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Keywords = pressure pulse wave

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18 pages, 5712 KiB  
Article
A Fractional Fourier Transform-Based Channel Estimation and Equalization Algorithm for Mud Pulse Telemetry
by Jingchen Zhang, Zitong Sha, Lei Wan, Yishan Su, Jiang Zhu and Fengzhong Qu
J. Mar. Sci. Eng. 2025, 13(8), 1468; https://doi.org/10.3390/jmse13081468 - 31 Jul 2025
Viewed by 131
Abstract
Mud pulse telemetry (MPT) systems are a promising approach to transmitting downhole data to the ground. During transmission, the amplitudes of pressure waves decay exponentially with distance, and the channel is often frequency-selective due to reflection and multipath effect. To address these issues, [...] Read more.
Mud pulse telemetry (MPT) systems are a promising approach to transmitting downhole data to the ground. During transmission, the amplitudes of pressure waves decay exponentially with distance, and the channel is often frequency-selective due to reflection and multipath effect. To address these issues, this work proposes a fractional Fourier transform (FrFT)-based channel estimation and equalization method. Leveraging the energy aggregation of linear frequency-modulated signals in the fractional Fourier domain, the time delay and attenuation parameters of the multipath channel can be estimated accurately. Furthermore, a fractional Fourier domain equalizer is proposed to pre-filter the frequency-selective fading channel using fractionally spaced decision feedback equalization. The effectiveness of the proposed method is evaluated through a simulation analysis and field experiments. The simulation results demonstrate that this method can significantly reduce multipath effects, effectively control the impact of noise, and facilitate subsequent demodulation. The field experiment results indicate that the demodulation of real data achieves advanced data rate communication (over 12 bit/s) and a low bit error rate (below 0.5%), which meets engineering requirements in a 3000 m drilling system. Full article
(This article belongs to the Section Ocean Engineering)
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11 pages, 421 KiB  
Article
Serum p-Cresyl Sulfate Is Independently Associated with Aortic Stiffness in Non-Dialysis Chronic Kidney Disease Patients
by Yahn-Bor Chern, Ken Lee Chia, Chin-Hung Liu, Yu-Li Lin, Jen-Pi Tsai and Bang-Gee Hsu
Life 2025, 15(7), 1116; https://doi.org/10.3390/life15071116 - 16 Jul 2025
Viewed by 224
Abstract
p-Cresyl sulfate (PCS), a gut-derived uremic toxin with proinflammatory and cytotoxic effects, has been implicated in cardiovascular injuries among patients with chronic kidney disease (CKD). Aortic stiffness (AS), assessed by carotid–femoral pulse wave velocity (cfPWV), is a recognized predictor of cardiovascular risk. [...] Read more.
p-Cresyl sulfate (PCS), a gut-derived uremic toxin with proinflammatory and cytotoxic effects, has been implicated in cardiovascular injuries among patients with chronic kidney disease (CKD). Aortic stiffness (AS), assessed by carotid–femoral pulse wave velocity (cfPWV), is a recognized predictor of cardiovascular risk. This study investigated the association between serum PCS levels and AS in patients with nondialysis-dependent CKD. In total, 165 patients with nondialysis-dependent CKD were enrolled. Clinical data and fasting blood samples were collected. Arterial stiffness (AS) was assessed bilaterally by measuring carotid–femoral pulse wave velocity (cfPWV) on both the left and right sides. A value above 10 m/s was considered indicative of increased stiffness. Serum PCS levels were quantified using high-performance liquid chromatography–mass spectrometry. Fifty patients (30.3%) had AS. The AS group was significantly older and had higher diabetes prevalence, systolic blood pressure, fasting glucose, urinary protein-creatinine ratio, and PCS levels than the control group. In the multivariate analysis, both PCS (odds ratio [OR]: 1.097; 95% confidence interval [CI]: 1.024–1.175; p = 0.008) and age (OR: 1.057; 95% CI: 1.025–1.090; p < 0.001) were independently associated with AS. In conclusion, elevated serum PCS and older age were independently associated with AS. Thus, PCS is a potential early marker of vascular damage in CKD. Full article
(This article belongs to the Special Issue Advances in Vascular Health and Metabolism)
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16 pages, 1070 KiB  
Article
Validation of the HFA-ICOS Score for Carfilzomib-Induced Cardiotoxicity in Multiple Myeloma: A Real-Life Perspective Study
by Anna Astarita, Giulia Mingrone, Lorenzo Airale, Anna Colomba, Cinzia Catarinella, Marco Cesareo, Fabrizio Vallelonga, Arianna Paladino, Giulia Bruno, Dario Leone, Francesca Gay, Sara Bringhen, Franco Veglio and Alberto Milan
Cancers 2025, 17(14), 2353; https://doi.org/10.3390/cancers17142353 - 15 Jul 2025
Viewed by 264
Abstract
Background: Despite the inference about the cardiotoxicity induced by Carfilzomib, no validated risk prediction models for adverse cardiovascular events in a real-life population are available. Objectives: The aim of this study was to evaluate the performance of the risk stratification score for Carfilzomib-induced [...] Read more.
Background: Despite the inference about the cardiotoxicity induced by Carfilzomib, no validated risk prediction models for adverse cardiovascular events in a real-life population are available. Objectives: The aim of this study was to evaluate the performance of the risk stratification score for Carfilzomib-induced cardiotoxicity of the Heart Failure Association of the European Society of Cardiology and the International Cardio-Oncology Society (HFA-ICOS) in patients with multiple myeloma (MM). Methods: This is a prospective, real-world study including MM patients consecutively enrolled prior to starting Carfilzomib, divided into levels of risk according to the HFA-ICOS proforma. Results: Of 169 patients, 11.8% were classified as ‘low risk’, 38.5% as ‘medium risk’, 45.6% as ‘high risk’ and 4.1% as ‘very high risk’ at baseline. A total of 89 (52.7%) patients experienced one of the following events: 36 (21.3%) had at least one cardiovascular event and 77 (45.6%) had almost one hypertension-related event. No significant differences were observed for the incidence of any cardiovascular events between the different levels of risk (p > 0.05), even considering the HFA-ICOS score as a continuous variable. The integration of the score with the baseline systolic blood pressure and pulse wave velocity enhanced the accuracy of the score (AUC 0.557 vs. 0.736). Conclusions: The HFA-ICOS score did not discriminate between patients at low, medium and high risk, showing a limited discriminatory power in predicting the risk of events in our population. The integration of other parameters in the HFA-ICOS score, such as systolic blood pressure and pulse wave velocity, improved the performance of the score. Full article
(This article belongs to the Special Issue Cardio-Oncology: An Emerging Paradigm in Modern Medicine: 2nd Edition)
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16 pages, 611 KiB  
Article
Non-Invasive Assessment of Metabolic Dysfunction-Associated Steatotic Liver Disease and Cardiovascular Risk in Acromegaly Indicates Persistence of Cardiac Risks Despite Biochemical Disease Control
by Yusuf Karadeniz and Melia Karakose
J. Clin. Med. 2025, 14(14), 4822; https://doi.org/10.3390/jcm14144822 - 8 Jul 2025
Viewed by 275
Abstract
Background/Objectives: Acromegaly is associated with multiple metabolic comorbidities, but the relationship between disease activity and metabolic dysfunction-associated steatotic liver disease (MASLD) or cardiovascular risk remains unclear. This study aimed to assess the prevalence and severity of MASLD and liver fibrosis in patients [...] Read more.
Background/Objectives: Acromegaly is associated with multiple metabolic comorbidities, but the relationship between disease activity and metabolic dysfunction-associated steatotic liver disease (MASLD) or cardiovascular risk remains unclear. This study aimed to assess the prevalence and severity of MASLD and liver fibrosis in patients with acromegaly relative to healthy controls and explore whether disease activity influences these parameters. We also evaluated cardiovascular risk indicators in acromegaly patients. Methods: A retrospective case-control study was conducted between 2000 and 2022, involving 58 acromegaly patients and 58 healthy controls. Patients were classified as active or in biochemical remission. MASLD was assessed using the fibrosis-4 (FIB-4) index, MASLD fibrosis score, body mass index, diabetes (BARD) score, the aspartate aminotransferase-to-platelet index (APRI), and the aspartate aminotransferase-to-alanine aminotransferase ratio. Cardiovascular evaluation included pulse wave velocity (PWV) and carotid intima–media thickness (CIMT). Results: The median age of the acromegaly group was 47.5 (39–57) years, compared to 42 (40–48) years in the control group (p = 0.041). APRI (p < 0.001), FIB-4 (p < 0.001), MASLD fibrosis score (p < 0.001), and BARD score (p < 0.001) were significantly higher in the acromegaly group. The prevalence of hepatic steatosis was also higher in the acromegaly group (p < 0.001). Diastolic blood pressure (p = 0.015) and PWV (p = 0.012) were significantly higher in the acromegaly group. Conclusions: Acromegaly patients have an increased risk of MASLD and fibrosis, but this risk is unassociated with disease activity. Similarly, cardiovascular risk parameters remain elevated regardless of disease activity. These findings suggest that the systemic effects of acromegaly may persist despite biochemical control. Full article
(This article belongs to the Section Endocrinology & Metabolism)
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13 pages, 2715 KiB  
Article
AI-Induced Vascular Ages Are a Measurable Residual Risk for Cardiovascular Diseases in the Japanese Population
by Hikaru Ueno, Kotaro Uchida, Honoka Kawashima, Hiroto Hommo, Takuya Sugawara, Shintaro Minegishi, Lin Chen, Rie Sasaki-Nakashima, Tabito Kino, Kentaro Arakawa, Michiko Sugiyama, Koichi Tamura, Kiyoshi Hibi and Tomoaki Ishigami
J. Clin. Med. 2025, 14(13), 4722; https://doi.org/10.3390/jcm14134722 - 3 Jul 2025
Viewed by 420
Abstract
Background: Cardiovascular diseases (CVDs) remain a leading cause of morbidity and mortality, despite advances in treatment. Early detection of vascular aging is critical, as preclinical atherosclerosis often remains undiagnosed. AI-determined vascular age, originally developed using carotid-femoral pulse wave velocity (cf-PWV), may help to [...] Read more.
Background: Cardiovascular diseases (CVDs) remain a leading cause of morbidity and mortality, despite advances in treatment. Early detection of vascular aging is critical, as preclinical atherosclerosis often remains undiagnosed. AI-determined vascular age, originally developed using carotid-femoral pulse wave velocity (cf-PWV), may help to identify individuals at elevated risk. This study aimed to evaluate the clinical utility of an alternative AI-determined vascular age model based on the arterial velocity pulse index (AVI) and arterial pressure volume index (API) in a Japanese hospital-based cohort. Methods: This retrospective, exploratory study analyzed electronic health records of 408 patients from Yokohama City University Hospital. This study was approved by the Clinical Research Ethics Committee (approval numbers: B180300040, F240500007), and patient consent was obtained through an opt-out process. AI-determined vascular age was estimated using a Generalized Additive Model (GAM) with backward stepwise regression, substituting cf-PWV with AVI and API. Correlations with chronological age were assessed, and comparisons of cardiovascular and renal function markers were performed across age-stratified groups. Results: AI-determined vascular age showed a strong correlation with chronological age (p < 0.05). Significant differences were observed in cardiac diastolic function parameters, B-type natriuretic peptide (BNP), and estimated glomerular filtration rate (eGFR) between the highest and lowest quintiles of AI-determined vascular age. Conclusions: AI-determined vascular age using AVI and API appears to be a feasible surrogate for cf-PWV in clinical settings. This index may aid in stratifying vascular aging and identifying individuals who could benefit from early cardiovascular risk management. Full article
(This article belongs to the Section Cardiology)
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20 pages, 7186 KiB  
Article
A Novel Approach to Non-Invasive Intracranial Pressure Wave Monitoring: A Pilot Healthy Brain Study
by Andrius Karaliunas, Laimonas Bartusis, Solventa Krakauskaite, Edvinas Chaleckas, Mantas Deimantavicius, Yasin Hamarat, Vytautas Petkus, Toma Stulge, Vytenis Ratkunas, Guven Celikkaya, Ingrida Januleviciene and Arminas Ragauskas
Sensors 2025, 25(13), 4042; https://doi.org/10.3390/s25134042 - 28 Jun 2025
Viewed by 551
Abstract
Intracranial pressure (ICP) pulse wave morphology, including the ratios of the three characteristic peaks (P1, P2, and P3), offers valuable insights into intracranial dynamics and brain compliance. Traditional invasive methods for ICP pulse wave monitoring pose significant risks, highlighting the need for non-invasive [...] Read more.
Intracranial pressure (ICP) pulse wave morphology, including the ratios of the three characteristic peaks (P1, P2, and P3), offers valuable insights into intracranial dynamics and brain compliance. Traditional invasive methods for ICP pulse wave monitoring pose significant risks, highlighting the need for non-invasive alternatives. This pilot study investigates a novel non-invasive method for monitoring ICP pulse waves through closed eyelids, using a specially designed, liquid-filled, fully passive sensor system named ‘Archimedes 02’. To our knowledge, this is the first technological approach that enables the non-invasive monitoring of ICP pulse waveforms via closed eyelids. This study involved 10 healthy volunteers, aged 26–39 years, who underwent resting-state non-invasive ICP pulse wave monitoring sessions using the ‘Archimedes 02’ device while in the supine position. The recorded signals were processed to extract pulse waves and evaluate their morphological characteristics. The results indicated successful detection of pressure pulse waves, showing the expected three peaks (P1, P2, and P3) in all subjects. The calculated P2/P1 ratios were 0.762 (SD = ±0.229) for the left eye and 0.808 (SD = ±0.310) for the right eye, suggesting normal intracranial compliance across the cohort, despite variations observed in some individuals. Physiological tests—the Valsalva maneuver and the Queckenstedt test, both performed in the supine position—induced statistically significant increases in the P2/P1 and P3/P1 ratios, supporting the notion that non-invasively recorded pressure pulse waves, measured through closed eyelids, reflect intracranial volume and pressure dynamics. Additionally, a transient hypoemic/hyperemic response test performed in the upright position induced signal changes in pressure recordings from the ‘Archimedes 02’ sensor that were consistent with intact cerebral blood flow autoregulation, aligning with established physiological principles. These findings indicate that ICP pulse waves and their dynamic changes can be monitored non-invasively through closed eyelids, offering a potential method for brain monitoring in patients for whom invasive procedures are not feasible. Full article
(This article belongs to the Special Issue Integrated Sensor Systems for Medical Applications)
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13 pages, 3624 KiB  
Article
Quasi-One-Dimensional Thermodynamic Analysis of Radially Expanding Laser-Supported Detonations
by Yuma Itakura, Kyohei Kato, Kimiya Komurasaki, Hokuto Sekine and Hiroyuki Koizumi
Aerospace 2025, 12(7), 584; https://doi.org/10.3390/aerospace12070584 - 28 Jun 2025
Viewed by 281
Abstract
Repetitively pulsed (RP) laser propulsion is regarded as an alternative to chemical rockets for space launches, potentially offering remarkable cost reductions. Understanding the physics of laser-supported detonation (LSD) is important for designing a high-performance propulsion system. Experimentally observed LSD propagation velocities are reportedly [...] Read more.
Repetitively pulsed (RP) laser propulsion is regarded as an alternative to chemical rockets for space launches, potentially offering remarkable cost reductions. Understanding the physics of laser-supported detonation (LSD) is important for designing a high-performance propulsion system. Experimentally observed LSD propagation velocities are reportedly lower than the Chapman–Jouguet (C-J) velocity; hence, a previous study that examined two-dimensional expansion behind the LSD to perform Hugoniot analysis using computational fluid dynamics (CFD) simulation resulted in strong detonation solution. In the present study, the effects of varying the relationship between heating and propagation velocity are investigated using CFD simulations. The findings indicate that a weak detonation solution was obtained with more realistic input of heating rate distribution and the pressure behind the LSD wave was lower than that in C-J detonation by a factor of three. The input LSD propagation velocity was changed by ±30% in the CFD simulation to examine the case of faster propagation in helium and slower propagation in argon and even so, a weak detonation mode was maintained. However, the input relaxation distance from the electron temperature to heavy particle temperature that is shorter in a light gas such as helium can produce a solution of C-J or strong detonation. Full article
(This article belongs to the Special Issue Laser Propulsion Science and Technology (2nd Edition))
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10 pages, 783 KiB  
Article
Accelerated Plethysmography in Glaucoma Patients
by Hinako Takei, Yuto Yoshida, Misaki Ukisu, Keigo Takagi and Masaki Tanito
Biomedicines 2025, 13(7), 1542; https://doi.org/10.3390/biomedicines13071542 - 24 Jun 2025
Viewed by 429
Abstract
Background: Systemic arterial stiffness and atherosclerosis have been increasingly recognized as potential contributors to the pathogenesis of glaucoma. Several studies have reported associations between glaucoma and various surrogate markers of vascular stiffness. However, despite the growing interest in the vascular components of glaucoma, [...] Read more.
Background: Systemic arterial stiffness and atherosclerosis have been increasingly recognized as potential contributors to the pathogenesis of glaucoma. Several studies have reported associations between glaucoma and various surrogate markers of vascular stiffness. However, despite the growing interest in the vascular components of glaucoma, no previous studies have specifically explored the relationship between the indices derived from acceleration plethysmography (APG) and glaucoma. This study seeks to address this gap by investigating the potential association between APG parameters and the presence of glaucoma. Methods: The subjects were 701 patients (mean age 68.6 years, 54% male) with open-angle glaucoma (primary open-angle glaucoma [POAG] or exfoliation glaucoma [EXG]), and 94 control subjects (mean age 60.1 years, 57% male) who had no eye diseases other than cataracts. The subjects were all cases in which APG was measured using a sphygmograph (TAS9 Pulse Analyzer Plus View; YKC Corp., Tokyo, Japan). The amplitude of waveform types (a, b, c, d, and e-waves) and derived vascular types (A, B, and C) of the accelerated pulse wave components were statistically compared between the cases and controls. Results: The accelerated pulse wave components (mean ± standard deviation) of the control and glaucoma groups were a-wave 785 ± 99 and 776 ± 93 (p = 0.40), b-wave −522 ± 161 and −491 ± 143 (p = 0.050), c-wave −142 ± 108 and −156 ± 105 (p = 0.24), d-wave −288 ± 144 and −322 ± 122 (p = 0.014), and e-wave 103 ± 79 and 90 ± 58 (p = 0.059), with differences between the groups being observed in the b and d-waves. For derived vascular types, compared with the controls and POAG, patients with EXG had a lower frequency of Type A and a higher frequency of Type C than the other groups (p = 0.044). Multivariate analysis showed that factors significantly associated with vascular type included age (p < 0.0001), sex (p < 0.0001), diastolic blood pressure (p = 0.021), and pulse rate (p < 0.0001), while BMI, systolic blood pressure, history of hypertension, history of diabetes, presence or absence of glaucoma, and presence or absence of pseudoexfoliation material were not significant. Conclusions: This is the first study to investigate the relationship between APG and glaucoma with a large sample size. In elderly glaucoma patients, particularly those with EXG, systemic vascular changes are often present. APG parameters may reflect vascular alterations in glaucoma. Full article
(This article belongs to the Special Issue Glaucoma: New Diagnostic and Therapeutic Approaches, 2nd Edition)
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24 pages, 1766 KiB  
Article
An Analysis of Arterial Pulse Wave Time Features and Pulse Wave Velocity Calculations Based on Radial Electrical Bioimpedance Waveforms in Patients Scheduled for Coronary Catheterization
by Kristina Lotamõis, Tiina Uuetoa, Andrei Krivošei, Paul Annus, Margus Metshein, Marek Rist, Sulev Margus, Mart Min and Gert Tamberg
J. Cardiovasc. Dev. Dis. 2025, 12(7), 237; https://doi.org/10.3390/jcdd12070237 - 20 Jun 2025
Viewed by 359
Abstract
The monitoring of peripheral electrical bioimpedance (EBI) variations is a promising method that has the potential to replace invasive or burdensome techniques for cardiovascular measurements. Segmental or continuous recording of peripheral pulse waves can serve as a basis for calculating prognostic markers like [...] Read more.
The monitoring of peripheral electrical bioimpedance (EBI) variations is a promising method that has the potential to replace invasive or burdensome techniques for cardiovascular measurements. Segmental or continuous recording of peripheral pulse waves can serve as a basis for calculating prognostic markers like pulse wave velocity (PWV) or include parameters such as pulse transit time (PTT) or pulse arrival time (PAT) for noninvasive blood pressure (BP) estimation, as well as potentially novel cardiovascular risk indicators. However, several technical, analytical, and interpretative aspects need to be resolved before the EBI method can be adopted in clinical practice. Our goal was to investigate and improve the application of EBI, executing its comparison with other cardiovascular assessment methods in patients hospitalized for coronary catheterization procedures. Methods: We analyzed data from 44 non-acute patients aged 45–74 years who were hospitalized for coronary catheterization at East Tallinn Central Hospital between 2020 and 2021. The radial EBI and electrocardiogram (ECG) were measured simultaneously with central and contralateral pressure curves. The Savitzky–Golay filter was used for signal smoothing. The Hankel matrix decomposer was applied for the extraction of cardiac waveforms from multi-component signals. After extracting the cardiac component, a period detection algorithm was applied to EBI and blood pressure curves. Results: Seven points of interest were detected on the pressure and EBI curves, and four with good representativeness were selected for further analysis. The Spearman correlation coefficient was low for all but the central and distal pressure curve systolic upstroke time points. A high positive correlation was found between PWV measured both invasively and with EBI. The median value of complimentary pulse wave velocity (CPWV), a parameter proposed in the paper, was significantly lower in patients with normal coronaries compared to patients with any stage of coronary disease. Conclusions: With regard to wearable devices, the EBI-derived PAT can serve as a substrate for PWV calculations and cardiovascular risk assessment, although these data require further confirmation. Full article
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20 pages, 2211 KiB  
Article
Electroacoustic Comparison and Optimization of Low-Power Impulse Sound-Source Needle Series Electrodes
by Xiao Du, Jing Zhou and Xu Gao
Energies 2025, 18(13), 3230; https://doi.org/10.3390/en18133230 - 20 Jun 2025
Viewed by 240
Abstract
The high-power drive of an impulse sound source with drilling makes the system’s life short and difficult to integrate. This report firstly establishes the pulse discharge experimental system and finite element model, and compares and verifies the typical parameters. Second, the study examines [...] Read more.
The high-power drive of an impulse sound source with drilling makes the system’s life short and difficult to integrate. This report firstly establishes the pulse discharge experimental system and finite element model, and compares and verifies the typical parameters. Second, the study examines how the energy storage capacitor’s charging voltage, discharge electrode gap, and liquid environment conductivity influence the electroacoustic performance of needle series electrodes. Subsequently, the optimal electrode configuration is identified under power constraints, yielding electroacoustic parameters and curves suitable for low-power impulsive sound sources. The findings reveal that the needle–plate electrode outperforms others in pre-breakdown duration, peak impulse wave strength, highest sound pressure level, and electroacoustic conversion efficiency. However, its higher power demand can be mitigated by lowering the charging voltage and narrowing the electrode gap. The charging voltage of the power-limited needle–plate electrode is only 3.5 kV, the impulse wave intensity reaches 1.27 MPa, and the peak system power is effectively controlled within 6.66 kW. A stable 288 dB SPL output is maintained up to 1 kHz, and above 250 dB in the wide bandwidth of 1–100 kHz. Needle–plate electrodes provide broadband excitation and high intensity SPL output despite power limitations. Full article
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20 pages, 751 KiB  
Article
Crosstalk Between Metabolic Biomarkers and Pulse Wave Analysis in Hypertensive Patients
by Mirela Baba, Mihaela Ioana Maris, Adina Bucur, Daniela Jianu, Simina Mariana Moroz, Dana Stoian, Constantin Tudor Luca and Ioana Mozos
Biomedicines 2025, 13(7), 1514; https://doi.org/10.3390/biomedicines13071514 - 20 Jun 2025
Viewed by 482
Abstract
Background/Objectives: Hypertension is strongly linked to changes in vascular function and lipid metabolism. This study aimed to examine the relationship between lipid profiles, various metabolic biomarkers, and pulse wave analysis in patients with hypertension. Methods: A group of 66 hypertensive patients, aged 64 [...] Read more.
Background/Objectives: Hypertension is strongly linked to changes in vascular function and lipid metabolism. This study aimed to examine the relationship between lipid profiles, various metabolic biomarkers, and pulse wave analysis in patients with hypertension. Methods: A group of 66 hypertensive patients, aged 64 ± 10 years, participated in pulse wave analysis utilizing an oscillometric device. Multiple lipid serum biomarkers were assessed, such as total cholesterol (TC), triglycerides (TG), and non-HDL cholesterol (non-HDL). Lipid balance index (LBI) was determined by considering TG, LDL, HDL levels, and lipid-lowering medications. Results: Notable correlations were observed for SBP, DBP, and early vascular aging (EVA) with lipid biomarkers. In addition to serum lipids, metabolic syndrome, insulin resistance, and non-alcoholic fatty liver disease (NAFLD) were significantly linked to pulse wave analysis variables. Multiple regression analysis showed that only TC continued to have a significant association with DBP. Conclusions: Total cholesterol, triglycerides, non-HDL cholesterol, and lipid balance index provide information about systolic and diastolic blood pressure, as well as early vascular aging in hypertensive patients. LBI offers valuable vascular insights in hypertensive individuals with cardiovascular risk factors, early vascular aging, insulin resistance, and NAFLD. The connection between metabolic biomarkers and pulse wave measurements in individuals with hypertension offers a comprehensive method for the early identification of vascular injury and could enhance the prediction of major cardiovascular events. Full article
(This article belongs to the Special Issue Lipids and Lipid Metabolism in Cardiovascular Health and Disease)
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19 pages, 4003 KiB  
Article
The Risk to the Undersea Engineering Ecosystem of Systems: Understanding Implosion in Confined Environments
by Craig Tilton and Arun Shukla
J. Mar. Sci. Eng. 2025, 13(6), 1180; https://doi.org/10.3390/jmse13061180 - 17 Jun 2025
Viewed by 633
Abstract
As humans continue to develop the undersea engineering ecosystem of systems, the consequences of catastrophic events must continue to be investigated and understood. Almost every undersea pressure vessel, from pipelines to sensors to unmanned vehicles, has the potential to experience a catastrophic collapse, [...] Read more.
As humans continue to develop the undersea engineering ecosystem of systems, the consequences of catastrophic events must continue to be investigated and understood. Almost every undersea pressure vessel, from pipelines to sensors to unmanned vehicles, has the potential to experience a catastrophic collapse, known as an implosion. This collapse can be caused by hydrostatic pressure or any combination of external loadings from natural disasters to pressure waves imparted by other implosion or explosion events. During an implosion, high-magnitude pressure waves can be emitted, which can cause adverse effects on surrounding structures, marine life, or even people. The imploding structure, known as an implodable volume, can be in a free-field or confined environment. Confined implosion is characterized by a surrounding structure that significantly affects the flow of fluid around the implodable volume. Often, the confining structure is cylindrical, with one closed end and one open end. This work seeks to understand the effect of fluid flow restriction on the physics of implosion inside a confining tube. To do so, a comprehensive experimental study is conducted using a unique experimental facility. Thin-walled aluminum cylinders are collapsed inside a confining tube within a large pressure vessel. High-speed photography and 3D Digital Image Correlation are used to gather structural displacement and velocities during the event while an array of dynamic pressure sensors capture the pressure data inside the confining tube. The results of this work show that by changing the size of the open end, referred to as the flow area ratio, there can be a significant effect on the structural deformations and implosion severity. It also reveals that only certain configurations of holes at the open end of the tube play a role in the dynamic pressure pulse measured at the closed end of the tube. By understanding the consequences of an implosion, designers can make decisions about where these pressure vessels should be in relation to other pressure vessels, critical infrastructure, marine life, or people. In the same way that engineers design for earthquakes and analyze the impact their structures have on the environment around them, contributors to the undersea engineering ecosystem should design with implosion in mind. Full article
(This article belongs to the Section Ocean Engineering)
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12 pages, 796 KiB  
Article
Maternal Vascular Adaptation in High-Risk Pregnancies: Effects of Early Smoking Cessation on Hemodynamic and Endothelial Function
by Kaltrina Kutllovci Hasani, Mila Cervar-Zivkovic, Ursula Hiden, Adam Saloň, Manurishi Nanda, Bianca Steuber, Katharina Eberhard, Patrick De Boever, Christina Stern, Karoline Mayer-Pickel and Nandu Goswami
Int. J. Mol. Sci. 2025, 26(12), 5781; https://doi.org/10.3390/ijms26125781 - 16 Jun 2025
Viewed by 419
Abstract
Cardiovascular adaptation is vital for a healthy pregnancy but may be impaired in women at high risk for preeclampsia (PE), a condition marked by endothelial dysfunction. Smoking may lower the PE risk but harms vessels, and the effects of early cessation remain unclear. [...] Read more.
Cardiovascular adaptation is vital for a healthy pregnancy but may be impaired in women at high risk for preeclampsia (PE), a condition marked by endothelial dysfunction. Smoking may lower the PE risk but harms vessels, and the effects of early cessation remain unclear. This prospective cohort study assessed vascular changes in high-risk pregnancies and the potential influence of early smoking cessation. Of 110 women screened for PE in the first trimester, 43 were classified as high-risk: 18 former smokers and 25 lifelong non-smokers. Vascular assessments were performed at 11–16, 24–28, and 34–37 weeks of gestation. Parameters included the carotid–femoral pulse wave velocity (cfPWV), asymmetric dimethylarginine (ADMA), mean arterial pressure (MAP), systolic and diastolic blood pressure (SBP, DBP), heart rate (HR), and retinal vessel calibers (central retinal arteriolar and venular equivalents (CRAE, CRVE)). Serum cotinine confirmed abstinence in former smokers. Across gestation, ADMA (p = 0.034), MAP (p = 0.001), SBP (p = 0.033), DBP (p = 0.004), and HR (p = 0.004) increased, while CRAE (p = 0.016) and CRVE (p = 0.004) narrowed in late pregnancy; cfPWV remained stable (p = 0.783). Non-smokers showed increases in their ADMA (p = 0.020), MAP (p = 0.001), and DBP (p = 0.0001) with no differences between groups. High-risk pregnancies showed vascular changes with similar profiles in former and non-smokers, underscoring the need for broader studies. Full article
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21 pages, 1076 KiB  
Article
Adherence to Mediterranean Diet and Implications for Cardiovascular Risk Prevention
by Giulia Frank, Barbara Pala, Paola Gualtieri, Giuliano Tocci, Giada La Placa and Laura Di Renzo
Nutrients 2025, 17(12), 1991; https://doi.org/10.3390/nu17121991 - 12 Jun 2025
Cited by 1 | Viewed by 1267
Abstract
Background/Objectives:Arterial hypertension, increased carotid intima-media thickness (cIMT), and arterial stiffness (AS) are recognized predictors of cardiovascular disease (CVD). Emerging evidence suggests that vascular remodeling may precede the full development of hypertension. Furthermore, body mass index (BMI), fat mass percentage (FM%), and visceral [...] Read more.
Background/Objectives:Arterial hypertension, increased carotid intima-media thickness (cIMT), and arterial stiffness (AS) are recognized predictors of cardiovascular disease (CVD). Emerging evidence suggests that vascular remodeling may precede the full development of hypertension. Furthermore, body mass index (BMI), fat mass percentage (FM%), and visceral adipose tissue (VAT), are significant risk factors for cardiovascular events. Conversely, adherence to the Mediterranean diet is associated with reduced cardiovascular risk due to its beneficial effects on lipid metabolism, inflammation, and vascular health. Methods: This observational study explored the association between nutritional care and cardiovascular risk in 55 Italian adults (27 women, 28 men) consecutively evaluated at the Section of Clinical Nutrition and Nutrigenomics, University of Rome “Tor Vergata”, in 2024. Nutritional and vascular assessments, including BMI, waist-to-hip ratio (WHR), BIA, DXA, lab tests, blood pressure (BP), pulse wave velocity (PWV), and cIMT, were recorded. Spearman’s rank correlation coefficient was used to evaluate the relationship between vascular and nutritional parameters. Wilcoxon rank sum test; Fisher’s exact test; and Pearson’s Chi-squared test were performed for statistical analysis. Participants were divided into two groups based on cIMT > 0.90 mm and ≤0.90 mm. Results: Significant correlations emerged between higher MEDAS scores and BMI (r = −0.53, p < 0.01), FM% (r = −0.49, p < 0.01), VAT (r = −0.63, p < 0.01), and cIMT (r = −0.88, p < 0.01). Higher WHR and VAT were associated with increased brachial and central BP and PWV. Notable dietary differences were significantly higher between cIMT groups. Total cholesterol/C-HDL, C-LDL/C-HDL, the Atherogenic Index of Plasma, and the HOMA Index differed significantly between groups. Significant differences were also observed in the left ventricular diastolic function (p = 0.04), LVM/BSA, and LVM/h2.7 in individuals with subclinical atherosclerosis (p < 0.05). Conclusions: These innovative findings underline the importance of multidisciplinary approaches to prevent CVD and suggest long-term benefits of Mediterranean diet adherence on vascular health. Full article
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14 pages, 322 KiB  
Article
Serum Indoxyl Sulfate as a Potential Biomarker of Peripheral Arterial Stiffness in Patients with Non-Dialysis Chronic Kidney Disease Stages 3 to 5
by Yahn-Bor Chern, Jen-Pi Tsai, Chin-Hung Liu, Yu-Li Lin, Chih-Hsien Wang and Bang-Gee Hsu
Toxins 2025, 17(6), 283; https://doi.org/10.3390/toxins17060283 - 5 Jun 2025
Viewed by 659
Abstract
Indoxyl sulfate (IS), which is a protein-bound uremic toxin, is involved in vascular dysfunction and cardiovascular risk in subjects with chronic kidney disease (CKD). However, its role in peripheral arterial stiffness (PAS) remains unclear. This cross-sectional study evaluated the relationship between IS and [...] Read more.
Indoxyl sulfate (IS), which is a protein-bound uremic toxin, is involved in vascular dysfunction and cardiovascular risk in subjects with chronic kidney disease (CKD). However, its role in peripheral arterial stiffness (PAS) remains unclear. This cross-sectional study evaluated the relationship between IS and PAS in patients diagnosed with CKD stages 3 through 5 who are not undergoing dialysis. Patients with CKD from a single center were enrolled. High-performance liquid chromatography analyzed the serum IS levels. PAS was evaluated using brachial–ankle pulse wave velocity (baPWV). IS was independently associated with PAS (odds ratio [OR]: 1.389 for 1 μg/mL increase in IS, 95% confidence interval [CI]: 1.086–1.775, p = 0.009) in a multivariable analysis after adjustment for age, hypertension, diabetes mellitus, blood pressure, lipid profiles, renal function, albumin, and proteinuria. Moreover, the mean baPWV (p = 0.010), left baPWV (p = 0.009), and right baPWV (p = 0.015) levels significantly correlated with the log-transformed IS (log-IS) levels. The area under the receiver operating characteristic curve for serum IS as a predictor of PAS was determined to be 0.667 (95% CI: 0.580−0.754; p = 0.0002). IS was associated with PAS in non-dialysis CKD stages 3–5, suggesting that IS may be a possible vascular risk marker. Future studies should address the nature of the relationship between IS and vascular dysfunction and assess therapeutic strategies to reduce IS. Full article
(This article belongs to the Special Issue The Role of Uremic Toxins in Comorbidities of Chronic Kidney Disease)
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