Search Results (986)

Background/Objectives: In many parts of the world, pharmacists hold the primary responsibility for providing safe and effective pharmacotherapy. A key aspect is the availability of appropriate medicines for each individual patient. When industrially manufactured medicines are unsuitable or unavailable, pharmacists can prepare tailor-made medicines. While this principle applies globally, practices vary between countries. In the Netherlands, the preparation of medicines in pharmacies is well-established and integrated into routine healthcare. This narrative review explores the role and significance of extemporaneous compounding, pharmacy preparations and related product care in the Netherlands. Methods: Pharmacists involved in pharmacy preparations across various professional sectors, including community and hospital pharmacies, central compounding facilities, academia, and the professional pharmacists’ organisation, provided detailed and expert insights based on the literature and policy documents while also sharing their critical perspectives. Results: We present arguments supporting the need for pharmacy preparations and examine their position and role in community and hospital pharmacies in the Netherlands. Additional topics are discussed, including the regulatory and legal framework, outsourcing, quality assurance, standardisation, education, and international context. Specific pharmacy preparation topics, often with a research component and a strong focus on product care, are highlighted, including paediatric dosage forms, swallowing difficulties and feeding tubes, hospital-at-home care, reconstitution of oncolytic drugs and biologicals, total parenteral nutrition (TPN), advanced therapy medicinal products (ATMPs), radiopharmaceuticals and optical tracers, clinical trial medication, robotisation in reconstitution, and patient-centric solid oral dosage forms. Conclusions: The widespread acceptance of pharmacy preparations in the Netherlands is the result of a unique combination of strict adherence to tailored regulations that ensure quality and safety, and patient-oriented flexibility in design, formulation, and production. This approach is further reinforced by the standardisation of a broad range of formulations and procedures across primary, secondary and tertiary care, as well as by continuous research-driven innovation to develop new medicines, formulations, and production methods. Full article

With the development of information and communication technologies, analysing new risks of moral harassment at work is becoming increasingly pertinent, especially with the expansion of teleworking and hybrid working (a mix of remote and face-to-face work per week) in the wake of the COVID-19 pandemic. In an attempt to respond to the new issues of labour regulation, this study places special emphasis on new risks of moral harassment in hybrid work and teleworking contexts, considering both the international and European framework and the legal regime in Portugal, identifying its specificities. With the rise in teleworking in the post-pandemic period, the online monitoring of workers has accentuated the difficulty in drawing the line between managerial power and harassment. Moral harassment at work is a persistent challenge and organisations must recognise, prevent and respond to inappropriate behaviour in the organisation. The results of this study—based on the results of an online survey completed by employees (with employment contracts)—show that teleworking employees recognise that they have been pressured, above all, both to respond to messages quickly and pressure to work beyond hours and suggest possible gender differences in the way harassment in hybrid work and teleworking contexts is reported. Full article

Shift work can have an adverse impact on sleep and wellbeing, as well as negative consequences for workplace safety and productivity. SleepShifters is a co-developed sleep management programme that aims to equip shift workers and employers with the skills needed to manage sleep from the onset of employment, thus preventing sleep problems and their associated consequences from arising. This paper describes the co-development process and resulting programme protocol of SleepShifters, designed in line with the Medical Research Council’s framework for the development and evaluation of complex interventions. Programme components were co-produced in partnership with stakeholders from four organisations across the United Kingdom, following an iterative, four-stage process based on focus groups and interviews. As well as a handbook containing guidance on shift scheduling, workplace lighting, and controlled rest periods, SleepShifters consists of five key components: (1) an annual sleep awareness event; (2) a digital sleep training induction module for new starters; (3) a monthly-themed sleep awareness campaign; (4) a website, hosting a digital Cognitive Behavioural Therapy for insomnia platform and supportive video case studies from shift-working peers; (5) a sleep scheduling app for employees. Future work will implement and assess the effectiveness of delivering SleepShifters in organisational settings. Full article

The designs of clinical trials of drugs for rare diseases are challenged by health technology assessment organisations and payers. Phase II pivotal studies, single-arm or open-label designs, the extensive use of non-final endpoints, and the limited use of patient-reported outcomes (PROs) are the main points of contention. The evidence on the actual design of these trials is limited, but corroborates the concerns of the above. Our aim is to scrutinise whether the design of pivotal studies of drugs for rare diseases to be launched into the Italian market by 2026 present similar issues. The drugs and the relevant pivotal studies were retrieved from Biomedtracker and US and European clinical trial databases. We identified 154 new drugs for rare diseases. Single-arm designs account for 36% of trials. Almost 50% of randomised control trials (RCTs) are designed using an active comparator and 61% are double-blinded. Primary endpoints are mostly (82%) surrogate. A total of 59% of studies include PROs. Our findings were partially expected (e.g., extensive use of surrogate endpoints) and partially not (e.g., RCTs and an active comparator), considering previous studies on the same topic. Having more head-to-head studies may reduce uncertainty concerning evidence at market launch, but different issues persist, including the still limited role of PROs. Full article

Bring them home, keep them home is research based in New South Wales (NSW) Australia, that aims to understand successful and sustainable reunification for Aboriginal families who have children in out-of-home care (OOHC). This research is led by Aboriginal researchers, and partners with Aboriginal organisations. It is informed by the experiences of 20 Aboriginal parents and family members, and more than 200 practitioners and professionals working in child protection and reunification. This paper traces the evolution of Bring them home, keep them home which is now at the forefront of influence for NSW child protection reforms. Using specific examples, it highlights the role of research advocacy and resistance in challenging and disrupting systems in ways that amplify the voices of Aboriginal families and communities and embeds these voices as the foundation for radical innovation for child reunification approaches. The paper shares lessons being learned and insights for Aboriginal-led research with communities in the pursuit of restorative justice, system change, and self-determination. Providing a framework for liberating Aboriginal families from child abduction systems, this paper seeks to offer a truth-telling and practical contribution to the international efforts of Indigenous resistance to child abduction systems. Full article

The implementation of Building Information Modelling (BIM) in public design processes enhances efficiency, transparency, and sustainability. However, public agencies often encounter significant barriers, particularly regarding organisational and managerial readiness. This study develops a BIM implementation framework tailored to the specific needs of an Italian public agency. The research adopts a qualitative approach, combining 15 semi-structured interviews with process mapping Using (Business Process Modeling Notation) BPMN. The current as-is workflows were analysed and validated by internal stakeholders. Based on this analysis, strategic objectives were defined, relevant (Building Information Modelling) BIM uses were selected, and revised to-be processes were proposed, integrating new roles and responsibilities according to the standards. The framework addresses both technical and organisational dimensions of BIM adoption, highlighting the need for training, coordination, and stakeholder engagement. The main outcomes include a structured process model, a priority-based selection of BIM uses, and a role matrix supporting organisational transformation. The added value for researchers lies in the replicable methodology that combines empirical process mapping with implementation planning. For practitioners, especially consultants in sustainable design, the study offers a practical roadmap for aligning BIM adoption with project goals, regulatory compliance, and environmental performance targets in complex public sector contexts. Full article

Advanced technologies, such as robotic process automation, blockchain, and machine learning, increase audit efficiency. Nonetheless, some Supreme Audit Institutions (SAIs) have not undergone digital transformation. This research aimed to develop a comprehensive framework for supreme audit institutions to adopt and integrate emerging technologies into their auditing processes using a hybrid theoretical approach based on the TAM (Technology Acceptance Model) and TOE (Technology–Organisation–Environment) models. The framework was informed by insights from nineteen highly experienced experts in the field from eight countries. Through a two-round Delphi questionnaire, the experts provided valuable input on the key factors, challenges, and strategies for successful technology adoption by public sector audit organisations. The findings of this research reveal that technology adoption in SAIs starts with solid management support led by the chief technology officer. They must evaluate the IT infrastructure and readiness for advanced technologies, considering the budget and funding. Integrating solutions like the SAI of Ghana’s Audit Management Information System can significantly enhance audit efficiency. Continuous staff training is essential to build a positive attitude toward new technologies, covering areas like data algorithm auditing and big data analysis. Assessing the complexity and compatibility of new technologies ensures ease of use and cost-effectiveness. Continuous support from technology providers and monitoring advancements will keep SAIs aligned with technological developments, enhancing their auditing capabilities. Full article

Cacti are of interest for new bio-inspired technologies because of their remarkable adaptations to extreme environments. Recently, they have inspired functional designs from nano fibres to optimised buildings and architectures. We investigate the diversity of cactus skin properties in terms of toughness and resistance to cutting damage. Cacti are well known for their extreme adaptations to harsh environments, with soft, fleshy stems that expand and contract with water uptake and storage. This functioning is made possible by an extendable outer envelope (skin) and a fluted 3-dimensional structure of the stem. We explore the mechanical toughness and underlying structural organisation of the cactus skin in four species of cactus showing different growth forms. The toughness properties of the cactus skin is only one part of a multi-functional structure for surviving in extreme environments. The study suggests that survival involves a relatively “light” investment of tough materials in the outer envelope instead of a rigid “defensive” layer. This is capable of elastic deformation and enables water storage in challenging, arid environments. The main purpose of this article is to demonstrate the diversity of skin toughness and underlying structures in the biological world as providing potential new designs for technical envelopes. Full article

Job advertisements play a key role in human resource management as they are the first contact between employers and potential employees. A well-written job advertisement communicates not only the requirements and expectations of the position but also the culture, values, and goals of the organisation. Transparent and attractive advertisements increase the number of applicants and help to select the right candidates, leading to more efficient recruitment and selection processes in the long run. From a human resource management perspective, effective job advertising can give organisations a competitive advantage. Continuous changes in the labour market and technological developments require new competencies. Digitalisation, automation, and data-driven decision-making have brought IT, analytical, and communication skills to the fore. There is a growing emphasis on soft skills such as problem solving, flexibility, and teamwork, which are essential in a fast-changing work environment. Job advertisements should reflect these expectations so that candidates are aware of the competencies and skills required for the position. The aim of the study is to carry out a cross-country comparative analysis for a few pre-selected jobs based on data extracted from the CEDEFOP database as it is assumed that there are differences between countries in the European Union in terms of the expectations of workers for the same jobs. Full article

The European Union’s developing rural development plan places digital and precision agriculture at the centre of agricultural modernisation and economic development. This article examines how agricultural practices in rural EU regions are being influenced by smart technology, such as drones, IoT sensors, satellite-based research, and AI-driven platforms, through an analysis of recent data from sources across the European Union. This study applies a mixed-methods approach, combining quantitative analysis of strategic policy documents and EU databases, to evaluate the ways in which precision agriculture reduces input consumption, increases productivity, reduces labour shortages and rural area depopulation, and improves sustainability. By investing in infrastructure, developing communities for data exchange, and organising training for farmers, European policies such as the Strategic Plans of the Common Agricultural Policy (CAP), the SmartAgriHubs initiative, and the AgData program actively encourage the transition to digital agriculture. Cyprus is analysed as a case study to show how targeted investments and initiatives supported by the EU can help smaller countries, with limited natural resources, to realise the benefits of digital transformation in agriculture. A special focus is placed on how solutions adapted to agro-climatic and socioeconomic conditions can contribute to strengthening the competitiveness of the agricultural sector, attracting young people to get involved in this field and opening up new economic opportunities. The results of previous research indicate that digital agriculture not only improves productivity but also proves to be a strategic mechanism for attracting and retaining young people in rural areas. Thus, this work additionally contributes to the broader goal of the European Union—the development of smart, inclusive, and sustainable rural areas, in which digital technologies are not only seen as tools for efficiency but also as key means for integrated and long-term rural development. Full article

Digitalisation can positively impact the efficiency of real-world business processes, but may also introduce new cybersecurity challenges. One area that is particularly vulnerable to cyber-attacks is the business logic embedded in processes in which flaws may exist. This is especially the case when these processes are within web-based applications and services, which is increasingly becoming the norm for many organisations. Business logic vulnerabilities (BLVs) can emerge following the software development process, which may be difficult to detect by vulnerability detection tools. Through a systematic literature review and interviews with industry practitioners, this study identifies key BLV types and the challenges in detecting them. The paper proposes an eight-stage operational framework that leverages Artificial Intelligence (AI) for enhanced BLV detection and mitigation. The research findings contribute to the rapidly evolving theory and practice in this field of study, highlighting the current reliance on manual detection, the contextual nature of BLVs, and the need for a hybrid, multi-layered approach integrating human expertise with AI tools. The study concludes by emphasizing AI’s potential to transform cybersecurity from a reactive to a proactive defense against evolving vulnerabilities and threats. Full article

One of the important parameters of the sheet metal forming process is the coefficient of friction (CoF). Therefore, monitoring the friction coefficient value is essential to ensure product quality, increase productivity, reduce environmental impact, and avoid product defects. Conventional CoF monitoring techniques pose a number of problems, including the difficulty in identifying the features of force signals that are sensitive to the variation in the coefficient of friction. To overcome these difficulties, this paper proposes a new approach to apply unsupervised artificial intelligence techniques with unbalanced data to classify the CoF of DP780 (HCT780X acc. to EN 10346:2015 standard) steel sheets in strip-drawing tests. During sheet metal forming (SMF), the CoF changes owing to the evolution of the contact conditions at the tool–sheet metal interface. The surface topography, the contact loads, and the material behaviour affect the phenomena in the contact zone. Therefore, classification is required to identify possible disturbances in the friction process causing the change in the CoF, based on the analysis of the friction process parameters and the change in the sheet metal’s surface roughness. The Kohonen self-organising map (SOM) was created based on the surface topography parameters collected and used for CoF classification. The CoF determinations were performed in the strip-drawing test under different lubrication conditions, contact pressures, and sliding speeds. The results showed that it is possible to classify the CoF using an SOM for unbalanced data, using only the surface roughness parameter Sq and selected friction test parameters, with a classification accuracy of up to 98%. Full article

Background/Objectives: This study protocol outlines the implementation of a professional development programme (ProDeveloP) designed to support newly graduated nurses (NGNs). NGNs often experience inadequacy and face challenges in developing their professional competence. Healthcare organisations can ease this transition through introduction programmes. However, effective implementation strategies in local healthcare settings remain unclear. This study aims to develop, implement, and evaluate a programme that enhances role clarity, task mastery, social acceptance, stress reduction, and recovery, contributing to increased job satisfaction and retention. Methods: ProDeveloP will be implemented at a regional hospital in mid-Sweden. This study will include a convenience sample of 110 NGNs from both the previous and the new introduction programmes, 20 dialogue facilitators involved in the programme, and 10 managers responsible for NGNs participating in the programme. Data will be collected throughout the ProDeveloP using questionnaires, individual interviews, and focus groups. The data will be analysed using both qualitative and quantitative analyses. Conclusions: This study has the potential to improve NGNs’ work-related health, job satisfaction, and retention while contributing to competence development. By offering structured reflection, mentorship, and organisational support, this research project addresses knowledge gaps in understanding the long-term impacts of introduction programmes and structured reflection, contributing to evidence-based improvements in nursing practice and healthcare leadership. Clinical trial number: NCT06742047. Registered in ClinicalTrials.gov, 19 December 2024. Full article

Aim: This article explores the contributing factors to the decline in the number of auditors globally and aims to provide the consequences and possible recommendations. Auditors play a critical role in ensuring transparency, trust, and credibility of financial statements. However, the profession is experiencing a decline across the globe. The decrease in the number of registered auditors has become a pressing issue, raising concerns about the future of the assurance industry’s ability to maintain the number of registered auditors and continue providing assurance services to public and private entities or companies. Methodology: A scoping-review methodology was adopted to analyse the existing literature on the global decline in the number of auditors. This approach utilises research evidence to identify trends, challenges, and opportunities within the audit profession. Relevant studies were sourced from databases such as ScienceDirect, Google Scholar, and ResearchGate, as well as the grey literature. Main findings: This study identifies a combination of factors driving the decline of auditors globally. Economic pressures, such as cost reduction initiatives and outsourcing, have impacted the demand for traditional auditing services. Complex regulatory requirements have increased barriers to entry, while technological advancements, such as artificial intelligence, are disrupting traditional auditing roles. Additionally, the profession suffers from negative perceptions regarding workload, remuneration, and work–life balance, discouraging new entrants. Practical implications: The findings emphasise the urgent need for the auditing profession to adapt to evolving challenges. Stakeholders, including regulatory bodies and professional organisations, must address issues such as technological integration, career development pathways, and regulatory simplification. Enhanced public awareness campaigns and training initiatives are critical to attracting and retaining professional talent. Contribution: This study contributes to the limited body of knowledge on the global decline of auditors by creating a broad spectrum of evidence. It highlights actionable strategies to address the profession’s challenges and provides a foundation for future research on sustaining the relevance of auditors in a dynamic global economy. Full article

The coastal region of Klaipėda (Lithuania) has experienced major political, economic, social, and cultural transformations since the 20th century. Landscapes as evolving expressions of land use and land cover patterns offer a valuable lens to analyse these changes. This study examines the evolution of physical landscape structures across the pre-Soviet, Soviet, and post-Soviet periods, using historical maps and open-access geospatial data. An ontological approach, combined with morphological and configurational metrics, reveals four major and relatively persistent landscape structures: hydrological systems (sea, lagoon, rivers), forest cover, farming intensity (from extensive grassland use to intensive arable farming), and semi-natural environments. Their structural evolution reflects broader cultural factors, such as contrasting land use traditions between former Prussian and Russian territories. The study also highlights the impact of Soviet collectivisation, marked by irrigation networks, agricultural intensification, and forest expansion. The post-Soviet period is characterised by widespread farmland abandonment and fragmentation, revealing new spatial dynamics and challenges in land reappropriation. Landscape transformations are predominantly structured around agricultural dynamics. Although the analysis was limited by the incomplete availability of data for this specific land use class, the centrality of agriculture in shaping territorial organisation is evident and reinforces the strong rural identity associated with the landscape. Full article