Brain Tumor: From Pathophysiology to Novel Therapies
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 16
Special Issue Editor
Interests: neuro-oncologia; cirurgia de tumores cerebrais com o doente acordado e mapeamento cerebral; cirurgia de tumores cerebrais com imunofluorescência; cirurgia de gliomas de baixo grau; cirurgia da epilepsia; cirurgia intracraniana; patologia da coluna vertebral
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Special Issue Information
Dear Colleagues,
Brain tumors comprise a heterogeneous group of neoplasms that pose major clinical challenges due to their location, aggressiveness, and limited treatment options. Their pathophysiology involves complex genetic and epigenetic alterations that disrupt normal signaling pathways, leading to uncontrolled cell proliferation, angiogenesis, and invasive growth into surrounding brain tissue. Glioblastoma is characterized by mutations in genes such as EGFR, PTEN, and IDH, as well as profound intratumoral heterogeneity, which contributes to therapeutic resistance and recurrence.
Standard treatment typically combines maximal safe surgical resection, radiotherapy, and temozolomide chemotherapy, but prognosis remains poor, with a median survival of around 15 months.
Population-based research is important and necessary, focused on age-specific incidence, identification of risk factors, and development of biomarkers with clinical applicability. Recent advances aim to overcome these limitations through targeted molecular therapies, immunotherapy, tumor-treating fields, and precision medicine approaches guided by genomic and transcriptomic profiling. Emerging research into the tumor microenvironment and cancer stem cells is opening new avenues for intervention. These innovations bring hope for more effective, personalized treatments, ultimately aiming to improve survival and quality of life for patients with brain tumors.
Prof. Dr. Paulo Linhares
Guest Editor
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Keywords
- glioblastoma
- immunotherapy
- molecular subtype
- radiotherapy
- molecular therapy
- emerging treatment
- drug resistance
- MRI
- immune surveillance
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