Search Results (2,478)

The validity and accuracy of photoplethysmography (PPG)-based wearable heart rate (HR) monitors remain debatable. This study aimed to determine the concurrent validity of HR records from a wide range of contemporary PPG monitors across the full spectrum of exercise intensities and running conditions. Ten well-trained male endurance athletes performed several incremental maximal aerobic (IMA) tests and high-intensity interval training (HIIT) sessions while wearing a Polar H9 chest strap, as the reference criterion; 16 PPG-based heart rate monitors were tested (Amazfit Fit5; Apple Ultra and SE; Garmin 35, 45, 235, and 935; Polar M200, M430, OH1, Vantage M, Vantage V, Vantage V3, and Verity Sense; Galaxy Watch 5, Suunto 3 Fitness). The results showed excellent ICC (>0.90) versus the reference device across IMA and HIIT tests. Overall, the ICC decreased, and magnitudes of error increased (BIAS, SEM, and CV) as the intensity increased. Moreover, lower ICC values and greater BIAS, SEM, and CV were observed during the HIIT compared to the IMA test. Nevertheless, notable differences between devices were observed in magnitude of errors, accuracy, data loss, and read failures. In conclusion, PPG-based HR monitor validity is device-dependent and therefore exercise data from running training and competitions should be interpreted with caution. Full article

Low-melting bioabsorbable polymers, such as poly(caprolactone-co-lactide) (PCLA), hold significant promise for biomedical applications. However, achieving high-precision micro- and nanotopographical functionalization remains a formidable challenge due to the material’s susceptibility to thermal deformation during conventional thermal molding processes. In this study, functional microstructured PCLA coatings were engineered via low-temperature nanoimprint lithography utilizing a TiO₂–SiO₂ gas-permeable mold. These molds were synthesized via a sol–gel method utilizing titanium dioxide and silicon precursors. The gas-permeable nature of the mold facilitated the efficient evacuation of trapped air and volatiles during the imprinting process, enabling the high-fidelity replication of microstructures (1.3 μm height, 3 μm pitch) and nanostructured PCLA coatings featuring linewidths as narrow as 600 nm. The resultant microstructured PCLA coatings demonstrated modulated surface wettability, evidenced by an increase in water contact angles from 70.1° to 91.4°, and exhibited enhanced FD4 elution kinetics. These results confirm morphology-driven functionalities, specifically hydrophobicity and controlled release capabilities. Collectively, these findings underscore the efficacy of this microfabrication approach for polycaprolactone-based materials and highlight its potential to catalyze the development of high-value-added biomaterials for advanced medical and life science applications. This study establishes a foundational framework for the practical deployment of next-generation bioabsorbable materials and is anticipated to drive innovation in precision medical manufacturing. Full article

The polar oxide Lithium Niobate Tantalate is probed using time-resolved luminescence spectroscopy with the goal of revealing an initial structural insight into the solid solution by analyzing the spectral properties and dynamics of radiatively decaying self-localization phenomena. A blue-green luminescence band can be induced by ultraviolet nanosecond laser pulses with a temperature-dependent intensity and spectral width, pointing to the radiative decay of optically generated self-trapped excitons as its origin, i.e., electron–hole pairs with strong coupling to either the NbO${}_6$- or TaO${}_6$-octahedra. The luminescence decay takes place in the microsecond time range and deviates significantly from a single exponential behavior, so the determined lifetime constants of up to ≈70 $\mathsf{\mu }$s and stretching factors (1/3–1/5) are validated in more detail using alternative evaluation methods. We discuss our findings, considering the interplay of radiative and non-radiative decay channels, the transition from self-trapped to free excitons, and the presence of a structural disorder of the oxygen octahedra in the solid solutions. Overall, our results suggest self-trapped excitons as local probes for an initial structural elucidation and provide essential information about further experimental and theoretical studies on the atomic structure of Lithium Niobate Tantalate, but also for improving the crystal quality in the framework of applications in photonics and quantum optics. Full article

Coastal Trapped Waves (CTWs) represent an important class of mesoscale fluctuations in nearshore shelf regions and play a crucial role in modulating coastal circulation. The South China Sea (SCS), the largest semi-enclosed marginal sea in the western Pacific Ocean, features a continental shelf approximately 200 km wide. During summer, the SCS is frequently impacted by typhoons, which often trigger significant CTWs. This study investigates the characteristics of CTWs generated by Typhoon ‘Soudelor’ (No. 1513) in the northwestern SCS, based on current observations and numerical model simulations. Under the influence of Soudelor, CTWs characterized by elevated water levels nearshore and depressed water levels offshore were initially generated by wind-induced Ekman transport in the Taiwan Strait. These waves subsequently propagated southwestward along the coastline with phase velocities ranging from 7.2 to 18.3 m/s. Model results indicate that the CTW influenced current fields up to 160 km offshore, with a maximum CTW-induced current velocity exceeding 0.7 m/s. The vertical structure of the CTW-induced current field exhibited a barotropic characteristic. The influence of CTWs on current fields diminished with propagation distance, accompanied by a reduction in the induced current velocity. This attenuation was particularly pronounced between Xiamen (XM) and Shanwei (SW). Sensitivity experiments further revealed that the slowed propagation phase velocity of CTWs between XM and SW was attributable to strong reflection, scattering, and nonlinear effects caused by the abrupt topographic changes of the Taiwan Bank. Full article

Under China’s “dual carbon” targets and deepening global climate governance, this paper investigates whether and how corporate green transformation (GTF) improves carbon performance (CP). Using panel data on Chinese A-share listed firms from 2008 to 2023 and multiple causal identification strategies (fixed effects, RD, DID and PSM), we find that GTF significantly enhances CP, with stronger marginal effects for firms with poorer initial carbon performance. Mechanism analyses show that carbon disclosure (CD) acts as a positive mediator in the GTF–CP nexus, whereas executives’ green perception (EGP) exerts a short-term suppressing effect. Policy analyses further indicate that the 2012 pilot emissions trading schemes and the 2021 national carbon market amplify the positive impact of GTF on CP, but local “compliance traps” around industry medians suggest strategic use of allowance trading. The study integrates EGP and CD into a cognition–disclosure framework linking GTF and CP and provides evidence on the emission-reduction effects of GTF under evolving carbon policies, with implications for carbon market design and corporate low-carbon governance. Full article

We report on the realization of a platform for trapping and manipulating individual ⁸⁸Sr atoms in optical tweezers. A first cooling stage based on a blue shielded magneto-optical trap (MOT) operating on the ${|}^1{\mathrm{S}}_0⟩\to {|}^1{\mathrm{P}}_1⟩$ transition at $461 \mathrm{n}\mathrm{m}$ enables us to trap approximately 4 × 10⁶ atoms at a temperature of 6.8 mK. Further cooling is achieved in a narrow-line red MOT using the ${|}^1{\mathrm{S}}_0⟩\to {|}^3{\mathrm{P}}_1⟩$ intercombination transition at 689 nm, bringing 5 × 10⁵ atoms down to $5\mu \mathrm{K}$ and reaching a density of 4 × 10¹⁰ cm³. Atoms are then loaded into 813 nm tweezer arrays generated by crossed acousto-optic deflectors and tightly focused onto the atoms with a high-numerical-aperture objective. Through light-assisted collision processes we achieve the collisional blockade, which leads to single-atom occupancy with a probability of about 50%. The trapped atoms are detected via fluorescence imaging with a fidelity of $99.986\left(6\right)\%$, while maintaining a survival probability of $97\left(2\right)\%$. The release-and-recapture measurement provides a temperature of $12.92\left(5\right)\mu \mathrm{K}$ for the atoms in the tweezers, and the ultra-high-vacuum environment ensures a vacuum lifetime higher than 7 min. These results demonstrate a robust alkaline-earth tweezer platform that combines efficient loading, cooling, and high-fidelity detection, providing the essential building blocks for scalable quantum simulation and quantum information processing with Sr atoms. Full article

Crayfish often become invasive when introduced to new waters. From the late 19th to the late 20th century, the commercial import of North American species (e.g., Faxonius limosus, Pacifastacus leniusculus, Procambarus clarkii) into Europe for food, ornamental aquaculture, and restocking native crayfish populations after crayfish plague succeeded due to their adaptability, high reproductive rates, and resilience. Extensive baited-trap monitoring of Piedmont lakes carried in 2025 confirmed the occurrence of two invasive crayfish species (F. limosus, and P. clarkii) in 10 of 17 lakes and recorded P. clarkii for the first time ever in lakes Pistono, San Michele, and Sirio, expanding our knowledge of their distribution in Piedmont freshwaters. Since all detected species are listed as Invasive Alien Species of Union Concern, protecting the ecological integrity of Piedmont’s freshwaters requires coordinated action by member states, regional authorities, policymakers, and water managers to prevent and control their spread and to improve information sharing. Non-native crayfish occurrence is influenced not only by hydrological and habitat connectivity and predator–prey interactions but also by illegal activities that supply the food market. Full article

CO₂ miscible flooding provides dual advantages in enhancing oil recovery and facilitating geological sequestration, and has become a key technical approach for developing low-permeability oil reservoirs and carbon emission reduction. The pore-scale flow mechanisms governing CO₂ behavior during miscible flooding are crucial for achieving efficient oil recovery and secure geological storage of CO₂. In this study, pore-scale two-phase flow simulations of CO₂ miscible flooding in porous media are performed using a coupled laminar-flow and diluted-species-transport framework. The model captures the effects of diffusion, concentration distribution, and pore structure on the behavior of CO₂ miscible displacement. The results indicate that: (1) during miscible flooding, CO₂ preferentially displaces oil in larger pore throats and subsequently invades smaller throats, significantly improving the mobilization of oil trapped in small pores; (2) increasing the injection velocity accelerates the displacement front and improves oil utilization in dead-end and trailing regions, but a “velocity saturation effect” is observed—when the inject velocity exceeds 0.02 m/s, the displacement pattern stabilizes and further gains in ultimate recovery become limited; (3) higher injected CO₂ concentration accelerates CO₂ accumulation within the pores, enlarges the miscible sweep area, promotes a more uniform concentration field, leads to a smoother displacement front, and reduces high-gradient regions, thereby suppressing local instabilities, and improves displacement efficiency, although its effect on overall recovery remains modest; (4) CO₂ dynamic viscosity strongly influences flow stability: low-viscosity conditions promote viscous fingering and severe local bypassing, whereas higher viscosity stabilizes flow but increases injection pressure drop and energy consumption, indicating a necessary trade-off between flow stability and operational efficiency. Full article

Background/Objectives. Self-harm is a heterogeneous behaviour with a lifetime prevalence of around 20% in young people aged 16–25 years old. Recent neurocognitive evidence suggests that, for some individuals, self-harm is associated with motivational processes similar to addiction, including maladaptive mental imagery, reward anticipation, and goal pursuit. However, our knowledge of young people’s subjective experiences of rewards and goals in relation to self-harm behaviour remains limited. Our study aimed to investigate how young people who self-harm experience enjoying and wanting rewards and pursuing goals in daily life and whether this experience changes during periods of self-harm. We also explored their use of mental imagery as a key cognitive process to support motivation. Methods. We conducted two parallel focus groups online (total of N = 12) with young people (mean age = 12.2, SD = 3; nine women, two men, and one non-binary) with a past-year history of self-harm behaviour. Qualitative data was analysed using inductive thematic analysis. Two young people with lived experience of self-harm informed the topic guide and data interpretation. Examples of questions were “Do you think your experiences of enjoying and/or looking forward to pleasant things are related in any way to self-harm, or not?” and “Do you visualise things you enjoy or may look forward to? If you do, how is that experience?”. Results. There were six themes: rewards need deserving, high self-standards, keeping control, trapped into long-term goals, unhelpful mental imagery, and self-harm alters the experience and anticipation of rewards and goal attainment. Most young people reported enjoying conditional rewards and working towards long-term goals that tend to be unattainable and beyond their control. Imagining these goals was experienced as unhelpful by most. For all young people, periods of self-harm thwarted enjoyment and goal achievement, shifted the preference to short-term immediate gratification, including from self-harm behaviour, and devalued long-term goals. However, our data cannot determine if these experiences are specific to young people who self-harm. Conclusions. Our findings indicate that the reciprocal relationship between motivational processes and self-harm behaviour in young people warrants further investigation. Helping individuals develop more adaptive rewards and goals, including appreciation of short-term goals and use of motivational mental imagery, could represent valued support for young people with self-harm. Full article

Visceral white spot disease caused by Pseudomonas plecoglossicida severely threatens marine aquaculture, highlighting the need for effective control strategies. To clarify the role of a novel small RNA, sRNA0024, in bacterial pathogenicity, we constructed an sRNA0024 deletion mutant (ΔsRNA0024) and compared its phenotype and virulence with those of the wild-type strain NZBD9. In vitro assays showed that deletion of sRNA0024 did not affect bacterial growth but significantly reduced biofilm formation and adhesion. In vivo infection experiments in orange-spotted grouper (Epinephelus coioides) demonstrated that the ΔsRNA0024 mutant had a 3.8-fold higher 50% lethal dose (LD₅₀), improved host survival, and milder splenic lesions than the wild type. Histopathology and host transcriptome analyses revealed weakened activation of complement–coagulation cascades, neutrophil extracellular traps, leukocyte migration, and inflammatory signaling pathways, indicating a lower-intensity immune response. Bacterial transcriptomics showed that deletion of sRNA0024 was associated with reduced luxR expression and attenuated quorum-sensing–associated virulence traits, supporting a possible role for this small RNA in modulating luxR expression and QS-related host immunopathology. These findings identify sRNA0024 as an important contributor to the virulence of P. plecoglossicida and highlight the sRNA0024–luxR module as a potential antivirulence target for controlling visceral white spot disease in aquaculture. Full article

Sestrin2 (SESN2) is a highly conserved stress-inducible protein that serves as a central hub for integrating cellular responses to nutrient availability, oxidative stress, and endoplasmic reticulum (ER) stress. A key function of SESN2 is its role as a direct sensor for the branched-chain amino acid (BCAA) leucine, which modulates the activity of the mechanistic target of rapamycin complex 1 (mTORC1), a master regulator of cell growth and metabolism. While the functional link between leucine and SESN2 is well-established, the precise molecular determinants that confer its high specificity for leucine over other BCAAs, such as isoleucine and valine, remain poorly understood. This study employs an integrated computational approach, spanning atomic interactions to global protein dynamics, combining molecular docking, extensive all-atom molecular dynamics (MD) simulations, and binding free energy calculations, to elucidate the structural and dynamic basis of BCAA-SESN2 recognition. Our thermodynamic analysis reveals a distinct binding affinity hierarchy (Leucine > Isoleucine > Valine), which is primarily driven by superior van der Waals interactions and the shape complementarity of leucine’s isobutyl side chain within the protein’s hydrophobic pocket. Critically, a quantitative analysis of the conformational ensemble reveals that leucine induces a dramatic collapse of the protein’s structural heterogeneity. This “conformational locking” mechanism funnels the flexible, high-entropy unbound protein—which samples 35 distinct conformations—into a sharply restricted ensemble of just 9 stable states. This four-fold reduction in conformational freedom is accompanied by a kinetic trapping effect, which significantly lowers the rate of transitions between states. This process of conformational selection stabilizes a well-defined, signaling-competent structure, providing a comprehensive, atom-to-global-scale model of SESN2’s function. In the context of these findings, this work provides a critical framework for understanding SESN2’s complex role in disease and offers a clear rationale for the design of next-generation allosteric therapeutics. Full article

The exploration of chalcogenides is on the rise owing to their desirable optical, electronic, thermoelectric, and thermal properties. Chalcogenide materials have been investigated for possible applications in areas such as non-linear optics and solar cells. Among these materials are BaTiS₃ and BaTiSe₃. BaTiS₃ has shown promise in the above-mentioned applications due to its low thermal conductivity. However, neither the thermal properties of BaTiSe₃ nor the mechanical properties of both BaTiS₃ and BaTiSe₃ have been reported. In this work, we performed a computational study of the mechanical and thermal properties of both materials within the density functional theory using Quantum Espresso and BoltzTrap2 codes, employing generalized gradient approximation. The results showed that the computed thermal conductivity of BaTiS₃ at 0.43 W/m/K is comparable to the literature values. The computed elastic constants of BaTiS₃ (bulk modulus of 44.7 GPa, shear modulus of 11.2 GPa, Young’s modulus of 29.6 GPa, and Vickers hardness of 1.053 GPa) were higher than those of BaTiSe₃. The calculated properties obtained in this work add to the literature on the properties of BaTiS₃ and BaTiSe₃. However, since the work was computational, the results can be verified by an experimental investigation. Full article

The peptidylarginine deiminase (PAD) family includes five isozymes (PAD1–4 and PAD6) with unique tissue distributions and substrate specificities. These enzymes facilitate citrullination, a post-translational modification where positively charged arginine residues are converted into neutral citrulline residues in the presence of calcium ions. This process significantly changes protein properties, affecting molecular interactions, structural stability, and biological functions. Over the past six years (2019–2025), there has been significant progress in understanding PAD activity mechanisms and their therapeutic potential. Recent discoveries include the regulated nuclear translocation of PAD2, PAD4’s specific role in forming cancer extracellular chromatin networks (CECNs), and the development of next-generation inhibitors with greatly improved pharmacological profiles. PAD4 is crucial in forming neutrophil extracellular traps (NETs). Citrullination of histones H3 and H4 by PAD4 destabilizes chromatin, helping release DNA-protein networks as an antibacterial defense. However, excessive NET formation can contribute to autoimmune diseases and thrombosis. Similarly, the bacterial peptidylarginine deiminase from Porphyromonas gingivalis (PPAD)—the only known prokaryotic citrullinating enzyme—plays a key role. Working with R-gingipains, PPAD triggers pathological citrullination of host proteins, leading to immune tolerance breakdown and linking periodontal disease with systemic autoimmune disorders such as rheumatoid arthritis, atherosclerosis, and Alzheimer’s disease. Once thought to be a rare post-translational modification, citrullination is now understood as a vital regulatory mechanism in both normal physiology and disease, involving both internal processes of homeostasis and external mechanisms of bacterial pathogenesis. Full article

Due to the influence of the complex underwater environment, the initial alignment method for Doppler velocity log (DVL)-aided strap-down inertial navigation systems (SINS) often suffer from performance degradation, especially when DVL measurements are contaminated by outliers. In this paper, an outlier-resistant Initial Alignment method with interference suppression for SINS/DVL integrated navigation system is proposed, by which, by constructing an improved Mahalanobis distance anomalous detection criterion, the anomaly of the residual vector composed of observation vectors is judged, and an adaptive weighting factor is introduced into the observation matrix to suppress the abnormal interference in the alignment process. Simulation and experimental results show that, compared with existing initial alignment methods, the proposed method achieves higher alignment accuracy in the presence of outliers, which is more suitable for the SINS/DVL integrated navigation system. Full article

Building drainage systems are essential for protecting occupant health and indoor air quality. While recent studies have focused on high-rise drainage dynamics and riser offset mitigation, ventilation components—particularly appliance vent pipes—remain underexplored. This study employed a full-scale proportional drainage experimental tower to assess appliance vent pipes on horizontal branches as a strategy for water seal protection in dual-riser systems. Maximum drainage capacities were quantified under varying pipe positions and diameters (DN50, DN75, DN100), alongside analyses of pressure transients and water seal losses. Results indicate that appliance vent pipes increase maximum drainage capacity from 6.5 L/s (baseline cast iron dual-riser) to 7.5 L/s, a 1.0 L/s gain, though improvements are modest. Position does not affect capacity (uniformly 7.5 L/s across configurations) but profoundly influences water seal losses: P-type trap placement yields the lowest losses on most floors, combined P-type trap/floor drain placement achieves intermediate values, and floor drain placement the highest. Thus, the P-type trap is optimal. Diameter similarly has no impact on capacity but shows nuanced effects on seals; DN75 minimizes losses on most floors, outperforming DN50 and DN100, indicating that appliance vent pipe design should adopt a height-zoned approach tailored to anticipated drainage loads and pressure characteristics. Appliance vent pipes effectively dampen positive/negative pressure fluctuations, reducing seal depletion and sewer gas risks. These findings guide engineering designs for healthier indoor environments in high-rise buildings. Full article