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19 pages, 2762 KB  
Article
Research on Foam Sand-Flushing Simulation of Coiled Tubing in Shale Gas Horizontal Wells
by Jianian Xu, Huajian Zhang, Ju Deng, Yichen Shao, Zhenjun Zhang and Hongli Liu
Processes 2026, 14(9), 1383; https://doi.org/10.3390/pr14091383 (registering DOI) - 25 Apr 2026
Abstract
To address the issues of easy leakage and low sand-flushing efficiency of coiled tubing working fluid in shale gas horizontal wells, this study investigates the flow behavior of foam fluid in both the coiled tubing and the annulus during foam sand-flushing operations, and [...] Read more.
To address the issues of easy leakage and low sand-flushing efficiency of coiled tubing working fluid in shale gas horizontal wells, this study investigates the flow behavior of foam fluid in both the coiled tubing and the annulus during foam sand-flushing operations, and optimizes operational parameters to enhance sand-flushing efficiency. Considering the dynamic variations in foam fluid properties with temperature and pressure, secondary flow effects in the spiral section, annular eccentricity, wellbore trajectory, and the solid phase in sand-carrying fluid, a one-dimensional steady-state hydraulic model incorporating flow and heat transfer is developed for the entire wellbore. This model covers the spiral, straight, jet, and annular sections of coiled tubing. Using field data from an example well, simulations yield the pressure distribution along the foam circulation path, the total circulation time, and key operational parameters. The feasibility of coiled tubing foam sand-flushing in shale gas horizontal wells is demonstrated, and the optimization of operational parameters to improve sand-flushing efficiency is analyzed. The findings provide important guidance for parameter design and equipment selection for safe and efficient sand-flushing operations in shale gas horizontal wells. Full article
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24 pages, 6282 KB  
Article
CFD–DEM-Based Analysis and Optimization of Biomimetic Jet Hole Design for Pneumatic Subsoiling Performance
by Shuhong Zhao, Changle Jiang, Xize Liu, Yueqian Yang, Mingxuan Du, Bin Lü and Shoukun Dong
Agriculture 2026, 16(9), 949; https://doi.org/10.3390/agriculture16090949 (registering DOI) - 25 Apr 2026
Abstract
Subsoiling can break the plough pan and improve the root growth environment. The effect of the traditional subsoiler is poor, as it relies only on the chisel tine, but pneumatic subsoiling can improve the soil structure more efficiently through the negative pressure generated [...] Read more.
Subsoiling can break the plough pan and improve the root growth environment. The effect of the traditional subsoiler is poor, as it relies only on the chisel tine, but pneumatic subsoiling can improve the soil structure more efficiently through the negative pressure generated by the jet hole. This research used computational fluid dynamics and the discrete element method to optimize the biomimetic structure of the jet hole, model the pneumatic subsoiling process at a depth of 330 mm, and observe the movement of soil particles as airflow passes through. The effect of the jet hole at different positions and sizes on the plough pan soil was analyzed, and fluid domains and measurement areas were set up to observe the upward movement, diffusion, stabilization, and settling of soil particles under the action of airflow. The results of the soil bin experiment validated the accuracy of the simulation model through draft force and vertical force, and the average error between the simulation and experimental data was 2.8%. The study revealed that the increase in the rate of soil porosity reached a maximum of 3.65% when the jet hole was positioned above the chisel tine with a radius of 4 mm. The biomimetic jet hole pneumatic subsoiler designed in this study, along with the established CFD-DEM coupled simulation model capable of predicting pneumatic subsoiling performance, can provide references for the design and application of a pneumatic subsoiler. Furthermore, it also provides a theoretical basis for understanding the mechanism of airflow on soil during pneumatic subsoiling operations. Full article
22 pages, 366 KB  
Article
Participation Under Pressure: Land Use Planning in Ireland and Serbia
by Ana Perić, Antonije Ćatić and Siniša Trkulja
Land 2026, 15(5), 730; https://doi.org/10.3390/land15050730 (registering DOI) - 25 Apr 2026
Abstract
Public participation in planning, though a foundational democratic principle, faces persistent implementation challenges across diverse planning systems. This paper examines participatory planning practice in Ireland and Serbia—two countries representing distinct planning traditions (discretionary and conformance-based, respectively) yet confronting shared structural pressures. Through comparative [...] Read more.
Public participation in planning, though a foundational democratic principle, faces persistent implementation challenges across diverse planning systems. This paper examines participatory planning practice in Ireland and Serbia—two countries representing distinct planning traditions (discretionary and conformance-based, respectively) yet confronting shared structural pressures. Through comparative analysis of four local land use planning instruments (the Development Plan and Local Area Plan in Ireland; the Municipal Spatial Plan and General Regulation Plan in Serbia), the study investigates how institutional design and legislative frameworks shape the depth and quality of participatory practice. Methodologically, the research triangulates statutory regulations, public hearing documentation, and non-statutory participation records across two planning scales (county/municipal and local/sub-municipal). A four-dimensional analytical framework—informing, consultation, collaboration, and monitoring—guides the systematic comparison of participatory mechanisms across the selected cases. Findings reveal that, while both systems remain predominantly at the informing and consultation levels, critical differences emerge in how participation is structured and documented in institutional practice. Ireland’s discretionary system enables multi-channel information dissemination, feedback-oriented consultation, and non-statutory collaborative experimentation beyond legal minimums. Serbia’s conformance-based system confines participation largely to statutory procedures, with objection-based consultation and limited collaborative mechanisms, though distinctive features, such as the public hearing session, provide direct opportunities for deliberation absent in the Irish context. The study contributes to European comparative planning scholarship by demonstrating that participatory depth is shaped less by the formal existence of legal provisions than by the interplay between institutional design, procedural arrangements, transparency, and responsiveness. Full article
(This article belongs to the Special Issue Urban Land Use Planning in Europe: A Comparative Perspective)
27 pages, 669 KB  
Systematic Review
Biomarkers and Psychological Factors Associated with Distress in Children, Adolescents, and Young Adults Undergoing MRI Neuroimaging: A Systematic Review of Observational Studies with Clinical Recommendations
by Guillermo Ceniza-Bordallo, Ana Belén del Pino, Dino Soldic and Angel Torrado-Carvajal
Healthcare 2026, 14(9), 1160; https://doi.org/10.3390/healthcare14091160 (registering DOI) - 25 Apr 2026
Abstract
Introduction: Distress during pediatric magnetic resonance imaging (MRI) neuroimaging can compromise scan quality and negatively impact children’s experiences. This review aimed to systematically synthesize biomarkers and psychological factors associated with distress in children, adolescents, and young adults undergoing neuroimaging. Methods: This [...] Read more.
Introduction: Distress during pediatric magnetic resonance imaging (MRI) neuroimaging can compromise scan quality and negatively impact children’s experiences. This review aimed to systematically synthesize biomarkers and psychological factors associated with distress in children, adolescents, and young adults undergoing neuroimaging. Methods: This systematic review was conducted according to PRISMA and AMSTAR-2 guidelines and preregistered in OSF. A systematic search was performed in six electronic databases, including observational articles published between 2000 and 2025 that assessed distress during MRI and functional MRI (fMRI). Data extraction and risk of bias assessment (QUIPS tool) were performed independently by two reviewers. Results: Ten studies (n = 558) examining distress during neuroimaging were included in this review. Distress was assessed through subjective self- and parent-reports, objective physiological measures, and qualitative interviews. Overall, distress levels were low to moderate; most participants tolerated scans well, though younger age, male sex, parental anxiety, procedure length, and chronic illness were associated with greater discomfort. Noise, immobility, and boredom emerged as the most frequent triggers, while strategies such as distraction, age-appropriate information, and reducing waiting times were perceived as helpful. Among participants with cancer, scan-related anxiety was closely linked to fear of recurrence and perceived stress. Risk of bias across studies was moderate to high, particularly in domains of attrition and statistical reporting. Conclusions: Distress during scanning is driven by anticipatory and parental anxiety, procedure length, and chronic illness. Biomarkers (e.g., cortisol, blood pressure) showed inconsistent links with subjective distress, highlighting the need for integrated measures. Full article
(This article belongs to the Special Issue Concussion Characteristics, Recovery Patterns, and Care Strategies)
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27 pages, 624 KB  
Systematic Review
Heavy Metal Contamination in Foods: Advances in Detection Technologies, Regulatory Challenges, Health Risks, and Implications for Sustainable Food Safety
by Diego A. Hernández-Montoya, Ana G. Castañeda-Miranda, Margarita L. Martinez-Fierro, Alfonso Talavera-Lopez, Remberto Sandoval-Aréchiga, Jose. R. Gomez-Rodriguez, Víktor I. Rodríguez-Abdalá, Rodrigo Castañeda-Miranda, Luis Alberto Flores-Chaires, Sodel Vazquez-Reyes and Salvador Ibarra Delgado
Sustainability 2026, 18(9), 4280; https://doi.org/10.3390/su18094280 (registering DOI) - 25 Apr 2026
Abstract
Heavy metal contamination of foods remains a persistent global challenge for food safety and public health, driven by industrialization, mining activities, intensive agriculture, and ongoing environmental degradation. This scoping review synthesizes peer-reviewed literature on the occurrence of priority toxic metals—arsenic, cadmium, lead, mercury, [...] Read more.
Heavy metal contamination of foods remains a persistent global challenge for food safety and public health, driven by industrialization, mining activities, intensive agriculture, and ongoing environmental degradation. This scoping review synthesizes peer-reviewed literature on the occurrence of priority toxic metals—arsenic, cadmium, lead, mercury, and nickel—in food matrices, with emphasis on contamination pathways, analytical detection strategies, and documented human health effects. The reviewed studies reveal widespread accumulation of heavy metals in staple foods, including cereals, vegetables, seafood, and processed products, with concentrations frequently approaching or exceeding international regulatory limits, particularly in regions exposed to strong anthropogenic pressure. Conventional laboratory-based techniques, such as atomic absorption spectrometry and inductively coupled plasma methods, remain the reference standards for quantitative determination and regulatory compliance; however, their application to large-scale or continuous monitoring is often constrained by cost, infrastructure, and operational complexity. Consequently, increasing attention has been directed toward emerging detection approaches, including portable X-Ray fluorescence, Raman/SERS spectroscopy, electrochemical biosensors, electronic tongues, and in situ magnetic measurements, as complementary tools for rapid screening and field-based surveillance. Among these, environmental magnetism and in situ magnetic techniques stand out as non-destructive, low-cost proxies capable of identifying metal-associated particulate contamination linked to food production systems. Chronic dietary exposure to heavy metals is consistently associated with neurotoxicity, nephrotoxicity, carcinogenicity, and oxidative stress, underscoring the need for integrated, multi-tiered monitoring frameworks to support early detection, risk assessment, and prevention. Full article
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14 pages, 684 KB  
Article
The Association Between Adherence to the Dutch Healthy Diet Index and Glaucoma Prevalence—The Maastricht Study
by Yu Yu, Tos T. J. M. Berendschot, Simone J. P. M. Eussen, Carla J. H. van der Kallen, Carroll A. B. Webers and Wishal D. Ramdas
Nutrients 2026, 18(9), 1360; https://doi.org/10.3390/nu18091360 (registering DOI) - 25 Apr 2026
Abstract
Objectives: To investigate the association between adherence to national nutritional guidelines (Dutch Healthy Diet Index [DHD-index]) and glaucoma prevalence and to explore whether this association changed after accounting for measured intraocular pressure (IOP). Methods: This cross-sectional study used baseline data 2010–2013 from The [...] Read more.
Objectives: To investigate the association between adherence to national nutritional guidelines (Dutch Healthy Diet Index [DHD-index]) and glaucoma prevalence and to explore whether this association changed after accounting for measured intraocular pressure (IOP). Methods: This cross-sectional study used baseline data 2010–2013 from The Maastricht Study, a population-based cohort in The Netherlands. Adults aged 40–75 years with implausible dietary intake were excluded. Dietary intake was evaluated using a validated food frequency questionnaire, and adherence was quantified by the DHD-index. All participants underwent ophthalmic examination including perimetry and IOP measurement. Logistic and linear regression models examined associations of DHD adherence with glaucoma prevalence and IOP. Additional exploratory analyses assessed whether the association with glaucoma was attenuated after accounting for measured IOP. Results: Among 5729 participants (mean age: 59.5 ± 8.7 years; 50.1% female), glaucoma prevalence was 9.7% (n = 558). Each 10-point increase in DHD-index score was associated with 12.5% lower odds of glaucoma prevalence (odds ratio [OR]: 0.88; 95% confidence interval [CI], 0.83 to 0.93) and lower IOP (β: −0.17; 95% CI, −0.25 to −0.09 mmHg). Individuals in the highest DHD adherence tertile had 38% lower odds of glaucoma than those in the lowest tertile (OR 0.62; 95% CI, 0.50 to 0.76). Additional adjustment for measured IOP yielded similar estimates. Conclusions: Higher adherence to the Dutch Healthy Diet was associated with a lower glaucoma prevalence. The association was only minimally attenuated after accounting for measured IOP. Longitudinal studies should examine whether adherence to national dietary guidelines is associated with glaucoma onset and progression. Full article
(This article belongs to the Section Nutritional Epidemiology)
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15 pages, 25979 KB  
Article
Investigation of Three-Dimensional Flow Around a Model Samara Wing Depending on the Angle of Attack
by Neslihan Aydın, Ebubekir Beyazoglu and Irfan Karagoz
Biomimetics 2026, 11(5), 299; https://doi.org/10.3390/biomimetics11050299 (registering DOI) - 25 Apr 2026
Abstract
One of the engineering applications inspired by nature is bio-inspired wings. The aerodynamic properties and autorotation characteristics of samara wing models have been studied extensively using both experimental and numerical methods. However, the three-dimensional flow behavior and angle of attack interaction around a [...] Read more.
One of the engineering applications inspired by nature is bio-inspired wings. The aerodynamic properties and autorotation characteristics of samara wing models have been studied extensively using both experimental and numerical methods. However, the three-dimensional flow behavior and angle of attack interaction around a natural samara wing are not yet fully understood. This study investigates the flow behavior around a samara wing model, with the aim of underlying physics and qualitatively analyzing the flow field, as well as the aerodynamic forces and stresses. Since the samara wing and the flow around it are three-dimensional, the difficulty of experimental investigation was taken into account, and the numerical analysis was performed using Computational Fluid Dynamics techniques. The results obtained from the numerical solution of the governing equations for three-dimensional turbulent flow were verified with experimental data. The calculations were performed by varying the angle of attack of the model wing between 0 and 50 degrees at 10-degree intervals. Depending on the angle of attack, the velocity field around the wing, surface pressure, and stress distributions, vortex structures formed on the wing and streamlines were analyzed, and the results were presented. This study and its results on this model may lead to the development and optimization of the model and its use in turbines or air vehicles. Full article
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18 pages, 1084 KB  
Article
From PPG to Blood Pressure at the Edge: Quantization-Aware Architecture Selection and On-MCU Validation
by Elisabetta Leogrande, Emanuele De Luca and Francesco Dell’Olio
Sensors 2026, 26(9), 2674; https://doi.org/10.3390/s26092674 (registering DOI) - 25 Apr 2026
Abstract
Blood pressure is a central marker of cardiovascular risk, but continuous monitoring remains difficult because cuff-based measurements are intermittent and uncomfortable. Photoplethysmography (PPG) is already ubiquitous in wearables and can, in principle, enable cuffless blood pressure estimation from a single optical signal. However, [...] Read more.
Blood pressure is a central marker of cardiovascular risk, but continuous monitoring remains difficult because cuff-based measurements are intermittent and uncomfortable. Photoplethysmography (PPG) is already ubiquitous in wearables and can, in principle, enable cuffless blood pressure estimation from a single optical signal. However, many deep learning approaches that perform well in floating-point are impractical for microcontroller-class devices, where memory budgets, latency, and integer-only arithmetic constrain what can be deployed. A key open question is which neural architectures retain accuracy after full-integer quantization, rather than only under desktop inference. Here, we show an end-to-end, microcontroller-oriented evaluation framework that benchmarks multiple 1D convolutional models for cuffless systolic and diastolic pressure estimation from single-channel PPG, jointly optimizing estimation error, model footprint, and quantization robustness. We find that floating-point accuracy alone is a poor predictor of deployability: some lightweight CNNs exhibit substantial performance drift after INT8 conversion, whereas a compact residual 1D CNN preserves its predictions with near-identical error statistics after integer quantization. We then deploy the selected integer-only model on an STM32N6 microcontroller using an industrial toolchain and confirm that on-device inference maintains low bias and limited error dispersion while meeting real-time constraints for continuous operation. These results highlight architecture-dependent quantization stability as a critical design dimension for sensor-edge intelligence and support the feasibility of fully on-device cuffless blood pressure monitoring without multimodal sensing or cloud processing. Full article
(This article belongs to the Section Biomedical Sensors)
17 pages, 2303 KB  
Article
Psychoacoustic Evaluation of Shared-Bike Electronic Alert Sounds: Effects of Brand, Sound Pressure Level, and Occurrence Frequency on Annoyance
by Kaishi Meng, Linda Liang and Yang Song
Appl. Sci. 2026, 16(9), 4221; https://doi.org/10.3390/app16094221 (registering DOI) - 25 Apr 2026
Abstract
This paper examines the subjective annoyance associated with shared-bike electronic alert sounds (SBeASs), an emerging urban noise source. A study was conducted by employing extensive questionnaire surveys and psychoacoustic experiments. A preliminary survey (N = 1340) indicated that 90.6% of participants reported being [...] Read more.
This paper examines the subjective annoyance associated with shared-bike electronic alert sounds (SBeASs), an emerging urban noise source. A study was conducted by employing extensive questionnaire surveys and psychoacoustic experiments. A preliminary survey (N = 1340) indicated that 90.6% of participants reported being impacted by SBeASs, with pronounced effects on nighttime rest and daytime work efficiency. In this study, SBeAS samples were taken from three prominent Chinese bike-sharing brands: Hello Bike, Meituan Bike, and DiDi Bike. Under laboratory conditions, subjective annoyance assessments (N = 28) for SBeASs were conducted at controlled sound pressure levels (SPLs) ranging from 45 to 65 dBA, with occurrence frequencies of 1, 3, and 5 s. Simultaneously, annoyance assessments were also conducted for two reference noise types: traffic noise and street noise. The results indicated a notable increase in annoyance levels related to SBeASs with rising SPL and increased occurrence frequency. Minor variations in annoyance were identified among different bike-sharing brands, which can be attributed to their distinct acoustic features. When the SPL was above 55 dBA, the DiDi Bike SBeASs produced considerably higher annoyance than those of other brands. This can be attributed to its elevated low-frequency energy, loudness, and roughness. Moreover, individuals exhibiting increased sensitivity to noise reported notably higher annoyance ratings on the SBeAS scale (p = 0.019). Under low-SPL conditions (45–55 dBA), the annoyance attributed to frequent SBeASs can exceed that caused by traffic noise and street noise at comparable SPLs, highlighting the distinct disruptive impact of abrupt sound sources. Full article
(This article belongs to the Section Acoustics and Vibrations)
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21 pages, 4724 KB  
Article
Drought Characterization in Southern Angola Using SPI and SPEI: Implications for Impacts and Adaptation
by Pedro Lombe, Elsa Carvalho and Paulo Rosa-Santos
Land 2026, 15(5), 728; https://doi.org/10.3390/land15050728 (registering DOI) - 25 Apr 2026
Abstract
Drought in Angola is a recurrent and cyclical natural phenomenon that poses significant environmental, economic, and social challenges, affecting water resources, agriculture, ecosystems, livestock, and vulnerable communities. This study investigates the temporal evolution and spatial behavior of drought in the provinces of Cunene, [...] Read more.
Drought in Angola is a recurrent and cyclical natural phenomenon that poses significant environmental, economic, and social challenges, affecting water resources, agriculture, ecosystems, livestock, and vulnerable communities. This study investigates the temporal evolution and spatial behavior of drought in the provinces of Cunene, Huila, and Namibe over the period 1980–2024. Drought conditions were assessed using the Standardized Precipitation Index (SPI) and the Standard Precipitation–Evapotranspiration Index (SPEI) at multiple time scales. Trends were evaluated using the Modified Mann–Kendall test and Sen’s slope estimator, while drought intensity was analyzed using run theory. The results reveal a clear intensification of drought conditions in the last decade, characterized by an increase in frequency and intensity, particularly after 2010. Extreme drought events were identified in the early 1980s, the mid-1990s, and more recently in 2019 and 2021. Despite some regional variability, the three provinces exhibit consistent temporal patterns, with drought events generally occurring simultaneously over the study period. These findings highlight the increasing pressure on water and environmental systems and underscore the need for improved drought monitoring and forecasting approaches to support more effective adaptation and decision-making. Full article
(This article belongs to the Special Issue Land and Drought: An Environmental Assessment Through Remote Sensing)
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28 pages, 4969 KB  
Article
Design and Optimization of a Combined Seed Cleaning Mechanism for an Air-Suction Seed Metering Device for Small-Seed Crops with Multi-Seed Hill
by Zhiwei Wang, Yu Chen, Sugirbay Adilet, Naishuo Wei, Jianguo Zhou, Deyi Zhang, Yanwu Jiang, Yunlei Fan, Wei Zhang and Jun Chen
Sustainability 2026, 18(9), 4274; https://doi.org/10.3390/su18094274 (registering DOI) - 25 Apr 2026
Abstract
To address the severe multiple-seed pickup problem during the seed-filling process of an air-suction seed metering device for small-seed crops with multiple seeds per hill, a combined seed-cleaning mechanism consisting of an upper seven-tooth seed-cleaning device and a lower seed-cleaning blade was developed [...] Read more.
To address the severe multiple-seed pickup problem during the seed-filling process of an air-suction seed metering device for small-seed crops with multiple seeds per hill, a combined seed-cleaning mechanism consisting of an upper seven-tooth seed-cleaning device and a lower seed-cleaning blade was developed based on an analysis of the causes of multiple pickup. Mathematical models of seed motion and force were established to describe the interaction between the seven-tooth seed-cleaning device and the seed population during the cleaning process. The installation position and adjustment mechanism of the device on the seed chamber housing were determined, and its tooth-profile parameters and major operating positions were theoretically analyzed. Accordingly, the design method and calculation models for the key parameters of the seven-tooth seed-cleaning device were established. A quadratic regression orthogonal rotational combination experiment was conducted using three factors affecting cleaning performance: the distance between the apex of the first tooth and the corresponding suction hole, the operating speed of the seed metering device, and the negative pressure. Regression equations were established and response surface analysis was performed. With the seed-cleaning qualification rate as the optimization objective, the optimal parameter combinations were obtained as follows: for millet, 3.36 mm, 3.59 km/h, and 1.43 kPa; for broomcorn millet, 3.49 mm, 4.22 km/h, and 2.11 kPa; and for rapeseed, 3.15 mm, 3.73 km/h, and 1.52 kPa. To reduce the influence of random error, 200 repeated bench tests were conducted for each seed type under its corresponding optimal parameter combination at operating speeds of 2.0–5.0 km/h. The seed-cleaning qualification rates for millet, broomcorn millet, and rapeseed were all above 90%, meeting the design requirements of the seed-cleaning mechanism. This study provides a theoretical basis and technical reference for seed-cleaning mechanisms for air-suction precision seed metering devices for small-seed crops with multiple seeds per hill. Full article
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21 pages, 528 KB  
Perspective
When Urban Tourism Growth Becomes a Moral Problem: An Ethical Framework for Sustainable Urban Tourism
by Angeliki N. Menegaki
Tour. Hosp. 2026, 7(5), 120; https://doi.org/10.3390/tourhosp7050120 (registering DOI) - 25 Apr 2026
Abstract
Urban tourism is frequently promoted as a driver of regeneration, competitiveness, and local economic growth. However, its expansion increasingly generates overtourism, environmental degradation, social inequality, gentrification pressures, and cultural commodification in densely populated cities. Although existing tourism research has examined these challenges from [...] Read more.
Urban tourism is frequently promoted as a driver of regeneration, competitiveness, and local economic growth. However, its expansion increasingly generates overtourism, environmental degradation, social inequality, gentrification pressures, and cultural commodification in densely populated cities. Although existing tourism research has examined these challenges from managerial, planning, and sustainability perspectives, less attention has been paid to their ethical foundations. This conceptual paper addresses that gap by developing an integrated ethical framework for sustainable urban tourism through a structured, theory-driven synthesis of literature in environmental ethics, social justice theory, virtue ethics, and urban tourism studies. The paper makes three main contributions: it reframes urban tourism growth as a moral and normative issue rather than merely an economic one; it organizes the key ethical dilemmas of urban tourism as interconnected outcomes of growth-oriented development; and it links ethical principles to stakeholder responsibilities and desired governance outcomes. The proposed framework positions tourists, businesses, and policymakers as moral agents and identifies ecological integrity, social equity, and cultural protection as core criteria for evaluating tourism development. As a conceptual study, however, the framework remains theoretical and requires future empirical application and testing across different urban contexts. Full article
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24 pages, 4691 KB  
Article
Balancing the Energy System: Simulating a Multi-Commodity Approach to Enhance Biomethane Injection Capacity in Gas Networks
by Sander Dijk, Marten van der Laan, Bastiaan Meijer, Jerry Palmers and Joàn Teerling
Energies 2026, 19(9), 2083; https://doi.org/10.3390/en19092083 (registering DOI) - 25 Apr 2026
Abstract
Biomethane is emerging as a key renewable gas in both mature and developing energy systems worldwide. Driven by climate-neutrality objectives, energy-security concerns, and rising waste-to-energy ambitions, global biomethane production is expected to expand rapidly in the coming decade. In Europe, this growth is [...] Read more.
Biomethane is emerging as a key renewable gas in both mature and developing energy systems worldwide. Driven by climate-neutrality objectives, energy-security concerns, and rising waste-to-energy ambitions, global biomethane production is expected to expand rapidly in the coming decade. In Europe, this growth is accelerated by the REPowerEU target of 35 billion m3 by 2030. However, as biomethane production increases and natural gas demand declines over time, distribution networks face growing operational challenges, including pressure build-up and biomethane curtailment caused by supply and demand mismatches. This study evaluates whether surplus biomethane can be converted into electricity as a multi-commodity strategy to alleviate these constraints. Using hourly operational data from two Dutch Distribution System Operators (DSOs), a simulation model was developed to assess the impact of generator-based biomethane-to-power conversion on both gas and electricity distribution networks. The results show that, for RENDO, the approach increases effective biomethane injection by 49.0%, reduces natural gas deliveries from the transmission system by 20.0%, and lowers electricity imports by 9.2%. For Coteq, the corresponding impacts are 106.8%, 30.6%, and 16.2%, respectively. These findings indicate that multi-commodity coupling through biomethane-to-power conversion provides a promising strategy for increasing biomethane injection and renewable electricity generation. Full article
(This article belongs to the Special Issue 11th International Conference on Smart Energy Systems (SESAAU2025))
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16 pages, 3813 KB  
Article
Usability Evaluation and Perceived Performance of the MoonWalking® Insole in Safety Footwear
by Pedro Castro-Martins, Arcelina Marques, Luís Pinto-Coelho and Mário Vaz
Sensors 2026, 26(9), 2668; https://doi.org/10.3390/s26092668 (registering DOI) - 25 Apr 2026
Abstract
Prolonged standing and repetitive lifting are routine occupational stressors that elevate plantar pressures across workers. In those with diabetes, these demands represent additional risk factors for diabetic foot pathology, highlighting the need for ergonomic interventions beyond standard safety footwear. This study evaluated the [...] Read more.
Prolonged standing and repetitive lifting are routine occupational stressors that elevate plantar pressures across workers. In those with diabetes, these demands represent additional risk factors for diabetic foot pathology, highlighting the need for ergonomic interventions beyond standard safety footwear. This study evaluated the perceived ergonomic performance of the MoonWalking® insole, a novel adaptive pneumatic system designed for real-time pressure stabilization and offloading when integrated into safety footwear. A comparative experimental protocol tested two conditions: safety footwear with the manufacturer’s original insole and the same footwear with the MoonWalking prototype. Twenty participants assessed perceived comfort using a VAS and binary ergonomic questionnaires. The results showed statistically significant improvements in perceived cushioning, foot fit, and overall comfort when using the MoonWalking insole. Participants consistently identified pressure-stabilizing and offloading functions across all plantar regions, indicating that adaptive pressure control was clearly perceptible. No pain or movement restrictions were reported. Although perceived fatigue did not reach statistical significance, a decreasing trend was observed. A slight reduction in intention to reuse the footwear occurred with the prototype, possibly due to its increased weight. These findings provide evidence that integrating an adaptive pneumatic insole into safety footwear may improve plantar pressure redistribution and user comfort. Full article
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17 pages, 6344 KB  
Review
From Epigenetic Constraint to Evolutionary Escape: Cell-State Transitions and Selective Pressures During Malignant Transformation in Lower-Grade Gliomas
by Hao Wu, Yi Wei, Xing-Ding Zhang and Lin Qi
Biomedicines 2026, 14(5), 985; https://doi.org/10.3390/biomedicines14050985 (registering DOI) - 25 Apr 2026
Abstract
Lower-grade gliomas (LGGs) often follow a relatively protracted clinical course; however, a substantial proportion eventually undergo malignant transformation to high-grade, treatment-refractory disease. This process has traditionally been interpreted in the context of stepwise histopathologic progression and recurrent genetic alterations. Increasing evidence, however, suggests [...] Read more.
Lower-grade gliomas (LGGs) often follow a relatively protracted clinical course; however, a substantial proportion eventually undergo malignant transformation to high-grade, treatment-refractory disease. This process has traditionally been interpreted in the context of stepwise histopathologic progression and recurrent genetic alterations. Increasing evidence, however, suggests that malignant transformation is more accurately understood as an evolutionary process shaped by the interplay among epigenetic constraints, cell-state plasticity, and selective pressures. In this review, we examine current evidence supporting a model in which early LGGs, particularly isocitrate dehydrogenase (IDH)-mutant tumors, are initially maintained in relatively restricted cellular states by metabolically imposed epigenetic programs, but progressively escape these constraints under the cumulative influence of therapy, hypoxia, immune remodeling, and genomic instability. We summarize recent advances demonstrating that progression from lower-grade to high-grade disease is accompanied by cell-state transitions characterized by altered lineage identity, acquisition of stem-like features, increased proliferative capacity, and adaptation to cellular stress. We further discuss how these transitions are reinforced by microenvironmental evolution, including vascular remodeling, extracellular matrix reorganization, and changes in immune composition, thereby creating conditions that favor clonal expansion, invasion, and therapeutic resistance. Particular attention is given to longitudinal, single-cell, and spatially resolved studies, which collectively indicate that malignant transformation is not a discrete event but a continuous process of evolutionary selection and phenotypic reprogramming. Finally, we discuss the translational implications of this framework for early risk stratification, biomarker development, and mechanism-based therapeutic intervention. By reframing malignant transformation in LGGs as a process of cell-state escape under persistent selective pressure, this review aims to provide an integrated view of glioma progression and to highlight new opportunities for precision monitoring and treatment. Full article
(This article belongs to the Special Issue Brain Tumor: From Pathophysiology to Novel Therapies)
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