4 Results Found

Advanced Search

Select all

Results per page

Select all

Article

35 Citations

4,009 Views

16 Pages

Polyphyllin II Induces Protective Autophagy and Apoptosis via Inhibiting PI3K/AKT/mTOR and STAT3 Signaling in Colorectal Cancer Cells

Jun-Kui Li,
Hai-Tao Sun,
Xiao-Li Jiang,
Yi-Fei Chen,
Zhu Zhang,
Ying Wang,
Wen-Qing Chen,
Zhang Zhang,
Stephen Cho Wing Sze and
Pei-Li Zhu
+ 1 author

Int. J. Mol. Sci.2022, 23(19), 11890;https://doi.org/10.3390/ijms231911890

6 October 2022

Polyphyllin II (PPII) is a natural steroidal saponin occurring in Rhizoma Paridis. It has been demonstrated to exhibit anti-cancer activity against a variety of cancer cells. However, the anti-colorectal cancer (CRC) effects and mechanism of action o...

Full Article

Article

5 Citations

3,294 Views

14 Pages

Disruption of Colorectal Cancer Network by Polyphyllins Reveals Pivotal Entities with Implications for Chemoimmunotherapy

Ram Siripuram,
Zinka Bartolek,
Ketki Patil,
Saj S. Gill and
S. Balakrishna Pai

Biomedicines2022, 10(3), 583;https://doi.org/10.3390/biomedicines10030583

2 March 2022

The prevalence of colorectal cancer has increased world-wide with high rates of mortality and morbidity. In the absence of efficacious drugs to treat this neoplasia, there is an imminent need to discover molecules with multifaceted effects. To this e...

Full Article

Article

4 Citations

2,472 Views

14 Pages

Response Surface Optimization for Water-Assisted Extraction of Two Saponins from Paris polyphylla var. yunnanensis Leaves

Yutian Jin,
Qing Qiao,
Linmei Dong,
Mokun Cao,
Ping Li,
Aizhong Liu and
Rui Sun

Molecules2024, 29(7), 1652;https://doi.org/10.3390/molecules29071652

6 April 2024

The process of extracting polyphyllin II and polyphyllin VII by water-assisted extraction was established and optimized in this study. Response surface methodology was used to establish a prediction model to optimize the extraction conditions. Based...

Full Article

Article

29 Citations

3,849 Views

18 Pages

Separation and Purification of Two Saponins from Paris polyphylla var. yunnanensis by a Macroporous Resin

Xiaoya Zhang,
Junli Wu,
Long Qin,
Guangxi Wang,
Ping Li,
Anmin Yu,
Aizhong Liu and
Rui Sun

Molecules2022, 27(19), 6626;https://doi.org/10.3390/molecules27196626

6 October 2022

An effective method for separating and purifying critical saponins (polyphyllin II and polyphyllin VII) from a Paris polyphylla var. yunnanensis extract was developed in this study which was environmentally friendly and economical. Static adsorption...

Full Article