Search Results (97)

Glioblastoma (GBM), the most common primary malignant brain tumor in adults, has a median survival of 14–15 months despite aggressive treatment. Monitoring relies on MRI, but differentiating tumor progression from pseudo-progression or radiation necrosis remains difficult. Plasma extracellular vesicles (EVs) are emerging as promising non-invasive biomarkers due to their molecular cargos and accessibility. This review evaluates studies that specifically isolated plasma EVs for molecular profiling in GBM diagnosis and monitoring. Biomarkers (miRNA, RNA, DNA, proteins), EV characterization methods, and advancements in enriching tumor-derived EV subpopulations and assessing their diagnostic and prognostic potential are highlighted. Plasma EVs carry diverse cargos, including miRNAs (e.g., miR-21, miR-15b-3p), mRNAs (e.g., EGFRvIII), circRNAs, and proteins (e.g., CD44, GFAP). Composite molecular signatures have achieved sensitivities of 87–100% and specificities of 73–100% for GBM diagnosis. Tumor-derived EVs, enriched using techniques like SEC-CD44 immunoprecipitation, microfluidic platforms, or 5-ALA-induced PpIX fluorescence, enhance biomarker detection. Non-tumor-derived EVs may also reflect GBM’s systemic effects. Challenges include EV heterogeneity, non-EV contamination, and variable biomarker expression across studies. Plasma-EV-based liquid biopsies offer significant potential for GBM monitoring, with advanced enrichment methods improving tumor-specific biomarker detection. Standardizing isolation protocols and validating biomarkers in larger cohorts are critical for clinical translation. Full article

This study investigates the use of Si and CdTe-based Timepix3 detectors for photovoltaic energy conversion using solar X-rays and other high-energy electromagnetic radiation in space. As space missions increasingly rely on miniaturized platforms like CubeSats, power generation in compact and radiation-prone environments remains a critical challenge. Conventional solar panels are limited by size and spectral sensitivity, prompting the need for alternative energy harvesting solutions—particularly in the high-energy X-ray domain. A novel CubeSat-compatible payload design incorporates a UV-visible filter to isolate incoming X-rays, which are then absorbed by semiconductor detectors to generate electric current through ionization. Laboratory calibration was performed using Fe-55, Ba-133, and Am-241 sources to compare spectral response and clustering behaviour. CdTe consistently outperformed Si in detection efficiency, spectral resolution, and cluster density due to its higher atomic number and material density. Equalization techniques further improved pixel threshold uniformity, enhancing spectroscopic reliability. In addition to experimental validation, simulations were conducted to quantify the expected energy conversion performance under orbital conditions. Under quiet-Sun conditions at 500 km LEO, CdTe absorbed up to 1.59 µW/cm² compared to 0.69 µW/cm² for Si, with spectral power density peaking between 10 and 20 keV. The photon absorption efficiency curves confirmed CdTe’s superior stopping power across the 1–100 keV range. Under solar flare conditions, absorbed power increased dramatically, up to 159 µW/cm² for X-class and 15.9 µW/cm² for C-class flares with CdTe sensors. A time-based energy model showed that a 10 min X-class flare could yield nearly 1 mJ/cm² of harvested energy. These results validate the concept of a compact photovoltaic payload capable of converting high-energy solar radiation into electrical power, with dual-use potential for both energy harvesting and radiation monitoring aboard small satellite platforms. Full article

Robotic arm-based antenna measurement systems offer the flexibility needed for advanced antenna measurement and diagnostics techniques but are typically limited by reach and sampling time. This work integrates two complementary contributions to overcome these constraints. First, a composite-plane range extension is introduced for a medium-size robot mounted on a mobile platform and monitored by an optical tracking system (OTS). Independent planar scans are acquired after manual repositioning of the robot and then accurately aligned and blended into a single, larger measurement plane, with positioning errors mitigated through a calibration process. Second, a localized sparse sampling strategy is proposed to accelerate planar near-field (PNF) measurements when only selected angular regions of the radiation pattern are required. The approach relies on reduced-order modeling and singular value decomposition (SVD) analysis to design non-redundant grids that preserve the degrees of freedom relevant to the truncated angular sector, thereby reducing both the number of samples and the scan area. Numerical examples for a general case and experimental validation in X-band demonstrate that the combined methodology extends the effective measurement aperture while significantly shortening acquisition time for narrow or tilted beams, enabling accurate and portable in situ characterization of complex modern antennas by means of cost-effective acquisition systems. Full article

This study addresses the observation of floating plastic debris in freshwater environments using an Unmanned Aerial Vehicle (UAV) multi-sensor strategy. An experimental campaign is described where an heterogeneous plastic assemblage, namely a plastic target, and a naturally occurring leaf-litter mat are observed by a UAV platform in the Lake Calore (Avellino, Southern Italy) within the framework of the “multi-layEr approaCh to detect and analyze cOastal aggregation of MAcRo-plastic littEr” (ECOMARE) Italian Ministry of Research (MUR)-funded project. Three UAV platforms, equipped with optical, multispectral, and thermal sensors, are adopted, which overpass the two targets with the objective of analyzing the sensitivity of optical radiation to plastic and the possibility of discriminating the plastic target from the natural one. Georeferenced orthomosaics are generated across the visible, multispectral (Green, Red, Red Edge, Near-Infrared—NIR), and thermal bands. Two novel indices, the Plastic Detection Index (PDI) and the Heterogeneity Plastic Index (HPI), are proposed to discriminate between the detection of plastic litter and natural targets. The experimental results highlight that plastics exhibit heterogeneous spectral and thermal responses, whereas natural debris showed more homogeneous signatures. Green and Red bands outperform NIR for plastic detection under freshwater conditions, while thermal imagery reveals distinct emissivity variations among plastic items. This outcome is mainly explained by the strong NIR absorption of water, the wetting of plastic surfaces, and the lower sensitivity of the Mavic 3′s NIR sensor under high-irradiance conditions. The integration of optical, multispectral, and thermal data demonstrate the robustness of UAV-based approaches for distinguishing anthropogenic litter from natural materials. Overall, the findings underscore the potential of UAV-mounted remote sensing as a cost-effective and scalable tool for the high-resolution monitoring of plastic pollution over inland waters. Full article

Land surface temperature (LST) is a critical variable for understanding energy exchanges and water balance at the Earth’s surface, as well as for calculating turbulent heat flux and long-wave radiation at the surface–atmosphere interface. Remote sensing techniques, particularly using satellite platforms like Landsat 8 OLI/TIRS and Sentinel-2A, have facilitated detailed LST mapping. Sentinel-2 offers high spatial and temporal resolution multispectral data, but it lacks thermal infrared bands, which Landsat 8 can provide a 30 m resolution with less frequent revisits compared to Sentinel-2. This study employs Sentinel-2 spectral indices as independent variables and Landsat 8-derived LST data as the target variable within a machine-learning framework, enabling LST prediction at a 10 m resolution. This method applies grid search-based hyperparameter-tuned machine learning algorithms—Random Forest (RF), Gradient Boosting Machine (GBM), Support Vector Machine (SVM), and k-Nearest Neighbours (kNN)—to model complex nonlinear relationships between the spectral indices (NDVI, NDWI, NDBI, and BSI) and LST. Grid search, combined with cross-validation, enhanced the model’s prediction accuracy for both pre- and post-monsoon seasons. This approach surpasses earlier methods that either employed untuned models or failed to integrate Sentinel-2 data. This study demonstrates that capturing urban thermal dynamics at fine spatial and temporal scales, combined with tuned machine learning models, can enhance the capability of urban heat island monitoring, climate adaptation planning, and sustainable environmental management models. Full article

In recent years, advancements in technologies related to hydrogen have facilitated the exploitation of this energy carrier in conjunction with renewable energies to meet the energy demands of diverse applications. This paper describes a pilot plant within the framework of a research and development (R&D) project aimed at utilizing hydrogen in both industrial and domestic sectors. To this end, this facility comprises six subsystems. Initially, a photovoltaic (PV) generator consisting of 48 panels is employed to generate electrical current from solar radiation. This PV array powers a proton exchange membrane (PEM) electrolyzer, which is responsible for producing green hydrogen by means of water electrolysis. The produced hydrogen is subsequently stored in a bottling storage system for later use in a PEM fuel cell that reconverts it into electrical energy. Finally, a programmable electronic load is utilized to simulate the electrical consumption patterns of various profiles. These physical devices exchange operational data with an open source supervisory system integrated by a set of Industry 4.0 (I4.0) and Internet of Things (IoT)-framed environments. Initially, Node-RED acts as middleware, handling communications, and collecting and processing data from the pilot plant equipment. Subsequently, this information is stored in MariaDB, a structured relational database, enabling efficient querying and data management. Ultimately, the Grafana environment serves as a monitoring platform, displaying the stored data by means of graphical dashboards. The system deployed with such I4.0/IoT applications places a strong emphasis on the continuous monitoring of the power inverter that serves as the backbone of the pilot plant, both from an energy flow and communication standpoint. This device ensures the synchronization, conversion, and distribution of electrical energy while simultaneously standing as a primary data source for the supervisory system. The results presented in this article describe the design of the system and provide evidence of its successful implementation. Full article

Low-carbon chemical fires pose significant hazards, and remote sensing of high-temperature gas emissions from these fires is a critical method for identifying and assessing their environmental impact. Analyzing the spectral characteristics of gases produced by low-carbon chemical pool fires and developing spectral radiation models can establish a foundation for remote pollution monitoring. However, such studies remain scarce. Using a custom-built high-temperature gas spectroscopy platform, this study extracts spectral features of gases emitted by low-carbon chemical pool fires. We investigate spectral interference mechanisms among combustion products and develop a high-precision spectral radiation model to support remote fire pollution monitoring. Experimental results reveal distinct spectral bands for key gases: CO₂ peaks near 2.7 μm and 4.35 μm, SO₂ at 4.05 μm, 7.5 μm, and 9.0 μm, NO at 5.5 μm, and NO₂ at 3.6 μm and 6.3 μm. The proposed spectral radiation model accurately simulates the position and shape of spectral peaks. For carbon disulfide and acetonitrile combustion products, the model achieves prediction accuracies of 83.4–96.9% and 79.2–95.3%, respectively. Full article

Total column water vapor (TCWV) is essential for assessing Earth’s radiation budget and hydrological cycle and plays a crucial role in accurate Land Surface Temperature (LST) retrieval from thermal infrared (TIR) imagery. Although TCWV is commonly estimated using near-infrared or microwave observations, TIR-based methods offer an efficient alternative; however, their long-term validation remains limited. This study evaluates TCWV retrieval from Landsat 8/9 Thermal Infrared Sensor (TIRS) using an updated version of the Modified Split-Window Covariance-Variance Ratio (MSWCVR) method, implemented on the Google Earth Engine platform, across Europe. Validation is conducted using AERONET sun photometer measurements (2013–2024) and GPS-based TCWV estimates enhanced with meteorological inputs (2020). Retrieval accuracy is evaluated analyzed in relation to seasonal variations, surface characteristics (e.g., land cover, altitude) and background climate. Results demonstrate robust performance of the TIR-based method, with an average Mean Absolute Error (MAE) of 0.6 gr/cm² across stations and datasets, supporting its applicability for LST retrieval and broader environmental monitoring applications. Full article

Despite advances in precision irrigation, no systematic review has yet integrated the roles of remote sensing, agro-meteorological data, and wireless sensor networks in high-value, water-sensitive crops such as mango, avocado, and vineyards. Existing research often isolates technologies or crop types, overlooking their convergence and joint performance in the field. This review fills that gap by examining how these tools estimate crop water demand and support sustainable, site-specific irrigation under variable climate conditions. A structured search across major databases yielded 365 articles, of which 92 met the inclusion criteria. Studies were grouped into four categories: remote sensing, agro-meteorology, wireless sensor networks, and integrated approaches. Remote sensing techniques, including multispectral and thermal imaging, enable the spatial monitoring of vegetation indices and stress indicators, such as the Crop Water Stress Index. Agro-meteorological data feed evapotranspiration models using temperature, humidity, wind, and radiation inputs. Wireless sensor networks provide continuous, localized data on soil moisture and canopy temperature. Integrated approaches combine these sources to improve irrigation recommendations. Findings suggest that combining remote sensing, wireless sensor networks, and agro-meteorological inputs can reduce water use by up to 30% without yield loss. Challenges include sensor calibration, data integration complexity, and limited scalability. This review also compares methodologies and highlights future directions, including artificial intelligence systems, digital twins, and affordable Internet of Things platforms for irrigation optimization. Full article

In 2024, Brazil experienced record-breaking wildfire activity, underscoring the escalating influence of climate change. This study examines the long-range transport of wildfire-generated aerosol plumes to São Paulo, combining multi-platform observations to trace their origin and properties. During August and September—a period marked by intense fire outbreaks in Pará and Mato Grosso do Sul—lidar measurements performed at São Paulo detected pronounced aerosol plumes. To investigate their source and characteristics, we integrated data from the Earth Cloud Aerosol and Radiation Explorer (EarthCARE) satellite, HYSPLIT back-trajectory modeling, and ground-based AERONET and Raman lidar measurements. Aerosol properties were derived from aerosol optical depth (AOD), Ångström exponent, and lidar ratio (LR) retrievals. Back-trajectory analysis identified three transport pathways originating from active fire zones, with coinciding AOD values (0.7–1.1) and elevated LR (60–100 sr), indicative of dense smoke plumes. Compositional analysis revealed a significant black carbon component, implicating wildfires near Corumbá (Mato Grosso do Sul) and São Félix do Xingu (Pará) as probable emission sources. These findings highlight the efficacy of satellite-based lidar systems, such as Atmospheric Lidar (ATLID) onboard EarthCARE, in atmospheric monitoring, particularly in data-sparse regions where ground instrumentation is limited. Full article

Plant growth monitoring is a complex and challenging task, which depends on a variety of environmental variables, such as temperature, humidity, nutrient availability, and solar radiation. Advances in optical sensors have significantly enhanced data collection on plant growth. These developments enable the optimization of agricultural practices and crop management through the integration of artificial vision techniques. Despite advances in the application of these technologies, limitations and challenges persist. This review aims to analyze the current state-of-the-art methodologies for using artificial vision and optical sensors in plant growth assessment. The systematic review was conducted following the guidelines for Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Relevant studies were analyzed from the Scopus and Web of Science databases. The main findings indicate that data collection in agricultural environments is challenging. This is due to the variability of climatic conditions, the heterogeneity of crops, and the difficulty in obtaining accurately and homogeneously labeled datasets. Additionally, the integration of artificial vision models and advanced sensors would enable the assessment of plant responses to these environmental factors. The advantages and limitations were examined, as well as proposed research areas to further contribute to the improvement and expansion of these emerging technologies for plant growth assessment. Finally, a relevant research line focuses on evaluating AI-based models on low-power embedded platforms to develop accessible and efficient decision-making solutions in both agricultural and urban environments. This systematic review was registered in the Open Science Framework (OSF). Full article

The National Institute of Earth Physics (NIEP) in Romania has upgraded its seismic monitoring stations into multifunctional platforms equipped with advanced devices for measuring gas emissions, magnetic fields, telluric fields, solar radiation, and more. This enhancement enabled the integration of a seismic forecasting system designed to extend the alert time of the existing warning system, which previously relied solely on seismic data. The implementation of an Operational Earthquake Forecast (OEF) aims to expand NIEP’s existing Rapid Earthquake Early Warning System (REWS) which currently provides a warning time of 25–30 s before an earthquake originating in the Vrancea region reaches Bucharest. The AFROS project (PCE119/4.01.2021) introduced fundamental research essential to the development of the OEF system. As a result, real-time analyses of radon and CO₂ emissions are now publicly available at afros.infp.ro, dategeofizice. The primary monitored area is Vrancea, known for producing the most destructive earthquakes in Romania, with impacts extending to neighboring countries such as Bulgaria, Ukraine, and Moldova. The structure and methodology of the monitoring network are adaptable to other seismic regions, depending on their specific characteristics. All collected data are stored in an open-access database available in real time, geobs.infp.ro. The monitoring methods include threshold-based event detection and seismic data analysis. Each method involves specific technical nuances that distinguish this monitoring network as a novel approach in the field. In conclusion, experimental results indicate that the Gutenberg-Richter law, combined with gas emission measurements (radon and CO₂), can be used for real-time earthquake forecasting. This approach provides warning times ranging from several hours to a few days, with results made publicly accessible. Another key finding from several years of real-time monitoring is that the value of fundamental research lies in its practical application through cost-effective and easily implementable solutions—including equipment, maintenance, monitoring, and data analysis software. Full article

High-precision hyperspectral remote sensing reflectance measurement of water bodies serves as the fundamental technical basis for accurately retrieving spatiotemporal distribution characteristics of water quality parameters, providing critical data support for dynamic monitoring of aquatic ecosystems and pollution source tracing. To address the critical issue of water surface glint interference significantly affecting measurement accuracy in aquatic remote sensing, this study innovatively developed a novel sensor system based on multi-field-of-view Kohler-polarization technology. The system incorporates three Kohler illumination lenses with exceptional surface uniformity exceeding 98.2%, effectively eliminating measurement errors caused by water surface brightness inhomogeneity. By integrating three core technologies—multi-field polarization measurement, skylight blocking, and high-precision radiometric calibration—into a single spectral measurement unit, the system achieves radiation measurement accuracy better than 3%, overcoming the limitations of traditional single-method glint suppression approaches. A glint removal efficiency (GRE) calculation model was established based on a skylight-blocked approach (SBA) and dual-band power function fitting to systematically evaluate glint suppression performance. Experimental results show that the system achieves GRE values of 93.1%, 84.9%, and 78.1% at ±3°, ±7°, and ±12° field-of-view angles, respectively, demonstrating that the ±3° configuration provides a 9.2% performance improvement over the ±7° configuration. Comparative analysis with dual-band power-law fitting reveals a GRE difference of 2.1% (93.1% vs. 95.2%) at ±3° field-of-view, while maintaining excellent consistency (ΔGRE < 3.2%) and goodness-of-fit (R² > 0.96) across all configurations. Shipborne experiments verified the system’s advantages in glint suppression (9.2%~15% improvement) and data reliability. This research provides crucial technical support for developing an integrated water remote sensing reflectance monitoring system combining in situ measurements, UAV platforms, and satellite observations, significantly enhancing the accuracy and reliability of ocean color remote sensing data. Full article

Background/Objectives: Medulloblastoma is a rare tumor that represents almost two-thirds of all embryonal pediatric brain tumor cases. Current treatments, including surgery, radiation, and chemotherapy, are often associated with adverse effects, such as toxicity, resistance, and lack of specificity. According to multiple bulk and single-cell omics-based approaches, it is now clear that each molecular subgroup of medulloblastoma possesses intrinsic genetic and molecular features that could drive the definition of distinct therapeutic targets, and of markers that have the potential to improve diagnosis. Nanomedicine offers a promising approach to overcome these challenges through precision-targeted therapies and theranostic platforms that merge diagnosis and treatment. This review explores the role of nanomedicine in medulloblastoma. Here, possible theranostic nanoplatforms combining targeted drug delivery and simultaneous imaging are reviewed, highlighting their potential as tools for personalized medicine. Methods: We performed a chronological analysis of the literature by using the major web-based research platforms, focusing on molecular targets, and the potential application of nanomedicine to overcome conventional treatment limitations. Results: Advances in nanoparticle-based drug delivery systems enable selective targeting of key molecular pathways, improving therapeutic efficacy while minimizing off-target effects. Additionally, nanotechnology-based imaging agents, including MRI contrast agents and fluorescent probes, improve diagnostic accuracy and treatment monitoring. Despite these advantages, some significant challenges remain, including overcoming the blood–brain barrier, ensuring biocompatibility, and addressing regulatory pathways for clinical translation. Conclusions: In conclusion, we sought to identify the current knowledge on the topic and hope to inspire future research to obtain new nanoplatforms for personalized medicine. Full article

Early detection of cancer is crucial for improving patient outcomes. Traditional modalities such as mammography and low-dose computed tomography are effective but exhibit inherent limitations, including radiation exposure and accessibility challenges. This review explores innovative, non-invasive cancer screening methods, focusing on liquid biopsy and volatile organic compound (VOC)-based detection platforms. Liquid biopsy analyzes circulating tumor DNA and other biomarkers in bodily fluids, offering potential for early detection and monitoring of treatment response. VOC-based detection leverages unique metabolic signatures emitted by cancer cells, detectable in exhaled breath or other bodily emissions, providing a rapid and patient-friendly screening option. We provide a comprehensive overview of these advanced multi-cancer detection techniques to enhance diagnostic accuracy, accessibility, and patient adherence, and ultimately enhance survival rates and patient outcomes. Full article