Search Results (31,398)

Background: Tendinopathy is a degenerative condition caused by mechanical overload, accounting for approximately 30% of musculoskeletal healthcare cases. It progresses through a process characterized by collagen disorganization, altered vascularization, and neuronal ingrowth. Traditional conservative treatments, such as therapeutic exercises, non-steroidal anti-inflammatory drugs, and physical therapies, are useful, but their effectiveness is sometimes only partial and there is a need to search for new potential solutions. Recent interest in oxygen–ozone (O₂-O₃) therapy stems from preliminary observations suggesting potential anti-inflammatory and regenerative effects. Nevertheless, its clinical role remains speculative and warrants thorough investigation beyond anecdotal evidence. Considering the heterogeneity of clinical presentations and treatment responses among patients, O₂-O₃ therapy has been proposed as a promising tool for tailoring personalized treatment strategies for tendinopathy. This review critically appraises the available literature concerning the mechanistic rationale and clinical applications of O₂-O₃ therapy in tendinopathy, with attention to both its theoretical underpinnings and the quality of empirical evidence. Methods: A literature search was conducted on O₂-O₃ therapy for tendinopathy using PubMed, Cochrane, and Embase, filtering for full-text articles published between 2004 and 2024. Recent clinical trials were included irrespective of evidence level, while excluding systematic reviews, duplicates, and irrelevant studies. Results: Ozone has been shown to modulate oxidative stress, promote neovascularization, and suppress pro-inflammatory cytokines. Both clinical and in vivo studies indicate that O₂-O₃ therapy relieves pain, enhances tendon healing, and improves biomechanical properties. Some comparative studies suggest that O₂-O₃ therapy might provide more sustained symptoms control than corticosteroids, but the heterogeneity of follow-up durations and outcome measures prevents definitive conclusions. Conclusions: O₂-O₃ therapy emerges as a potentially valuable adjunct in the management of chronic tendinopathy, particularly in cases unresponsive to conventional treatments. However, its clinical role remains to be clearly defined and its possible role in personalized medicine needs further exploration, particularly in relation to patient stratification and individualized treatment protocols. Further high-quality randomized controlled trials are warranted to validate its efficacy, determine long-term outcomes, and standardize treatment protocols to ensure safety and reproducibility. Full article

Background/Objectives: Diabetic neuropathy (DN) is a prevalent complication of diabetes mellitus, affecting up to 50% of long-term patients and causing significant pain, reduced quality of life, and healthcare burden. Conventional treatments, including anticonvulsants, antidepressants, and opioids, offer limited efficacy and are associated with adverse effects. Emerging evidence suggests that cannabis, acting via the endocannabinoid system, may provide analgesic and neuroprotective benefits. This study evaluates the long-term effects of inhaled cannabis as adjunctive therapy for refractory painful DN. Inhaled cannabis exhibits rapid onset pharmacokinetics (within minutes, lasting 2–4 h) due to pulmonary absorption, targeting CB1 and CB2 receptors to modulate pain and inflammation. Methods: In this prospective, observational study, 52 patients with confirmed painful DN, unresponsive to at least three prior analgesics plus non-pharmacological interventions, were recruited from a single clinic. Following a 1-month washout, patients initiated inhaled medical-grade cannabis (20% THC, <1% CBD), titrated individually. Assessments occurred at baseline and annually for 5 years, including the Brief Pain Inventory (BPI) for pain severity and interference; the degree of pain relief; Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) score; HbA1c; and medication usage. Statistical analyses used repeated-measures ANOVA, Kruskal–Wallis tests, Welch’s t-tests, and Pearson’s correlations via Analyze-it for Excel. Results: Of 52 patients (mean age 45.3 ± 17.8 years; 71.2% male; diabetes duration 23.3 ± 17.8 years), 50 completed follow-up visits. Significant reductions occurred in BPI pain severity (9.0 ± 0.8 to 2.0 ± 0.7, p < 0.001), interference (7.5 ± 1.7 to 2.2 ± 0.9, p < 0.001), LANSS score (19.4 ± 3.8 to 10.2 ± 6.4, p < 0.001), and HbA1c (9.77% ± 1.50 to 7.79% ± 1.51, p < 0.001). Analgesic use decreased markedly (e.g., morphine equivalents: 66.8 ± 49.2 mg to 4.5 ± 9.6 mg). Cannabis dose correlated positively with pain relief (r = 0.74, p < 0.001) and negatively with narcotic use (r = −0.43, p < 0.001) and pain interference (r = −0.43, p < 0.001). No serious adverse events were reported; mild side effects (e.g., dry mouth or euphoria) occurred in 15.4% of patients. Conclusions: Inhaled cannabis showed sustained pain relief, improved glycemic control, and opioid-sparing effects in refractory DN over 5 years, with a favorable safety profile. These findings are associative due to the observational design, and randomized controlled trials (RCTs) are needed to confirm efficacy and determine optimal usage, addressing limitations such as single-center bias and small sample size (n = 52). Future studies incorporating biomarker analysis (e.g., endocannabinoid levels) could elucidate mechanisms and enhance precision in cannabis therapy. Full article

Multiple unmanned aerial vehicle (UAV) systems have attracted considerable research interest due to their broad applications, such as formation control. However, decentralized UAV formation faces challenges stemming from limited local observations, which may lead to consistency conflicts, and excessive communication. To address these issues, this paper proposes SemanticBC-DecAF, a decentralized adaptive formation (DecAF) framework under a leader–follower architecture, incorporating a semantic broadcast communication (SemanticBC) mechanism. The framework consists of three modules: (1) a proximal policy optimization (PPO)-based semantic broadcast module, where the leader UAV transmits semantically encoded global obstacle images to followers to enhance their perception; (2) a YOLOv5-based detection and position estimation module, enabling followers to infer obstacle locations from recovered images; and (3) a multi-agent proximal policy optimization (MAPPO)-based formation module, which fuses global and local observations to achieve adaptive formation and obstacle avoidance. Experiments in the multi-agent simulation environment MPE show that the proposed framework significantly improves global perception and formation efficiency compared with methods that rely on local observations. Full article

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-β (Aβ) accumulation, synaptic dysfunction, and cognitive decline. Current pharmacological treatments provide only symptomatic relief without altering disease progression. Photobiomodulation therapy (PBMT), a light-based intervention, has shown neuroprotective potential, although its exact neurobiological mechanisms in AD pathogenesis remain obscure. In this study, we investigated the effects of PBMT using a 660 nm wavelength light-emitting diode (LED) in 5xFAD transgenic mouse, a well-established model of early-onset AD. Mice were subjected to once daily PBMT sessions over a defined treatment period and outcomes were assessed through immunohistochemical analysis of hippocampal regions (CA1, CA2, CA3, and dentate gyrus) alongside behavioral testing using the Y-maze spontaneous alternation task. PBMT significantly reduced Aβ plaque load across hippocampal regions, accompanied by improved preservation of neuronal morphology. Furthermore, PBMT significantly upregulated SIRT1 expression, a critical regulator of synaptic plasticity and memory processes. Behaviorally, PBMT-treated mice displayed enhanced spatial working memory compared with controls, indicating a functional benefit linked to the observed molecular and structural changes. These findings suggest that 660 nm PBMT attenuates hallmark AD pathology, promotes neuroprotective pathways, and improves cognition, highlighting its potential as a disease-modifying therapy that warrants further preclinical and clinical investigation. Full article

Dynamic environments pose significant challenges for Visual Simultaneous Localization and Mapping (VSLAM), as moving objects can introduce outlier observations that severely degrade localization and mapping performance. To address this problem, we propose YSAG-VINS, a VSLAM algorithm specifically designed for dynamic scenes. The system integrates an enhanced YOLOv8 object detection network with an adaptive epipolar constraint strategy to effectively identify and suppress the impact of dynamic features. In particular, a lightweight YOLOv8n model augmented with ODConv and UIB modules is employed to balance detection accuracy with real-time efficiency. Based on semantic detection results, images are divided into static background and potentially dynamic regions, and the motion state of these regions is further verified using geometric constraints. Features belonging to truly dynamic objects are then removed to enhance robustness. Comprehensive experiments on multiple public datasets demonstrate that YSAG-VINS achieves superior pose estimation accuracy compared with VINS-Fusion, VDO-SLAM, and Dynamic-VINS. On three dynamic sequences of the KITTI dataset, the proposed method achieves average RMSE improvement rates of 48.62%, 12.18%, and 13.50%, respectively. These results confirm that YSAG-VINS provides robust and high-accuracy localization performance in dynamic environments, making it a promising solution for real-world applications such as autonomous driving, service robotics, and augmented reality. Full article

Brewer’s spent grain enhances nutritional quality by increasing fiber and plant-based proteins and reducing the need for synthetic additives. Technologies such as extrusion and fermentation transform BSG into functional ingredients that improve texture and stability. A significant increase in antioxidant capacity was observed in enriched foods; for example, in burgers, BSG improved fiber and protein levels, while decreasing fat and calories without negatively affecting sensory acceptance. In sausages, substituting 5% of pork with BSG achieved acceptance similar to traditional formulations, and hybrid formulations with BSG maintained improved protein content while preserving texture. However, concentrations above 20% may negatively impact sensory and technological properties, by introducing undesirable flavors or altering texture. Thus, BSG is a promising source of high-value functional ingredients that contribute to the circular economy and healthier, sustainable foods. Nonetheless, more in vivo studies are needed to validate the health benefits, understand the interactions in complex matrices, assess the shelf life, and evaluate the long-term sensory perception. The “Silent Revolution” of BSG requires a multidisciplinary approach that integrates science, technology, sustainability, and effective communication with consumers. Full article

The contribution of meal kits to the waste problem has become a significant concern, leading consumers to demand sustainable practices from meal-kit companies. This study proposes a framework to understand customer behavior toward sustainable meal-kit brands that promote practices such as recycling and waste reduction. This study applies warm glow theory to investigate how pure and impure altruism affect consumers’ perceptions of a meal-kit brand’s sustainability, perceived price fairness, and continuance intention. The findings confirmed that meal-kit brands’ sustainable practices significantly enhanced consumers’ perceptions of brand sustainability, which in turn influenced their perceived price fairness and continuance intention. Furthermore, warm glow and altruistic values were found to significantly moderate the relationship between consumers’ perceptions of brand sustainability and their continuance intention. However, no significant moderating effects were observed between consumers’ perceptions of brand sustainability and perceived price fairness. This study contributes to a deeper understanding of the psychological mechanisms underlying consumer attitudes and behaviors toward meal-kit brands’ sustainability efforts. Full article

The interconnection between health and environment is increasingly recognised, as is the role of healthcare professionals in raising awareness among patients and healthcare policymakers. To explore the relevance of enhancing patients’ awareness of the links between health and environment in ambulatory care, we conducted a qualitative study on General Practitioner (GP) practices in Switzerland. Using a co-benefit approach, we designed materials on meat consumption and active mobility, which were displayed in the waiting rooms. We conducted observations in five practices and interviewed five patients and five GPs to examine patients’ understanding of the messages and assess the acceptability of discussing them during medical encounters. Patients and GPs were receptive to the co-benefit approach. However, barriers were identified in promoting co-benefits during clinical encounters, including time constraints and lack of knowledge. Patients showed reactance to the messages and questioned the reliability of messages related to climate change. GPs were reluctant to compromise relationships with patients and were ambivalent, viewing environmental discussions as political. Positive message display and community promotion were identified as facilitators. This study highlights the need to develop clear educational materials to support GPs, to adapt messages to patients’ backgrounds, and to address the dichotomy between GPs’ political and scientific perspectives. Full article

Remote sensing technologies are increasingly integrated with autonomous robotic platforms to enhance data-driven decision-making in precision agriculture. Rather than replacing conventional platforms such as satellites or UAVs, autonomous ground robots complement them by enabling high-resolution, site-specific observations in real time, especially at the plant level. This review analyzes how remote sensing sensors—including multispectral, hyperspectral, LiDAR, and thermal—are deployed via robotic systems for specific agricultural tasks such as canopy mapping, weed identification, soil moisture monitoring, and precision spraying. Key benefits include higher spatial and temporal resolution, improved monitoring of under-canopy conditions, and enhanced task automation. However, the practical deployment of such systems is constrained by terrain complexity, power demands, and sensor calibration. The integration of artificial intelligence and IoT connectivity emerges as a critical enabler for responsive, scalable solutions. By focusing on how autonomous robots function as mobile sensor platforms, this article contributes to the understanding of their role within modern precision agriculture workflows. The findings support future development pathways aimed at increasing operational efficiency and sustainability across diverse crop systems. Full article

Harmonic summation and amplification by winds blowing contrary to currents are known contributions to rogue waves in the region of the Agulhas current, but the causes of the observed wave steepness, asymmetric form, and non-breaking are poorly understood. The potential effect of bathymetric and meteorological features has not been addressed. Vortex theory was applied to develop a theory of wave formation, based on conceptual reasoning. Rogue wave formation is attributed to the following: (1) wind lee vortices causing steepening of a wave’s leeward face, and suppressing wave breaking; (2) boundary layer vortices from the meteorological cold front transferring energy to the wind lee vortices thereby sharpening the wave; (3) Agulhas current boundary layer vortices interacting with water lee vortices to accelerate a jet of water between them, thereby steepening the wave and enhancing the preceding trough; (4) bathymetric topology, especially a canyon on the continental slope, generating a vortex in the Agulhas current. This vortex is detached from the canyon by prising of the coastal downwelling current (induced by the meteorological cold front) and combines with the water lee vortex to heighten the wave, and (5) jetting, which arises when the canyon vortex and the Agulhas current boundary layer vortices pass each other, thereby accentuating wave height, steepness, and asymmetry. Full article

Graesiella emersonii, an aeroterrestrial green microalga, exhibits high adaptability to extreme environmental conditions, making it of interest for biotechnological applications. Investigating photosynthetic performance is essential to select high-yield strains and optimize the sustainable production of biomass and bio-products. In this study, two strains (053 and 054) were cultured under atmospheric (0.04%) and elevated (2%) CO₂ conditions to analyze growth, pigment content, and photosynthesis. Strain 053 showed superior photosynthetic performance and productivity under atmospheric conditions, whereas 2% CO₂ enhanced growth in both strains, with a significant increase in photosynthetic efficiency in strain 054. The observed differences highlight strain-specific adaptations to CO₂ availability and suggest the potential of each strain depending on the cultivation environment. Full article

In recent years, China’s economic and social development has faced challenges such as urban-rural imbalance and ecological pressure. Digital inclusive finance and ecological resilience have become key concerns in academia and policymaking. This study empirically examines whether digital inclusive finance can enhance ecological resilience and its underlying mechanisms, drawing on quantitative evidence from provincial panel data covering 2011–2020. By providing robust empirical results, it contributes to understanding the role of digital finance in supporting high-quality growth and ecological civilization. While the findings align with national strategies such as the “dual carbon” goal and rural revitalization, the study’s primary contribution lies in advancing interdisciplinary exploration through rigorous evidence rather than solely at the policy level. By constructing a double fixed effects model and panel data from 30 Chinese provinces (2011–2020), the study finds that digital inclusive finance significantly enhances ecological resilience, both directly and indirectly through channels such as environmental regulation, artificial intelligence development, and green credit. Moreover, its ecological impact is moderated by regional economic levels and digital infrastructure, with stronger effects observed in eastern and digitally advanced regions. In summary, this study reveals the mechanisms through which digital inclusive finance promotes ecological resilience, offering a theoretical foundation and practical guidance for policy formulation. Its key contribution lies in systematically analyzing the link between digital inclusive finance and ecological resilience, enriching the theoretical framework and providing data support for policy optimization and financial institutions’ strategic adjustments. Future efforts should focus on strengthening policy coordination to enhance the ecological role of digital finance, promoting financial innovation to support resilience, and advancing regional coordination to narrow the digital divide and achieve shared ecological protection. Full article

Aim: The rationale for combining various extracorporeal blood purification techniques to improve patient outcomes is currently being discussed extensively. The combined use of CytoSorb^®, with high capacity for cytokine removal, and Oxiris^®, which adsorbs endotoxins and smaller cytokines, may enhance the efficacy of blood purification in sepsis. Study Design: Retrospective analysis of efficacy and safety of simultaneous use of CytoSorb^® and Oxiris^® in 12 consecutive critically ill patients with COVID-19, who developed secondary bacterial sepsis and persistent hemodynamic instability. Results: Most of the patients (n = 8) treated with combination of the Oxiris^® and CytoSorb^® had a significant decrease in vasopressor requirement. Pre- and post-haemoadsorption data were analysed in 9 patients, who completed a 24 h course of treatment. A significant decrease in mean SOFA score (16.3 ± 1.7 to 15.0 ± 2.0 points), median vasopressor requirement (0.56 ± 0.29 to 0.11 ± 0.21 µg/kg/min), median procalcitonin levels (6.5 ± 27.0 to 1.6 ± 6.0 ng/mL), median IL-6 levels (584 ± 6279 to 107 ± 571 pg/mL), and mean leucocyte count (36.0 ± 20.6 to 20.9 ± 10.1 × 10³/mL) was observed. Furthermore, there was significant increase in PaO₂/FiO₂ ratio (108 ± 30 to 185 ± 55). We did not observe any device-associated adverse events or technical problems. A 27.5% drop in platelet count (269 ± 116 to 195 ± 82 × 10⁶/mL) and an 11.8% drop in haemoglobin level (10.7 ± 2.9 to 9.5 ± 2.0 g/dL) was noted. Conclusions: Our data suggests that combined use of Oxiris^® and CytoSorb^® for simultaneous cytokine and endotoxin removal in patients with underlying viral infection may be a promising therapeutic option. Our findings may serve as a guide for future research and provide directions for further development in this field. Full article

Background/Objectives: Whole-body vibration (WBV) has been widely studied for its effects on neuromuscular activation, circulation, and balance. This study investigates the effect of wearing frequency of vibrating sneakers (18 Hz) on lower limb muscle activation during walking and squatting in middle-aged Koreans (40–60 years old). The objective is to assess whether WBV footwear enhances muscle engagement in both active and sedentary individuals. Methods: A 16-week randomized controlled trial was conducted with 64 participants divided into exercise (walking 30 min, three times a week) and non-exercise groups. Each group was further divided into wearing and non-wearing vibrating sneaker subgroups. Muscle activation of the quadriceps and gastrocnemius was measured using surface electromyography before and after the intervention. Results: Participants wearing vibrating sneakers showed significantly increased quadriceps and gastrocnemius activation during squatting and walking compared to non-wearers (p < 0.05). The exercise group wearing WBV sneakers exhibited greater improvements in muscle activation than the non-exercise group, indicating that WBV enhances the benefits of regular walking. However, no significant differences were observed in some lower leg muscles, suggesting that WBV effects may vary based on movement type and muscle group. Conclusions: Findings suggest that WBV sneakers (18 Hz) can enhance muscle activation during dynamic movements, potentially offering a low-impact training alternative for improving lower limb strength. These results provide valuable insights for exercise professionals, rehabilitation specialists, and wearable sensor developers, highlighting the potential of WBV footwear in neuromuscular conditioning and injury prevention. Full article

To address critical limitations of ultra-low viscosity supercritical CO₂ fracturing fluids, including excessive fluid loss and inadequate proppant transport capacity, a series of thickeners designed to significantly enhance CO₂ viscosity were synthesized. Initially, FT-IR and ¹H NMR characterization confirmed successful chemical reactions and incorporation of both solvation-enhancing and -thickening functional groups. Subsequently, dissolution and thickening performance were evaluated using a custom-designed high-pressure vessel featuring visual observation capability, in-line viscosity monitoring, and high-temperature operation. All thickener systems exhibited excellent solubility, with 5 wt% loading elevating CO₂ viscosity to 3.68 mPa·s. Ultimately, molecular simulations performed in Materials Studio elucidated the mechanistic basis, electrostatic potential (ESP) mapping, cohesive energy density analysis, intermolecular interaction energy, and radial distribution function comparisons. These computational approaches revealed dissolution and thickening mechanisms of polymeric thickeners in CO₂. Full article