Search Results (211)

Background/Objectives: Gut-derived tryptophan (Trp) metabolites play important roles in metabolic and cardiovascular regulation. Although animal studies suggest their protective effects against metabolic dysfunction, data in adolescents, particularly those with obesity, remain limited. The objective of this study was to evaluate associations between circulating gut-derived Trp metabolites and markers of cardiometabolic, vascular, and platelet health in adolescents with obesity. Methods: Data were analyzed from 28 adolescents (ages 13–18; mean BMI = 36 ± 6.4 kg/m²). Fasting blood was collected to assess lipid profiles using a clinical analyzer and insulin resistance using the homeostatic model assessment for insulin resistance (HOMA-IR). Gut-derived Trp metabolites were measured by UPLC–mass spectrometry, peak oxygen uptake (VO_{2 peak}) by gas exchange during an incremental cycle ergometer test, and body composition by dual-energy X-ray absorptiometry. Platelet spare respiratory capacity (SRC), endothelial function, and liver fat were measured using high-resolution respirometry, flow-mediated dilation (FMD) of the brachial artery, and magnetic resonance imaging respectively. Results: Indole-3-propionic acid was inversely associated with diastolic blood pressure (rho = −0.39, p = 0.047), total cholesterol (rho = −0.55, p = 0.002), and LDL-C (rho = −0.57, p = 0.0014), independent of sex and obesity severity. Indoxyl sulfate was positively correlated with fasting glucose (rho = 0.47, p = 0.012), and adolescents with impaired fasting glucose had 1.6-fold higher IS levels. Indole-3-acetaldehyde declined with age (rho = −0.50, p = 0.007), and Indole-3-acetic acid and indole were higher in Hispanics vs. non-Hispanics. No significant associations were observed between Trp metabolites and FMD, VO₂ peak, or SRC. Conclusions: Gut-derived Trp metabolites, particularly indole-3-propionic and indoxyl sulfate, are associated with markers of cardiometabolic risk in adolescents with obesity. These findings support their potential relevance in early-onset cardiovascular disease risk. Full article

The Eastern Huang–Huai region of China is a representative mining area with a high groundwater level. High-intensity underground mining activities have not only induced land cover and land use changes (LUCC) but also significantly changed the watershed hydrological behavior. This study integrated the land use prediction model PLUS and the hydrological simulation model MIKE 21. Taking the Bahe River Watershed in Huaibei City, China, as an example, it simulated the hydrological response trends of the watershed in 2037 under different land use scenarios. The results demonstrate the following: (1) The land use predictions for each scenario exhibit significant variation. In the maximum subsidence scenario, the expansion of water areas is most pronounced. In the planning scenario, the increase in construction land is notable. Across all scenarios, the area of cultivated land decreases. (2) In the maximum subsidence scenario, the area of high-intensity waterlogging is the greatest, accounting for 31.35% of the total area of the watershed; in the planning scenario, the proportion of high-intensity waterlogged is the least, at 19.10%. (3) In the maximum subsidence scenario, owing to the water storage effect of the subsidence depression, the flood peak is conspicuously delayed and attains the maximum value of 192.3 m³/s. In the planning scenario, the land reclamation rate and ecological restoration rate of subsidence area are the highest, while the regional water storage capacity is the lowest. As a result, the total cumulative runoff is the greatest, and the peak flood value is reduced. The influence of different degrees of subsidence on the watershed hydrological behavior varies, and the coal mining subsidence area has the potential to regulate and store runoff and perform hydrological regulation. The results reveal the mechanism through which different land use scenarios influence hydrological processes, which provides a scientific basis for the territorial space planning and sustainable development of coal mining subsidence areas. Full article

This study was conducted through in vivo and in vitro experiments and aimed to reveal the regulatory effect of water extract of Artemisia annua L. (WEAA) on the antioxidant function of mutton sheep and the underlying mechanism. In the in vivo experiment, 32 Dorper × Han female sheep (3 months old; avg. body weight: 24 ± 0.09 kg) were allocated to four groups (eight lambs/group) and fed a diet containing 0, 500, 1000, and 1500 mg/kg WEAA, respectively. In the in vitro experiments, peripheral blood lymphocytes (PBLs) were cultured with different doses of WEAA (0, 25, 50, 100, 200, 400 µg/mL) to determine the optimal concentration, followed by a 2 × 2 factorial experiment with four treatment groups (six replicates per treatment group): the ML385(−)/WEAA(−) group, the ML385(−)/WEAA(+) group, the ML385(+)/WEAA(−) group, and the ML385(+)/WEAA(+) group. The results showed that WEAA supplementation dose-dependently increased serum, liver and spleen tissue total antioxidant capacity, glutathione peroxidase (GSH-Px), and catalase (CAT) activity while reducing malondialdehyde level (p < 0.05). Moreover, WEAA supplementation significantly upregulated the liver and spleen expression of nuclear factor erythroid 2-related factor 2, superoxide dismutase 2, GSH-Px, CAT and NAD(P)H quinone dehydrogenase 1 (p < 0.05) while significantly downregulating the kelch-like ECH associated protein 1 expression in a dose-dependent manner (p < 0.05), thereby activating the Keap1/Nrf2 pathway with the peak effect observed in the 1000 mg/kg WEAA group. Additionally, supplementation with 100 µg/mL of WEAA had significant antioxidation activity in the culture medium of PBLs. Its action mechanism involved the Keap1/Nrf2 pathway; specifically, WEAA exerted its antioxidant effect by upregulating the gene expression related to the Keap1/Nrf2 pathway. In conclusion, WEAA enhances sheep’s antioxidant capacity by up-regulating Keap1/Nrf2 pathway genes and boosting antioxidant enzyme activity. The results provided experimental support for the potential application of WEAA in intensive mutton sheep farming. Full article

This study investigates the dynamic response mechanisms of discharge capacity in the Han River Estuary to hydrological process changes at the Yangtze–Han River confluence. By constructing a one-dimensional hydrodynamic model for the 265 km Xinglong–Hankou reach, we quantitatively decouple the synergistic effects of riverbed scouring (mean annual incision rate: 0.12 m) and Three Gorges Dam (TGD) operation through four orthogonal scenarios. Key findings reveal: (1) Riverbed incision dominates discharge variation (annual mean contribution >84%), enhancing flood conveyance efficiency with a peak flow increase of 21.3 m³/s during July–September; (2) TGD regulation exhibits spatiotemporal intermittency, contributing 25–36% during impoundment periods (September–October) by reducing Yangtze backwater effects; (3) Nonlinear interactions between drivers reconfigure flow paths—antagonism occurs at low confluence ratios (R < 0.15, e.g., Cd increases to 45 under TGD but decreases to 8 under incision), while synergy at high ratios (R > 0.25) reduces Hanchuan Station flow by 13.84 m³/s; (4) The 180–265 km confluence-proximal zone is identified as a sensitive area, where coupled drivers amplify water surface gradients to −1.41 × 10⁻³ m/km (2.3× upstream) and velocity increments to 0.0027 m/s. The proposed “Natural/Anthropogenic Dual-Stressor Framework” elucidates estuary discharge mechanisms under intensive human interference, providing critical insights for flood control and trans-basin water resource management in tide-free estuaries globally. Full article

Against the backdrop of the increasing penetration rate of new energy year by year, power systems face a continuously growing demand for flexibility. Under the structure of such a new power system, it is essential not only to introduce diverse flexible power sources but also to explore the flexible regulation capabilities of existing conventional power sources. To fully utilize the flexibility of thermal power units (TPUs), this study proposes a real-time optimal scheduling strategy for a wind–thermal energy-storage integrated system with an adaptive time division and variable objectives. Based on the evaluation results of the real-time flexible supply–demand relationship within a regional power grid, the operation modes of TPUs are categorized into three types: economic mode, peak shaving mode, and coordination mode. For each operation mode, corresponding optimization objectives are defined, and an energy storage control strategy is developed to assist in the peak shaving of TPUs. While effectively harnessing the flexibility of TPUs, the proposed method reduces both the frequency and capacity of TPUs entering deep peak shaving. Using data from a province in Northwest China as a case study, simulation calculations and analyses demonstrate that the proposed method increases renewable energy consumption by 314.37 MWh while decreasing system economic benefits by CNY 129,000. Compared with traditional scheduling methods for TPUs to accommodate renewable energy, the system benefit increases by CNY 297,000, and an additional 13.53 MWh of peak wind power is accommodated. These results confirm that the proposed scheduling strategy can significantly enhance the system’s ability to integrate new energy while maintaining its economic efficiency. Full article

As a crucial manifestation of ecosystem water regulation and supply functions, water conservation plays a vital role in regional ecosystem development and sustainable water resource management. This study investigates nine major Chinese river basins (Songliao, Haihe, Huaihe, Yellow, Yangtze, Pearl, Southeast Rivers, Southwest Rivers, and Inland Rivers) through integrated application of the InVEST model and geographical detector model. We systematically examine the spatiotemporal heterogeneity of water conservation capacity and its driving mechanisms from 1990 to 2020. The results reveal a distinct northwest–southeast spatial gradient in water conservation across China, with lower values predominating in northwestern regions. Minimum conservation values were recorded in the Inland River Basin (15.88 mm), Haihe River Basin (42.07 mm), and Yellow River Basin (43.55 mm), while maximum capacities occurred in the Pearl River Basin (483.68 mm) and Southeast Rivers Basin (517.21 mm). Temporal analysis showed interannual fluctuations, peaking in 2020 at 130.98 mm and reaching its lowest point in 2015 at 113.04 mm. Precipitation emerged as the dominant factor governing spatial patterns, with higher rainfall correlating strongly with enhanced conservation capacity. Land cover analysis revealed superior water retention in vegetated areas (forests, grasslands, and cultivated land) compared to urbanized and bare land surfaces. Our findings demonstrate that water conservation dynamics result from synergistic interactions among multiple factors rather than single-variable influences. Accordingly, we propose that future water resource policies adopt an integrated management approach addressing climate patterns, land use optimization, and socioeconomic factors to develop targeted conservation strategies. Full article

The hard-seed coat of Ormosia henryi significantly impedes germination efficiency in massive propagation, while conventional physical dormancy-breaking methods often result in compromised seed vigor, asynchronous seedling emergence, and diminished stress tolerance. Seed biopriming, an innovative technique involving the inoculation of beneficial microorganisms onto seed surfaces or into germination substrates, enhances germination kinetics and emergence uniformity through microbial metabolic functions and synergistic interactions with seed exudates. Notably, spermosphere-derived functional bacteria isolated from native spermosphere soil demonstrate superior colonization capacity and sustained bioactivity. This investigation employed selective inoculation of these indigenous functional strains to systematically analyze dynamic changes in endogenous phytohormones, enzymatic activities, and storage substances during critical germination phases, thereby elucidating the physiological mechanisms underlying biopriming-enhanced germination. The experimental results demonstrated significant improvements in germination parameters through biopriming. Inoculation with the Bacillus sp. strain achieved a peak germination rate (76.19%), representing a 16.19% increase over the control (p < 0.05). The biopriming treatment effectively improved the seed vigor, broke the impermeability of the seed coat, accelerated the germination speed, and positively regulated physiological indicators, especially amylase activity and the ratio of gibberellic acid to abscisic acid. This study establishes a theoretical framework for microbial chemotaxis and rhizocompetence in seed priming applications while providing an eco-technological solution for overcoming germination constraints in O. henryi cultivation. The optimized biopriming protocol addresses both low germination rates and post-germination growth limitations, providing technical support for the seedling cultivation of O. henryi. Full article

As urbanization accelerates and urban hydrological cycles evolve, roof typology emerges as a pivotal role in water retention capacity and drainage efficiency. To systematically evaluate the influence of various roof types on urban hydrological processes, this study designed four distinct catchment scenarios: Thiessen Polygon Scenarios (TS), Roof Type Consideration Scenarios (RS), Full Flat-Roof Scenarios (FS), and Full Pitched-Roof Scenarios (PS). This study employed the Urban Flood Intelligent Model (UFIM) to simulate urban flooding scenarios, utilizing precipitation data from 21 August 2024 combined with four distinct return periods (1a, 5a, 10a, and 20a) as hydrological inputs. The results show that roof types significantly affected hydrological processes in urban communities. Flat roofs accumulate water and drain slowly, making it easy to form larger areas of accumulated water during peak rainfall periods, thereby increasing the risk of urban flooding. Pitched roofs drain quickly but experience a brief rise in water level during peak hours due to rapid drainage. Based on these insights, priority should be given to the use of sloped roof design in areas prone to accumulated water to accelerate drainage. In areas requiring runoff mitigation, the strategic integration of flat roofs with green roofs enhances rainwater retention capacity, thereby optimizing urban hydrological regulation and bolstering flood resilience. Full article

With the expansion of the scale of high-proportion wind and solar power grid connections, the problems of abandoned wind and solar power and insufficient peak shaving have become increasingly prominent. The electric–hydrogen coupling system has greater potential in flexible regulation, providing a new technological approach for the consumption of new energy. This paper proposes a two-layer optimization model for an electricity–hydrogen coupled distributed power generation system. The model is based on the collaborative regulation of flexible loads by electrolytic cells and fuel cells. Through the collaborative optimization of capacity configuration and operation scheduling, it breaks through the strong dependence of traditional systems on the distribution network and enhances the autonomous consumption capacity of new energy. The upper-level optimization model aims to minimize the total life-cycle cost of the system, and the lower-level optimization model aims to minimize the system’s operating cost. The capacity configuration of each module before and after the integration of flexible loads is compared. The simulation results show that the integration of flexible loads can not only effectively reduce the level of wind and solar power consumption in distributed power generation systems, but also play a role in load peak shaving and valley filling. At the same time, it can effectively reduce the system’s peak electricity purchase and sale cost and reduce the system’s dependence on the distribution network. Based on this, with the premise of meeting the load demand, the capacity configuration results of each module were compared when connecting electrolytic cells of different capacities. The results show that the simulated area has the best economic benefits when connected to a 4 MW electrolytic cell. This optimization model can increase the high wind and solar power consumption rate by 23%, reduce the peak purchase and sale cost of electricity by 40%, and achieve an economic benefit coefficient of up to 0.097. Full article

To clarify the response mechanisms of soil nematodes as bioindicators of ecosystem health to precipitation variations in loess hilly forests, this study investigated soil nematodes in pure Populus hopeiensis forests across different precipitation gradients in Wuqi County. Through soil physicochemical analysis and high-throughput sequencing of soil nematodes, we analyzed the characteristics of soil nematode communities and their responses to precipitation variation. The results demonstrated the following: (1) Dominant genera and trophic groups of soil nematodes were significantly influenced by precipitation, with Acrobeloides prevailing across all gradients while Paratylenchus reached maximum abundance (26.8%) in moderate precipitation zones. (2) Bacterivorous nematodes prevailed in both low- and high-precipitation zones, while herbivorous nematodes constituted the highest proportion in moderate precipitation zones. The abundances of herbivorous and fungivorous nematodes exhibited an initial increase followed by a decrease with rising precipitation, whereas predatory–omnivorous nematodes displayed the opposite trend. (3) The Chao1 and Shannon indices of soil nematodes initially increased and then decreased with increasing precipitation, reaching a peak in the Jinfoping site. Moreover, there were significant differences in nematode community structure among different precipitation gradients. (4) Redundancy analysis and PLS-PM modeling identified soil water content (SWC), total nitrogen (TN), and capillary water holding capacity (CWHC) as key drivers of nematode communities. Precipitation indirectly regulated nematode functionality by modifying soil physicochemical properties and microbial activity. (5) Ecological function analysis revealed bacterial-dominated organic matter decomposition (Nematode Channel Ratio, NCR > 0.75) in the Changcheng and Baibao sites, contrasting with fungal channel predominance (NCR < 0.75) in Jinfoping. This research elucidates the mechanism whereby precipitation drives nematode community divergence through regulating soil physicochemical properties and microbial activity. The findings provide scientific basis for soil biodiversity conservation and ecological restoration benefit assessment in regional ecological restoration projects, and soil health management and sustainable land use in agricultural ecosystems. Full article

This study aimed to reveal the characteristics of returned water in paddy fields at different scales and the rules of its reuse in China’s Ganfu Plain Irrigation District through multiscale (field, lateral canal, main canal, small watershed) observations, thereby optimizing water resource management and improving water use efficiency. Subsequent investigations during the 2021–2022 double-cropping rice seasons revealed that the tillering stage emerged as a critical drainage period, with 49.5% and 52.2% of total drainage occurring during this phase in early and late rice, respectively. Multiscale drainage heterogeneity displayed distinct patterns, with early rice following a “decrease-increase” trend while late rice exhibited “decrease-peak-decline” dynamics. Smaller scales (field and lateral canal) produced 37.1% higher drainage than larger scales (main canal and small watershed) during the reviving stage. In contrast, post-jointing-booting stages showed 103.6% higher drainage at larger scales. Return flow utilization peaked at the field-lateral canal scales, while dynamic regulation of Fangxi Lake’s storage capacity achieved 60% reuse efficiency at the watershed scale. We propose an integrated optimization strategy combining tillering-stage irrigation/drainage control, multiscale hydraulic interception (control gates and pond weirs), and dynamic watershed storage scheduling. This framework provides theoretical and practical insights for enhancing water use efficiency and mitigating non-point source pollution in plain irrigation districts. Full article

Electricity market reforms and decreasing technology costs have propelled residential solar PV growth leading distribution network operators to face operational challenges including reverse power flows and voltage regulation during peak solar generation. Traditional mono-facial south-facing PV systems concentrate production at midday when demand may be low, leading to high curtailment, especially for downstream households. This study proposes vertically installed east–west-facing bifacial PV systems (BiE and BiW), characterized by two energy peaks (morning and evening), which are better aligned with residential demand and alleviate grid constraints. Using load flow simulations, the performance of vertical bifacial configurations was compared against mono-facial systems across PV capacities from 1 to 20 kW. Fairness in curtailment was evaluated at 10 kW using Jain’s fairness index, the Gini index, and the Curtailment index. Simulation results show that BiE and BiW installations, especially at higher capacities, not only generate more energy but also are better at managing curtailment. At 10 kW, BiE and BiW increased bid energies by 815 kWh and 787 kWh, and reduced curtailed energy by 1566 kWh and 1499 kWh, respectively. These findings highlight the potential of bifacial PV installations in mitigating curtailment and improving fairness in energy distribution, supporting the demand for residential PV systems. Full article

As the integration of renewable energy sources continues to increase, thermal power units are increasingly required to enhance their operational flexibility to accommodate grid fluctuations. However, frequent load variations in conventional thermal power plants result in decreased efficiency, accelerated equipment wear, and high operational costs. In this context, molten-salt thermal energy storage (TES) has emerged as a promising solution due to its high specific heat capacity and thermal stability. By enabling the storage of surplus energy and its regulated release during peak demand periods, molten salt TES contributes to improved grid stability, reduced start-up frequency, and minimized operational disturbances. This study employs comprehensive thermodynamic simulations to investigate three representative schemes for heat storage and release. The results indicate that the dual steam extraction configuration (Scheme 3) offers the highest thermal storage capacity and peak-load regulation potential, albeit at the cost of increased heat consumption. Conversely, the single steam extraction configurations (Scheme 1 and 2) demonstrate improved thermal efficiency and reduced system complexity. Furthermore, Scheme 3, which involves extracting feedwater from the condenser outlet, provides enhanced operational flexibility but necessitates a higher initial investment. These findings offer critical insights into the optimal integration of molten-salt thermal-storage systems with conventional thermal power units. The outcomes not only highlight the trade-offs among different design strategies but also support the broader objective of enhancing the efficiency and adaptability of thermal power generation in a renewable-dominated energy landscape. Full article

Under the dual carbon objectives, wind power penetration has accelerated markedly. However, the inherent volatility and insufficient peak regulation capability in energy storage allocation hamper efficient grid integration. To address these challenges, this paper presents a hybrid storage capacity configuration method that combines Symplectic Geometry Mode Decomposition (SGMD) with Particle Swarm Optimization (PSO). SGMD provides fine-grained, multi-scale decomposition of load–power curves to reduce modal aliasing, while PSO determines globally optimal ESS capacities under peak-shaving constraints. Case-study simulations showed a 25.86% reduction in the storage investment cost compared to EMD-based baselines, maintenance of the state of charge (SOC) within 0.3–0.6, and significantly enhanced overall energy management efficiency. The proposed framework thus offers a cost-effective and robust solution for energy storage at renewable energy plants. Full article

With the spread of electric vehicles (EVs), the EV load will have a significant impact on the planning and operation of the grid and the operation of the electricity market. Due to the charging and discharging characteristics of EVs, as well as their randomness and dispersion, it is feasible and challenging to introduce EV loads into the grid as a means of frequency regulation and peak shaving of the power system. In this paper, considering multi-subject distribution networks and the interaction of source–grid–load–storage with Intelligent Transportation Systems (ITS), a density peak clustering (DPC) algorithm based on principal component analysis is employed to analyze the spatial and temporal characteristics of EV loads and identify the access status of EV charging stations and EV load status in each region in real time, as well as analyze the adjustable capacity and adjustable range of EV loads. Based on the adjustable capacity of the EV load, the optimization objectives include the maximum regulation of the EV load and the most economical operation cost. An accurate load regulation strategy based on automatic active control (APC) is proposed to reduce the maximum frequency deviation by 25% by integrating the load regulation of electric vehicles into the original AGC frequency regulation. At the same time, the feasibility of electric vehicles in peaking and standby scenarios is studied and verified through simulation cases, which can reduce the peak value of thermal power generation by 15% and 10% in the morning and evening. Full article