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Review

323 Citations

18,751 Views

17 Pages

Roles of Oxidative Stress, Apoptosis, PGC-1α and Mitochondrial Biogenesis in Cerebral Ischemia

Shang-Der Chen,
Ding-I Yang,
Tsu-Kung Lin,
Fu-Zen Shaw,
Chia-Wei Liou and
Yao-Chung Chuang

Int. J. Mol. Sci.2011, 12(10), 7199-7215;https://doi.org/10.3390/ijms12107199

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21 October 2011

The primary physiological function of mitochondria is to generate adenosine triphosphate through oxidative phosphorylation via the electron transport chain. Overproduction of reactive oxygen species (ROS) as byproducts generated from mitochondria hav...

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Article

3 Citations

3,379 Views

14 Pages

Cudratricusxanthone A Inhibits Lipid Accumulation and Expression of Inducible Nitric Oxide Synthase in 3T3-L1 Preadipocytes

Hyo-Shin Kwon,
Gil-Saeng Jeong and
Byeong-Churl Jang

Int. J. Mol. Sci.2021, 22(2), 505;https://doi.org/10.3390/ijms22020505

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6 January 2021

Cudratricusxanthone A (CTXA) is a natural bioactive compound extracted from the roots of Cudrania tricuspidata Bureau and has been shown to possess anti-inflammatory, anti-proliferative, and hepatoprotective activities. However, at present, anti-adip...

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Article

6 Citations

2,714 Views

13 Pages

Protective Action of Betulinic Acid on Cerebral Ischemia/Reperfusion Injury through Inflammation and Energy Metabolic Homeostasis

Wenjiao Jiang and
Kun Hao

Appl. Sci.2020, 10(7), 2578;https://doi.org/10.3390/app10072578

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9 April 2020

This work evaluated the protective effects of betulinic acid (BA) in vitro cerebral ischemia/reperfusion and provides clues about its pharmacological mechanism. A rat model of middle cerebral artery occlusion (MCAO) was established to investigate the...

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