Search Results (273,720)

Fixed-wing unmanned aerial vehicles, with their advantages of long endurance and substantial payload capacity, are poised to be a key platform for the future low-altitude economy. However, the challenge of achieving precise attitude tracking control under unknown time-varying disturbances persists. To tackle this difficulty, this article introduces a soft-sign function-based active disturbance rejection control (SSADRC) method, and develops a hybrid grey wolf optimizer (HGWO) with balanced exploration–exploitation mechanisms for intelligent parameter tuning. Specifically, SSADRC utilizes a novel smooth nonlinear function with saturation constraints to reconstruct the nonlinear feedback controller and the extended state observer, ensuring smooth and stable control output. Subsequently, HGWO integrates the good point set-based initialization strategy, the fitness-based dynamic-weight strategy, the diversity-based adaptive-mutation strategy, and the logistic chaotic map-based survival-of-the-fittest strategy, addressing the tuning of multiple coupled parameters in SSADRC. Additionally, the SSADRC-based pitch attitude controller is designed for a fixed-wing unmanned aerial vehicle, and an HGWO and seven other swarm optimization algorithms are employed to tune the parameters. The results demonstrate that the HGWO exhibits the best convergence accuracy in the SSADRC parameter optimization task, and SSADRC illustrates better command tracking performance and state estimation accuracy than typical ADRC. Full article

Founded in 1703, St. Petersburg was the capital of the Russian Empire. Its historic center and associated monuments are inscribed as a UNESCO World Heritage Site. Its components are classified as cultural rather than natural or mixed. We hypothesized that a part of them has an additional ecotourism value. We carried out field observations along with a review of the literature. Our results confirmed the hypothesis: many of these sites retain important elements of biodiversity that can be used for environmental education. Large congregations of birds can be observed in close proximity to Heritage monuments. Wintering bats occupy the interiors of historic fortifications, and in summer, concentrations of feeding bats can be found nearby. Seal haul-out sites have been documented on small islands near the city. The ecotourism and nature-conservation value of these Heritage landscapes is usually linked to the original logic of their selection. The best locations were chosen for palace construction—dry, scenic areas with fertile soils suitable for park creation. Proximity to bodies of water was equally important, both for aesthetic reasons and for sanitation. These same qualities also make such areas highly favorable for biodiversity. Even after centuries of development, many natural features have persisted. Full article

Background/Objectives: The healthcare sector, despite its mission to protect health, is a major consumer of resources and emitter of greenhouse gases, giving rise to an ethical and governance paradox: how to reconcile the duty of care with the environmental impact of its activities. In the Spanish healthcare system, which is highly decentralized and regulated at multiple levels, this tension shapes the implementation of environmental policies. This study analyzes the governance and implementation of environmental regulations in Spanish healthcare institutions and the associated experiences. Methods: A qualitative, exploratory, descriptive study was conducted using effective meetings and semi-structured interviews with 20 participants, working in healthcare provision and environmental management within health institutions, across different regions of Spain, between September 2024 and November 2025. In addition, a documentary analysis of relevant regulations was undertaken. Results: The results indicate that Spanish healthcare institutions improve their environmental performance through the implementation of standards such as ISO or EMAS, although their adoption varies according to each institution’s level of development in environmental management. In addition, differences were observed in the environmental dynamics of healthcare institutions, linked to the decentralization of the Spanish healthcare system, as well as administrative barriers to accessing funding and gender disparities in environmental leadership. Conclusions: The standardization of environmental regulations and measures across the country, along with strengthening organizational capacity, could strengthen progress toward more sustainable healthcare. Full article

Cognitive stress, also known as mental workload, constitutes a central topic within the field of psychophysiology due to its role in modulating attention, autonomic regulation, and stress reactivity. Furthermore, it bears direct relevance to practical monitoring systems that employ non-invasive sensing techniques. This study investigates whether a multimodal, non-invasive measurement setup can detect systematic physiological differences between Resting periods and short episodes of cognitive load within the same individuals. Additionally, it explores the capacity of such a system to differentiate tasks characterized by varying cognitive demands. A sequential, within-subject protocol was employed, comprising five consecutive phases (rest 1, Stroop, rest 12, subtraction, rest 3), during which five modalities were recorded concurrently: EEG, heart rate (HR), galvanic skin response (GSR), facial surface temperature, and oxygen saturation (SpO₂). Beyond phase-wise inspection of time-series data, an exploratory assessment of similarity across participants was conducted using correlation coefficients. The maximum cross-participant correlations observed were 0.88 (HR), 0.90 (GSR), 0.83 (facial temperature), and 0.77 (SpO₂); however, these correlations were used only as exploratory descriptors of inter-individual similarity and did not imply a significant phase effect. For inferential analysis, phase-wise epoch means were evaluated through one-factor repeated-measures ANOVA. The heart rate exhibited a robust main effect of phase (F(4, 32) = 10.5862, p_GG = 0.01044, ηp² = 0.5696), with higher HR observed during cognitive load epochs (e.g., 77.841 ± 11.777 bpm at rest 1 versus 83.926 ± 14.532 bpm during subtraction). The relatively large standard deviation reflects variability between subjects rather than variability within epochs. Regarding processed baseline-referenced GSR, the omnibus phase effect was not statistically significant under the conservative Greenhouse–Geisser correction; therefore, GSR was interpreted as exploratory in this dataset. Facial temperature and SpO₂ likewise did not show statistically significant omnibus phase effects under Greenhouse–Geisser correction (e.g., SpO₂: p_GG = 0.1209). EEG-derived measures provide supplementary central evidence of task engagement; entropy variations within an approximate dynamic range of 0.2 to 0.8 were observed, and the α/θ ratios demonstrated nearly a twofold distinction between rest and cognitive load epochs across different leads. Full article

Whether the enactment effect benefits from motor information activation is a key concern in action memory; meanwhile, the degree of enactability may influence this activation. Accordingly, this study aims to examine the explanatory role of motor information reactivation in the enactment effect and to further clarify whether a certain degree of motor information activation is necessary for this effect to emerge. To this end, we manipulated the degree of enactability and separately investigated its impact on the enactment effect at the encoding stage (Experiment 1) and the retrieval stage (Experiment 2). Experiment 1 required participants to either silently read phrases or both silently read and physically enact the actions represented by the phrases during encoding. The research showed that an enactment effect was only observed for the high-enactability-phrases condition, but not for the low-enactability-phrases condition. Experiment 2 additionally required participants to either verbally recall (verbal retrieval) or verbally recall while simultaneously performing corresponding actions (enactment retrieval) during retrieval. The findings showed that under the verbal retrieval condition, the enactment effect was observed for the high-enactability-phrases condition but not for the low-enactability-phrases condition; under the enactment retrieval condition, the enactment effect was observed both for the high-enactability phrases and low-enactability-phrases conditions. Thus, motor information activation during encoding and retrieval is crucial for the enactment effect, which emerges only when motor information activation reaches a threshold, supporting and expanding motor information reactivation theory. Full article

Legal decision-making is expected to meet high standards of consistency and rationality, yet human judgments in this domain are known to be influenced by procedural factors such as evidence order and intermediate evaluations. Recent work has shown that even legal professionals, including judges, are susceptible to such biases when assessing criminal cases. This raises a critical question: do large language models, which are increasingly proposed as decision-support tools in legal contexts, exhibit similar procedural biases—and if so, can these biases be mitigated? To address this question, we tested GPT-4o and GPT-5.2 using a controlled legal judgment task adapted from prior human research. The task involved simplified criminal cases in which we systematically manipulated (i) the order of incriminating and exonerating evidence and (ii) whether an intermediate guilt judgment was required before a final decision. Model responses were directly compared to human judgments from the original study. We additionally examined whether prompt engineering strategies, based on current best-practice recommendations, could reduce observed biases. GPT-4o exhibited robust order effects and a form of evaluation bias, although the latter differed in structure from the human pattern. GPT-5.2 showed similar but attenuated effects. Across both models, prompt engineering had limited and inconsistent impact, failing to reliably eliminate procedural sensitivity. These findings suggest that even advanced large language models remain vulnerable to normatively irrelevant procedural influences. More broadly, they advise caution in treating large language models as inherently rational or bias-resistant decision-support systems in high-stakes professional domains such as law. Full article

Introduction: In patients with conductive and mixed hearing loss, implantable hearing devices such as active middle ear implants (AMEIs) and bone conduction implants (BCIs) are established alternatives when conventional hearing aids fail. Although bone conduction (BC) thresholds are routinely used as eligibility criteria, their role as frequency-specific predictors of postoperative functional outcomes remains poorly defined. This study aimed to evaluate the influence of preoperative BC thresholds across the audiometric spectrum on postoperative speech recognition outcomes after implantation with AMEIs and BCIs. Methods: A retrospective observational study was conducted at a tertiary referral center including patients implanted with BCIs or AMEIs. Pre- and postoperative audiological data were analyzed, including air and bone conduction thresholds, frequency-segmented BC measures (low, mid, and high frequencies), cochlear frequency gradient (ΔBC Slope), and speech recognition scores (SRSs) at 65 dB HL one year after implantation. Results: 102 patients were included (50 BCI, 52 AMEI). Both implant types achieved significant postoperative improvements in tonal thresholds and SRS compared with pre-implantation values (all p < 0.001). High-frequency BC thresholds (BC-High, 4–6 kHz) showed a significant inverse correlation with postoperative SRS in both BCI (r = −0.382, p = 0.001) and AMEI users (r = −0.398, p < 0.001), and emerged as the only independent predictor in multivariable models (BCI: β = −0.533, p = 0.022; AMEI: β = −0.491, p = 0.020). Low- and mid-frequency BC measures were not associated with postoperative speech outcomes (all p > 0.05). ROC analyses demonstrated excellent discriminative performance of BC-High for identifying suboptimal outcomes, with area under the curve values of 0.92 for BCI (p = 0.001) and 0.94 for AMEI (p = 0.002), and implant-specific cutoff values of >47 dB HL and >61 dB HL, respectively. Conclusions: High-frequency BC thresholds showed the strongest association with postoperative speech recognition after implantable hearing rehabilitation. BC-High could function as a prognostic marker of functional outcome rather than an eligibility criterion, providing clinically meaningful information to refine preoperative counseling and individualized decision-making within current indication frameworks. Full article

Background and Objectives: Functional dyspepsia (FD) often overlaps with Pancreatic Exocrine Insufficiency (PEI), leading to diagnostic delays. We aimed to evaluate the prevalence of PEI in patients presenting dyspeptic symptoms using the survey-based PEI test and to assess the clinical response to Pancreatic Enzyme Replacement Therapy (PERT). Methods: This study included 91 patients with PEI and 58 control subjects. PEI was evaluated using the PEI Patient-Reported Outcome (PRO) instrument and classified as mild, moderate, or severe according to the 18-item PEI test. Objective fat malabsorption was assessed by the acid steatocrit method using a gravimetric assay. Patients diagnosed with PEI received PERT, and treatment response was evaluated at follow-up with a repeat PEI test. Results: When the case and control groups were compared in terms of PEI scores, a statistically significant difference was found (p < 0.001). Fecal steatocrit value was found to be statistically significant with the PEI score (p = 0.017). No statistically significant difference was found between amylase, lipase, vitamin D, vitamin B12, and folic acid and the PEI score (p = 0.789, p = 0.299, p = 0.865, p = 0.153, and p = 0.855, respectively). A statistically significant difference was found between the pre-treatment PEI score and the post-treatment PEI score (p < 0.001). The mean pre-treatment PEI score was 1.52 ± 0.50, while the post-treatment PEI score was 0.42 ± 0.48. Approximately 72% reduction in PEI score was observed with treatment. Conclusions: The PEI test may represent a useful, non-invasive tool for identifying suspected pancreatic dysfunction in patients initially diagnosed with functional dyspepsia. Early integration of this tool into clinical practice can improve symptom control and prevent the misclassification of PEI as a purely functional disorder. Full article

In traditional wind turbine (WT) operation and maintenance, fault diagnosis and repair have long been relied on, yet the demand for continuous operation under faults persists. To address this, this study proposes a triggered fault-tolerant control framework for wind turbines with zonotope-based interval estimation. The method enhances safety from point to range estimation of FDI, reduces network traffic load via a WT load region-based adaptive event-triggered mechanism, and enables fast, robust fault diagnosis/isolation using interval residuals. A damage equivalent load (DEL)-sensitive cost term balances structural fatigue suppression while ensuring power tracking and safety constraints. Theoretically, Linear Matrix Inequality (LMI) conditions based on common quadratic Lyapunov ensure closed-loop stability and bounded observation errors, with proven interval residual fault sensitivity and triggering reliability. Numerically, on the standard NREL 5-MW WT model under multi-conditions (turbulence, faulty communication), it achieves an average power tracking accuracy of 95.56%, 28.68% fatigue suppression, and 67.40% bandwidth saving. Overall, it synergistically optimizes robust estimation, economical communication, and fatigue-aware control, providing a theoretically rigorous and experimentally validated technical framework for engineering-scale WT reliability improvement and lifespan extension. Full article

The transcriptomic effects of hybridization and triploidization were investigated in diploid and triploid rainbow trout, diploid brook trout, as well as triploid hybrids of rainbow trout and brook trout. The examined fish were reared under identical conditions for about two and a half years after hatching. Expression of ten genes involved in cellular respiration (Atp5bp, Slc25a5), mitochondrial functioning (Mrpl28, Micu2), ribosome biogenesis (Rpl24, Rps24), proteasome-mediated protein turnover (Derl1, Psmc2), and protein chaperoning (Hsp90B1, Pdia4) was studied in liver and muscle tissues. Most of the analyzed genes (Atp5bp, Slc25a5, Mrpl28, Micu2, Rpl24, Rps24, Derl1, and Psmc2) displayed comparable expression levels in the liver tissue across the examined triploid hybrids and diploid parental species, with stabilization of genes that were both positively and negatively compensated in the triploid rainbow trout. In turn, significant upregulation of Slc25a5, Derl1, Rps24, and Rpl24 genes, together with downregulation of Micu2 gene, was observed in the triploid rainbow trout liver and muscle, respectively. On the other hand, triploid hybrids showed marked transcriptional upregulation of genes primarily associated with energy metabolism and protein synthesis (Atp5pb, Slc25a5, Rpl24, Rps24, and Pdia4) relative to all the fish groups examined. Although protein-synthesis- and energy-related genes were upregulated in the muscles of triploid hybrids, the recorded growth performance data did not indicate clear evidence of growth heterosis (MPH = −14.3% for body weight; MPH = −0.4% for body length), suggesting that potential benefits of increased heterozygosity in this cross may not be fully reflected in enhanced growth. Three- to four-fold downregulation of the heat shock protein (Hsp90B1) gene was also observed in both tissues of triploid hybrids compared with purebred diploid and triploid trout, which may reflect potential maladaptive genomic effects commonly observed in distant salmonid crosses, suggesting altered stress-response regulation in the examined triploid hybrids. Full article

This study investigates the phytochemical composition and biological activity of eight Thymus species distributed in Bulgaria, with a focus on taxa from section Hyphodromi. High-performance liquid chromatography (HPLC) and gas chromatography–mass spectrometry (GC–MS) were used to characterize the methanolic (MeOH) and diethyl ether (Et₂O) extracts, respectively. MeOH extracts revealed high concentrations of phenolic acids, particularly rosmarinic acid, salicylic acid, and flavonoid glycosides, with T. atticus, T. jalasianus, and T. leucotrichus showing the most diverse profiles. Et₂O extracts were dominated by triterpenic acids (ursolic and oleanolic) and monoterpenes such as thymol and carvacrol, especially in T. zygioides and T. leucotrichus. All MeOH extracts exhibited significant antioxidant activity in the DPPH assay (IC₅₀ < 50 µg/mL), with T. jalasianus and T. atticus demonstrating the strongest effects. Radical scavenging potential generally followed the trend of total phenolic content. Moderate acetylcholinesterase-inhibitory activity was observed only in T. zygioides and T. leucotrichus. The study reports for the first time data on the biological activity and metabolic composition of extracts from endemic and rare species and from the species of Bulgarian origin. The results provide new data on the phytochemical composition and in vitro antioxidant and acetylcholinesterase-inhibitory activities of selected Thymus species, contributing to the characterization of their overall in vitro biochemical profiles. Full article

In this work, the electrochemical behavior of potassium jarosite-type solid solutions synthesized via a controlled hydrothermal method was evaluated. Structural characterization by X-ray diffraction (XRD) confirmed the formation of potassium jarosite. FTIR spectra complemented these findings, revealing bands characteristic of Fe–O metal coordination (625 and 505 cm⁻¹). Voltammetric tests evidenced redox processes attributable to the Fe³⁺/Fe²⁺ couple, suggesting that iron within the jarosite framework contributes electrochemically to the observed conductivity. The assembled galvanic cells demonstrated the capability for electrical energy microgeneration, and the presence of jarosite was found to enhance ionic transport within the system. Overall, these results suggest an intergranular ionic-conduction mechanism, possibly facilitated by the mineral matrix, which would act as a structural medium enabling the mobility of charged species. Full article

Permeability is affected by nanopores and pore structure, and anisotropic permeability is the result of shale lamination, orientation, and stratification of minerals. To understand the reasons for permeability anisotropy, the pore networks of over-mature shale has been studied. The mineral compositions, petrophysical properties, and pore structures of the Lower Cambrian Niutitang Formation shales were analyzed using subcritical gas adsorption, field-emission scanning electron microscopic, and X-ray micro-computed tomographic methods. Quartz, clay minerals, and carbonate are the dominant minerals in the shales. The bedding-parallel and bedding-perpendicular permeabilities are 1.25–46.21 × 10⁻² and 1.38–6.62 × 10⁻² mD, respectively. The anisotropy of permeability, which is the ratio between the bedding-parallel and bedding-perpendicular permeability, is 0.21–26.87. The micropore and Barrett–Joyner–Halenda pore volumes are 0.54–3.62 and 0.05–0.69 mL/100 g, respectively. The bedding-parallel permeability is correlated positively with the micropore and Barrett–Joyner–Halenda pore volumes. Thin-section observations indicate the shales exhibit a bedding-parallel alignment of phyllosilicate minerals and planar deformation bands. The scanning electron microscopy shows deformation of the lamination and parallel alignment of the clay minerals due to compaction or differential compaction over coarser-grained quartz grains. The scanning electron microscopy images and subcritical gas adsorption data indicate that the pore fracture system is parallel to bedding and formed after diagenesis. Furthermore, X-ray micro-computed tomographic analysis shows that the micro-fractures are also preferentially oriented, parallel to bedding. Full article

The high energy consumption in the building sector and the increasing impacts of climate change have necessitated the transition to net-zero-energy buildings (NZEBs), in which energy retrofit strategies play a key role. However, neglecting moisture transport and climatic design while improving energy efficiency often leads to reduced building performance, material deterioration, worse occupant health, and indoor environmental problems. This review examines in detail the basic mechanisms of moisture transport, including diffusion, capillary action, and airborne moisture transport, and illustrates how poor moisture control affects thermal performance and resident health. Additionally, a comparative analysis of the impact of retrofit strategies implemented in different climatic regions on energy efficiency, carbon emission reduction, moisture-related failures and net-zero goals is conducted. At the same time, the need exists to incorporate awareness regarding the adverse effects on the health of occupants. This systematic review analyzed 120 peer-reviewed studies published from 1994 to 2026, covering different climatic regions (e.g., cold, temperate, warm–humid, etc.). The analysis found that the energy savings rates were reported to range from 18% to 45%, while the moisture-related failures in inappropriately retrofitted buildings were observed to increase by up to 32% in some cold regions. This research review provides a comprehensive advisory framework for domestic residents to take remedial steps until retrofit experts gain access in order to prevent health risks from mold and moisture ingress, which can contribute to a healthy lifestyle and a net-zero-energy building. Full article

Background/Objectives: Chronic alcohol use accelerates biological and cognitive aging, yet it remains unclear how cognitive aging progresses during abstinence in alcohol use disorder (AUD). It is also unknown to what extent this follows models such as accelerated aging or the age-related decline as proposed by the vulnerability hypothesis. This study examined age-related changes and cognitive recovery during abstinence in patients with AUD. Methods: A total of 197 clinically admitted patients, referred for detoxification and extensive neuropsychological examination, were included. Neuropsychological testing was administered in the second and sixth week of admission using well-normed instruments. Using both multi-assessment and cross-sectional data, relationships between age and normed cognitive outcome scores were examined. Results: After six weeks of abstinence, age-related deviations were observed for perceptual reasoning (PRI), verbal comprehension (VCI), and short-term memory (SMI) but not for ten other cognitive indices. During admission, age significantly influenced the change in belonging to a specific recovery category. Each additional year of age reduced the odds of showing no cognitive impairment by 5% and reduced the odds of cognitive recovery by approximately 4%, compared to non-improvers. Conclusions: Age-related influences appear limited to specific cognitive functions and do not follow a uniform or easily interpretable pattern. Perceptual reasoning seems negatively affected after age 60 for participants with six weeks of abstinence. Older participants showed a reduced likelihood of cognitive recovery and a reduced likelihood of having no cognitive problems at all. The findings do not support accelerated aging and are still too weak to be considered evidence for the vulnerability hypothesis. Implications for future research are discussed. Full article