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Keywords = primary packaging

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14 pages, 3150 KiB  
Article
Research on the Influence Mechanism of Thermal Load on the Au-Sn Sealing Weld State on Three-Dimensional DPC Substrates
by Heran Zhao, Lihua Cao, ShiZhao Wang, He Zhang and Mingxiang Chen
Materials 2025, 18(15), 3678; https://doi.org/10.3390/ma18153678 - 5 Aug 2025
Abstract
Direct copper-plated ceramic (DPC) substrates have emerged as a favored solution for power device packaging due to their unique technical advantages. AuSn, characterized by its high hermeticity and environmental adaptability, represents the optimal sealing technology for DPC substrates. Through the application of vacuum [...] Read more.
Direct copper-plated ceramic (DPC) substrates have emerged as a favored solution for power device packaging due to their unique technical advantages. AuSn, characterized by its high hermeticity and environmental adaptability, represents the optimal sealing technology for DPC substrates. Through the application of vacuum sintering techniques and adjustment of peak temperatures (325 °C, 340 °C, and 355 °C), the morphology and composition of interfacial compounds were systematically investigated, along with an analysis of their formation mechanisms. A gradient aging experiment was designed (125 °C/150 °C/175 °C × oxygen/argon dual atmosphere × 600 h) to elucidate the synergistic effects of environmental temperature and atmosphere on the growth of intermetallic compounds (IMCs). The results indicate that the primary reaction in the sealing weld seam involves Ni interacting with Au-Sn to form (Ni, Au)3Sn2 and Au5Sn. However, upon completion of the sealing process, this reaction remains incomplete, leading to a coexistence state of (Ni, Au)3Sn2, Au5Sn, and AuSn. Additionally, Ni diffuses into the weld seam center via dendritic fracture and locally forms secondary phases such as δ(Ni) and ζ’(Ni). These findings suggest that the weld seam interface exhibits a complex, irregular, and asymmetric microstructure comprising multiple coexisting compounds. It was determined that Tpeak = 325 °C to 340 °C represents the ideal welding temperature range, where the weld seam morphology, width, and Ni diffusion degree achieve optimal states, ensuring excellent device hermeticity. Aging studies further demonstrate that IMC growth remains within controllable limits. These findings address critical gaps in the understanding of the microstructural evolution and interface characteristics of asymmetric welded joints formed by multi-material systems. Full article
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22 pages, 5646 KiB  
Article
Preparation and Characterization of D-Carvone-Doped Chitosan–Gelatin Bifunctional (Antioxidant and Antibacterial Properties) Film and Its Application in Xinjiang Ramen
by Cong Zhang, Kai Jiang, Yilin Lin, Rui Cui and Hong Wu
Foods 2025, 14(15), 2645; https://doi.org/10.3390/foods14152645 - 28 Jul 2025
Viewed by 318
Abstract
In this study, a composite film with dual antioxidant and antibacterial properties was prepared by combining 2% chitosan and 7% gelatin (2:1, w:w), with D-carvone (0–4%) as the primary active component. The effect of D-carvone content on the performance of the composite films [...] Read more.
In this study, a composite film with dual antioxidant and antibacterial properties was prepared by combining 2% chitosan and 7% gelatin (2:1, w:w), with D-carvone (0–4%) as the primary active component. The effect of D-carvone content on the performance of the composite films was systematically investigated. The results showed that adding 1% D-carvone increased the water contact angle by 28%, increased the elongation at break by 35%, and decreased the WVTR by 18%. FTIR and SEM confirmed that ≤2% D-carvone uniformly bonded with the substrate through hydrogen bonds, and the film was dense and non-porous. In addition, the DPPH scavenging rate of the 1–2% D-carvone composite film increased to about 30–40%, and the ABTS+ scavenging rate increased to about 35–40%; the antibacterial effect on Escherichia coli and Staphylococcus aureus increased by more than 70%. However, when the addition amount was too high (exceeding 2%), the composite film became agglomerated, microporous, and phase-separated, affecting the film performance, and due to its own taste, it reduced the sensory quality of the noodles. Comprehensively, the composites showed better performance when the content of D-carvone was 1–2% and also the best effect for freshness preservation in Xinjiang ramen. This study provides a broad application prospect for natural terpene compound-based composite films in the field of high-moisture, multi-fat food preservation, and provides a theoretical basis and practical guidance for the development of efficient and safe food packaging materials. In the future, the composite film can be further optimized, and the effect of flavor can be further explored to meet the needs of different food preservation methods. Full article
(This article belongs to the Section Food Packaging and Preservation)
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16 pages, 1043 KiB  
Article
Sustainable Packaging Design: Packaging Optimization and Material Reduction for Environmental Protection and Economic Benefits to Industry and Society
by Elias D. Georgakoudis, Georgia G. Pechlivanidou and Nicoleta S. Tipi
Appl. Sci. 2025, 15(15), 8289; https://doi.org/10.3390/app15158289 - 25 Jul 2025
Viewed by 262
Abstract
This paper analyzes the concept of packaging redesign, with the primary objective of improving material utilization. It further examines the potential environmental and economic benefits that may result from effective packaging redesign for both industry and society. The research is based on a [...] Read more.
This paper analyzes the concept of packaging redesign, with the primary objective of improving material utilization. It further examines the potential environmental and economic benefits that may result from effective packaging redesign for both industry and society. The research is based on a specific case study comparing two alternative bottle designs with identical capacity, focusing on shape, material usage, and space efficiency. A detailed numerical comparison highlights the advantages and disadvantages of each option. The analysis demonstrates that an optimized bottle design can lead to substantial material savings and waste reduction. For example, an 8% reduction in bottle weight could eliminate approximately 1.6 million tons of material annually, potentially translating into economic savings exceeding 3 billion U.S. dollars per year. The study underscores how strategic packaging redesign can yield significant benefits in terms of material efficiency and cost savings for companies. It also contributes to the field of Life Cycle Analysis by linking packaging design innovation to key environmental and economic outcomes, while ensuring that packaging continues to protect products and meet the needs of the end consumer. Full article
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29 pages, 4008 KiB  
Article
Food Culture: Strengthening Collaborative Entrepreneurship Between Tourism and Agri-Food Businesses
by Maria Spilioti and Konstantinos Marinakos
Adm. Sci. 2025, 15(8), 291; https://doi.org/10.3390/admsci15080291 - 25 Jul 2025
Viewed by 337
Abstract
This research aims to determine the utilization levels of local products and the challenges and opportunities of creating a recognizable food-centered cultural identity based on collaborative networks developed between agriculture and tourism. This has the potential to strengthen collaborative entrepreneurship. It uniquely contributes [...] Read more.
This research aims to determine the utilization levels of local products and the challenges and opportunities of creating a recognizable food-centered cultural identity based on collaborative networks developed between agriculture and tourism. This has the potential to strengthen collaborative entrepreneurship. It uniquely contributes to the existing literature by exploring the connections between agri-food and tourism, while proposing strategies to maximize business opportunities centered on food culture. Descriptive and inferential statistics are conducted based on primary data collected by distributing a questionnaire to 59 public and private organizations in the Peloponnese region in Greece, which has significant agricultural production but limited tourist flows. The results indicate a lack of collective action and business recognition of the value of regional food culture among participants. The human resources employed in tourism lack the skills to highlight traditional food heritage. The presence of structural and operational barriers undermines efforts to facilitate communication, manage suppliers, and enhance the visibility of products designated with Geographical Indications. This paper offers preliminary results; however, extensive future studies are needed to validate the findings fully. The study highlights key implications: Improved communication between stakeholders could enhance the management of the local food network. Agri-food and tourism businesses can develop educational programs and food-focused tourism packages that promote social cohesion and preserve cultural heritage. Full article
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16 pages, 1319 KiB  
Article
Key Factors Influencing Bacillus cereus Contamination in Hot Ready-to-Eat Meal Delivery
by Tomáš Komprda, Olga Cwiková, Vojtěch Kumbár, Gabriela Franke, Petr Kouřil, Ondřej Patloka, Josef Kameník, Marta Dušková and Alena Zouharová
Foods 2025, 14(15), 2605; https://doi.org/10.3390/foods14152605 - 24 Jul 2025
Viewed by 343
Abstract
With increasing popularity of food delivery services, the microbial safety of transported meals should be ensured. An effect of the type of a meal (cooked rice; mashed potatoes; mushroom sauce), inner primary packaging (sugarcane bagasse [SB] tray; polypropylene [PP] tray), secondary container (polyester/polyethylene [...] Read more.
With increasing popularity of food delivery services, the microbial safety of transported meals should be ensured. An effect of the type of a meal (cooked rice; mashed potatoes; mushroom sauce), inner primary packaging (sugarcane bagasse [SB] tray; polypropylene [PP] tray), secondary container (polyester/polyethylene foam/aluminum foil [PPA] bag; PP box) on the time interval of the internal hot ready-to-eat (RTE) meal temperature decrease to the value critical for Bacillus cereus growth (40 °C) was tested during a simulated delivery; in aliquot samples of the same meals, B. cereus growth was quantified presuming a natural contamination of the meals. Type of a meal had no effect on the tested time interval (p > 0.05). Packaging a meal in the PP tray as compared to the SB tray and inserting primary trays into the PP box instead of PPA bag delayed (p < 0.05) the internal meal temperature decrease by 50 and 15 min, respectively. Average B. cereus counts in the naturally contaminated meals after the four-hour culturing at 40 °C was 2.99 log CFU·g−1. It was concluded that a hot RTE meal delivered up to four hours under the tested conditions is not likely to facilitate B. cereus growth above unacceptable levels. Full article
(This article belongs to the Section Food Quality and Safety)
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26 pages, 2472 KiB  
Article
Incorporating Recyclates Derived from Household Waste into Flexible Food Packaging Applications: An Environmental Sustainability Assessment
by Trang T. Nhu, Anna-Sophie Haslinger, Sophie Huysveld and Jo Dewulf
Recycling 2025, 10(4), 142; https://doi.org/10.3390/recycling10040142 - 17 Jul 2025
Viewed by 334
Abstract
Integrating recyclates into food packaging is key towards circularity while meeting functionality and safety requirements; however, associated environmental impacts remain underexplored. This gap was addressed through a cradle-to-gate life cycle assessment, using the Environmental Footprint method, along with substitution and cut-off approaches for [...] Read more.
Integrating recyclates into food packaging is key towards circularity while meeting functionality and safety requirements; however, associated environmental impacts remain underexplored. This gap was addressed through a cradle-to-gate life cycle assessment, using the Environmental Footprint method, along with substitution and cut-off approaches for handling the multifunctionality of recycling. Recyclates were derived from polyethylene (PE)-rich household food packaging waste, purified via delamination-deinking. Firstly, results show that shifting from virgin multi-material to mono-material multilayer structures with or without recyclates, while maintaining functionality, offers environmental benefits. Secondly, recyclates should sufficiently substitute virgin materials in quantity and quality, decreasing the need for primary plastics and avoiding recyclate incorporation without functionality. Otherwise, thicker laminates are obtained, increasing processability challenges and environmental impacts, e.g., 12% for particulate matter, and 14% for mineral-metal resource use when the recycle content rises from 34 to 50%. Thirdly, a fully closed loop for flexible food packaging is not yet feasible. Key improvements lie in reducing residues generated during recycling, especially in delamination-deinking, lowering energy use in recompounding, and using more efficient transport modes for waste collection. Further research is essential to optimise the innovative technologies studied for flexible food packaging and refine them for broader applications. Full article
(This article belongs to the Special Issue Challenges and Opportunities in Plastic Waste Management)
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24 pages, 237 KiB  
Article
Student Perceptions of Sustainability in the HoReCa Sector: Awareness, Engagement, and Challenges
by Marian Mocan, Larisa Ivascu, Timea Agache and Andrei Agache
Sustainability 2025, 17(14), 6384; https://doi.org/10.3390/su17146384 - 11 Jul 2025
Viewed by 321
Abstract
The HoReCa (Hotels, Restaurants, and Cafes) sector plays a pivotal role in the economy due to its strong connections with various other industries, including agriculture, food and beverage, construction, packaging, waste management, water, and textiles. Given its broad impact, understanding the perceptions of [...] Read more.
The HoReCa (Hotels, Restaurants, and Cafes) sector plays a pivotal role in the economy due to its strong connections with various other industries, including agriculture, food and beverage, construction, packaging, waste management, water, and textiles. Given its broad impact, understanding the perceptions of students—emerging consumers and future professionals—could provide valuable insights for businesses seeking to enhance sustainable practices in ways that resonate with younger generations and improve their competitiveness. However, there is still limited understanding of how students perceive and engage with sustainability in this sector. This study explores student perceptions of sustainability practices within the HoReCa sector, examining their awareness levels, expectations, and behavior. The objective is to assess how effectively current business approaches align with student values regarding sustainability initiatives and identify key factors influencing their engagement. A structured questionnaire was distributed among university students, and the collected data was analyzed using statistical techniques to identify meaningful trends and correlations. Findings revealed a notable disconnect between students’ professed sustainability values and their actual behavior. Primary obstacles included price sensitivity, skepticism toward environmental marketing claims, and insufficient access to clear sustainability information from businesses. Despite supporting sustainable initiatives in principle, students often struggle to translate their values into purchasing decisions. The research suggests that greater business transparency, enhanced sustainability education, and incentive programs could foster increased student engagement. Full article
25 pages, 4955 KiB  
Article
Optimized MaxEnt Modeling of Catalpa bungei Habitat for Sustainable Management Under Climate Change in China
by Xiaomeng Shi, Jingshuo Zhao, Yanlin Wang, Guichun Wu, Yingjie Hou and Chunyan Yu
Forests 2025, 16(7), 1150; https://doi.org/10.3390/f16071150 - 11 Jul 2025
Viewed by 366
Abstract
Catalpa bungei C. A. Mey, an economically and ecologically important tree species endemic to China, exhibits notable drought resistance; however, the spatial dynamics of its habitat under future climate change have not been thoroughly investigated. We employed a parameter-optimized MaxEnt modeling framework to [...] Read more.
Catalpa bungei C. A. Mey, an economically and ecologically important tree species endemic to China, exhibits notable drought resistance; however, the spatial dynamics of its habitat under future climate change have not been thoroughly investigated. We employed a parameter-optimized MaxEnt modeling framework to project current and future suitable habitats for C. bungei under two Shared Socioeconomic Pathway scenarios, SSP126 (low-emission) and SSP585 (high-emission), based on CMIP6 climate data. We incorporated 126 spatially rarefied occurrence records and 22 environmental variables into a rigorous modeling workflow that included multicollinearity assessment and systematic variable screening. Parameter optimization was performed using the kuenm package in R version 4.2.3, and the best-performing model configuration was selected (Regularization Multiplier = 2.5; Feature Combination = LQT) based on the AICc, omission rate, and evaluation metrics (AUC, TSS, and Kappa). Model validation demonstrated robust predictive accuracy. Four primary environmental predictors obtained from WorldClim version 2.1—the minimum temperature of the coldest month (Bio6), annual precipitation (Bio12), maximum temperature of the warmest month (Bio5), and elevation—collectively explained over 90% of habitat suitability. Currently, the optimal habitats are concentrated in central and eastern China. By the 2090s, the total suitable habitats are projected to increase by approximately 4.25% under SSP126 and 18.92% under SSP585, coupled with a significant northwestward shift in the habitat centroid. Conversely, extremely suitable habitats are expected to markedly decline, particularly in southern China, due to escalating climatic stress. These findings highlight the need for adaptive afforestation planning and targeted conservation strategies to enhance the climate resilience of C. bungei under future climate change. Full article
(This article belongs to the Section Forest Inventory, Modeling and Remote Sensing)
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21 pages, 2201 KiB  
Article
Evaluating China’s Electric Vehicle Adoption with PESTLE: Stakeholder Perspectives on Sustainability and Adoption Barriers
by Daniyal Irfan and Xuan Tang
Sustainability 2025, 17(14), 6258; https://doi.org/10.3390/su17146258 - 8 Jul 2025
Viewed by 513
Abstract
The electric vehicle (EV) business model integrates advanced battery technology, dynamic power train architectures, and intelligent energy management systems with ecosystem strategies and digital services. It incorporates environmental sustainability through lifecycle analysis and renewable energy integration. China, with 9.49 million EV sales in [...] Read more.
The electric vehicle (EV) business model integrates advanced battery technology, dynamic power train architectures, and intelligent energy management systems with ecosystem strategies and digital services. It incorporates environmental sustainability through lifecycle analysis and renewable energy integration. China, with 9.49 million EV sales in 2023 (33% market share), faces infrastructure gaps constraining further growth. China is strategically mitigating CO2 emissions while fostering economic expansion, notwithstanding constraints such as suboptimal battery technology advancements, elevated production expenditure, and enduring ecological impacts. This Political, Economic, Social, Technological, Legal, Environmental (PESTLE) assessment, operationalized through a survey of 800 stakeholders and Statistical Package for the Social Sciences IBM SPSS SPSS (Version 28) quantitative analysis (factor loading = 0.73 for Technology; eigenvalue = 4.12), identifies infrastructure gaps as the dominant barrier (72% of stakeholders). Political factors (β = 0.82) emerged as the strongest adoption predictor, outweighing economic subsidies in significance. The adoption of EVs in China presents a significant prospect for reducing CO2 emissions and advancing technology. However, economic barriers, market dynamics, inadequate infrastructure, regulatory uncertainty, and social acceptance issues are addressed in the assessment. The study recommends prioritizing infrastructure investment (e.g., 500 K fast-charging stations by 2027) and policy stability to overcome adoption barriers. This study provides three key advances: (1) quantification of PESTLE factor weights via factor analysis, revealing technological (infrastructure) and political factors as dominant; (2) identification of infrastructure gaps, not subsidies, as the primary adoption barrier; and (3) demonstration of infrastructure’s persistence post-subsidy cuts. These insights redefine EV adoption priorities in China. Full article
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19 pages, 2082 KiB  
Article
De Novo Expressed Vpr Stimulates HIV-1 Replication in T Cells
by Blessing Enya and Jacek Skowronski
Viruses 2025, 17(7), 958; https://doi.org/10.3390/v17070958 - 7 Jul 2025
Viewed by 395
Abstract
Vpr, a virion-associated accessory virulence factor of HIV-1, promotes virus replication in both T cells and macrophages. Although Vpr’s early activity—antagonism of preintegration silencing and host restriction factors—has been documented, the relative contribution of virion-associated versus de novo expressed Vpr to HIV-1 replication [...] Read more.
Vpr, a virion-associated accessory virulence factor of HIV-1, promotes virus replication in both T cells and macrophages. Although Vpr’s early activity—antagonism of preintegration silencing and host restriction factors—has been documented, the relative contribution of virion-associated versus de novo expressed Vpr to HIV-1 replication fitness remains unclear. Here, we developed a T cell-based system that genetically separates early and late Vpr functions by combining tetracycline-inducible Vpr expression in CEM.SS T cells with vpr-deficient HIV-1 constructs and Gag p6 mutations that block Vpr packaging. CEM.SS T cells have been shown to recapitulate the positive effect of Vpr on HIV-1 replication observed in activated primary T cells. Using pairwise replication fitness assays under spreading infection conditions, we demonstrate that de novo synthesized Vpr exerts the dominant effect on HIV-1 replication in T cells, while virion-associated Vpr plays a lesser role. Somewhat unexpectedly, our findings reveal that antagonism of preintegration HIV-1 silencing by virion-associated Vpr is unlikely to be the major driver of enhanced HIV-1 replication in proliferating T cells. Instead, this function may play a more prominent role in the infection of non-dividing T cells and/or other cell types. Full article
(This article belongs to the Section Human Virology and Viral Diseases)
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22 pages, 1308 KiB  
Article
Novel Active Films with Semolina and Jatoba (Hymenaea courbaril L.): Preparation, Properties, and Sustainability Aspects
by Cristiani Viegas Brandão Grisi, Flávia Cosmo Guedes da Silva, Rita de Cassia Andrade Silva, Rene Pinto da Silva, Fábio Anderson Pereira da Silva and Angela Maria Tribuzy de Magalhães Cordeiro
Foods 2025, 14(13), 2391; https://doi.org/10.3390/foods14132391 - 6 Jul 2025
Viewed by 415
Abstract
The aim of this study was to develop and characterize antioxidant-active films for potential food packaging applications. The films were produced by casting aqueous solutions containing semolina flour (6% w/w), pectin extracted from passion fruit (1% w/w), [...] Read more.
The aim of this study was to develop and characterize antioxidant-active films for potential food packaging applications. The films were produced by casting aqueous solutions containing semolina flour (6% w/w), pectin extracted from passion fruit (1% w/w), inverted sugar (1% w/w), and sucrose (1% w/w), incorporating hydroalcoholic extracts from jatoba stem bark (X1) and pods (X2) at concentrations ranging from 0 to 1% (w/w). The films were characterized in terms of their functional, physical, chemical, structural, and degradation properties. The formulation that showed the best performance, referred to as the optimized formulation (FO), contained 0.5% X1 and 0.5% X2, presenting a high phenolic compound content (8.80 mg GAE/g), strong antioxidant activity as determined by the DPPH method (75.28%) and FRAP assay (6.02 mmol FeSO4/g), good thermal stability (350 °C), and a high soil degradation rate (83.47% in 15 days). These results indicate that the FO film has potential application as a primary packaging material with antioxidant function for oxidation-sensitive foods, meeting the demand for biodegradable and environmentally sustainable solutions in the food industry. Full article
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18 pages, 1933 KiB  
Article
LTBWTB: A Mathematica Software to Evaluate the Lateral-Torsional Buckling Load of Web-Tapered Mono-Symmetric I-Section Beams
by Tolga Yılmaz
Appl. Sci. 2025, 15(13), 7572; https://doi.org/10.3390/app15137572 - 6 Jul 2025
Viewed by 305
Abstract
Web-tapered beams with I-sections, which are aesthetic and structurally efficient, have been widely used in steel structures. Web-tapered I-section beams bent about the strong axis may undergo out-of-plane buckling through lateral deflection and twisting. This primary stability failure mode in slender beams is [...] Read more.
Web-tapered beams with I-sections, which are aesthetic and structurally efficient, have been widely used in steel structures. Web-tapered I-section beams bent about the strong axis may undergo out-of-plane buckling through lateral deflection and twisting. This primary stability failure mode in slender beams is known as lateral-torsional buckling (LTB). Unlike prismatic I-beams, the complex mode shape of web-tapered I-section beams makes it challenging or even impossible to derive a closed-form expression for the LTB load under certain transverse loading conditions. Therefore, the LTB assessment of web-tapered I-section beams is primarily performed using finite element analysis (FEA). However, this method involves multiple steps, requires specialized expertise, and demands significant computational resources, making it impractical in certain cases. This study proposes an analytical approach based on the Ritz method to evaluate the LTB of simply supported web-tapered beams with doubly or mono-symmetric I-sections. The proposed analytical method accounts for web tapering, I-section mono-symmetry, types and positions of transverse loads, and beam slenderness. The method was implemented in Mathematica to allow the rapid evaluation of the LTB capacity of web-tapered I-beams. The study validates the LTB loads computed using the developed Mathematica package against results from shell-based FEA. An excellent agreement was observed between the analytically and numerically calculated LTB loads. Full article
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33 pages, 5065 KiB  
Article
Comparative Evaluation of Diagnostic Tests for Brucellosis in Humans and Animals: A Meta-Analytical Approach
by Shahid Nazir, Muhammad Farooq, Raheel Khan, Aman Ullah Khan, Ali Husnain, Muhammad Ali Hassan, Hosny El-Adawy and Heinrich Neubauer
Vet. Sci. 2025, 12(7), 638; https://doi.org/10.3390/vetsci12070638 - 3 Jul 2025
Viewed by 1826
Abstract
Brucellosis is a highly contagious, neglected, and re-emerging zoonotic bacterial disease that poses significant health and economic challenges globally for both humans and animals. Extensive literature is available for various diagnostic strategies; however, no comprehensive meta-analysis comparing the diagnostic tests used has been [...] Read more.
Brucellosis is a highly contagious, neglected, and re-emerging zoonotic bacterial disease that poses significant health and economic challenges globally for both humans and animals. Extensive literature is available for various diagnostic strategies; however, no comprehensive meta-analysis comparing the diagnostic tests used has been published. The present study aimed to estimate the relative risk (RR) of diagnostic tests used in humans and animals published between 2013 and 2023. Four databases were systematically searched, and the articles were screened using predefined inclusion and exclusion criteria. Ultimately, the screening process resulted in a total of 135 studies, including 328 comparisons of relevant data of 19,921 humans and 64,145 animals. The data from these studies were extracted, and the subgroup meta-analyses were conducted using the METABIN procedure in the “meta” package of the R statistical software (version 4.4.1). The forest plots were generated to estimate RR, and the funnel plots were used to assess publication and report bias. The subgroup analysis revealed that primary binding assays had higher comparative detection rates than the Rose Bengal plate test (RBPT) for brucellosis in humans [RR = 1.75 (95% CI: 1.35–2.26), I2 = 73%]. Slow agglutination tests had lower detection rates than the RBPT, both in humans [RR = 0.68 (95% CI: 0.48–0.96), I2 = 90%] and cattle [RR = 0.41 (95% CI: 0.25–0.68), I2 = 96%]. Similarly, the complement fixation test (CFT) had a lower detection rate than the RBPT for brucellosis both in cattle [RR = 0.97 (95% CI: 0.94–0.99), I2 = 9%] and sheep [RR = 0.97 (95% CI: 0.95–0.99), I2 = 0%]. This meta-analysis demonstrated that, for the screening of brucellosis in both humans and animals, primary binding assays are the preferred diagnostic tools, followed by the RBPT and slow agglutination tests. However, their effective implementation requires context-specific diagnostic strategies and combined testing approaches to enhance accuracy and reliability. Full article
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18 pages, 5570 KiB  
Article
SPICE-Compatible Degradation Modeling Framework for TDDB and LER Effects in Advanced Packaging BEOL Based on Ion Migration Mechanism
by Shao-Chun Zhang, Sen-Sen Li, Ying Ji, Ning Yang, Yuan-Hao Shan, Li Hong, Hao-Gang Wang, Wen-Sheng Zhao and Da-Wei Wang
Micromachines 2025, 16(7), 766; https://doi.org/10.3390/mi16070766 - 29 Jun 2025
Viewed by 567
Abstract
The time-dependent dielectric breakdown (TDDB) degradation mechanism, governed by the synergistic interaction of multiphysics fields, plays a pivotal role in the performance degradation and eventual failure of semiconductor devices and advanced packaging back-end-of-line (BEOL) structures. This work specifically focuses on the dielectric breakdown [...] Read more.
The time-dependent dielectric breakdown (TDDB) degradation mechanism, governed by the synergistic interaction of multiphysics fields, plays a pivotal role in the performance degradation and eventual failure of semiconductor devices and advanced packaging back-end-of-line (BEOL) structures. This work specifically focuses on the dielectric breakdown mechanism driven by metal ion migration within inter-metal dielectric layers, a primary contributor to TDDB degradation. A SPICE-compatible modeling approach is developed to accurately capture the dynamics of this ion migration-induced degradation. The proposed model is rooted in the fundamental physics of metal ion migration and the evolution of conductive filaments (CFs) within the dielectric layer under operational stress conditions. By precisely characterizing the degradation behavior induced by TDDB, a SPICE-compatible degradation model is developed. This model facilitates accurate predictions of resistance changes across a range of operational conditions and lifetime, encompassing variations in stress voltages, temperatures, and structural parameters. The predictive capability and accuracy of the model are validated by comparing its calculated results with numerical ones, thereby confirming its applicability. Furthermore, building upon the established degradation model, the impact of line-edge roughness (LER) is incorporated through a process variation model based on the power spectral density (PSD) function. This PSD-derived model provides a quantitative characterization of LER-induced fluctuations in critical device dimensions, enabling a more realistic representation of process-related variability. By integrating this stochastic variability model into the degradation framework, the resulting lifetime prediction model effectively captures reliability variations arising from real-world fabrication non-uniformities. Validation against simulation data demonstrates that the inclusion of LER effects significantly improves the accuracy of predicted lifetime curves, yielding closer alignment with observed device behavior under accelerated stress conditions. Full article
(This article belongs to the Special Issue Advanced Interconnect and Packaging, 3rd Edition)
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29 pages, 921 KiB  
Review
Upcycling Wine Industry Waste: Dealcoholized Grape Pomace as a Platform for Bio-Based Material Innovation
by Jorge Miguel Matias, Fernando Braga and Alice Vilela
Appl. Sci. 2025, 15(13), 7215; https://doi.org/10.3390/app15137215 - 26 Jun 2025
Viewed by 511
Abstract
The wine industry produces substantial amounts of organic waste, particularly in the form of dealcoholized grape pomace—the primary residual biomass that remains after the fermentation process and the extraction of alcohol from winery by-products. This study explores the potential of upcycling dealcoholized pomace, [...] Read more.
The wine industry produces substantial amounts of organic waste, particularly in the form of dealcoholized grape pomace—the primary residual biomass that remains after the fermentation process and the extraction of alcohol from winery by-products. This study explores the potential of upcycling dealcoholized pomace, an often-overlooked by-product, into a sustainable platform for innovative bio-based materials. Using a multidisciplinary approach that combines materials science, biotechnology, and principles of the circular economy, we carefully examine the physical, chemical, and mechanical properties of dealcoholized pomace. Our research includes comprehensive analyses of its structural integrity, biodegradability, and potential applications, including biocomposites, eco-friendly packaging solutions, and other sustainable materials. The results of our study highlight not only the promising performance characteristics of dealcoholized pomace, such as its strength-to-weight ratio and biocompatibility, but also underscore its significant role in advancing waste valorization strategies. By effectively transforming waste into valuable resources, we contribute to the development of sustainable materials, thereby supporting a more circular economy within the wine industry and beyond. Full article
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