African trypanosomiasis occurs in 36 countries in sub-Saharan Africa with 10,000 reported cases annually. No definitive remedy is currently available and if left untreated, the disease becomes fatal. Structural and biochemical studies of trypanosomal...
Small-molecule drug design aims to identify inhibitors that can specifically bind to a functionally important region on the target, i.e., an active site of an enzyme. Identification of potential binding pockets is typically based on static three-dime...
G protein-coupled receptors (GPCRs) are the largest class of drug targets and undergo substantial conformational changes in response to ligand binding. Despite recent progress in GPCR structure determination, static snapshots fail to reflect the conf...
Single-crystal graphene has attracted much attention due to its excellent electrical properties in recent years, and many growth methods have been proposed, including the copper pockets method. In the copper pockets method, a piece of copper foil is...
The filling-and-emptying valve and downstream shaft are crucial components of navigation-lock systems. Under insufficient downstream submergence, air can be drawn through the shaft and trapped in the post-valve culvert, altering the flow structure an...
This study presents insights into how existing faults in pipe systems, like leaks and air pockets, modify transient pressure waves in terms of shape, damping, and phase shift, based on experimental tests conducted at the Hydraulics Laboratory of the...
Objectives: The aim of this study was to evaluate the association between amniotic fluid volume at preterm prelabor rupture of membranes (PPROM) diagnosis and latency, short-term delivery risk, and perinatal outcomes across different gestational ages...
Previous studies have used magnetic resonance imaging (MRI) to quantify the fluid in the stomach and small intestine of children, and the stomach, small intestine and colon of adults. This is the first study to quantify fluid volumes and distribution...
Multidrug resistance in Pseudomonas aeruginosa is a noticeable and ongoing major obstacle for inhibitor design. In P. aeruginosa, uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) acetyltransferase (PaLpxA) is an essential enzyme of lipid A biosyn...
This paper presents the results of a study of the dynamic performance of an aerostatic thrust bearing with a microgroove and simple diaphragms. The objective of this study was to determine the influence of the lubrication gap thickness and the volume...
This paper describes the most important results of a theoretical, experimental and in situ investigation developed in connection with a water supply pumping pipeline failure. This incident occurred after power failure of the pumping system that cause...
Folate receptor alpha (FRα) is known as a biological marker for many cancers due to its overexpression in cancerous epithelial tissue. The folic acid (FA) binding affinity to the FRα active site provides a basis for designing more specific targets fo...
An experimental assessment of an air pocket (AP), confined in a compressed air vessel (CAV), has been investigated under several different water hammer (WH) events to better define the use of protection devices or compressed air energy storage (CAES)...
The beneficial effect of autologous blood products in the post-extraction period has been proven regarding acceleration of soft tissue healing, pain reduction, swelling and trismus, but data concerning bone healing are contradictory. The objective of...
30 August 2023
A hybrid two-phase flow solver is proposed, based on an Euler–Euler two-fluid model with continuous blending of a Volume-of-Fluid method when phase interfaces of coherent gas pockets are to be resolved. In a preceding study on a two-dimensional...
This paper investigates air–water interactions during a controlled filling process of an actual water pipeline using a two-dimensional Computational Fluid Dynamics (CFD) model. The main objectives are to understand the dynamic interaction of th...
Transient flows in stormwater systems can lead to damaging and dangerous operational conditions, as exemplified by geysering events created by the uncontrolled release of entrapped air pockets. Extreme rain and associated rapid inflows may result in...
The use of antiretroviral drugs is accompanied by the emergence of HIV-2 resistances. Thus, it is important to elucidate the mechanisms of resistance to antiretroviral drugs. Here, we propose a structural analysis of 31 drug-resistant mutants of HIV-...
PocketQube-class satellites have emerged as a cost-effective platform for space access; however, their extreme mass, volume, and dimensional constraints challenge conventional manufacturing approaches. This systematic review examines the state of the...
Background and Clinical Significance: The widespread use of cardiac implantable electronic devices (CIEDs) has led to an increasing number of pocket-related complications. While early hematoma and infection are common, late-onset non-infective cystic...
The P2Y12 receptor is an important member of the purinergic receptor family, known for its critical role in platelet activation and thrombosis. In our previously published study, the acridinone analogue NSC618159 was identified as a potent antagonist...
Background/Objectives: Prepectoral implant positioning has become an established option for implant-based breast reconstruction (IBBR) following a mastectomy. The impact of the implant position on the selected implant pocket thickness and the presenc...
This study investigates the transient flow dynamics and pressure interactions within Tesla valve configurations through comprehensive computational fluid dynamics (CFD) simulations. Previous observations indicated that Tesla valves effectively reduce...
Background: Innovations and advancements with implant-based breast reconstruction, such as the use of ADMs, fat grafting, NSMs, and better implants, have enabled surgeons to now place breast implants in the pre-pectoral space rather than under the pe...
Chitin deacetylases (CDAs), which catalyze the deacetylation of chitin to produce chitosan, have garnered significant interest due to their environmental compatibility and ability to control product quality. However, the low conversion efficiency res...
Pressurized pipelines are critical components in hydraulic engineering systems, including urban water supply networks and hydroelectric power plants. These systems are susceptible to air entrapment during operations such as filling and emptying, whic...
A 7224C high-speed angular contact ball bearing used in a multi-wire sawing machine is selected as the research object to investigate the cage dynamic characteristics under oil-lubricated operating conditions. First, in order to determine the oil-pha...
δ-opioid receptor (DOR) is a promising therapeutic target for developing safer treatments for pain and neuroprotection. In this study, we applied a structure-guided drug-repurposing workflow to identify FDA-approved drugs with predicted DOR-bin...
This study employs a multimethod approach to investigate the sediment distribution in two pocket beaches, Ramla Beach and Mellieha S Beach, in Malta. Both study sites were digitally reconstructed using unmanned aerial vehicle (UAV) photogrammetry. Fo...
Cytochrome P450 monooxygenases (CYPs; P450s) are a superfamily of heme-containing enzymes that are recognized for their vast substrate range and oxidative multifunctionality. CYP107 family members perform hydroxylation and epoxidation processes, prod...
The disadvantage of aerostatic bearings is their low dynamic quality. The negative impact on the dynamic characteristics of the bearing is exerted by the volume of air contained in the bearing gap, pockets, and microgrooves located at the outlet of t...
17 January 2023
Some studies have reported a significant association between periodontal condition and obesity status. We hypothesized that visceral fat area (VFA) and subcutaneous fat area (SFA) volumes might be correlated with periodontal condition. The purpose of...
Kinases play an important role in regulating various intracellular signaling pathways that control cell proliferation, differentiation, survival, and other cellular processes, and their deregulation causes more than 400 diseases. Consequently, macroc...
Infections involving cardiac implantable electronic devices (CIEDs) occur at different times after device-related procedures. The aim of this study was to investigate the timing of onset and factors influencing the occurrence of all types of CIED inf...
Predicting pump performance and ensuring operational reliability under two-phase conditions is a major goal of three-dimensional (3D) computational fluid dynamics (CFD) analysis of liquid/gas radial centrifugal pump flows. Hence, 3D CFD methods are i...
This study investigates the transient flow dynamics and pressure interactions within Tesla valve configurations through comprehensive CFD simulations. Tesla valves offer efficient passive fluid control without the need for external power, making them...
18 May 2018
The difference of smoker’s topography has been found to be a function many factors, including sex, personality, nicotine yield, cigarette type (i.e., flavored versus non-flavored) and ethnicity. We evaluated the puffing behaviors of Korean smok...
The organophosphorous hydrolase (PTE) from Brevundimonas diminuta is capable of degrading extremely toxic organophosphorous compounds with a high catalytic turnover and broad substrate specificity. Although the natural substrate for PTE is unknown, i...
Natural supersymmetry with light higgsinos is most favored to emerge from the string landscape, since the volume of a scan parameter space shrinks to tiny volumes for electroweak unnatural models. Rather general arguments favor a landscape selection...
Various implant wrapping methods with acellular dermal matrix (ADM) have been introduced, but most focus on random trimming and suturing aimed to maximize implant coverage. Here we present our clinical experience using a “tear-drop appearance&r...
In a commercial building, a significant amount of energy is used by the ventilation systems to condition the air for the indoor environments to satisfy the required quantity (temperature and humidity) and quality (amount of fresh air). For many years...
Hydraulic fracturing is used widely to stimulate coalbed methane production in coal mines. However, some factors associated with conventional hydraulic fracturing, such as the simple morphology of the fractures it generates and inhomogeneous stress r...
In axial piston pumps under variable loading, the system-level excitation and local tribological responses of the slipper pair can become temporally and spatially decoupled. The scientific contribution of this paper is a phase-consistent chain that a...
Background: According to observational studies, two polymorphisms in the apolipoprotein L1 (APOL1) gene have been linked to an increased risk of chronic kidney disease (CKD) in Africans. One polymorphism involves the substitution of two amino-acid re...
Friction is one of the most important technological phenomena and has a large influence on the flow characteristics of a deformed material. A strip drawing friction test was used to evaluate the friction characteristics of 0.8 mm thick DC04 steel she...
In this study, in order to reveal the influence mechanism of bearing parameters on pneumatic hammering, an aerostatic bearing with a multi-orifice-type restrictor is analyzed. Firstly, the flow field is investigated, and the vortex-induced excitation...
A deep understanding of oil behavior inside roller bearings is important for the precise design of bearing configurations and oil systems in aircraft engines. The numerical method is employed to track oil distribution inside cylindrical roller bearin...
This study used the strengthening grinding process (SGP) to treat the surface of 30CrMnSiA bearing steels. The effect of the jet angle of SGP on the tribological properties of 30CrMnSiA bearing steels under lubrication was investigated. The principle...
The traces of carbon fibers along the cracked surfaces of mortar prisms, being 40 mm x 40 mm x 160 mm in size, are studied, assuming that the cracked surfaces in the prisms are the places with the lowest resistance to the stresses they are exposed to...
(1) Background: Virtual screening campaigns require target structures in which the pockets are properly arranged for binding. Without these, MD simulations can be used to relax the available target structures, optimizing the fine architecture of thei...
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