Search Results (411)

Urban residents require space-efficient interventions to mitigate chronic stress. While indoor digital nature shows promise, the precise impact of interactive design parameters remains unclear. This study investigated how interactive feedback intensity (none, slow, fast) and color hue (neutral, warm, cool) influence psychological and physiological restoration. Following negative emotion induction, healthy participants engaged in within-subject conditions evaluated via multimodal assessments, including EEG, HRV, and subjective scales (PANAS, PRS, SAM/PAD). Results identified interactive feedback intensity as the primary driver of restoration. Specifically, fast feedback improved positive affect by up to 20.4% and reduced negative affect by 20.8% compared to passive self-restoration. Neurologically, interactive engagement was associated with elevated EEG alpha-band activity by up to 97.8% relative to standing controls, a pattern consistent with cortical relaxation. Furthermore, while physical interaction was uniformly associated with physiological indices broadly consistent with recovery, color hue significantly moderated subjective outcomes. Neutral and warm hues generated significantly higher overall perceived restorativeness (M = 73.18 and M = 70.14, respectively) than the self-restoration control (M = 61.26). Notably, neutral tones were uniquely associated with modest changes in HRV time-domain indices suggestive of parasympathetic autonomic modulation. These findings provide actionable, empirically validated guidelines for deploying responsive digital interventions to support mental well-being in dense urban interiors. Full article

Basal blood pressure (BP) is partly determined by systemic vascular resistance, which is modulated by vasoactive pathways, including gaseous messengers. Carbon monoxide (CO), continuously generated by the constitutive enzyme heme oxygenase-2 (HO-2) encoded by HMOX2, promotes vascular smooth muscle relaxation and may contribute to interindividual variability in resting BP. The functional single-nucleotide polymorphism rs4786504_T>C has been associated with higher HMOX2 expression in C-allele carriers, providing a plausible biological link between genetic variation in the HO-2/CO pathway and vascular redox signaling. We investigated this association in forty young, healthy, normotensive adults studied under controlled laboratory conditions during a 4-day sleep deprivation protocol, with repeated standardized daytime BP measurements (478 observations). Linear mixed-effects models were adjusted for major physiological and behavioral covariates. T-allele carriers (C/T + T/T) exhibited higher diastolic BP (β = +6.08 mmHg, 95%CI [1.32–10.84], p = 0.017) and mean arterial pressure (β = +5.28 mmHg, 95%CI [0.28–10.29], p = 0.046) than C/C homozygotes, with no effect on systolic BP or heart rate. The association remained consistent across sensitivity and additive genetic models. This hypothesis-generating study provides preliminary evidence in humans, albeit limited by sample size, of a link between a functional HMOX2 variant and resting BP, consistent with a possible contribution of constitutive HO-2 activity to BP regulation. Full article

As a core tenet of Green Urbanism, fostering social sustainability through restorative urban environments is essential for enhancing the psychological resilience of active urban generations. While urban parks are recognized as critical blue-green infrastructure, the micro-mechanisms through which their morphological configurations influence perceived restoration remain insufficiently understood. The aim of this study is to investigate how specific landscape element types and proportions in urban parks modulate the visual behavior and psychological restorative outcomes of young urban populations through a multimodal experimental approach. This study employs a novel assessment framework, integrating VR-based eye-tracking and physiological monitoring (HRV, EDA, EEG), with a sample of 77 young adults (aged 18–30) to investigate how landscape element types and proportions modulate visual behavior and restorative outcomes. The findings indicate that landscape components drive restoration through divergent visual cognitive pathways: natural elements promote recovery by fostering sustained visual engagement and exploratory saccades, whereas artificial elements function as cognitive stressors that fragment visual continuity. Mediation analysis further reveals a “quality-over-quantity” effect, demonstrating that restorative efficacy is governed by specific morphological configurations rather than mere green coverage. We identify critical restorative thresholds where the systematic reduction in artificial visibility, combined with the strategic prioritization of multi-layered vegetation and optimized sky openness, significantly maximizes restorative fascination and physiological relaxation. These evidence-based design strategies offer a precise toolkit for sustainable urban renewal, allowing urban planners to optimize the restorative quality of public spaces. By aligning micro-scale visual perception with macro-scale social sustainability goals, this research contributes to the development of resilient and health-promoting cities under the principles of Green Urbanism. Full article

Intervertebral disc degeneration is the most recognized cause of low back pain, characterized by the decline in tissue structure and mechanics. Image-based mechanical parameters (e.g., strain, stiffness) may provide an ideal assessment of disc function that is lost with degeneration, but unfortunately, these remain underdeveloped. Moreover, it is unknown whether strain or stiffness of the disc may be predicted by MRI relaxometry (e.g., T₁ or T₂), an increasingly accepted quantitative measure of disc structure. In this study, we quantified T₁ and T₂ relaxation times and compared to in-plane strains measured with displacement-encoded MRI within human cadaveric discs under physiological levels of compression and bending. Using a novel inverse approach, we then estimated shear modulus in orthogonal image planes and regionally compared these values to relaxation times and 2D strains. Intratissue strain depended on the loading mode, and shear modulus in the nucleus pulposus was typically an order of magnitude lower than the annulus fibrosus. Relative shear moduli estimated from strain data derived under compression generally did not correspond with those from bending experiments. Only one anatomical region showed a significant correlation between relative shear modulus and relaxometry (T₁ vs. µ_rel, coronal plane under bending). Together, these results suggest that future inverse analyses may be improved by incorporating multiple loading conditions into the same model and that image-based elastography and relaxometry should be viewed as complementary measures of disc structure and function to assess degeneration in future studies. Full article

Street vegetation is an important component of urban green space which plays a crucial role in promoting human well-being. To examine the impact of different types of street vegetation on individuals’ mental health, we presented two types of four street vegetation scenes in the real environment, concerning the form and species. One type consisted of random shrubs and regular shrubs. The other type consists of trees with single species and trees with diverse species. Forty participants took part in an experimental design to evaluate psychological and physiological changes before and after exposure to the street vegetation using the measures of EEG, HRV and eye movement. Our results identified that exposure to street vegetation enhanced alpha brain activity and reduced the HRV. In addition, eye movement was used to enhance restorative effects. The effect of different types of street vegetation varied significantly. It indicated that regular shrubs had a more positive effect on measures of relaxation compared with the random shrubs. The type of street vegetation of trees with diverse species had a more positive effect on measures of relaxation than the type of single species. The POMS scores of the regular shrubs decreased compared to the random shrubs and the diverse species decreased compared to the single species. The ROS scores of the regular and diverse types are higher than the random and single. The study suggests that the type manual-pruned street vegetation and the type of trees combined with plant diversity are generally more favorable in enhancing subjective comfort in the street vegetation. These findings underscore the importance of form and species in landscape planning and design to promote relaxation and comfort in the urban street environment. Full article

Low back pain is common in road cyclists and has been associated with prolonged lumbar flexion during cycling. The flexion–relaxation (FR) phenomenon reflects neuromuscular control of the lumbar spine, but its response to prolonged cycling under physiologically individualized conditions remains unclear. Thirty-one pain-free road cyclists completed a laboratory protocol in which exercise intensity was prescribed at 50% of the range between the first and second ventilatory thresholds (VT1 and VT2). Surface electromyography (sEMG) was recorded during trunk flexion extension tasks performed before and after a 60 min cycling trial. FR responses were characterized at both the individual and group levels using the flexion–relaxation ratio (FRR), descriptive classification of altered patterns, and exploratory estimates of mean change, effect size, and 95% confidence intervals. Four cyclists (12.9%; 95% CI: 3.6–29.8%) exhibited altered FR responses: three showed persistent alterations already present before cycling, and one showed an exercise-associated alteration. Group-level changes were minimal (effect sizes: −0.20 to 0.04). These findings suggest that prolonged cycling under controlled physiological load primarily reveals heterogeneous subject-specific neuromuscular patterns rather than a uniform average response. FR assessment using sEMG may therefore be useful as a complementary tool for identifying individual neuromuscular behavior in pain-free cyclists. Full article

Emotion recognition from physiological signals has immense applications in healthcare and human–computer interaction. We developed an electrodermal activity (EDA)-graph signal processing pipeline that produces highly sensitive features for detecting the affective dimensions (arousal and valence) of emotions. Using the Continuously Annotated Signals of Emotion dataset, we compared our graph-based EDA features (EDA-graph) with traditional time- and frequency-domain EDA features and features derived from other signals (heart rate variability, pulse transit time, electromyography, skin temperature, and respiration) for detecting affective dimensions using machine learning regression models. The EDA-graph features showed superior performance in continuous affective dimension recognition compared to the most accurate state-of-the-art models, achieving RMSE values of 0.801 for arousal and 0.714 for valence. Furthermore, we used a variety of traditional and recently published datasets collected in laboratory and ambulatory settings to perform a comprehensive evaluation of the robust generalization capabilities of our approach across different emotional contexts. The models demonstrated exceptional performance in classifying emotional states across the datasets, achieving 98.2% accuracy in detecting positive, negative, and mixed emotions; 92.75% in discriminating between emotions (relaxed, amused, bored, scared, and neutral); and 86.54% in detecting stress vs. no stress. These results highlight the potential of a graph-based analysis of EDA in emotion recognition systems in different contexts, especially for real-world applications. Full article

Stress states are increasing with global urbanization, but evidence on the physiological impact of urban blue-space exposure remains limited compared to green spaces. In this randomized within-subject crossover study, we examined the physiological effects of seascape viewing from the 29th floor of an office building in 44 healthy young adults. Each participant underwent visual stimulation with a seascape window view (blue space) and a blind-covered window (control) for 90 s each after a 60 s rest. Prefrontal cortex activity was recorded using near-infrared spectroscopy, and the left–right difference (LRD) in Δoxy-Hb concentrations was used as an indicator. Autonomic nervous system activity was assessed using heart rate variability, and psychological outcomes were measured using a semantic differential scale and the Profile of Mood States—2 short form. Seascape viewing significantly increased LRD, indicating left-dominant prefrontal activation relative to the control. It also increased comfort and relaxation and improved mood states. Correlation analyses showed that LRD was positively correlated with comfort and relaxation. These findings suggest that intentional window-view design, including exposure to high-rise blue-space views, represents a promising environmental approach to support occupants’ well-being and provide practical implications for window-view design and operation in high-rise office environments. Full article

Background and Clinical Significance: Deep thalamic and periventricular lesions are uncommon in adults but can result in significant loss of function because of their convergence on three interdependent processes: thalamocortical state regulation, throughput of periventricular long association systems, and ventricular compartmental compliance. The resulting combination of executive control collapse, retrieval-weighted language fragility, and load-sensitive gait instability may occur early after a lesion forms an atrial/posterior horn interface, and pressure-linked autonomic symptoms may be late to develop. Screening deficits will likely be minimal and therefore underreported. Objective/Aim: To present a thalamic–atrial/posterior horn tumor case with quantified load-sensitive cognitive–language–gait dysfunction and to detail a physiology-guided, sequence-driven decompression approach emphasizing ventricular relaxation and perforator-preserving, interface-limited thalamic resection. Case Presentation: A 56-year-old female patient experienced a 3-month, rapidly progressive decline in her cognitive and language abilities. The clinical progression was not stepwise or punctuated by a single “sentinel” event. She had a moderate level of cognitive impairment consistent with both Broca’s and Wernicke’s aphasias (MoCA: 22/30) and suffered from significant interference effects and increased cost of task-switching. Her ability to generate novel responses and name objects was significantly impaired; however, she was able to repeat words and phrases appropriately. In addition, she exhibited a severe sustained attention signature and a high error rate during dual-task performance, indicating severe gait instability, although her overall global anchors were nearly neutral (GCS 15; FOUR 15/16; NIHSS 2). Nausea and vomiting occurred simultaneously with the cognitive and language decline, suggesting decreased intracranial compliance. MRI revealed a heterogeneous left-sided thalamic tumor extending into the posterior horn of the lateral ventricle. The tumor caused deformation of the lateral ventricle and midline displacement. The patient underwent microsurgical intervention using a physiology-conscious sequence of graded cerebrospinal fluid (CSF) equilibration and primary mechanical removal of the tumor from the ventricular system. Additionally, decompression of the thalamus was performed in a manner that was cognizant of the boundaries formed by the perforating arteries of the thalamus. Early resolution of pressure symptoms was noted postoperatively. Objective measures demonstrated significant improvement in the patient’s executive functioning, language skills, attentional errors, and dual-task performance stability. The patient remained functionally independent at discharge and at subsequent follow-up visits. Surveillance imaging did not demonstrate any evidence of tumor recurrence. Conclusions: The clinical presentation described above is supportive of a model in which the synergy between deep network damage and distortion of the posterior ventricular compartment amplifies network dysfunction. Additionally, the use of quantitative stress-phenotyping makes it possible to identify deep network pathology early in its course. Finally, the physiology-guided decompression approach that was used in this case has the potential to increase functional reserve in patients with pathology that requires millimeter transitions. Full article

Although windows are known to modulate occupant well-being, the specific capacity of window dimensions to alleviate stress requires deeper empirical validation. To address this, we evaluated 36 young, healthy subjects (aged 20–27) within a virtual office configured with four window-to-wall ratios (WWR: 0%, 25%, 50%, and 75%). Stress levels were quantified by integrating subjective evaluations with EEG time–frequency domains and microstate transitions. The results demonstrated that windowed conditions consistently elevated subjective comfort ratings and α-wave activity, reflecting enhanced psychological relaxation. Notably, measured brain activity exhibited a peak at 0% WWR and a global minimum at 50% WWR, suggesting a potential physiological threshold for maximum relaxation within the tested demographic. Subsequent microstate analysis confirmed that windowed environments extended the duration of states B (visual processing), C (saliency network), and D (attention orientation), alongside increased transition shifts from state A to B and from state B to C. Utilizing these extracted physiological biomarkers, a developed neural network model predicted human comfort with 78.79% accuracy. Ultimately, these preliminary findings indicate that optimized window scaling can measurably mitigate urban stress, providing a data-driven theoretical framework for architectural design. Full article

Short auditory cues in enclosed built environments (such as elevator calls, access control, navigation, and heating, ventilation, and air conditioning (HVAC) notifications) influence not only usability but also stress and perceptions of well-being in daily indoor life. However, acoustic research remains largely focused on physical properties, and the psychophysiological impact of such short auditory cues remains under-quantified. To address this gap, a neuroscience-based evaluation approach, the Acoustic User Experience and Emotion (AUEX) model, is proposed. This model integrates functional near-infrared spectroscopy (fNIRS), electrodermal activity (EDA), and the User Experience Questionnaire (UEQ). With 33 in-cabin prompt sounds as a controlled typology of short auditory cues in an enclosed setting, we set up a simulated interaction experiment with 20 participants in a driving simulator vehicle cabin to investigate the relationship between acoustic properties and cognitive load, arousal, and user experience. The results show that timbre is the key factor, which was correlated positively with overall UX (r = 0.414) and negatively with prefrontal ΔHbO (CH3: r = −0.368; l-DLPFC: r = −0.449), indicating a decrease in cognitive load and a relaxed affective state. Conversely, high-frequency signals improved pragmatic quality but increased physiological arousal, which negatively affected hedonic assessment. To facilitate the translation of evaluation results into practice, we also completed a design phase that converted the AUEX results into scenario-based parameter targets and prototype designs for functional, warning, and brand/affective cues, illustrating how evidence-based relationships can be translated into design-ready outputs for enclosed built environments. These results confirm the AUEX approach as a transferable method for designing short auditory cues for well-being and provide parameter-level implications for therapeutic and human-centered sound design in smart buildings, intelligent vehicles, and other enclosed built environments. Overall, the AUEX approach provides a transferable evaluation-to-design workflow for short auditory cues in enclosed interactive contexts; however, direct generalization from a single controlled vehicle cabin setting to real-world building environments should be validated through future field studies. Accordingly, the present findings are positioned as evidence from a controlled enclosed case rather than universal conclusions for all enclosed spaces. Full article

University campus green spaces function as critical microcosms of urban building environments, directly advancing Sustainable Development Goals 3 (Good Health and Well-being) and 11 (Sustainable Cities and Communities) through evidence-based landscape design. Taking a large university in China as the research object, this study integrates virtual reality (VR) simulations with synchronized psychophysiological measurements and perceptual scales to quantify how three planting modes—clustered, scattered, and regular—influence restorative experiences across teaching, living, and administrative areas. Rigorous data processing ensured robustness. The results revealed functional-area-specific restoration pathways: clustered planting enhanced relaxation in living zones, scattered planting elevated vitality in teaching areas, and regular planting reinforced security perception in administrative spaces. A path model was used to elucidate how four-dimensional (4D) landscape indicators (openness, pleasantness, diversity, focus) mediate psychological and physiological responses. Theoretically, this 4D framework translates abstract restorative experiences into operable design dimensions; methodologically, VR-based multi-source measurement offers a replicable technical pathway for scheme verification; practically, it serves as a quantitative tool for planting optimization. Critically, these campus-derived insights offer transferable design principles for enhancing well-being across urban building environments, delivering a replicable VR-assisted framework that directly contributes to sustainable cities through human-centered, evidence-based landscape solutions. Full article

Background/Objectives: Anesthesia for intracranial neurosurgery presents unique challenges because of the sensitivity of the brain to perioperative physiological disturbances, yet neuroanesthetic practice remains highly variable and supported by a limited high-level evidence base. We conducted a scoping review to map and characterize multicenter randomized controlled trials (RCTs) evaluating perioperative management strategies in adults undergoing intracranial neurosurgery. Methods: This scoping review was reported in accordance with the PRISMA extension for Scoping Reviews. MEDLINE, PubMed, EMBASE, Cochrane Central, and Web of Science were searched from inception to 25 June 2025. Multicenter RCTs enrolling adults undergoing intracranial neurosurgery and evaluating anesthetic, hemodynamic, ventilatory, or perioperative interventions were included. We prioritized mapping multicenter designs for their greater external validity and implementation potential. Data were extracted in duplicate and summarized descriptively. Results: Of 417 records identified, 13 multicenter trials (≥2 recruiting sites) involving 2765 participants across nine countries from 1997–2025 were included. Most trials evaluated anesthetic maintenance or opioid regimens (7/13), followed by post-craniotomy pain control (3/13), ventilation/brain relaxation strategies (1/13), antiemetic prophylaxis (1/13), and temperature management (1/13). Outcomes were predominantly short-term and process-based (hemodynamics 7/13, opioid use 7/13, emergence metrics 5/13). Patient-centered outcomes were rarely measured (mortality 1/13, functional neurological outcome 1/13, cognitive outcome 1/13; quality of life 0/13). Only one trial assessed outcomes at ≥72 h postoperatively. Over half of the included trials were judged at high risk of bias. Conclusions: Multicenter RCT activity in neuroanesthesia remains sparse and narrowly focused, highlighting the need for larger, methodologically robust trials targeting patient-centered and long-term outcomes. Full article

Urban mental health burdens are increasing, prompting interest in how nearby green spaces aid emotional restoration. Bamboo-dominant green spaces are widespread in East Asia, but evidence connecting their management and structural features to restorative experiences is limited. This study conducted a controlled photo-exposure experiment in Ya’an, China, to examine how bamboo space typology and structural attributes relate to visual attention, affective responses, and short-term physiological recovery. One hundred and twenty participants viewed 50 photographs representing five bamboo space types (ecological conservation, productive–economic, protective–greenbelt, landscape–recreational, and understory–composite). Each image was linked to a matched field plot, enabling integration of structural indicators with eye tracking, EEG β/α, and repeated ratings of relaxation, pleasure, and preference. Results showed that landscape–recreational spaces received the highest affective ratings, while understory–composite spaces had longer fixations, indicating higher visual processing demands. Vertical stratification and groundcover coverage were robust predictors of affect beyond typology. Eye-movement metrics did not mediate structure–affect associations, and EEG β/α, as an auxiliary and context-dependent indicator under brief photo-based exposure, showed limited sensitivity. These findings offer insights into structural elements that can inform the design and management of bamboo green spaces for improved emotional restoration. Full article

Lavender essential oil (LEO) is commonly used in aromatherapy for stress reduction, relaxation and recovery from (muscle) fatigue. However, molecular mechanisms underlying its potential physiological effects on the skeletal muscle remain unclear. This study investigates whether LEO affects the intracellular signaling pathways in skeletal muscle cells that respond to physical activity. Prior to the experiment, GC-MS analysis confirmed linalyl acetate and linalool as the main components of LEO used in this study. Transdermal permeability was assessed using a reconstructed human epidermis model, which showed that linalool permeated the epidermal layer, while linalyl acetate showed minimal permeation. Following this confirmation, the differentiated C2C12 myotubes were treated with LEO in an in vitro muscle contraction model using electrical pulse stimulation (EPS). LEO significantly increased Interleukin 6 (IL-6) mRNA expression under EPS, and DNA whole-genome microarray analysis showed that LEO induced different gene expression profiles depending on the contraction state of the muscle cells. These results provide the first molecular evidence that LEO modulates skeletal muscle gene networks in a stimulation-dependent manner and may indicate its potential use as an aid to recovery (from fatigue) after exercise. Notably, the skin permeation of LEO components showed a saturation trend at concentrations above 5%, suggesting the presence of an optimal concentration range for topical application in sports aromatherapy. Full article