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Article

11 Citations

4,418 Views

20 Pages

Two Beats One: Osteosarcoma Therapy with Light-Activated and Chemo-Releasing Keratin Nanoformulation in a Preclinical Mouse Model

Elisa Martella,
Barbara Dozza,
Claudia Ferroni,
Clement Osuru Obeyok,
Andrea Guerrini,
Daniele Tedesco,
Ilse Manet,
Giovanna Sotgiu,
Marta Columbaro and
Serena Duchi
+ 5 authors

Pharmaceutics2022, 14(3), 677;https://doi.org/10.3390/pharmaceutics14030677

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19 March 2022

Osteosarcoma treatment is moving towards more effective combination therapies. Nevertheless, these approaches present distinctive challenges that can complicate the clinical translation, such as increased toxicity and multi-drug resistance. Drug co-e...

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Article

1,028 Views

17 Pages

Establishing Human and Canine Xenograft Murine Osteosarcoma Models for Application of Focused Ultrasound Ablation

Alayna N. Hay,
Alex Simon,
Lauren N. Ruger,
Jessica Gannon,
Sheryl Coutermarsh-Ott,
Elliana R. Vickers,
William Eward,
Nathan J. Neufeld,
Eli Vlaisavljevich and
Joanne Tuohy

Biomedicines2025, 13(9), 2122;https://doi.org/10.3390/biomedicines13092122

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30 August 2025

Background: Osteosarcoma (OS) is the most commonly occurring type of bone cancer in both humans and canines. The survival outcomes for OS patients have not improved significantly in decades. A novel and innovative treatment option that is currently u...

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Article

5 Citations

2,769 Views

25 Pages

Pyridazinone Derivatives Limit Osteosarcoma-Cells Growth In Vitro and In Vivo

Aurélie Moniot,
Julien Braux,
Camille Bour,
Christine Guillaume,
Fabien Lamret,
Ingrid Allart-Simon,
Sandra Audonnet,
Sarah Renault,
Francoise Rédini and
Frédéric Velard
+ 4 authors

Cancers2021, 13(23), 5992;https://doi.org/10.3390/cancers13235992

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28 November 2021

Osteosarcoma is a rare primary bone cancer that mostly affects children and young adults. Current therapeutic approaches consist of combining surgery and chemotherapy but remain unfortunately insufficient to avoid relapse and metastases. Progress in...

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