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51,734 Results Found

  • Article
  • Open Access
5 Citations
3,606 Views
8 Pages

In this study, we observed physiological reactions of premature infants during sponge bathing in the neonatal intensive care unit (NICU). The infants’ body temperature, heart rate, and oxygen saturation were monitored to examine hypothermia risks dur...

  • Review
  • Open Access
9 Citations
8,576 Views
12 Pages

Physiologic Insulin Resensitization as a Treatment Modality for Insulin Resistance Pathophysiology

  • Frank Greenway,
  • Brian Loveridge,
  • Richard M. Grimes,
  • Tori R. Tucker,
  • Michael Alexander,
  • Scott A. Hepford,
  • Justin Fontenot,
  • Candi Nobles-James,
  • Carol Wilson and
  • Jonathan R. T. Lakey
  • + 3 authors

8 February 2022

Prevalence of type 2 diabetes increased from 2.5% of the US population in 1990 to 10.5% in 2018. This creates a major public health problem, due to increases in long-term complications of diabetes, including neuropathy, retinopathy, nephropathy, skin...

  • Review
  • Open Access
27 Citations
6,885 Views
20 Pages

Leptin is a well-known hunger-sensing peptide hormone. The role of leptin in weight gain and metabolic homeostasis has been explored for the past two decades. In this review, we have tried to shed light upon the impact of leptin signaling on health a...

  • Article
  • Open Access
8 Citations
3,502 Views
13 Pages

Distinction of Physiologic and Epileptic Ripples: An Electrical Stimulation Study

  • Jan Schönberger,
  • Anja Knopf,
  • Kerstin Alexandra Klotz,
  • Matthias Dümpelmann,
  • Andreas Schulze-Bonhage and
  • Julia Jacobs

Ripple oscillations (80–250 Hz) are a promising biomarker of epileptic activity, but are also involved in memory consolidation, which impairs their value as a diagnostic tool. Distinguishing physiologic from epileptic ripples has been particularly ch...

  • Review
  • Open Access
194 Citations
20,469 Views
30 Pages

Dietary Proteins as Determinants of Metabolic and Physiologic Functions of the Gastrointestinal Tract

  • Alireza Jahan-Mihan,
  • Bohdan L. Luhovyy,
  • Dalia El Khoury and
  • G. Harvey Anderson

11 May 2011

Dietary proteins elicit a wide range of nutritional and biological functions. Beyond their nutritional role as the source of amino acids for protein synthesis, they are instrumental in the regulation of food intake, glucose and lipid metabolism, bloo...

  • Article
  • Open Access
1 Citations
2,140 Views
21 Pages

FGFR4 Is Required for Concentric Growth of Cardiac Myocytes during Physiologic Cardiac Hypertrophy

  • Isaac Campos,
  • Beatrice Richter,
  • Sarah Madison Thomas,
  • Brian Czaya,
  • Christopher Yanucil,
  • Dominik Kentrup,
  • Abul Fajol,
  • Qing Li,
  • Stephen M. Secor and
  • Christian Faul

Fibroblast growth factor (FGF) 23 is a bone-derived hormone that promotes renal phosphate excretion. Serum FGF23 is increased in chronic kidney disease (CKD) and contributes to pathologic cardiac hypertrophy by activating FGF receptor (FGFR) 4 on car...

  • Review
  • Open Access
150 Citations
21,698 Views
35 Pages

10 January 2023

The phospholipase A2 (PLA2) superfamily of phospholipase enzymes hydrolyzes the ester bond at the sn-2 position of the phospholipids, generating a free fatty acid and a lysophospholipid. The PLA2s are amphiphilic in nature and work only at the water/...

  • Review
  • Open Access
1 Citations
294 Views
8 Pages

The mind-body problem represents one of the most debated topics in the neurosciences. From a psychological standpoint, abstract/non-material data are an intrinsic part of the mind, intervening to a large extent in reasoning and decision making proces...

  • Article
  • Open Access
1,177 Views
19 Pages

Integrating Physiologic Assessment into Virtual Reality-Based Pediatric Pain Intervention: A Feasibility Study

  • Harsheen Marwah,
  • Stefania R. Moldovanu,
  • Talis Reks,
  • Brian Anthony and
  • Deirdre E. Logan

This feasibility study explored the integration of physiological monitoring into a virtual reality (VR) intervention for pediatric pain management. The goal of this study is to identify a feasible strategy for collecting physiologic data in the conte...

  • Article
  • Open Access
11 Citations
4,320 Views
10 Pages

Kynurenic Acid and Its Analogs Are Beneficial Physiologic Attenuators in Bdelloid Rotifers

  • Zsolt Datki,
  • Zita Galik-Olah,
  • Zsuzsanna Bohar,
  • Denes Zadori,
  • Ferenc Fulop,
  • Istvan Szatmari,
  • Bence Galik,
  • Janos Kalman and
  • Laszlo Vecsei

10 June 2019

The in vivo investigation of kynurenic acid (KYNA) and its analogs is one of the recent exciting topics in pharmacology. In the current study we assessed the biological effects of these molecules on bdelloid rotifers (Philodina acuticornis and Adinet...

  • Review
  • Open Access
11 Citations
10,302 Views
11 Pages

A Receptor Story: Insulin Resistance Pathophysiology and Physiologic Insulin Resensitization’s Role as a Treatment Modality

  • Stanley T. Lewis,
  • Frank Greenway,
  • Tori R. Tucker,
  • Michael Alexander,
  • Levonika K. Jackson,
  • Scott A. Hepford,
  • Brian Loveridge and
  • Jonathan R. T. Lakey

Physiologic insulin secretion consists of an oscillating pattern of secretion followed by distinct trough periods that stimulate ligand and receptor activation. Apart from the large postprandial bolus release of insulin, β cells also secrete sma...

  • Review
  • Open Access
8 Citations
2,453 Views
28 Pages

Multivariate Modelling and Prediction of High-Frequency Sensor-Based Cerebral Physiologic Signals: Narrative Review of Machine Learning Methodologies

  • Nuray Vakitbilir,
  • Abrar Islam,
  • Alwyn Gomez,
  • Kevin Y. Stein,
  • Logan Froese,
  • Tobias Bergmann,
  • Amanjyot Singh Sainbhi,
  • Davis McClarty,
  • Rahul Raj and
  • Frederick A. Zeiler

20 December 2024

Monitoring cerebral oxygenation and metabolism, using a combination of invasive and non-invasive sensors, is vital due to frequent disruptions in hemodynamic regulation across various diseases. These sensors generate continuous high-frequency data st...

  • Review
  • Open Access
49 Citations
8,894 Views
33 Pages

Towards Physiologic Culture Approaches to Improve Standard Cultivation of Mesenchymal Stem Cells

  • Ilias Nikolits,
  • Sabrina Nebel,
  • Dominik Egger,
  • Sebastian Kreß and
  • Cornelia Kasper

13 April 2021

Mesenchymal stem cells (MSCs) are of great interest for their use in cell-based therapies due to their multipotent differentiation and immunomodulatory capacities. In consequence of limited numbers following their isolation from the donor tissue, MSC...

  • Article
  • Open Access
9 Citations
5,183 Views
13 Pages

20 August 2022

Competitive indoor climbing has increased in popularity at the youth, collegiate, and Olympic levels. A critical aspect for improving performance is characterizing the physiologic response to different climbing strategies (e.g., work/rest patterns, p...

  • Systematic Review
  • Open Access
504 Views
15 Pages

Re-Evaluating the Progesterone Challenge Test as a Physiologic Marker of Endometrial Cancer Risk: A Systematic Review and Meta-Analysis

  • Rachel J. Woima,
  • Derek S. Chiu,
  • Elise Abi Khalil,
  • Sabine El-Halabi,
  • Andrea Neilson,
  • Laurence Bernard,
  • Jessica N. McAlpine and
  • Aline Talhouk

Background/Objectives: With the rising incidence of obesity-related endometrial cancer, there is renewed interest in physiologic, low-cost approaches to identify women with hormonally active endometrium who may benefit from early preventive intervent...

  • Review
  • Open Access
9 Citations
4,449 Views
14 Pages

Effect of N95 Respirator on Oxygen and Carbon Dioxide Physiologic Response: A Systematic Review and Meta-Analysis

  • Kampanat Wangsan,
  • Ratana Sapbamrer,
  • Wachiranun Sirikul,
  • Jinjuta Panumasvivat,
  • Vithawat Surawattanasakul and
  • Pheerasak Assavanopakun

During the COVID-19 pandemic, N95 respirators were commonly used in many situations. Respiratory problems from prolonged use of respirators were discussed in many studies, which show varied results. From the inconclusive results, the current systemat...

  • Article
  • Open Access
12 Citations
3,778 Views
17 Pages

Metabolic Tumor Microenvironment Characterization of Contrast Enhancing Brain Tumors Using Physiologic MRI

  • Andreas Stadlbauer,
  • Franz Marhold,
  • Stefan Oberndorfer,
  • Gertraud Heinz,
  • Max Zimmermann,
  • Michael Buchfelder,
  • Elisabeth Heynold and
  • Thomas M. Kinfe

29 September 2021

The tumor microenvironment is a critical regulator of cancer development and progression as well as treatment response and resistance in brain neoplasms. The available techniques for investigation, however, are not well suited for noninvasive in vivo...

  • Article
  • Open Access
15 Citations
4,375 Views
25 Pages

Agro-Physiologic Responses and Stress-Related Gene Expression of Four Doubled Haploid Wheat Lines under Salinity Stress Conditions

  • Ibrahim Al-Ashkar,
  • Walid Ben Romdhane,
  • Rania A. El-Said,
  • Abdelhalim Ghazy,
  • Kotb Attia and
  • Abdullah Al-Doss

14 January 2021

Salinity majorly hinders horizontal and vertical expansion in worldwide wheat production. Productivity can be enhanced using salt-tolerant wheat genotypes. However, the assessment of salt tolerance potential in bread wheat doubled haploid lines (DHL)...

  • Review
  • Open Access
1,855 Views
18 Pages

Physiologic Lymphedema Surgery: Current Treatments and Future Trends

  • Ethan L. MacKenzie,
  • Anne Huang,
  • Min-Jeong Cho,
  • Roman J. Skoracki and
  • Rohini L. Kadle

Lymphedema is a chronic, progressive, and debilitating disease of the lymphatic system with no current cure. Physiologic procedures, which address the underlying pathophysiology of lymphatic dysfunction, have gained traction in both treatment and pre...

  • Article
  • Open Access
3,488 Views
16 Pages

24 December 2021

Environmental Physiology at Boise State University, Idaho, is a multidisciplinary course that expands students’ understanding of human regulatory physiology through acute and chronic responses to environmental extremes. Students explore the phy...

  • Review
  • Open Access
1 Citations
2,650 Views
29 Pages

7 July 2025

Driver monitoring systems (DMSs) are increasingly important for road safety, aiming to reduce driver-caused accidents. Traditional DMSs, focusing on behavioral and observable signals, lack the sensitivity to detect changes in the driver’s healt...

  • Review
  • Open Access
11 Citations
5,091 Views
15 Pages

Primary cell culture is a powerful model system to address fundamental questions about organismal physiology at the cellular level, especially for species that are difficult, or impossible, to study under natural or semi-natural conditions. Due to th...

  • Article
  • Open Access
12 Citations
6,709 Views
20 Pages

This paper proposes a real-time emotion recognition system that utilizes photoplethysmography (PPG) and electromyography (EMG) physiological signals. The proposed approach employs a complex-valued neural network to extract common features from the ph...

  • Article
  • Open Access
30 Citations
5,678 Views
17 Pages

Concepts and New Implements for Modified Physiologically Equivalent Temperature

  • Yung-Chang Chen,
  • Wei-Nai Chen,
  • Charles C.-K. Chou and
  • Andreas Matzarakis

30 June 2020

Different kinds of thermal indices have been applied in several decades as essential tools to investigate thermal perception, environmentally thermal conditions, occupant thermal risk, public health, tourist attractiveness, and urban climate. Physiol...

  • Review
  • Open Access
28 Citations
5,870 Views
15 Pages

7 August 2015

Determination of the humaneness of methods used to produce unconsciousness in animals, whether for anesthesia, euthanasia, humane slaughter, or depopulation, relies on our ability to assess stress, pain, and consciousness within the contexts of metho...

  • Review
  • Open Access
248 Citations
14,368 Views
23 Pages

A Systematic Review of Physiological Measures of Mental Workload

  • Da Tao,
  • Haibo Tan,
  • Hailiang Wang,
  • Xu Zhang,
  • Xingda Qu and
  • Tingru Zhang

Mental workload (MWL) can affect human performance and is considered critical in the design and evaluation of complex human-machine systems. While numerous physiological measures are used to assess MWL, there appears no consensus on their validity as...

  • Review
  • Open Access
759 Citations
44,131 Views
41 Pages

A Review of Emotion Recognition Using Physiological Signals

  • Lin Shu,
  • Jinyan Xie,
  • Mingyue Yang,
  • Ziyi Li,
  • Zhenqi Li,
  • Dan Liao,
  • Xiangmin Xu and
  • Xinyi Yang

28 June 2018

Emotion recognition based on physiological signals has been a hot topic and applied in many areas such as safe driving, health care and social security. In this paper, we present a comprehensive review on physiological signal-based emotion recognitio...

  • Review
  • Open Access
9 Citations
5,094 Views
17 Pages

Human–robot collaboration has emerged as a prominent research topic in recent years. To enhance collaboration and ensure safety between humans and robots, researchers employ a variety of methods. One such method is physiological computing, whic...

  • Review
  • Open Access
12 Citations
8,176 Views
14 Pages

18 February 2019

Coronary angiography has been the principle modality for assessing the severity of atherosclerotic coronary artery disease for several decades. However, there is a complex relationship between angiographic coronary stenosis and the presence or absenc...

  • Review
  • Open Access
27 Citations
8,837 Views
13 Pages

The Circadian Physiology: Implications in Livestock Health

  • Hao Li,
  • Kaiqi Li,
  • Kexin Zhang,
  • Yanwei Li,
  • Haotian Gu,
  • Haoyu Liu,
  • Zhangping Yang and
  • Demin Cai

20 February 2021

Circadian rhythms exist in almost all types of cells in mammals. Thousands of genes exhibit approximately 24 h oscillations in their expression levels, making the circadian clock a crucial regulator of their normal functioning. In this regard, enviro...

  • Review
  • Open Access
11 Citations
4,421 Views
13 Pages

Biomechatronics (bionics) is an applied science that creates interdisciplinary bonds between biology and engineering. The lower gastrointestinal (GI) tract is difficult to study but has gained interest in recent decades from a bionics point of view....

  • Article
  • Open Access
31 Citations
3,325 Views
13 Pages

The Physiological Restorative Role of Soundscape in Different Forest Structures

  • Xin-Chen Hong,
  • Shi Cheng,
  • Jiang Liu,
  • Emily Dang,
  • Jia-Bing Wang and
  • Yuning Cheng

15 November 2022

Natural soundscape is considered a dominant type of hearing in forested areas and contributes to health and recovery effects from exposure to the biophilic outdoor environment. This study focuses on the different forest structures, and aims to explor...

  • Review
  • Open Access
40 Citations
12,463 Views
22 Pages

Diabetic Proteinuria Revisited: Updated Physiologic Perspectives

  • Samuel N. Heyman,
  • Itamar Raz,
  • Jamie P. Dwyer,
  • Roni Weinberg Sibony,
  • Julia B. Lewis and
  • Zaid Abassi

18 September 2022

Albuminuria, a hallmark of diabetic nephropathy, reflects not only injury and dysfunction of the filtration apparatus, but is also affected by altered glomerular hemodynamics and hyperfiltration, as well as by the inability of renal tubular cells to...

  • Article
  • Open Access
176 Views
11 Pages

Physiological Noise in Cardiorespiratory Time-Varying Interactions

  • Dushko Lukarski,
  • Dushko Stavrov and
  • Tomislav Stankovski

19 January 2026

The systems in nature are rarely isolated and there are different influences that can perturb their states. Dynamic noise in physiological systems can cause fluctuations and changes on different levels, often leading to qualitative transitions. In th...

  • Review
  • Open Access
213 Citations
21,189 Views
39 Pages

Deep Learning in Physiological Signal Data: A Survey

  • Beanbonyka Rim,
  • Nak-Jun Sung,
  • Sedong Min and
  • Min Hong

11 February 2020

Deep Learning (DL), a successful promising approach for discriminative and generative tasks, has recently proved its high potential in 2D medical imaging analysis; however, physiological data in the form of 1D signals have yet to be beneficially expl...

  • Feature Paper
  • Review
  • Open Access
32 Citations
9,670 Views
16 Pages

Why Seed Physiology Is Important for Genebanking

  • Katherine J. Whitehouse,
  • Fiona R. Hay and
  • Charlotte Lusty

2 May 2020

Genebank management is a field in its own right; it is multifaceted, requiring a diverse set of skills and knowledge. Seed physiology is one area that is critical to the successful operation of seed genebanks, requiring understanding of seed quality...

  • Systematic Review
  • Open Access
1 Citations
3,098 Views
18 Pages

Morpho-Physiological Adaptations of Rice Cultivars Under Heavy Metal Stress: A Systematic Review and Meta-Analysis

  • Esmeth C. Espinola,
  • Monica Maricris N. Cabreros and
  • Mark Christian Felipe R. Redillas

27 January 2025

Soil contamination, including in rice fields, arises from a variety of natural processes and anthropogenic activities, leading to an accumulation of heavy metals. While extensive research has addressed the bioaccumulation of heavy metals in rice, onl...

  • Article
  • Open Access
6 Citations
2,343 Views
19 Pages

Multi-Angle Detection of Spatial Differences in Tea Physiological Parameters

  • Dandan Duan,
  • Longyue Chen,
  • Chunjiang Zhao,
  • Fan Wang and
  • Qiong Cao

8 February 2023

Chlorophyll and nitrogen contents were used as leaf physiological parameters. Based on multispectral images from multiple detection angles and the stoichiometric data of tea (Camellia sinensis) leaves in different positions on plants, the spatial dif...

  • Review
  • Open Access
3 Citations
3,938 Views
25 Pages

26 October 2021

Calcineurin, also known as protein phosphatase 2B, is a heterodimeric serine threonine phosphatase involved in numerous signaling pathways. During the past 50 years, calcineurin has been the subject of extensive investigation. Many of its cellular an...

  • Review
  • Open Access
14 Citations
23,517 Views
12 Pages

There is increasing debate as to whether transwoman athletes should be included in the elite female competition. Most elite sports are divided into male and female divisions because of the greater athletic performance displayed by males. Without the...

  • Proceeding Paper
  • Open Access
3,151 Views
8 Pages

GPCRs of Diverse Physiologic and Pathologic Effects with Fingerprints in COVID-19

  • Reza Nejat,
  • Ahmad Shahir Sadr,
  • Maziar Fayaz Torshizi and
  • David J. Najafi

G-protein-coupled receptors (GPCR) belong to a large family of molecules eliciting different responses to a variety of signaling molecules. These receptors participate in various physiological functions such as metabolism, growth, immune responses, i...

  • Review
  • Open Access
294 Citations
48,942 Views
17 Pages

Humans have evolved into what they are today after the passage of 6–7 million years. If we define the beginning of urbanization as the rise of the industrial revolution, less than 0.01% of our species’ history has been spent in modern surroundings. H...

  • Feature Paper
  • Article
  • Open Access
2 Citations
2,677 Views
17 Pages

Towards a Physiological Modeling of Sweet Cherry Blossom

  • Frank-M. Chmielewski and
  • Klaus-Peter Götz

For several years, there has been a need in phenological modeling to better account for physiological processes during the winter dormancy of woody plants, which is here addressed to the sweet cherry cultivar ‘Summit’ (Prunus avium L.). T...

  • Review
  • Open Access
182 Citations
23,174 Views
23 Pages

Contact with nature has been proposed as a solution to achieve physiological relaxation and stress recovery, and a number of scientific verification outcomes have been shown. Compared with studies of the other senses, studies investigating the visual...

  • Article
  • Open Access
7 Citations
3,529 Views
13 Pages

The Role of Interventional Irisin on Heart Molecular Physiology

  • Foad Alzoughool,
  • Mohammad Borhan Al-Zghoul,
  • Bayan Y. Ghanim,
  • Michael Gollob,
  • Nasir Idkaidek and
  • Nidal A. Qinna

Irisin, encoded by the FNDC5 (fibronectin type III domain containing 5) gene, is a novel myokine that has been implicated as an essential mediator of exercise benefits. Effects of irisin on heart physiology is still ambiguous. This study aimed to eva...

  • Review
  • Open Access
152 Views
21 Pages

Coronary Physiology Across the Whole Spectrum of Ischemic Heart Disease

  • Ciro Pollio Benvenuto,
  • Luigi Cappannoli,
  • Andrea Viceré,
  • Vincenzo Viccaro,
  • Simona Todisco,
  • Chiara Giuliana,
  • Faisal Sharif and
  • Domenico Galante

6 February 2026

Acute and Chronic Coronary Syndromes represent two major medical challenges and are the leading cause of cardiovascular mortality and morbidity. While Chronic Coronary Syndrome (CCS) can be defined as the whole group of structural and/or functional a...

  • Article
  • Open Access
186 Citations
20,983 Views
26 Pages

Detecting Moments of Stress from Measurements of Wearable Physiological Sensors

  • Kalliopi Kyriakou,
  • Bernd Resch,
  • Günther Sagl,
  • Andreas Petutschnig,
  • Christian Werner,
  • David Niederseer,
  • Michael Liedlgruber,
  • Frank H. Wilhelm,
  • Tess Osborne and
  • Jessica Pykett

3 September 2019

There is a rich repertoire of methods for stress detection using various physiological signals and algorithms. However, there is still a gap in research efforts moving from laboratory studies to real-world settings. A small number of research has ver...

  • Article
  • Open Access
13 Citations
16,409 Views
16 Pages

Effects of Fasting on the Physiological and Psychological Responses in Middle-Aged Men

  • Krzysztof Stec,
  • Karol Pilis,
  • Wiesław Pilis,
  • Paweł Dolibog,
  • Sławomir Letkiewicz and
  • Alicja Głębocka

3 August 2023

Tracking changes in the body during fasting takes into account indicators of mental well-being and physiological parameters. The aim of the study was to measure psychological and physiological reactions, along with their mutual relations, caused by 8...

  • Article
  • Open Access
55 Citations
9,508 Views
25 Pages

Physiological signals are the most reliable form of signals for emotion recognition, as they cannot be controlled deliberately by the subject. Existing review papers on emotion recognition based on physiological signals surveyed only the regular step...

  • Systematic Review
  • Open Access
42 Citations
13,940 Views
21 Pages

Implementation of Thermal Camera for Non-Contact Physiological Measurement: A Systematic Review

  • Martin Clinton Tosima Manullang,
  • Yuan-Hsiang Lin,
  • Sheng-Jie Lai and
  • Nai-Kuan Chou

23 November 2021

Non-contact physiological measurements based on image sensors have developed rapidly in recent years. Among them, thermal cameras have the advantage of measuring temperature in the environment without light and have potential to develop physiological...

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