses to biological inputs are context-dependent and often non-linear. Key knowledge gaps and priorities for mechanism-informed sustainable management of passion fruit quality are identified. Full article
(This article belongs to the Special Issue Fruit Quality Formation and Regulation in Fruit Trees)
27 pages, 1036 KB  
Review
Upcycling Apple and Carrot Pomace into Fortified Food Ingredients: Advancing Sustainability and Resource Efficiency
by Ramona Căpruciu and Simona Mariana Popescu
Foods 2026, 15(9), 1514; https://doi.org/10.3390/foods15091514 - 27 Apr 2026
Viewed by 242
Abstract
The generation of byproducts during the production of apple and carrot juices can negatively impact the environment. Using these byproducts as functional ingredients represents an integrated and innovative strategy for today’s food industry. This review aims to provide a comprehensive analysis of the [...] Read more.
The generation of byproducts during the production of apple and carrot juices can negatively impact the environment. Using these byproducts as functional ingredients represents an integrated and innovative strategy for today’s food industry. This review aims to provide a comprehensive analysis of the progress made over the past decade in the applications of apple and carrot pomace in the food industry, with an emphasis on qualitative analyses (compositional, sensory, functional) in the context of promoting sustainability and resource efficiency. The main quality parameters of apple and carrot pomace and pomace powders, as well as of the composite food products in which they were incorporated, were examined with the optimal dosage. The analysis reveals the extent to which the studied powders can improve—or fail to improve—the nutritional, functional, or sensory parameters of composite products, while accounting for environmental impact and sustainable practices within the context of circular economy. It is found that the industrial reintegration of apple and carrot pomace has nutritional, functional, and bio-packaging development potential, with the main remaining challenge being the development of solutions to preserve the color and rheology of composite products. Full article
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13 pages, 415 KB  
Article
Artmaking Across Media: An Expressive Therapies Continuum Perspective on Stress Reduction Through Artmaking with Digital vs. Traditional Materials
by Or Chen Halbrecht-Shaked, Johanna Czamanski-Cohen and Aviv Sion
Behav. Sci. 2026, 16(5), 645; https://doi.org/10.3390/bs16050645 - 25 Apr 2026
Viewed by 212
Abstract
Artmaking is recognized as an effective means of supporting emotional regulation and reducing stress, yet little empirical work has directly compared the psychological and physiological effects of digital versus traditional art materials. Guided by the Expressive Therapies Continuum (ETC), this study examined whether [...] Read more.
Artmaking is recognized as an effective means of supporting emotional regulation and reducing stress, yet little empirical work has directly compared the psychological and physiological effects of digital versus traditional art materials. Guided by the Expressive Therapies Continuum (ETC), this study examined whether drawing with oil pastels on paper or drawing on a digital tablet differentially influenced emotional state, physiological stress, and subjective creative experience following a validated group stress induction. Forty-eight healthy adult women were randomly assigned to create art for 45 min using either oil pastels or a tablet with a digital stylus. Measures included state anxiety, salivary cortisol, emotional valence, arousal, dominance, flow experience, and artmaking experience. Both modalities produced significant reductions in state anxiety, with no differences between groups. Emotional responses also changed significantly from pre- to post-artmaking, again without between-group differences. Cortisol levels did not significantly decrease in either condition, and no differences emerged across flow dimensions or artmaking experience scales. These findings indicate that tablet-based and traditional oil pastel drawing generate comparable emotional and experiential benefits following acute stress. Interpreted through the ETC, results suggest that therapeutic mechanisms of artmaking may be activated across a wider range of media than previously assumed. Digital tools appear capable of facilitating sensory–affective and integrative processes often attributed to traditional materials, thereby supporting their integration into trauma-informed practice. Full article
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28 pages, 5518 KB  
Article
Low-Frequency Electrical Stimulation Optimizes Neurotrophic and Neuroimmune Signaling in Bisvinyl Sulfonemethyl-Based Nerve Guidance Conduits
by Ching-Feng Su, Chung-Chia Chen, Wei-Cheng Hsu, Ming-Hsuan Lu, Joanna Pi-Jung Lee, Yung-Hsiang Chen and Yueh-Sheng Chen
Int. J. Mol. Sci. 2026, 27(9), 3820; https://doi.org/10.3390/ijms27093820 - 25 Apr 2026
Viewed by 268
Abstract
Peripheral nerve injuries involving critical-sized gaps remain a major clinical challenge. Although autologous nerve grafting is considered the gold standard for peripheral nerve repair, its clinical application is limited by the availability of donor nerve tissue and the risk of donor-site morbidity, including [...] Read more.
Peripheral nerve injuries involving critical-sized gaps remain a major clinical challenge. Although autologous nerve grafting is considered the gold standard for peripheral nerve repair, its clinical application is limited by the availability of donor nerve tissue and the risk of donor-site morbidity, including sensory deficits and functional impairment. Therefore, nerve guidance conduits (NGCs) have emerged as a promising alternative when combined with bioactive modulation strategies. In this study, we evaluated bisvinyl sulfonemethyl (BVSM)-crosslinked gelatin conduits integrated with electrical stimulation (ES) at different frequencies (0, 2, 20, and 200 Hz) in a rat sciatic nerve defect model over a 4-week recovery period (n = 10 per group). Structural regeneration was assessed by morphometric analysis, electrophysiology, macrophage infiltration, CGRP immunoreactivity, retrograde Fluorogold tracing, quantitative PCR of growth factors and inflammatory cytokines, and behavioral testing. Among all stimulation paradigms, low-frequency ES at 2 Hz produced the most pronounced regenerative effects. The 2 Hz group demonstrated significantly greater axon number, axonal density, and regenerated nerve area compared with control and high-frequency groups (p < 0.05). Electrophysiological assessments revealed improved nerve conduction velocity, higher MAP amplitudes, and shorter latencies. Enhanced macrophage recruitment and elevated CGRP expression were observed, suggesting coordinated neuroimmune and neurochemical activation. Gene expression analysis indicated upregulation of neurotrophic factors and balanced inflammatory cytokine responses under low-frequency stimulation. In contrast, high-frequency stimulation (200 Hz) failed to enhance overall regeneration and showed reduced axonal metrics, suggesting possible overstimulation-associated suppression. Collectively, these findings demonstrate that BVSM-crosslinked conduits provide a stable and biocompatible regenerative scaffold, and that appropriately tuned low-frequency electrical stimulation (2 Hz) optimally enhances structural, molecular, and functional recovery. The integration of material engineering with bioelectrical modulation represents a promising strategy for next-generation bioelectronic interfaces in peripheral nerve repair. Full article
(This article belongs to the Special Issue Advancements in Regenerative Medicine Research)
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32 pages, 4458 KB  
Article
Developing a Protocol-Based Expressive Therapies Continuum Assessment Profile (ETC-AP): Current Achievements and Future Perspectives
by Elza Strazdiņa, Viktorija Perepjolkina, Anda Upmale-Puķīte, Elīna Akmane, Jana Duhovska and Kristīne Mārtinsone
Behav. Sci. 2026, 16(5), 640; https://doi.org/10.3390/bs16050640 - 24 Apr 2026
Viewed by 327
Abstract
Art therapy assessment benefits from analytical clarity while preserving non-directive, process-sensitive practice. Although the Expressive Therapies Continuum (ETC) is widely used to conceptualize sensory, affective, cognitive, and symbolic processes in art-making, ETC-informed assessment often relies on implicit clinical reasoning, limiting transparency and interdisciplinary [...] Read more.
Art therapy assessment benefits from analytical clarity while preserving non-directive, process-sensitive practice. Although the Expressive Therapies Continuum (ETC) is widely used to conceptualize sensory, affective, cognitive, and symbolic processes in art-making, ETC-informed assessment often relies on implicit clinical reasoning, limiting transparency and interdisciplinary communication. This article presents the developmental stage of a protocol-based Expressive Therapies Continuum Assessment Profile (ETC-AP) developed at Rīga Stradiņš University. The ETC-AP differentiates activation and inhibition patterns around integration midpoints and organizes observation in a defined five-step interpretive sequence without positioning the method as a psychometrically validated test. It combines (i) a uniform three-task, non-directive administration with a brief post-task inquiry; (ii) criteria-guided coding of observable features across three artworks and process notes; and (iii) 0–100 descriptive profile indicators to support within-case pattern description and professional dialogue. An illustrative case vignette shows how the ETC-AP can generate trauma-informed, regulation-oriented hypotheses about channel accessibility and cautious regulation-oriented sequencing, while remaining subordinate to clinical judgment and context. Key boundaries include incomplete operational coverage in some inhibition ranges, limits of static documentation for process-dependent markers, and the need for structured training materials and programmatic studies of reliability, feasibility, and sensitivity to change. Full article
22 pages, 1113 KB  
Review
Neurocosmetics and the Skin–Brain Axis from a Psychological and Psychiatric Standpoint
by Giuseppe Marano, Oksana Di Giacomi, Marco Lanzetta, Camilla Scialpi, Antonio Sottile, Gianandrea Traversi, Osvaldo Mazza, Claudia d’Abate, Eleonora Gaetani and Marianna Mazza
Cosmetics 2026, 13(3), 102; https://doi.org/10.3390/cosmetics13030102 - 24 Apr 2026
Viewed by 220
Abstract
The skin–brain axis constitutes a complex, bidirectional network integrating cutaneous sensory, immune, and neuroendocrine systems with central neural circuits involved in emotion regulation, stress responsivity, and social cognition. Advances in psychodermatology and cosmetic science have progressively extended this framework to the emerging field [...] Read more.
The skin–brain axis constitutes a complex, bidirectional network integrating cutaneous sensory, immune, and neuroendocrine systems with central neural circuits involved in emotion regulation, stress responsivity, and social cognition. Advances in psychodermatology and cosmetic science have progressively extended this framework to the emerging field of neurocosmetics, which explores how topical formulations, sensorial properties, and cutaneous neuromodulators may influence psychological well-being, affective states, and perceived stress. The aim of this narrative review is to synthesize current evidence on the biological foundations of the skin–brain axis and to critically examine the implications of these mechanisms for neurocosmetic interventions from a psychological and psychiatric perspective. It describes the biological substrates underlying skin–brain communication, including the cutaneous hypothalamic–pituitary–adrenal axis, neuropeptides, neurotrophins, transient receptor potential channels, and endocannabinoid signaling, and examines how these pathways are targeted by neurocosmetic interventions. Particular attention is devoted to neuroactive compounds, such as peptides, cannabinoids, botanicals, and aromatherapeutic molecules, as well as to sensorial strategies involving texture, temperature, and olfactory cues, which may modulate mood, anxiety, and self-perception through peripheral mechanisms. From a psychological and psychiatric perspective, the review discusses the intersection between stress-related skin conditions, body image disturbances, and emotional dysregulation, highlighting how cosmetic practices may influence subjective well-being beyond purely aesthetic outcomes. Methodological limitations of the existing literature, including the heterogeneity of study designs and outcome measures, as well as ethical considerations related to mood- and stress-related claims in cosmetic products, are critically examined. Finally, future research directions are outlined, and a translational framework is proposed to integrate dermatology, neuroscience, and mental health within next-generation cosmetic science. Full article
(This article belongs to the Special Issue Feature Papers in Cosmetics in 2026)
33 pages, 2873 KB  
Review
Modern Trends in Alternative Proteins and Processing Technologies for Sustainable Food Systems with Antioxidant Implications
by Young-Hwa Hwang, Abdul Samad, Ayesha Muazzam, AMM Nurul Alam, SoHee Kim, ChanJin Kim and Seon-Tea Joo
Antioxidants 2026, 15(5), 535; https://doi.org/10.3390/antiox15050535 (registering DOI) - 24 Apr 2026
Viewed by 485
Abstract
Alternative proteins and novel processing technologies are crucial to transforming contemporary food systems into ones with lower environmental impact while meeting the rising global demand for protein. Alternative protein sources from plants, microbes, insects, and cultivated cells offer diverse nutritional and techno-functional attributes [...] Read more.
Alternative proteins and novel processing technologies are crucial to transforming contemporary food systems into ones with lower environmental impact while meeting the rising global demand for protein. Alternative protein sources from plants, microbes, insects, and cultivated cells offer diverse nutritional and techno-functional attributes that can partially or fully replace conventional animal proteins in meat analogs and related products. This review synthesizes the current knowledge on major categories of alternative protein sources, including plant-based ingredients, microbial- and fermentation-derived proteins, insect and other emerging sources, and cultivated (cell-based) meat, with a specific focus on their suitability for structured meat analog applications. Modern structuring and processing technologies are discussed, including the traditional wet and dry extrusion to modern technologies like high-moisture extrusion, high-pressure processing, shear-cell technology, 3D printing, fermentation-based structuring, and enzymatic protein modification. Furthermore, this review critically evaluates product design and quality attributes of meat analogs, including physicochemical properties, sensory performance, nutritional aspects, and safety considerations. This review highlights technological and scale-up challenges, as well as the necessity of multi-criteria optimization in sensory quality, nutrition, sustainability, and affordability, and presents research priorities focused on combining multiple protein sources and advanced processing pathways for next-generation meat analog. This review provides an integrated framework linking protein sources, processing technologies, antioxidant functionality, and sustainability considerations to support the development of next-generation meat analogs. In addition, this review highlights the intrinsic antioxidant potential of alternative proteins, emphasizing the role of bioactive peptides, polyphenols, and structure–function relationships in enhancing oxidative stability and product quality. Full article
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