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Search Results (844)

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Keywords = radio localization

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19 pages, 1107 KiB  
Article
A Novel Harmonic Clocking Scheme for Concurrent N-Path Reception in Wireless and GNSS Applications
by Dina Ibrahim, Mohamed Helaoui, Naser El-Sheimy and Fadhel Ghannouchi
Electronics 2025, 14(15), 3091; https://doi.org/10.3390/electronics14153091 (registering DOI) - 1 Aug 2025
Abstract
This paper presents a novel harmonic-selective clocking scheme that facilitates concurrent downconversion of spectrally distant radio frequency (RF) signals using a single low-frequency local oscillator (LO) in an N-path receiver architecture. The proposed scheme selectively generates LO harmonics aligned with multiple RF bands, [...] Read more.
This paper presents a novel harmonic-selective clocking scheme that facilitates concurrent downconversion of spectrally distant radio frequency (RF) signals using a single low-frequency local oscillator (LO) in an N-path receiver architecture. The proposed scheme selectively generates LO harmonics aligned with multiple RF bands, enabling simultaneous downconversion without modification of the passive mixer topology. The receiver employs a 4-path passive mixer configuration to enhance harmonic selectivity and provide flexible frequency planning.The architecture is implemented on a printed circuit board (PCB) and validated through comprehensive simulation and experimental measurements under continuous wave and modulated signal conditions. Measured results demonstrate a sensitivity of 55dBm and a conversion gain varying from 2.5dB to 9dB depending on the selected harmonic pair. The receiver’s performance is further corroborated by concurrent (dual band) reception of real-world signals, including a GPS signal centered at 1575 MHz and an LTE signal at 1179 MHz, both downconverted using a single 393 MHz LO. Signal fidelity is assessed via Normalized Mean Square Error (NMSE) and Error Vector Magnitude (EVM), confirming the proposed architecture’s effectiveness in maintaining high-quality signal reception under concurrent multiband operation. The results highlight the potential of harmonic-selective clocking to simplify multiband receiver design for wireless communication and global navigation satellite system (GNSS) applications. Full article
(This article belongs to the Section Microwave and Wireless Communications)
11 pages, 556 KiB  
Article
Added Value of SPECT/CT in Radio-Guided Occult Localization (ROLL) of Non-Palpable Pulmonary Nodules Treated with Uniportal Video-Assisted Thoracoscopy
by Demetrio Aricò, Lucia Motta, Giulia Giacoppo, Michelangelo Bambaci, Paolo Macrì, Stefania Maria, Francesco Barbagallo, Nicola Ricottone, Lorenza Marino, Gianmarco Motta, Giorgia Leone, Carlo Carnaghi, Vittorio Gebbia, Domenica Caponnetto and Laura Evangelista
J. Clin. Med. 2025, 14(15), 5337; https://doi.org/10.3390/jcm14155337 - 29 Jul 2025
Viewed by 219
Abstract
Background/Objectives: The extensive use of computed tomography (CT) has led to a significant increase in the detection of small and non-palpable pulmonary nodules, necessitating the use of invasive methods for definitive diagnosis. Video-assisted thoracoscopic surgery (VATS) has become the preferred procedure for nodule [...] Read more.
Background/Objectives: The extensive use of computed tomography (CT) has led to a significant increase in the detection of small and non-palpable pulmonary nodules, necessitating the use of invasive methods for definitive diagnosis. Video-assisted thoracoscopic surgery (VATS) has become the preferred procedure for nodule resections; however, intraoperative localization remains challenging, especially for deep or subsolid lesions. This study explores whether SPECT/CT improves the technical and clinical outcomes of radio-guided occult lesion localization (ROLL) before uniportal video-assisted thoracoscopic surgery (u-VATS). Methods: This is a retrospective study involving consecutive patients referred for the resection of pulmonary nodules who underwent CT-guided ROLL followed by u-VATS between September 2017 and December 2024. From January 2023, SPECT/CT was systematically added after planar imaging. The cohort was divided into a planar group and a planar + SPECT/CT group. The inclusion criteria involved nodules sized ≤ 2 cm, with ground glass or solid characteristics, located at a depth of <6 cm from the pleural surface. 99mTc-MAA injected activity, timing, the classification of planar and SPECT/CT image findings (focal uptake, multisite with focal uptake, multisite without focal uptake), spillage, and post-procedure complications were evaluated. Statistical analysis was performed, with continuous data expressed as the median and categorical data as the number. Comparisons were made using chi-square tests for categorical variables and the Mann–Whitney U test for procedural duration. Cohen’s kappa coefficient was calculated to assess agreement between imaging modalities. Results: In total, 125 patients were selected for CT-guided radiotracer injection followed by uniportal-VATS. The planar group and planar + SPECT/CT group comprised 60 and 65 patients, respectively. Focal uptake was detected in 68 (54%), multisite with focal uptake in 46 (36.8%), and multisite without focal uptake in 11 patients (8.8%). In comparative analyses between planar and SPECT/CT imaging in 65 patients, 91% exhibited focal uptake, revealing significant differences in classification for 40% of the patients. SPECT/CT corrected the classification of 23 patients initially categorized as multisite with focal uptake to focal uptake, improving localization accuracy. The mean procedure duration was 39 min with SPECT/CT. Pneumothorax was more frequently detected with SPECT/CT (43% vs. 1.6%). The intraoperative localization success rate was 96%. Conclusions: SPECT/CT imaging in the ROLL procedure for detecting pulmonary nodules before u-VATs demonstrates a significant advantage in reclassifying radiotracer positioning compared to planar imaging. Considering its limited impact on surgical success rates and additional procedural time, SPECT/CT should be reserved for technically challenging cases. Larger sample sizes, multicentric and prospective randomized studies, and formal cost–utility analyses are warranted. Full article
(This article belongs to the Section Nuclear Medicine & Radiology)
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19 pages, 4251 KiB  
Article
A Complete Solution for Ultra-Wideband Based Real-Time Positioning
by Vlad Ratiu, Ovidiu Ratiu, Olivier Raphael Smeyers, Vasile Teodor Dadarlat, Stefan Vos and Ana Rednic
Sensors 2025, 25(15), 4620; https://doi.org/10.3390/s25154620 (registering DOI) - 25 Jul 2025
Viewed by 172
Abstract
Real-time positioning is a technological field with a multitude of applications, which expand across many scopes: from positioning within a large area to localization within smaller spaces; from locating people to locating equipment; from large-scale industrial or military applications to commercially available solutions. [...] Read more.
Real-time positioning is a technological field with a multitude of applications, which expand across many scopes: from positioning within a large area to localization within smaller spaces; from locating people to locating equipment; from large-scale industrial or military applications to commercially available solutions. There are at least as many implementations of real-time positioning as there are applications and challenges. Within the domain of Radio Frequency (RF) systems, positioning has been approached from multiple angles. Some of the more common solutions involve using Time of Flight (ToF) and time difference of arrival (TDoA) technologies. Within TDoA-based systems, one common limitation stems from the computational power necessary to run the multi-lateration algorithms at a high enough speed to provide high-frequency refresh rates on the tag positions. The system presented in this study implements a complete hardware and software TDoA-based real-time positioning system, using wireless Ultra-Wideband (UWB) technology. This system demonstrates improvements in the state of the art by addressing the above limitations through the use of a hybrid Machine Learning solution combined with algorithmic fine tuning in order to reduce computational power while achieving the desired positioning accuracy. This study presents the design, implementation, verification and validation of the aforementioned system, as well as an overview of similar solutions. Full article
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18 pages, 1643 KiB  
Communication
A Localization Enhancement Method Based on Direct-Path Identification and Tracking for Future Networks
by Yuhong Huang and Youping Zhao
Sensors 2025, 25(15), 4538; https://doi.org/10.3390/s25154538 - 22 Jul 2025
Viewed by 243
Abstract
Localization is one of the essential problems in the Internet of Things (IoT). Dynamic changes in the radio environment may lead to poor localization accuracy or discontinuous localization in non-line-of-sight (NLOS) scenarios. To address this problem, this paper proposes a localization enhancement method [...] Read more.
Localization is one of the essential problems in the Internet of Things (IoT). Dynamic changes in the radio environment may lead to poor localization accuracy or discontinuous localization in non-line-of-sight (NLOS) scenarios. To address this problem, this paper proposes a localization enhancement method based on direct-path identification and tracking. More specifically, the proposed method significantly reduces the range error and localization error by quickly identifying the line-of-sight (LOS) to NLOS transition and effectively tracking the direct path. In a large testing hall, localization experiments based on the ultra-wideband (UWB) signal have been carried out. Experimental results show that the proposed method achieves a root mean square localization error of less than 0.3 m along the user equipment (UE) movement trajectory with serious NLOS propagation conditions. Compared with conventional methods, the proposed method significantly improves localization accuracy while ensuring continuous localization. Full article
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18 pages, 20327 KiB  
Article
The Effect of Scratch-Induced Microscale Surface Roughness on Signal Transmission in Radio Frequency Coaxial Connectors
by Yuqi Zhou, Tianmeng Zhang, Gang Xie and Jinchun Gao
Micromachines 2025, 16(8), 837; https://doi.org/10.3390/mi16080837 - 22 Jul 2025
Viewed by 282
Abstract
Electrical connectors play a vital role in ensuring reliable signal transmission in high-frequency microsystems. This study explores the impact of microscale scratch-induced surface roughness on the alternating current (AC) contact impedance of RF coaxial connectors. Unlike traditional approaches that assume idealized surface conditions, [...] Read more.
Electrical connectors play a vital role in ensuring reliable signal transmission in high-frequency microsystems. This study explores the impact of microscale scratch-induced surface roughness on the alternating current (AC) contact impedance of RF coaxial connectors. Unlike traditional approaches that assume idealized surface conditions, controlled micro-defects were introduced at the central contact interface to establish a quantitative relationship between surface morphology and signal degradation. An equivalent circuit model was constructed to account for local impedance variations and the cumulative effects of cascaded connector interfaces. The model was validated using S-parameter measurements obtained from vector network analyzer (VNA) testing, showing strong agreement with simulation results. Experimental results reveal that the low-roughness (0.4 μm) contact surfaces lead to degraded signal integrity due to insufficient micro-contact formation. In contrast, scratch-induced moderate roughness (0.8–4.8 μm) improves transmission performance, although signal quality declines as roughness increases within this range. These effects are further amplified in multi-connector configurations due to accumulated impedance mismatches. This work provides new insight into the coupling between microscale surface features and frequency-domain transmission characteristics, offering practical guidance for surface engineering, contact design, and the development of miniaturized, high-reliability radio frequency interconnects for next-generation communication systems. Full article
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15 pages, 1529 KiB  
Article
Peak Age of Information Optimization in Cell-Free Massive Random Access Networks
by Zhiru Zhao, Yuankang Huang and Wen Zhan
Electronics 2025, 14(13), 2714; https://doi.org/10.3390/electronics14132714 - 4 Jul 2025
Viewed by 290
Abstract
With the vigorous development of Internet of Things technologies, Cell-Free Radio Access Network (CF-RAN), leveraging its distributed coverage and single/multi-antenna Access Point (AP) coordination advantages, has become a key technology for supporting massive Machine-Type Communication (mMTC). However, under the grant-free random access mechanism, [...] Read more.
With the vigorous development of Internet of Things technologies, Cell-Free Radio Access Network (CF-RAN), leveraging its distributed coverage and single/multi-antenna Access Point (AP) coordination advantages, has become a key technology for supporting massive Machine-Type Communication (mMTC). However, under the grant-free random access mechanism, this network architecture faces the problem of information freshness degradation due to channel congestion. To address this issue, a joint decoding model based on logical grouping architecture is introduced to analyze the correlation between the successful packet transmission probability and the Peak Age of Information (PAoI) in both single-AP and multi-AP scenarios. On this basis, a global Particle Swarm Optimization (PSO) algorithm is designed to dynamically adjust the channel access probability to minimize the average PAoI across the network. To reduce signaling overhead, a PSO algorithm based on local topology information is further proposed to achieve collaborative optimization among neighboring APs. Simulation results demonstrate that the global PSO algorithm can achieve performance closely approximating the optimum, while the local PSO algorithm maintains similar performance without the need for global information. It is especially suitable for large-scale access scenarios with wide area coverage, providing an efficient solution for optimizing information freshness in CF-RAN. Full article
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12 pages, 1145 KiB  
Article
Non-Iterative Reconstruction and Selection Network-Assisted Channel Estimation for mmWave MIMO Communications
by Jing Yang, Yabo Guo, Xinying Guo and Pengpeng Wang
Sensors 2025, 25(13), 4172; https://doi.org/10.3390/s25134172 - 4 Jul 2025
Viewed by 254
Abstract
Millimeter-wave (mmWave) MIMO systems have emerged as a key enabling technology for next-generation wireless networks, addressing the growing demand for ultra-high data rates through the utilization of wide bandwidths and large-scale antenna configurations. Beyond communication capabilities, these systems offer inherent advantages for integrated [...] Read more.
Millimeter-wave (mmWave) MIMO systems have emerged as a key enabling technology for next-generation wireless networks, addressing the growing demand for ultra-high data rates through the utilization of wide bandwidths and large-scale antenna configurations. Beyond communication capabilities, these systems offer inherent advantages for integrated sensing applications, particularly in scenarios requiring precise object detection and localization. The sparse mmWave channel in the beamspace domain allows fewer radio-frequency (RF) chains by selecting dominant beams, boosting both communication efficiency and sensing resolution. However, existing channel estimation methods, such as learned approximate message passing (LAMP) networks, rely on computationally intensive iterations. This becomes particularly problematic in large-scale system deployments, where estimation inaccuracies can severely degrade sensing performance. To address these limitations, we propose a low-complexity channel estimator using a non-iterative reconstruction network (NIRNet) with a learning-based selection matrix (LSM). NIRNet employs a convolutional layer for efficient, non-iterative beamspace channel reconstruction, significantly reducing computational overhead compared to LAMP-based methods, which is vital for real-time sensing. The LSM generates a signal-aware Gaussian measurement matrix, outperforming traditional Bernoulli matrices, while a denoising network enhances accuracy under low SNR conditions, improving sensing resolution. Simulations show the NIRNet-based algorithm achieves a superior normalized mean squared error (NMSE) and an achievable sum rate (ASR) with lower complexity and reduced training overhead. Full article
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21 pages, 2725 KiB  
Article
A Strategy for Improving Millimeter Wave Communication Reliability by Hybrid Network Considering Rainfall Attenuation
by Jiaqing Sun, Chunxiao Li, Junfeng Wei and Jiajun Shen
Symmetry 2025, 17(7), 1054; https://doi.org/10.3390/sym17071054 - 3 Jul 2025
Viewed by 325
Abstract
With the rapid development of smart connected vehicles, vehicle network communications demand high-speed data transmission to support advanced automotive services. Millimeter Wave (mmWave) communication offers fast data rates, strong anti-interference capabilities, high precision localization and low-latency, making it suitable for high-speed in-vehicle communications. [...] Read more.
With the rapid development of smart connected vehicles, vehicle network communications demand high-speed data transmission to support advanced automotive services. Millimeter Wave (mmWave) communication offers fast data rates, strong anti-interference capabilities, high precision localization and low-latency, making it suitable for high-speed in-vehicle communications. However, mmWave communication performance in vehicular networks is hindered by high path loss and frequent beam alignment updates, significantly degrading the coverage and connectivity of vehicle nodes (VNs). In addition, atmospheric propagation attenuation further deteriorates signal quality and limits system performance due to raindrop absorption and scattering. Therefore, the pure mmWave networks cannot meet the high requirements of highway vehicular communications. To address these challenges, this paper proposes a hybrid mmWave and microwave network architecture to improve VNs’ coverage and connectivity performances through the strategic deployment of Roadside Units (RSUs). Using Radio Access Technology (RAT), mmWave and microwave RSUs are symmetrically deployed on both sides of the road to communicate with VNs located at the road center. This symmetric RSUs deployment significantly improves the network reliability. Analytical expressions for coverage and connectivity in the proposed hybrid networks are derived and compared with the pure mmWave networks, accounting for rainfall attenuation. The study results show that the proposed hybrid network shows better performance than the pure mmWave network in both coverage and connectivity. Full article
(This article belongs to the Special Issue Symmetry/Asymmetry in Future Wireless Networks)
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16 pages, 3538 KiB  
Article
Performance Measurement of an Electromagnetic Guided-Wave Liquid Level Sensor
by Parisa Esmaili, Federico Cavedo and Michele Norgia
Metrology 2025, 5(3), 38; https://doi.org/10.3390/metrology5030038 - 1 Jul 2025
Viewed by 213
Abstract
Slight changes in the local properties of a transmission line, dipped in a liquid, can be used to estimate its level through two different determination techniques, involving the capacitance and electromagnetic wave speed, measured by the time of flight. Indeed, the overall capacitance [...] Read more.
Slight changes in the local properties of a transmission line, dipped in a liquid, can be used to estimate its level through two different determination techniques, involving the capacitance and electromagnetic wave speed, measured by the time of flight. Indeed, the overall capacitance of a transmission line varies linearly with the liquid level, as well as the time of flight of the electromagnetic wave. Both quantities can be estimated via the measurement of a phase shift at radio frequencies, and the simultaneous measurements can be realized using a compact and low-cost design working at a few megahertz. This paper presents a further improvement in sensitivity to challenge the performance of this kind of level sensor, dealing with liquids with low dielectric constants. To better describe this effect, a study on the overall capacitance of different transmission path segments was conducted in COMSOL Multiphysics. The level measurement was performed experimentally on the realized prototype while considering the measured phase shift as a function of the liquid level, for both an unshielded twisted-pair and magnet wires. As the results showed, with the magnet wires the sensitivity was improved by a factor of about 4, consistently aligning with the simulation results and providing a predictable phase shift response with increasing liquid levels. Consequently, magnet wire is a good choice for precise level measurements through RF phase shifts, especially in the case of low relative permittivity liquids. Full article
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23 pages, 678 KiB  
Article
Unified Probabilistic and Similarity-Based Position Estimation from Radio Observations
by Max Werner, Markus Bullmann, Toni Fetzer and Frank Deinzer
Sensors 2025, 25(13), 4092; https://doi.org/10.3390/s25134092 - 30 Jun 2025
Viewed by 260
Abstract
We propose a modeling approach for position estimation based on the observed radio propagation in an environment. The approach is purely similarity-based and therefore free of explicit physical assumptions. What distinguishes it from classical related methods are probabilistic position estimates. Instead of just [...] Read more.
We propose a modeling approach for position estimation based on the observed radio propagation in an environment. The approach is purely similarity-based and therefore free of explicit physical assumptions. What distinguishes it from classical related methods are probabilistic position estimates. Instead of just providing a point estimate for a given signal sequence, our model returns the distribution of possible positions as continuous probability density function, which allows for appropriate integration into recursive state estimation systems. The estimation procedure starts by using a kernel to compare incoming data with reference recordings from known positions. Based on the obtained similarities, weights are assigned to the reference positions. An arbitrarily chosen density estimation method is then applied given this assignment. Thus, a continuous representation of the distribution of possible positions in the environment is provided. We apply the solution in a Particle Filter (PF) system for smartphone-based indoor localization. The approach is tested both with radio signal strength (RSS) measurements (Wi-Fi and Bluetooth Low Energy RSSI) and round-trip time (RTT) measurements, given by Wi-Fi Fine Timing Measurement. Compared to distance-based models, which are dedicated to the specific physical properties of each measurement type, our similarity-based model achieved overall higher accuracy at tracking pedestrians under realistic conditions. Since it does not explicitly consider the physics of radio propagation, the proposed model has also been shown to work flexibly with either RSS or RTT observations. Full article
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24 pages, 1307 KiB  
Article
A Self-Supervised Specific Emitter Identification Method Based on Contrastive Asymmetric Masked Learning
by Dong Wang, Yonghui Huang, Tianshu Cui and Yan Zhu
Sensors 2025, 25(13), 4023; https://doi.org/10.3390/s25134023 - 27 Jun 2025
Viewed by 298
Abstract
Specific emitter identification (SEI) is a core technology for wireless device security that plays a crucial role in protecting wireless communication systems from various security threats. However, current deep learning-based SEI methods heavily rely on large amounts of labeled data for supervised training, [...] Read more.
Specific emitter identification (SEI) is a core technology for wireless device security that plays a crucial role in protecting wireless communication systems from various security threats. However, current deep learning-based SEI methods heavily rely on large amounts of labeled data for supervised training, facing challenges in non-cooperative communication scenarios. To address these issues, this paper proposes a novel contrastive asymmetric masked learning-based SEI (CAML-SEI) method, effectively solving the problem of SEI under scarce labeled samples. The proposed method constructs an asymmetric auto-encoder architecture, comprising an encoder network based on channel squeeze-and-excitation residual blocks to capture radio frequency fingerprint (RFF) features embedded in signals, while employing a lightweight single-layer convolutional decoder for masked signal reconstruction. This design promotes the learning of fine-grained local feature representations. To further enhance feature discriminability, a learnable non-linear mapping is introduced to compress high-dimensional encoded features into a compact low-dimensional space, accompanied by a contrastive loss function that simultaneously achieves feature aggregation of positive samples and feature separation of negative samples. Finally, the network is jointly optimized by combining signal reconstruction and feature contrast tasks. Experiments conducted on real-world ADS-B and Wi-Fi datasets demonstrate that the proposed method effectively learns generalized RFF features, and the results show superior performance compared with other SEI methods. Full article
(This article belongs to the Section Communications)
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19 pages, 2592 KiB  
Article
Investigating the Variation and Periodicity of TXS 0506+056
by Xianglin Miao and Yunguo Jiang
Universe 2025, 11(7), 204; https://doi.org/10.3390/universe11070204 - 23 Jun 2025
Viewed by 260
Abstract
TXS 0506+056 is a blazar associated with neutrino events. The study on its variation mechanics and periodicity analysis is meaningful to understand other BL Lac objects. The local cross-correlation function (LCCF) analysis presents a 3σ correlation in both the γ-ray versus [...] Read more.
TXS 0506+056 is a blazar associated with neutrino events. The study on its variation mechanics and periodicity analysis is meaningful to understand other BL Lac objects. The local cross-correlation function (LCCF) analysis presents a 3σ correlation in both the γ-ray versus optical and optical versus radio light curves. The time lag analysis suggests that the optical and γ-ray band share the same emission region, located upstream of the radio band in the jet. We use both the weighted wavelet Z-transform and generalized Lomb–Scargle methods to analyze the periodicity. We find two plausible quasi-periodic oscillations (QPOs) at 50656+133 days and 1757+15 days for the light curve of the optical band. For the γ-ray band, we find that the spectrum varies with the softer when brighter (SWB) trend, which could be explained naturally if a stable very high energy component exists. For the optical band, TXS 0506+056 exhibits a harder when brighter (HWB) trend. We discover a trend transition from HWB to SWB in the X-ray band, which could be modeled by the shift in peak frequency assuming that the X-ray emission is composed of the synchrotron and the inverse Compton (IC) components. The flux correlations of γ-ray and optical bands behave anomalously during the period of neutrino events, indicating that there are possible other hadronic components associated with neutrino. Full article
(This article belongs to the Special Issue Blazar Bursts: Theory and Observation)
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12 pages, 732 KiB  
Systematic Review
Gut-Microbiome Signatures Predicting Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer: A Systematic Review
by Ielmina Domilescu, Bogdan Miutescu, Florin George Horhat, Alina Popescu, Camelia Nica, Ana Maria Ghiuchici, Eyad Gadour, Ioan Sîrbu and Delia Hutanu
Metabolites 2025, 15(6), 412; https://doi.org/10.3390/metabo15060412 - 18 Jun 2025
Viewed by 538
Abstract
Background and Objectives: Rectal cancer management increasingly relies on watch-and-wait strategies after neoadjuvant chemoradiotherapy (nCRT). Accurate, non-invasive prediction of pathological complete response (pCR) remains elusive. Emerging evidence suggests that gut-microbiome composition modulates radio-chemosensitivity. We systematically reviewed primary studies that correlated baseline or on-treatment [...] Read more.
Background and Objectives: Rectal cancer management increasingly relies on watch-and-wait strategies after neoadjuvant chemoradiotherapy (nCRT). Accurate, non-invasive prediction of pathological complete response (pCR) remains elusive. Emerging evidence suggests that gut-microbiome composition modulates radio-chemosensitivity. We systematically reviewed primary studies that correlated baseline or on-treatment gut-microbiome features with nCRT response in locally advanced rectal cancer (LARC). Methods: MEDLINE, Embase and PubMed were searched from inception to 30 April 2025. Eligibility required (i) prospective or retrospective human studies of LARC, (ii) faecal or mucosal microbiome profiling by 16S, metagenomics, or metatranscriptomics, and (iii) response assessment using tumour-regression grade or pCR. Narrative synthesis and random-effects proportion meta-analysis were performed where data were homogeneous. Results: Twelve studies (n = 1354 unique patients, median sample = 73, range 22–735) met inclusion. Four independent machine-learning models achieved an Area Under the Receiver Operating Characteristic curve AUROC ≥ 0.85 for pCR prediction. Consistently enriched taxa in responders included Lachnospiraceae bacterium, Blautia wexlerae, Roseburia spp., and Intestinimonas butyriciproducens. Non-responders showed over-representation of Fusobacterium nucleatum, Bacteroides fragilis, and Prevotella spp. Two studies linked butyrate-producing modules to radiosensitivity, whereas nucleotide-biosynthesis pathways conferred resistance. Pooled pCR rate in patients with a “butyrate-rich” baseline profile was 44% (95% CI 35–54) versus 21% (95% CI 15–29) in controls (I2 = 18%). Conclusions: Despite heterogeneity, convergent functional and taxonomic signals underpin a microbiome-based radiosensitivity axis in LARC. Multi-centre validation cohorts and intervention trials manipulating these taxa, such as prebiotics or live-biotherapeutics, are warranted before clinical deployment. Full article
(This article belongs to the Special Issue Advances in Gut Microbiome Metabolomics)
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15 pages, 5363 KiB  
Article
Compact and Handheld SiPM-Based Gamma Camera for Radio-Guided Surgery and Medical Imaging
by Fabio Acerbi, Aramis Raiola, Cyril Alispach, Hossein Arabi, Habib Zaidi, Alberto Gola and Domenico Della Volpe
Instruments 2025, 9(2), 14; https://doi.org/10.3390/instruments9020014 - 15 Jun 2025
Viewed by 582
Abstract
In the continuous pursuit of minimally invasive interventions while ensuring a radical excision of lesions, Radio-Guided Surgery (RGS) has been for years the standard for image-guided surgery procedures, such as the Sentinel Lymph Node biopsy (SLN), Radio-guided Seed Localization (RSL), etc. In RGS, [...] Read more.
In the continuous pursuit of minimally invasive interventions while ensuring a radical excision of lesions, Radio-Guided Surgery (RGS) has been for years the standard for image-guided surgery procedures, such as the Sentinel Lymph Node biopsy (SLN), Radio-guided Seed Localization (RSL), etc. In RGS, the lesion has to be identified precisely, in terms of position and extension. In such a context, going beyond the current one-point probes, introducing portable but high-resolution cameras, handholdable by the surgeon, would be highly beneficial. We developed and tested a novel compact, low-power, handheld gamma camera for radio-guided surgery. This is based on a particular position-sensitive Silicon Photomultiplier (SiPM) technology—the FBK linearly graded SiPM (LG-SiPM). Within the camera, the photodetector is made up of a 3 × 3 array of 10 × 10 mm2 SiPM chips having a total area of more than 30 × 30 mm2. This is coupled with a pixelated scintillator and a parallel-hole collimator. With the LG-SiPM technology, it is possible to significantly reduce the number of readout channels to just eight, simplifying the complexity and lowering the power consumption of the readout electronics while still preserving a good position resolution. The novel gamma camera is light (weight), and it is made to be a fully stand-alone system, therefore featuring wireless communication, battery power, and wireless recharge capabilities. We designed, simulated (electrically), and tested (functionally) the first prototypes of the novel gamma camera. We characterized the intrinsic position resolution (tested with pulsed light) as being ~200 µm, and the sensitivity and resolution when detecting gamma rays from Tc-99m source measured between 134 and 481 cps/MBq and as good as 1.4–1.9 mm, respectively. Full article
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17 pages, 1538 KiB  
Article
AI-Driven Adaptive Communications for Energy-Efficient Underwater Acoustic Sensor Networks
by A. Ur Rehman, Laura Galluccio and Giacomo Morabito
Sensors 2025, 25(12), 3729; https://doi.org/10.3390/s25123729 - 14 Jun 2025
Viewed by 745
Abstract
Underwater acoustic sensor networks, crucial for marine monitoring, face significant challenges, including limited bandwidth, high delay, and severe energy constraints. Addressing these limitations requires an energy-efficient design to ensure network survivability, reliability, and reduced operational costs. This paper proposes an artificial intelligence-driven framework [...] Read more.
Underwater acoustic sensor networks, crucial for marine monitoring, face significant challenges, including limited bandwidth, high delay, and severe energy constraints. Addressing these limitations requires an energy-efficient design to ensure network survivability, reliability, and reduced operational costs. This paper proposes an artificial intelligence-driven framework aimed at enhancing energy efficiency and sustainability in applications of marine wildlife monitoring in underwater sensor networks, according to the vision of implementing an underwater acoustic sensor network. The framework integrates intelligent computing directly into underwater sensor nodes, employing lightweight AI models to locally classify marine species. Transmitting only classification results, instead of raw data, significantly reduces data volume, thus conserving energy. Additionally, a software-defined radio methodology dynamically adapts transmission parameters such as modulation schemes, packet length, and transmission power to further minimize energy consumption and environmental disruption. GNU Radio simulations evaluate the framework effectiveness using metrics like energy consumption, bit error rate, throughput, and delay. Adaptive transmission strategies implicitly ensure reduced energy usage as compared to non-adaptive transmission solutions employing fixed communication parameters. The results illustrate the framework ability to effectively balance energy efficiency, performance, and ecological impact. This research contributes directly to ongoing development in sustainable and energy-efficient underwater wireless sensor network design and deployment. Full article
(This article belongs to the Special Issue Energy Efficient Design in Wireless Ad Hoc and Sensor Networks)
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