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14 pages, 3371 KiB  
Article
A Symmetry-Driven Broadband Circularly Polarized Magnetoelectric Dipole Antenna with Bandpass Filtering Response
by Xianjing Lin, Zuhao Jiang, Miaowang Zeng and Zengpei Zhong
Symmetry 2025, 17(7), 1145; https://doi.org/10.3390/sym17071145 - 17 Jul 2025
Viewed by 111
Abstract
This paper presents a symmetry-driven broadband circularly polarized magnetoelectric dipole antenna with bandpass filtering response, where the principle of symmetry is strategically employed to enhance both radiation and filtering performance. The antenna’s circular polarization is achieved through a symmetrical arrangement of two orthogonally [...] Read more.
This paper presents a symmetry-driven broadband circularly polarized magnetoelectric dipole antenna with bandpass filtering response, where the principle of symmetry is strategically employed to enhance both radiation and filtering performance. The antenna’s circular polarization is achieved through a symmetrical arrangement of two orthogonally placed metallic ME dipoles combined with a phase delay line, creating balanced current distributions for optimal CP characteristics. The design further incorporates symmetrical parasitic elements—a pair of identical inverted L-shaped metallic structures placed perpendicular to the ground plane at −45° relative to the ME dipoles—which introduce an additional CP resonance through their mirror-symmetric configuration, thereby significantly broadening the axial ratio bandwidth. The filtering functionality is realized through a combination of symmetrical modifications: grid slots etched in the metallic ground plane and an open-circuited stub loaded on the microstrip feed line work in tandem to create two radiation nulls in the upper stopband, while the inherent symmetrical properties of the ME dipoles naturally produce a radiation null in the lower stopband. This comprehensive symmetry-based approach results in a well-balanced bandpass filtering response across a wide operating bandwidth. Experimental validation through prototype measurement confirms the effectiveness of the symmetric design with compact dimensions of 0.96λ0 × 0.55λ0 × 0.17λ0 (λ0 is the wavelength at the lowest operating frequency), demonstrating an impedance bandwidth of 66.4% (2.87–5.05 GHz), an AR bandwidth of 31.9% (3.32–4.58 GHz), an average passband gain of 5.5 dBi, and out-of-band suppression levels of 11.5 dB and 26.8 dB at the lower and upper stopbands, respectively, along with good filtering performance characterized by a gain-suppression index (GSI) of 0.93 and radiation skirt index (RSI) of 0.58. The proposed antenna is suitable for satellite communication terminals requiring wide AR bandwidth and strong interference rejection in L/S-bands. Full article
(This article belongs to the Special Issue Symmetry Study in Electromagnetism: Topics and Advances)
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14 pages, 2184 KiB  
Article
A Wideband Circularly Polarized Filtering Dipole Antenna
by Xianjing Lin, Ruishan Huang, Miaowang Zeng and An Yan
Symmetry 2025, 17(7), 1047; https://doi.org/10.3390/sym17071047 - 3 Jul 2025
Viewed by 240
Abstract
This paper presents a circularly polarized (CP) antenna based on crossed dipoles with bandpass-type filtering radiation response. The antenna employs a pair of crossed dipole arms as radiators, which are printed on the upper and lower planes of the substrate. To achieve bandpass [...] Read more.
This paper presents a circularly polarized (CP) antenna based on crossed dipoles with bandpass-type filtering radiation response. The antenna employs a pair of crossed dipole arms as radiators, which are printed on the upper and lower planes of the substrate. To achieve bandpass filtering effects, radiation nulls are introduced on both sides of the passband. By vertically extending the ends of the four dipole arms, a ring-shaped current is formed between adjacent dipoles, generating the upper-band radiation null. Additionally, four parasitic patches are introduced parallel to the ends of the crossed dipole arms, creating another upper-band radiation null, further enhancing the frequency selectivity at the band edges and broadening the axial ratio (AR) bandwidth. Moreover, a square-ring slot is etched on the ground plane to introduce a lower-band radiation null, ultimately achieving a good bandpass filtering response. The proposed wideband CP filtering dipole antenna is implemented and tested. The antenna has a compact size of 0.49λ0× 0.49λ0× 0.16λ0 (where λ0 denotes the wavelength corresponding to the lowest operating frequency). The measured results show that the proposed antenna has an impedance bandwidth of 75% (1.65–3.66 GHz) and an overlapping AR bandwidth of 46.9% (2.25–3.63 GHz). Without additional filtering circuits, the antenna exhibits a stable gain of approximately 7 dB and three radiation nulls, with suppression levels of 20 dB in both the lower and upper stopbands, achieving good bandpass filtering performance. Full article
(This article belongs to the Section Engineering and Materials)
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25 pages, 1220 KiB  
Article
Convex Formulations for Antenna Array Pattern Optimization Through Linear, Quadratic, and Second-Order Cone Programming
by Álvaro F. Vaquero and Juan Córcoles
Mathematics 2025, 13(11), 1796; https://doi.org/10.3390/math13111796 - 28 May 2025
Viewed by 487
Abstract
This work presents a comprehensive study on formulations for the radiation pattern design of antenna arrays through convex optimization techniques, with a focus on linear, quadratic, and second-order cone programming. The proposed approaches heavily rely on the construction of Hermitian forms to systematically [...] Read more.
This work presents a comprehensive study on formulations for the radiation pattern design of antenna arrays through convex optimization techniques, with a focus on linear, quadratic, and second-order cone programming. The proposed approaches heavily rely on the construction of Hermitian forms to systematically build convex optimization problems for synthesizing desired beam patterns while including practical constraints such as sidelobe levels (SLLs), maximum directivity, and null placement. By formulating the radiation pattern synthesis problem through a convex formulation, global optimality and computational efficiency are ensured. The paper introduces the mathematical foundations of the proposed methodologies, detailing the structure and benefits of each convex optimization model. Numerical examples demonstrate the effectiveness of the proposed methodologies in achieving high-performance radiation patterns for circular and planar arrays. The results highlight trade-offs between formulation complexity and pattern performance across different optimization models, providing valuable insights for antenna array pattern synthesis. Overall, this work underscores the potential of convex optimization in antenna array pattern synthesis methodologies. Full article
(This article belongs to the Section E: Applied Mathematics)
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13 pages, 12023 KiB  
Article
Wideband Dual-Polarized Filtering Antennas Using Short-Circuited Coupling Structure for 4G/5G Multi-Input-Multi-Output (MIMO) Antenna Decoupling Design
by Haitao Song, Feifei Zhang and Baoxing Duan
Photonics 2025, 12(3), 259; https://doi.org/10.3390/photonics12030259 - 13 Mar 2025
Viewed by 538
Abstract
A short-circuited coupling structure (SCCS) is proposed to obtain a gain-filtering response for dual-polarized antennas. A conventional dipole is designed with two intrinsic radiation nulls. By introducing an SCCS, an additional radiation null is obtained, and the impedance bandwidth of an antenna can [...] Read more.
A short-circuited coupling structure (SCCS) is proposed to obtain a gain-filtering response for dual-polarized antennas. A conventional dipole is designed with two intrinsic radiation nulls. By introducing an SCCS, an additional radiation null is obtained, and the impedance bandwidth of an antenna can be further improved. Based on this design principle, two dual-polarized filtering antennas are designed for 4G and 5G wireless communication devices. The impedance bandwidth of the proposed 4G filtering antenna is 1.63–2.97 GHz (|S11| < −15 dB), with four radiation nulls at 1.1 GHz, 3.25 GHz, 3.5 GHz, and 4.0 GHz. The impedance bandwidth of the proposed 5G filtering antenna is 3.23–4.21 GHz (|S33| < −15 dB), with four radiation nulls at 1.7 GHz, 2.5 GHz, 3 GHz, and 4.6 GHz. Further, the decoupling function of the SCCS on 4G/5G MIMO antenna designs is also discussed. When introducing an SCCS, the port isolation levels of two elements between the 4G and 5G antennas, as well as the adjacent 5G antennas, can be improved by 14 dB and 6 dB, respectively. The port isolation levels of five elements between the 4G and 5G antennas, as well as the adjacent 5G antennas, can be improved by 15.2 dB and 9.5 dB, respectively. This technique could also be a potential candidate for optical antenna designs in optical front-ends and other multi-wavelength fiber lasers with microstructures. Full article
(This article belongs to the Special Issue Advanced Fiber Laser Technology and Its Application)
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19 pages, 5010 KiB  
Article
Quad-Beam 4 × 2 Array Antenna for Millimeter-Wave 5G Applications
by Parveez Shariff Bhadravathi Ghouse, Tanweer Ali, Pallavi R. Mane, Sameena Pathan, Sudheesh Puthenveettil Gopi, Bal S. Virdee, Jaume Anguera and Prashant M. Prabhu
Electronics 2025, 14(5), 1056; https://doi.org/10.3390/electronics14051056 - 6 Mar 2025
Viewed by 917
Abstract
This article presents the design of a novel, compact, 4 × 2 planar-array antenna that provides quad-beam radiation in the broadside direction, and it enhances coverage and serviceability for millimeter-wave applications. The antenna utilizes a corporate (parallel) feed network to deliver equal power [...] Read more.
This article presents the design of a novel, compact, 4 × 2 planar-array antenna that provides quad-beam radiation in the broadside direction, and it enhances coverage and serviceability for millimeter-wave applications. The antenna utilizes a corporate (parallel) feed network to deliver equal power and phase to all elements. Non-uniform element spacing in the two orthogonal planes, exceeding 0.5λ1 (λ1 being the wavelength at 30 GHz), results in a quad-beam radiation pattern. Two beams are formed in the xz-plane and two in the yz-plane, oriented at angles of θ=±54°. However, this spacing leads to null radiation at the center and splits the radiation energy, reducing the overall gain. The measured half-power beamwidth (HPBW) is 30° in the xz-plane and 35° in the yz-plane, with X-polarization levels of −20.5 dB and −26 dB, respectively. The antenna achieves a bandwidth of 28.5–31.1 GHz and a peak gain of 10.6 dBi. Furthermore, increasing the aperture size enhances the gain and narrows the beamwidth by replicating the structure and tuning the feed network. These features make the proposed antenna suitable for 5G wireless communication systems. Full article
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11 pages, 7727 KiB  
Communication
Differentially Fed, Wideband Dual-Polarized Filtering Dielectric Resonator Patch Antenna Using a Sequentially Rotated Shorting Coupling Structure
by Haitao Song, Baoxing Duan and Feifei Zhang
Photonics 2025, 12(3), 239; https://doi.org/10.3390/photonics12030239 - 6 Mar 2025
Viewed by 639
Abstract
A wideband dual-polarized dielectric resonator antenna (DRA) with gain-filtering response was proposed in this paper. First, a differentially fed, low-profile crossed-DRA was used to obtain orthogonal polarizations with two resonant modes. A radiation null at upper band edge was also generalized. Second, with [...] Read more.
A wideband dual-polarized dielectric resonator antenna (DRA) with gain-filtering response was proposed in this paper. First, a differentially fed, low-profile crossed-DRA was used to obtain orthogonal polarizations with two resonant modes. A radiation null at upper band edge was also generalized. Second, with the introduction of four parasitic patches at the top of the crossed DRA, another resonant mode at lower band was excited, and the bandwidth was greatly expanded. Moreover, the introduction of parasitic patches could also help improve the selectivity of realized gain with another radiation null at the upper band edge. Furthermore, four sequentially rotated shorting coupling structures (SRSCSs) were proposed for the first time to generalize two additional radiation nulls. Finally, a wideband bandpass filtering response of the realized gain with four radiation nulls was obtained. Prototypes of the proposed antennas were fabricated, and the testing results showed that the antenna had a wide operation band of 57.1% from 2.75 GHz to 4.95 GHz with sharp roll-off at the band edge. This technique could also be used in wireless communication devices at millimeter/optical front ends and other multi-wavelength fiber lasers with micro structures. Full article
(This article belongs to the Special Issue Advanced Fiber Laser Technology and Its Application)
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22 pages, 2706 KiB  
Article
DMR-SCL: A Design and Verification Framework for Redundancy-Based Resilient Asynchronous Sleep Convention Logic Circuits
by Mithun Datta, Dipayan Mazumder, Alexander C. Bodoh and Ashiq A. Sakib
Electronics 2025, 14(5), 884; https://doi.org/10.3390/electronics14050884 - 23 Feb 2025
Viewed by 714
Abstract
The digital integrated circuit (IC) design industry is continuously evolving. However, the rapid advancements in technology are accompanied by major reliability concerns. Conventional clock-based synchronous designs become exceedingly susceptible to transient errors, caused by radiation rays, power jitters, electromagnetic interferences (EMIs), and/or other [...] Read more.
The digital integrated circuit (IC) design industry is continuously evolving. However, the rapid advancements in technology are accompanied by major reliability concerns. Conventional clock-based synchronous designs become exceedingly susceptible to transient errors, caused by radiation rays, power jitters, electromagnetic interferences (EMIs), and/or other noise sources, primarily due to aggressive device and voltage scaling. quasi-delay-insensitive (QDI) asynchronous (clockless) circuits demonstrate inherent robustness against such transient errors, owing to their unique architecture. However, they are not completely immune. This article presents a hardened QDI Sleep Convention Logic (SCL) asynchronous architecture, which can fully recover from radiation-induced single-event effects such as single-event upset (SEU) and single-event latch-up (SEL). Multiple benchmark circuits are designed based on the proposed architecture. The simulation results indicate that the proposed designs offer substantial energy savings per operation, dissipate substantially less power during idle phases, and have lower area footprints in comparison to designs based on an existing resilient Null Convention Logic (NCL) architecture at the cost of increased latency. In addition, a formal verification framework for the proposed architecture is also presented. The performance and scalability of the proposed verification scheme are demonstrated using several multiplier benchmark circuits of varying width. Full article
(This article belongs to the Section Circuit and Signal Processing)
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29 pages, 9790 KiB  
Article
Pattern Synthesis Design of Linear Array Antenna with Unequal Spacing Based on Improved Dandelion Optimization Algorithm
by Jianhui Li, Yan Liu, Wanru Zhao, Tianning Zhu, Zhuo Chen, Anyong Liu and Yibo Wang
Sensors 2025, 25(3), 861; https://doi.org/10.3390/s25030861 - 31 Jan 2025
Viewed by 903
Abstract
With the rapid development of radio technology and its widespread application in the military field, the electromagnetic environment in which radar communication operates is becoming increasingly complex. Among them, human radio interference makes radar countermeasures increasingly fierce. This requires radar systems to have [...] Read more.
With the rapid development of radio technology and its widespread application in the military field, the electromagnetic environment in which radar communication operates is becoming increasingly complex. Among them, human radio interference makes radar countermeasures increasingly fierce. This requires radar systems to have strong capabilities in resisting electronic interference, anti-radiation missiles, and radar detection. However, array antennas are one of the effective means to solve these problems. In recent years, array antennas have been extensively utilized in various fields, including radar, sonar, and wireless communication. Many evolutionary algorithms have been employed to optimize the size and phase of array elements, as well as adjust the spacing between them, to achieve the desired antenna pattern. The main objective is to enhance useful signals while suppressing interference signals. In this paper, we introduce the dandelion optimization (DO) algorithm, a newly developed swarm intelligence optimization algorithm that simulates the growth and reproduction of natural dandelions. To address the issues of low precision and slow convergence of the DO algorithm, we propose an improved version called the chaos exchange nonlinear dandelion optimization (CENDO) algorithm. The CENDO algorithm aims to optimize the spacing of antenna array elements in order to achieve a low sidelobe level (SLL) and deep nulls antenna pattern. In order to test the performance of the CENDO algorithm in solving the problem of comprehensive optimization of non-equidistant antenna array patterns, five experimental simulation examples are conducted. In Experiment Simulation Example 1, Experiment Simulation Example 2, and Experiment Simulation Example 3, the optimization objective is to reduce the SLL of non-equidistant arrays. The CENDO algorithm is compared with DO, particle swarm optimization (PSO), the quadratic penalty function method (QPM), based on hybrid particle swarm optimization and the gravity search algorithm (PSOGSA), the whale optimization algorithm (WOA), the grasshopper optimization algorithm (GOA), the sparrow search algorithm (SSA), the multi-objective sparrow search optimization algorithm (MSSA), the runner-root algorithm (RRA), and the cat swarm optimization (CSO) algorithms. In the three examples above, the SLLs obtained using the CENDO algorithm optimization are all the lowest. The above three examples all demonstrate that the improved CENDO algorithm performs better in reducing the SLL of non-equidistant antenna arrays. In Experiment Simulation Example 4 and In Experiment Simulation Example 5, the optimization objective is to reduce the SLL of a non-uniform array and generate some deep nulls in a specified direction. The CENDO algorithm is compared with the DO algorithm, PSO algorithm, CSO algorithm, pelican optimization algorithm (POA), and grey wolf optimizer (GWO) algorithm. In the two examples above, optimizing the antenna array using the CENDO algorithm not only results in the lowest SLL but also in the deepest zeros. The above examples both demonstrate that the improved CENDO algorithm has better optimization performance in simultaneously reducing the SLL of non-equidistant antenna arrays and reducing the null depth problem. In summary, the simulation results of five experiments show that the CENDO algorithm has better optimization ability in the comprehensive optimization problem of non-equidistant antenna array patterns than all the algorithms compared above. Therefore, it can be regarded as a strong candidate to solve problems in the field of electromagnetism. Full article
(This article belongs to the Section Radar Sensors)
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10 pages, 715 KiB  
Article
Association of GSTM1 and GSTT1 Copy Number Variation with Chromosomal Aberrations in Nuclear Power Plant Workers Exposed to Occupational Ionizing Radiation
by Joong won Lee, Younghyun Lee and Yang Jee Kim
Toxics 2025, 13(2), 73; https://doi.org/10.3390/toxics13020073 - 22 Jan 2025
Viewed by 810
Abstract
Exposure to low-dose ionizing radiation in occupational settings raises concerns about chromosomal aberrations (CAs) and their potential impact on genomic stability. Copy number variations (CNVs), structural genomic changes, influence susceptibility to environmental stressors and radiation-induced damage. This study analyzed CAs in 180 nuclear [...] Read more.
Exposure to low-dose ionizing radiation in occupational settings raises concerns about chromosomal aberrations (CAs) and their potential impact on genomic stability. Copy number variations (CNVs), structural genomic changes, influence susceptibility to environmental stressors and radiation-induced damage. This study analyzed CAs in 180 nuclear power plant workers exposed to occupational radiation and 45 controls, stratified by GSTM1 and GSTT1 CNVs. Workers exhibited significantly higher frequencies of chromatid-type and chromosome-type aberrations, of 5.47 and 3.01 per 500 cells, respectively, compared to 3.57 and 0.64 in controls (p < 0.001 for both). In the relatively high-exposure group, chromatid-type aberrations decreased with increasing GSTM1 and GSTT1 copy numbers. For GSTM1, individuals with zero copies showed 6.37 ± 3.47 aberrations per 500 cells, compared to 5.02 ± 3.05 for one copy and 4.67 ± 2.40 for two or more copies (p = 0.06). A similar trend was observed for GSTT1, with 6.00 ± 3.29 aberrations per 500 cells for zero copies, 5.38 ± 2.79 for one copy, and 4.11 ± 4.26 for two or more copies (p = 0.05). Poisson regression analysis further supported these findings after adjusting for potential confounders such as age, smoking status, and alcohol intake. Workers with null genotypes exhibited a 1.36-fold increase in chromatid-type aberrations compared to those with higher copy numbers under relatively high-exposure conditions, suggesting a synergy effect between GSTM1 and GSTT1 null genotypes in modulating radiation-induced aberrations. These findings underscore the role of genetic susceptibility, particularly involving GSTM1 and GSTT1 CNVs, in modulating radiation-induced chromosomal damage. The observed gene–environment interaction in the relatively high-exposure group suggests that pre-existing CNVs contribute to chromosomal instability under radiation exposure. Full article
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14 pages, 10756 KiB  
Article
Gravitational Waves from Black Hole Emission
by Tousif Islam, Gaurav Khanna and Steven L. Liebling
Universe 2025, 11(1), 21; https://doi.org/10.3390/universe11010021 - 14 Jan 2025
Viewed by 837
Abstract
Using adiabatic point-particle black hole perturbation theory, we simulate plausible gravitational wave (GW) signatures in two exotic scenarios (i) where a small black hole is emitted by a larger one (‘black hole emission’) and (ii) where a small black hole is emitted by [...] Read more.
Using adiabatic point-particle black hole perturbation theory, we simulate plausible gravitational wave (GW) signatures in two exotic scenarios (i) where a small black hole is emitted by a larger one (‘black hole emission’) and (ii) where a small black hole is emitted by a larger one and subsequently absorbed back (‘black hole absorption’). While such scenarios are forbidden in general relativity (GR), alternative theories (such as certain quantum gravity scenarios obeying the weak gravity conjecture, white holes, and Hawking radiation) may allow them. By leveraging the phenomenology of black hole emission and absorption signals, we introduce straightforward modifications to existing gravitational waveform models to mimic gravitational radiation associated with these exotic events. We anticipate that these (incomplete but) initial simulations, coupled with the adjusted waveform models, will aid in the development of null tests for GR using GWs. Full article
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11 pages, 2338 KiB  
Communication
Optimization Tools for the Design of Meta-Covers for Linear Antenna with Beam- and Null-Steering Capabilities
by Michela Longhi, Stefano Vellucci, Mirko Barbuto, Alessio Monti, Filiberto Bilotti and Alessandro Toscano
Appl. Sci. 2025, 15(2), 553; https://doi.org/10.3390/app15020553 - 8 Jan 2025
Viewed by 1150
Abstract
This paper investigates the optimization of cylindrical metasurface meta-covers designed to enable beamforming capabilities in single linear antennas. This study focuses on the development and application of advanced optimization tools to tailor the electromagnetic response of these metasurfaces, enabling precise control over the [...] Read more.
This paper investigates the optimization of cylindrical metasurface meta-covers designed to enable beamforming capabilities in single linear antennas. This study focuses on the development and application of advanced optimization tools to tailor the electromagnetic response of these metasurfaces, enabling precise control over the radiation patterns of the antenna. In particular, we develop a genetic algorithm-based optimization tool, which achieves precise manipulation of the main beam direction and null placement in the radiation pattern. The results further expand the applications of metasurface-based meta-covers in enhancing the functionality of dipole antennas in various communication and sensing systems. Full article
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12 pages, 5698 KiB  
Article
A Miniaturized Loaded Open-Boundary Quad-Ridge Horn with a Stable Phase Center for Interferometric Direction-Finding Systems
by Zibin Weng, Chen Liang, Kaibin Xue, Ziming Lv and Xing Zhang
Micromachines 2025, 16(1), 44; https://doi.org/10.3390/mi16010044 - 30 Dec 2024
Cited by 1 | Viewed by 891
Abstract
In order to achieve high accuracy in interferometric direction-finding systems, antennas with a stable phase center in the working bandwidth are required. This article proposes a miniaturized loaded open-boundary quad-ridge horn (LOQRH) antenna with dimensions of 40 mm × 40 mm × 49 [...] Read more.
In order to achieve high accuracy in interferometric direction-finding systems, antennas with a stable phase center in the working bandwidth are required. This article proposes a miniaturized loaded open-boundary quad-ridge horn (LOQRH) antenna with dimensions of 40 mm × 40 mm × 49 mm. First, to stabilize the phase center of the antenna, the design builds on the foundation of a quad-ridge horn antenna, where measures such as optimizing the ridge structure and introducing resistive loading were implemented to achieve size reduction. Second, electrically small-sized antennas are more susceptible to the effects of common-mode currents (CMCs), which can reduce the symmetry of the radiation pattern and the stability of the phase center. To avoid the generation of common-mode currents during operation, a self-balanced feed structure was introduced into the proposed antenna design. This structure establishes a balanced circuit and routes the feedline at the voltage null point, effectively suppressing the common-mode current. As a result, the miniaturization of the LOQRH antenna was achieved while ensuring the suppression of the common-mode current, thereby maintaining the stability of the antenna’s electromagnetic performance. The measured results show that the miniaturized antenna has a small phase center change of less than 20.3 mm within 2–18 GHz, while the simulated phase center fluctuation is only 14.6 mm. In addition, when taking 18.5 mm in front of the antenna’s feed point as the phase center, the phase fluctuation is less than 22.5° within the required beam width. Along with the desired stable phase center, the miniaturized design makes the proposed antenna suitable for interferometric direction-finding systems. Full article
(This article belongs to the Special Issue Recent Advances in Electromagnetic Devices)
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29 pages, 5048 KiB  
Article
DNA Damage and Inflammatory Response of p53 Null H358 Non-Small Cell Lung Cancer Cells to X-Ray Exposure Under Chronic Hypoxia
by Hasan Nisar, Melanie Brauny, Frederik M. Labonté, Claudia Schmitz, Bikash Konda and Christine E. Hellweg
Int. J. Mol. Sci. 2024, 25(23), 12590; https://doi.org/10.3390/ijms252312590 - 23 Nov 2024
Cited by 1 | Viewed by 1655
Abstract
Hypoxia-induced radioresistance limits therapeutic success in cancer. In addition, p53 mutations are widespread in tumors including non-small cell lung carcinomas (NSCLCs), and they might modify the radiation response of hypoxic tumor cells. We therefore analyzed the DNA damage and inflammatory response in chronically [...] Read more.
Hypoxia-induced radioresistance limits therapeutic success in cancer. In addition, p53 mutations are widespread in tumors including non-small cell lung carcinomas (NSCLCs), and they might modify the radiation response of hypoxic tumor cells. We therefore analyzed the DNA damage and inflammatory response in chronically hypoxic (1% O2, 48 h) p53 null H358 NSCLC cells after X-ray exposure. We used the colony-forming ability assay to determine cell survival, γH2AX immunofluorescence microscopy to quantify DNA double-strand breaks (DSBs), flow cytometry of DAPI-stained cells to measure cell cycle distribution, ELISAs to quantify IL-6 and IL-8 secretion in cell culture supernatants, and RNA sequencing to determine gene expression. Chronic hypoxia increased the colony-forming ability and radioresistance of H358 cells. It did not affect the formation or resolution of X-ray-induced DSBs. It reduced the fraction of cells undergoing G2 arrest after X-ray exposure and delayed the onset of G2 arrest. Hypoxia led to an earlier enhancement in cytokines secretion rate after X-irradiation compared to normoxic controls. Gene expression changes were most pronounced after the combined exposure to hypoxia and X-rays and pertained to senescence and different cell death pathways. In conclusion, hypoxia-induced radioresistance is present despite the absence of functional p53. This resistance is related to differences in clonogenicity, cell cycle regulation, cytokine secretion, and gene expression under chronic hypoxia, but not to differences in DNA DSB repair kinetics. Full article
(This article belongs to the Special Issue Molecular Biology of Hypoxia)
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18 pages, 23937 KiB  
Article
A Dual-Band Patch Antenna with Combined Self-Decoupling and Filtering Properties and Its Application in Dual/Squad-Band Two-Element MIMO Array
by Jun-Yi Lv, Jun-Ming Zhang, Peng-Fei Lv and Li-Xin Xu
Sensors 2024, 24(21), 6833; https://doi.org/10.3390/s24216833 - 24 Oct 2024
Viewed by 1632
Abstract
This paper proposes a dual-band patch antenna with combined self-decoupling and filtering properties, designed to suppress mutual coupling between two antenna elements both within the same dual-band and across different dual-bands. Initially, a dual-band aperture-coupled filtering patch antenna is designed, featuring a forked [...] Read more.
This paper proposes a dual-band patch antenna with combined self-decoupling and filtering properties, designed to suppress mutual coupling between two antenna elements both within the same dual-band and across different dual-bands. Initially, a dual-band aperture-coupled filtering patch antenna is designed, featuring a forked short-circuited SIR feedline with a quarter-wavelength open-ended stub and a U-shaped patch with two U-slots, which generate three controllable radiation nulls while introducing two additional resonant modes. The design steps are also provided in detail. Subsequently, the low mutual coupling phenomenon of two vertically placed aperture-coupled patch antennas is investigated, successfully developing a high-isolated dual-band two-element MIMO array I. Furthermore, the other quad-band two-element MIMO array II is designed, which utilizes the filtering response to significantly reduce mutual coupling across four bands. Finally, a dual-band filtering patch antenna element and two two-element MIMO arrays are fabricated and measured. The measurements and simulations validate the antenna’s low mutual coupling performance in multi-band MIMO arrays and demonstrate its strong potential for future wireless communication applications. Full article
(This article belongs to the Special Issue Antenna Design and Array Signal Processing)
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30 pages, 2989 KiB  
Review
Metal Peroxide Nanoparticles for Modulating the Tumor Microenvironment: Current Status and Recent Prospects
by Jagadeesh Rajaram and Yaswanth Kuthati
Cancers 2024, 16(21), 3581; https://doi.org/10.3390/cancers16213581 - 24 Oct 2024
Cited by 3 | Viewed by 1832
Abstract
Background: The significant expansion of nanobiotechnology and nanomedicine has led to the development of innovative and effective techniques to combat various pathogens, demonstrating promising results with fewer adverse effects. Metal peroxide nanoparticles stand out among the crucial yet often overlooked types of nanomaterials, [...] Read more.
Background: The significant expansion of nanobiotechnology and nanomedicine has led to the development of innovative and effective techniques to combat various pathogens, demonstrating promising results with fewer adverse effects. Metal peroxide nanoparticles stand out among the crucial yet often overlooked types of nanomaterials, including metals. These nanoparticles are key in producing oxygen (O2) and hydrogen peroxide (H2O2) through simple chemical reactions, which are vital in treating various diseases. These compounds play a crucial role in boosting the effectiveness of different treatment methods and also possess unique properties due to the addition of metal ions. Methods: This review discusses and analyzes some of the most common metal peroxide nanoparticles, including copper peroxide (CuO2), calcium peroxide (CaO2), magnesium peroxide (MgO2), zinc peroxide (ZnO2), barium peroxide (BaO2), and titanium peroxide (TiOx) nanosystems. These nanosystems, characterized by their greater potential and treatment efficiency, are primarily needed in nanomedicine to combat various harmful pathogens. Researchers have extensively studied the effects of these peroxides in various treatments, such as catalytic nanotherapeutics, photodynamic therapy, radiation therapy, and some combination therapies. The tumor microenvironment (TME) is particularly unique, making the impact of nanomedicine less effective or even null. The presence of high levels of reactive oxygen species (ROS), hypoxia, low pH, and high glutathione levels makes them competitive against nanomedicine. Controlling the TME is a promising approach to combating cancer. Results: Metal peroxides with low biodegradability, toxicity, and side effects could reduce their effectiveness in treating the TME. It is important to consider the distribution of metal peroxides to effectively target cancer cells while avoiding harm to nearby normal cells. As a result, modifying the surface of metal peroxides is a key strategy to enhance their delivery to the TME, thereby improving their therapeutic benefits. Conclusions: This review discussed the various aspects of the TME and the importance of modifying the surface of metal peroxides to enhance their therapeutic advantages against cancer, as well as address safety concerns. Additionally, this review covered the current challenges in translating basic research findings into clinical applications of therapies based on metal peroxide nanoparticles. Full article
(This article belongs to the Topic Nanomaterials and Diseases)
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