Search Results (46,972)

Spontaneous coronary artery dissection (SCAD) is an important non-atherosclerotic cause of acute coronary syndrome, predominantly affecting younger women without traditional cardiovascular risk factors. In hemodynamically stable patients, accumulating evidence supports a conservative management strategy owing to the high rate of spontaneous vessel healing, while technically challenging invasive interventions should be reserved for selected high-risk cases. Despite growing evidence regarding acute management, recurrent SCAD and other adverse cardiovascular events have been reported during follow-up, underscoring the need for surveillance. However, optimal strategies for post-acute follow-up and for assessing the appropriateness of treatment decisions remain insufficiently established. This review focuses on clinical decision-making in the management of SCAD, with particular emphasis on follow-up assessment. We summarize the existing evidence regarding indications for conservative versus invasive treatment and discuss the clinical rationale for longitudinal imaging surveillance. Special attention is given to the role of non-invasive follow-up using coronary computed tomography angiography, including confirmation of vessel healing, evaluation of residual intramural hematoma, and assessment of distal coronary flow. Given the heterogeneity of SCAD and the risk of recurrence, individualized treatment decisions and structured follow-up strategies are essential to optimize management, avoid unnecessary invasive procedures, and support care and risk stratification in patients with SCAD. Full article

Plaque-disclosing agents are widely used to enhance visualization of dental biofilm. However, their chromogenic components may adhere to enamel surfaces, resulting in transient extrinsic discoloration. This study evaluated the extent and short-term recovery of such discoloration and compared three removal modalities in terms of enamel color change (CIEDE2000, ΔE₀₀), surface roughness (Ra), and gloss (GU). Extracted human anterior teeth with intact buccal enamel were stained using an erythrosine-based disclosing agent and randomly allocated into three groups (n = 15): manual brushing with conventional toothpaste, rubber-cup polishing with a perlite-containing paste (1000 rpm, 5 s), or erythritol-based air-polishing (5 s; 50% power/100% water). ΔE₀₀ was measured at baseline, immediately after cleaning, and after 1 week of storage in artificial saliva. Ra and GU were recorded at baseline and post-cleaning. Data were analyzed using appropriate tests (p < 0.05). All modalities were associated with a reduction in visible discoloration without significantly affecting Ra or GU (p > 0.05). Immediate ΔE₀₀ values remained above commonly reported acceptability thresholds, indicating residual discoloration. Partial color recovery occurred after artificial saliva storage. Within the limitations of this study, the findings indicate no statistically significant differences among the tested procedures, without evidence of superiority of any single modality. Full article

Background/Objectives: Pest management strategies rely on insecticides such as deltamethrin (DM), a commonly applied type II pyrethroid. As a natural component of food-associated microflora, Saccharomyces cerevisiae inevitably encounters DM residues in crops used for fermentation processes, including dough leavening and winemaking. However, the prolonged effect of DM exposure on yeast fermentation performance and its capacity to remove DM remained unclear. Methods: In this study, S. cerevisiae was continuously exposed to a non-lethal concentration (10 mg/L) and a low-inhibition toxic concentration (30 mg/L) of DM for 30 days. Results: Yeast exhibited high removal capacity, removing 98.05 ± 1.2% and 98.28 ± 0.4% of DM at 10 mg/L and 30 mg/L, respectively. Prolonged exposure to DM at both concentrations did not significantly affect biomass formation, glucose consumption, ethanol production, or acetic acid levels. In contrast, glycerol production increased markedly, reaching 1.1 g/L and 1.5 g/L in cultures exposed to 10 mg/L and 30 mg/L DM, respectively. Consistent with these changes, the expression levels of GPD1 and GPD2, which encode rate-limiting enzymes in glycerol biosynthesis, were upregulated in a dose-dependent manner. Conclusions: Given the fact that Saccharomyces cerevisiae is a workhorse for the biotechnological industry and has a wide range of applications, including in the food industry, elevated glycerol production in yeast under DM exposure is noteworthy in terms of yeast-based applications. Full article

The increasing global demand for sustainable production of high-nutritional-value food and feed has emerged the need of harnessing the agro-industrial residues applying various innovative bioconversion strategies. In this context, the utilization of legume production wastes constitutes an intriguing subject because of their high content in nutritious molecules. The study herein concerns the incorporation of Fava Santorinis (Lathyrus clymenum) pericarps, an agro-industrial byproduct, into Black Soldier Fly (BSF, Hermetia illucens) larvae rearing diets to produce nutritious insect meals. Thus, four dietary treatments of BSF larvae were evaluated consisting of a commercial feed as control diet and three experimental diets incorporating 15%, 30% and 45% inclusion levels of fava bean pericarps. When BSF larvae reached their sixth instar stage, their growth performance and the nutritional content of the produced insect meal were assessed. Best results were obtained for BSF rearing with feed containing 30% and 45% pericarps, establishing the valorization of a large amount of pericarp, achieving a high growth rate and a rich protein content exceeding 30%. On the other hand, the presence of saponines was not determined, although the overall larvae performance indicates a high tolerance to their presence. Finally, the assessment of insect meals lipidic profiles revealed the prevalence of saturated lauric acid, an established potent antimicrobial agent, along with lower amounts of unsaturated Ω-6 linolenic acid and Ω-3 linoleic acid acids. The results herein demonstrate a sustainable strategy for the bioconversion of Fava Santorinis production waste to nutritious animal feed in the context of circular economy. Full article

An integrated numerical method is proposed for analyzing the nonlinear seismic response of near-fault building clusters, comprising three algorithms: (1) a structural investigated lump algorithm for elastoplastic dynamic response of structure; (2) a connecting investigated lump algorithm for bidirectional wave propagation between the site and elastoplastic building clusters; (3) a geomedia investigated lump algorithm for seismic wave propagation with an improved viscoelastic constitutive model, which allows independent definition of P/S-wave quality factors to characterize geomedia attenuation. Validated for its capability in simulating site-city dynamic interaction problems via a shaking table test, the method is applied to study the seismic response of near-fault building clusters in Xichang City under a hypothetical M_w6.8 earthquake. It is shown that irrespective of whether shallow geological structures are considered, clusters (c2–c4) situated in rupture-forward surface area within ~1.5 km of the fault trace entered the elastoplastic stage, while others (c1, c5) remained elastic. Shallow geological structures may reverse locally hanging-wall/footwall effects of both near-fault structural seismic response and ground motion. A notable seismic-response characteristic of near-fault structures undergoing the elastoplastic stage is that the permanent structural motion displacement (PSMD) at the slab of a specific floor incorporates not only the non-zero permanent ground motion displacement (PGMD) but also the non-zero final structural residual displacement (FSRD) relative to the supporting ground. The developed method could provide support for seismic damage assessment, site selection, and structural optimization design of near-fault building clusters. Full article

Mussel foot proteins (Mfps) are renowned for their underwater adhesion, whereas their biotechnological potential for cutaneous wound repair remains largely underexplored. In this study, we identified and characterized a cysteine-rich mussel foot protein, Mfp6-1, from Mytilus coruscus and investigated its therapeutic potential for wound healing. Sequence analysis showed that Mfp6-1 is enriched in cysteine (11.0%) and tyrosine (~16.5%). We successfully expressed recombinant Mfp6-1 (rMfp6-1) in E. coli. Structural prediction based on the mature peptide sequence suggested that rMfp6-1 adopts a relatively compact fold containing several short β-structural elements. In vitro assays demonstrated that rMfp6-1 possesses antioxidant activity in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, and alkylation experiments suggested that cysteine residues contribute importantly to this activity. Dithio-bis-nitrobenzoic acid (DTNB)-based thiol quantification further demonstrated that rMfp6-1 contained abundant accessible free sulfhydryl groups, supporting an important contribution of cysteine-derived thiols to its antioxidant activity. Experiments on a full-thickness mouse wound model showed that rMfp6-1 treatment resulted in significantly faster wound contraction. Morphological analysis further revealed that rMfp6-1 optimizes the healing microenvironment by promoting collagen accumulation and re-epithelialization. Additionally, the treatment was found to trigger vascular endothelial growth factor (VEGF)-mediated angiogenesis, thereby improving the overall quality of the regenerated tissue. Furthermore, rMfp6-1 treatment significantly reduced interleukin-6 (IL-6) expression, suggesting that its antioxidant capacity creates a permissive microenvironment for tissue regeneration by suppressing excessive inflammation. These findings indicate that recombinant rMfp6-1 is a promising bioactive candidate for wound-healing applications. Full article

Reference-driven humanoid motion tracking aims to reproduce a source motion on a target humanoid while preserving physical executability under actuation limits and changing contact conditions. The problem becomes particularly challenging for dynamic motions involving rapid support transitions, landing impacts, mixed hand–foot contacts, and moderate topology-preserving morphology variation. Existing pipelines often rely heavily on morphology-specific world-frame targets or treat balance and contact quality only indirectly during execution, which limits their reliability under dynamic contact variation. This paper presents a task and cost formulation for reference-driven humanoid tracking within the residual-based MuJoCo model predictive control (MPC) framework. The source motion is decomposed into a pelvis-centered canonical local reference, pelvis height and tilt references, and a pelvis-derived horizontal center-of-mass (CoM) velocity intent, and is tracked online with a zero moment point (ZMP)-aware contact-conditioned residual design including slip, penetration, posture, and control regularization. The formulation is compatible with standard MuJoCo MPC planners, and the evaluation is conducted under a shared iterative linear quadratic Gaussian (iLQG) setting on nominal and morphology-varied humanoids against tracking-only and two-stage inverse-kinematics (IK)-based baselines. The proposed formulation improves success rate, support quality, slip reduction, and progression accuracy, with the clearest gains on contact-sensitive motions; for example, success rate increases from 56.7% to 76.7% on Jump–Turn and from 46.7% to 70.0% on Cartwheel relative to the tracking-only MPC baseline. These results support the use of execution-oriented reference representation and contact-conditioned residual design for physically reliable reference-driven humanoid tracking. Full article

Ball-end copy-milling is widely used for finishing complex components, yet its influence on surface integrity is generally overlooked and remains insufficiently addressed. Milling often generates tensile residual stresses at the machined surface, which are detrimental to fatigue performance and commonly require costly postprocessing, particularly in fatigue-critical parts such as turbine blades. In this context, the present study evaluates the capability of Prestress-Assisted Machining under uniform bending loads to improve the surface integrity of ball-end copy-milled Aluminium 5083 workpieces. Experimental tests were conducted on slender specimens with different thicknesses and curvature radii while maintaining constant cutting conditions. After machining and unclamping, surface residual stresses were measured by X-ray diffraction, and the effects of prestressing on geometry, cutting forces and surface roughness were also assessed. The results demonstrate that this method markedly increases compressive residual stresses in the prestressing direction, from approximately 30 MPa to about 180 MPa, and that this variation can be accurately described by subtracting the elastic prestressing stress from the residual stresses obtained without external loads applied. Moreover, no relevant adverse effects were observed in cutting forces or roughness, and corrected toolpaths allowed a uniform slot depth. These findings identify bending-based Prestress-Assisted Machining as an effective and predictable strategy for improving surface integrity in ball-end copy-milling and extend its applicability beyond previously reported pocket and slot milling operations. Full article

The intensity of lipid oxidation after cooking and after in vitro gastrointestinal digestion of pork and chicken burgers was assessed. Pan frying with olive or sunflower oils and oven treatment were used as cooking technologies in both types of burgers. Thiobarbituric acid reactive substances (TBARs) were measured after cooking and in the micellar (bioaccessible) and residual (pellet) fractions after gastrointestinal in vitro digestion. Genotoxicity was assessed in the micellar fraction using the SOS/umu genotoxicity test. Lipid fraction suffered significant oxidation increases in all samples during the digestion process, especially in oven-treated samples. In general, the bioaccessible fraction showed a higher amount of oxidation products than the residual phase. None of the samples showed genotoxicity activity in the SOS/umu test. Full article

During the COVID-19 pandemic, Health Canada temporarily exempted pharmacists from specific restrictions under the Controlled Drugs and Substances Act (CDSA), allowing them to prescribe opioids. However, it is not yet established whether opioid dispensing patterns differ between urban and rural pharmacists. This study aims to assess the impact of the CDSA subsection 56(1) temporary exemption on opioid prescribing practices among urban and rural pharmacists between 1 February 2018 and 30 April 2022. Descriptive statistics and visualizations assessed differences in opioid prescribing between urban and rural pharmacists under the CDSA exemption. Initial analyses employed linear regression to examine changes, followed by evaluation of temporal dependence using autocorrelation and residual analysis. When appropriate, a suitable time series model was subsequently applied. Following the CDSA exemption, the mean weekly proportion of opioid claims prescribed by urban pharmacists increased from 0.0% to 1.03%. In contrast, rural pharmacists’ prescriptions rose from 0.0% to 0.35%. The estimated mean level change was 0.667% for urban pharmacists (95% CI: 0.520–0.838%, p < 0.0001) and 0.201% for rural pharmacists (95% CI: 0.140–0.291%, p < 0.0001). The study identified distinct differences in opioid prescribing practices between urban and rural pharmacists in Nova Scotia. Furthermore, opioid prescriptions increased steadily across all patient groups, indicating evolving patterns of opioid use within the province. Full article

The management of obstructive hypertrophic cardiomyopathy (HCM) has been transformed by the advent of cardiac myosin inhibitors (CMIs), such as mavacamten and aficamten. Unlike traditional pharmacotherapy, which primarily addresses symptoms, CMIs target the underlying mechanism of sarcomeric hypercontractility, offering significant reductions in left ventricular outflow tract (LVOT) gradients and improved functional capacity. This review evaluates the evolving role of CMIs in refining surgical candidate selection and postoperative care. Clinically, CMIs function as an in vivo “biological test” to distinguish between dynamic, functional obstruction—often manageable with medication—and fixed anatomical obstruction driven by complex septal or mitral substrates. While clinical trials demonstrate that CMIs can delay or prevent the need for SRT in a significant proportion of patients, surgery remains the definitive solution for those with dominant structural anomalies or drug intolerance. Consequently, the therapeutic paradigm is shifting from a binary “drugs or surgery” approach to a synergistic model. In this framework, CMIs optimize the identification of patients truly requiring structural myectomy while serving as a valuable adjunct for managing residual hypercontractility, ultimately facilitating a personalized, multidisciplinary approach to HCM treatment. Full article

This paper examines whether a residual structural state extracted from cross-asset downside-risk dependence contains incremental information for forecasting next-day market downside risk beyond a strong heterogeneous autoregressive (HAR) benchmark. The empirical analysis uses Binance intraday data from September 2019 to December 2025 and a fixed sample of 24 liquid cryptocurrencies obtained through explicit data-quality screening and sample diagnostics. The forecasting target is the log of an equal-weight cross-sectional downside-risk index constructed from strictly valid asset-level realized downside semivariance measures. The empirical design is deliberately conservative: the market sample is fixed ex ante, the target is evaluated against Bitcoin (BTC) and Ethereum (ETH) dominance diagnostics, and asset-level HAR-type models are estimated recursively to generate ex-ante one-step-ahead residuals, from which rolling residual-dependence matrices and structural signatures are constructed. The selected residual state contains four components: average residual correlation, Frobenius-type deformation, influence concentration, and influential-set turnover. The evidence supports three qualified conclusions. First, the full residual state attains the lowest average QLIKE loss relative to the HAR benchmark, although the corresponding Diebold–Mariano test under the primary QLIKE loss does not reject equal predictive accuracy at conventional levels. Complementary Clark–West evidence on the nested log-scale comparison supports incremental predictive content for the level-state and full-state augmentations. Second, the strongest forecasting evidence comes from the full state rather than from deformation-only specifications. Third, event-window diagnostics show that structural reorganization is most pronounced around stress-entry and extreme-risk episodes, supporting an onset-sensitive rather than a long-lead early-warning interpretation. Overall, the evidence supports a cautious and statistically qualified predictive conclusion: residual market structure may contain incremental information for short-horizon downside-risk forecasting in cryptocurrency markets, especially around stress onset, but the result should not be interpreted as a decisive primary-loss improvement or as evidence that deformation alone dominates a strong benchmark. Full article

The Akseki–Kuyucak bauxite deposits, located in the Western Taurus Belt in southwestern Türkiye, represent karst-type bauxite mineralization derived from carbonate platform phases. This work integrates field observations, X-ray diffraction (XRD) analysis, and extensive geochemical data, including major, trace, and rare earth elements (REEs), to clarify the mineralogical characteristics, geochemical processes, and genetic implications of the deposits. Field and petrographic investigations indicate that the bauxite deposits occur as irregular fills and lens-shaped formations on paleokarstic surfaces of carbonate substrates. The XRD examination reveals that the major minerals in the bauxite samples are boehmite, hematite, and anatase, with some samples exhibiting a predominance of calcite, indicating a strong genetic relationship between the ore bodies and the carbonate host rocks. Major oxide analysis reveals a distinct compositional disparity between bauxitic and carbonate-dominated materials: bauxitic samples exhibit elevated Al₂O₃ and Fe₂O₃ levels, with reduced SiO₂ and CaO concentrations. In contrast, carbonate-rich samples show higher CaO and loss-on-ignition values. Ternary discrimination diagrams categorize most bauxitic samples into the ferritic bauxite and robust lateritization domains, indicating substantial weathering and residual enrichment processes. The trace element and REE studies reveal ΣLREE values ranging from 22.3 to 240.2 ppm, with a right-skewed distribution indicating heterogeneous enrichment. Correlation studies indicate that ΣLREE has a positive correlation with SiO₂ and K₂O, suggesting that the enrichment of REEs is more closely associated with silicate/clay minerals than with iron oxide phases. Furthermore, spider diagrams and the study of immobile components emphasize the significance of residual concentration processes in bauxitization. In contrast, modest TiO₂ levels indicate a composite source derived from both insoluble carbonate remnants and detrital siliciclastic materials. In summary, the Akseki–Kuyucak deposits are categorized as intricate karst bauxite systems, characterized by significant lateritization, regulated accumulation governed by paleokarst characteristics, and a complex geochemical evolution. The results demonstrate that integrating mineralogical, geochemical, and statistical methods provides a thorough framework for evaluating REE behaviors and the effects of source-related factors in karst bauxite deposits. Full article

Weeds represent a major constraint in the cultivation of medicinal and aromatic plants (MAPs), causing significant reductions in yield, biomass, and essential oil quality while increasing labor and production costs. Effective weed management is particularly critical during early crop growth, when young plants are most vulnerable to competition. Non-chemical strategies, including cultural practices, mechanical and thermal weeding, mulching, and crop diversification, have proven effective in suppressing weeds, enhancing crop competitiveness, and maintaining yield and quality, especially in organic or low-input systems. Mulching and optimized cultivation strategies consistently provide reliable weed control, improve soil moisture and nutrient use efficiency, and can influence secondary metabolite accumulation. Chemical weed control, including selective pre- and post-emergence herbicides, remains important in slow-growing MAPs but is increasingly constrained by regulatory restrictions and concerns over residues in raw plant material and essential oils. Integrated weed management combining cultural, physical, and reduced chemical approaches offers the most effective solution, balancing efficacy, crop safety, and product quality. Emerging strategies such as bioherbicides, precision agriculture, and robotic systems hold promise but require further research. Advancing weed management in MAPs will depend on interdisciplinary studies, field-scale validation, and technology-driven innovations to support sustainable, high-quality production. Full article

Background/Objective: Sesame (Sesamum indicum L.) is a nutritionally and economically important oilseed crop that is grown predominantly by smallholder farmers in Mozambique. However, its breeding process is constrained by a limited understanding of the genetic diversity in sesame germplasm. Therefore, this study determined the genetic diversity and population structure of a panel of 109 sesame accessions from Instituto de Investigação Agrária de Mocambique (IIAM) using DArTseq SNPs. Methods: The generated 14,763 SNPs were filtered, retaining 11,502 high-quality SNPs for this study. Results: Overall genetic diversity was moderate (mean He = 0.30, Ho = 0.30, MAF = 0.21, PIC = 0.25). Population structure analysis using sparse non-negative matrix factorization identified eight subpopulations, consistent with principal component analysis implemented via the Latent factor mixed model. Discriminant analysis of principal components (DAPC) and Ward’s hierarchical clustering based on Nei’s distance resolved the same eight clusters, although DAPC revealed overlap among clusters, consistent with extensive admixture. Analysis of molecular variance showed that 85.85% of total molecular variation was within subpopulations and 14.15% among the subpopulations. Pairwise fixation indices (ranging from 0.02 to 0.10) identified divergent subpopulations 7 and 1 as suitable candidates for hybridization. Within subpopulations, observed heterozygosity exceeded expected heterozygosity, likely reflecting residual heterozygosity in sesame landraces, admixture, reverse Wahlund effect and scoring of paralogs as heterozygous SNPs. Conclusions: Overall, this study provided insights into sesame’s genetic diversity in Mozambique, contributing to germplasm conservation and informed parental selection. Full article