2 Results Found

Advanced Search

Select all

Results per page

Select all

Article

13 Citations

5,071 Views

15 Pages

Indoline-6-Sulfonamide Inhibitors of the Bacterial Enzyme DapE

Cory T. Reidl,
Tahirah K. Heath,
Iman Darwish,
Rachel M. Torrez,
Maxwell Moore,
Elliot Gild,
Boguslaw P. Nocek,
Anna Starus,
Richard C. Holz and
Daniel P. Becker

Antibiotics2020, 9(9), 595;https://doi.org/10.3390/antibiotics9090595

-

11 September 2020

Inhibitors of the bacterial enzyme dapE-encoded N-succinyl-l,l-diaminopimelic acid desuccinylase (DapE; EC 3.5.1.18) hold promise as antibiotics with a new mechanism of action. Herein we describe the discovery of a new series of indoline sulfonamide...

Full Article

Article

11 Citations

4,405 Views

10 Pages

A Simple Protocol for the Determination of Lysostaphin Enzymatic Activity

Alexander V. Grishin,
Svetlana V. Konstantinova,
Irina V. Vasina,
Nikita V. Shestak,
Anna S. Karyagina and
Vladimir G. Lunin

Antibiotics2020, 9(12), 917;https://doi.org/10.3390/antibiotics9120917

-

17 December 2020

Antibacterial lysins are enzymes that hydrolyze bacterial peptidoglycan, which results in the rapid death of bacterial cells due to osmotic lysis. Lysostaphin is one of the most potent and well-studied lysins active against important nosocomial patho...

Full Article