Search Results (639)

Stated preference surveys have been utilized in the field of sustainable multimodal transport planning for some time. Stated preference, which relies on hypothetical scenarios to determine user preferences, offers critical insights into travelers’ choices between different transport modes. The stated preference method is used in a wide range of transport studies, such as the mode choice, route choice, service attribute analysis, pricing and fare policies, and technical innovations. On the basis of the collected data in stated preference studies, it is possible to optimize current services, forecast future demand, or analyze the possibilities of nonexistent services. A literature review reveals that there are certain gaps regarding the calibration of utility functions in multimodal and new services. Full article

In order to study the generation, management, and disposal status of waste mineral oil in China’s railway transport industry, this article takes the Beijing Railway Bureau and its subordinate Tangshan Locomotive Depot as the research objects and comprehensively applies the survey, case study, and statistical analysis methods to analyze the source of the generation of railway waste mineral oil, the distribution of the disposal enterprises and locomotive depots, the management mode, and the economic and environmental benefits of recycling waste engine oil. The results show that waste oil mainly originates from locomotive overhaul and maintenance. There is significant regional imbalance in the generation and disposal capacity of railway waste oil. The Beijing Railway Bureau can achieve the timely disposal of waste mineral oil and reduce transport risks. Waste mineral oil management integrates generation, storage, transfer, and disposal. If cooperation is initiated with waste oil disposal enterprises, the use of recycled oil can save up to RMB 178,600/year and reduce carbon emission by 76.42 tCO₂/year for this locomotive depot. In view of the current situation, the railway industry should improve the management and disposal deficiencies and explore the new model of waste oil reduction, reuse, and recycling. Full article

With the acceleration of urbanization, Autonomous-rail Rapid Transit (ART), as a new type of public transportation mode, plays an important role in alleviating traffic congestion and optimizing urban transportation structure. However, the operation of ART faces various problems, such as the route and station design problems considering passengers’ convenience and transferring efficiency, and there is a gap between passenger perception and expectation for the ART service quality. Therefore, it is crucial to comprehensively evaluate the service quality of ART, so as to improve passenger satisfaction and promote the sustainable development of ART. Taking Yibin ART as the research object, this study is based on the Service Quality (SERVQUAL) model, combined with the Analytic Hierarchy Process (AHP) and Fuzzy Comprehensive Evaluation (FCE), to analyze the service quality of Yibin ART. Firstly, a service quality evaluation indicator system for Yibin ART is constructed based on the extended SERVQUAL model that includes six dimensions of reliability, responsiveness, assurance, empathy, tangibility, and convenience, as well as 19 secondary indicators. Then, the research collects 110 valid samples through a questionnaire survey, and the rationality of the questionnaire is verified through reliability and validity analysis. Later, the weights of the indicators are calculated by AHP, and a comprehensive evaluation of Yibin ART service quality is conducted with the FCE method. Finally, based on the evaluation results, the study shows that the core indicators of the ART service quality are the service reliability and responsiveness, as well as the convenience; further, the results find the significant differences between participants’ perceptions and expectations for ART service quality, especially in the aspects of smooth driving, cleanliness, station location, ticket service and transferring, and the corresponding targeted strategies are proposed for improving the Yibin ART service quality. Additionally, future research will expand the sample and conduct in-depth research on passenger travel characteristics, carefully grasp the needs of passengers, continuously optimize operational service plans, and strive to improve the service level of ART. Full article

This paper is aimed at exploring and expanding the concept of mobility culture(s) (MC), with regard to its influence on public transportation (PT) usage share. Despite some factors being positively correlated with collective modes, the modal split is often skewed in favour of private or individual ones. To this end, a comprehensive analysis of 70 cities in Germany and Italy is conducted, employing geographically weighted regression (GWR) to assess the impact of some factors on the local share of PT. Factors examined include land use diversity, fare integration, service quality (measured as level of service), scheduling regularity and characteristics of the transit network maps. The findings of the study provide new perspectives on MC and suggest strategies for promoting sustainable and equitable transportation systems. Full article

Airport-bound access and egress trips comprise a significant portion of total ground transportation trips, especially in regions served by large airports. Connecting urban areas with airports under minimal travel delays can be challenging, with traffic congestion along busy connecting corridors being a common phenomenon. Urban Air Mobility (UAM) is a new transportation mode envisioned to reduce travel times using specific aircraft, such as electric (and non-electric) Vertical or Short Take-off and Landing aircraft (e/VTOLs and STOLs, respectively). The operation of these aircraft requires take-off and landing infrastructure known as vertiports. A strategic infrastructure placement framework was introduced, utilizing and adapting the Capacitated Facility Location Problem (a-CFLP) and the Maximal Covering Location Problem (a-MCLP) with capacity constraints. An adapted capacitated k-means algorithm and a greedy heuristic were considered for the solution of the a-CFLP, while the a-MCLP was formulated as a mixed-integer linear programming problem. The proposed framework was applied in the Chicago Metropolitan Area, revealing that various trade-offs regarding coverage and accessibility, versus operational costs (number of facilities, facility capacity, and service radius), exist. The results showed that, depending on vertiport capacity and service radius capabilities, a range of 5 to 12 vertiports can sufficiently address the demand (above 95% demand coverage) and, with respect to accessibility, serve a moderate UAM demand scenario of 6124 daily requests, as identified for this region. Full article

Eugenol is a compound with promising antimicrobial properties. The rising phenomenon of multidrug resistance of Candida albicans is driving researchers to search for new, alternative therapeutics that would synergize with conventional antifungal drugs. The aim of the present study is to investigate how eugenol and eugenol-based extracts impair C. albicans growth by generation of reactive oxygen species (ROS) and plasma membrane (PM) disruption. The methods that we applied involve structural analysis of eugenol extracts by HPLC, ATR-FTIR, and polyphenol detection. Additionally, determination of ROS level in C. albicans was performed using microscopic and flow cytometry studies and analysis of PM integrity (PI-staining, observation of PM transporter—Cdr1p—localization) and fluidity (fluorometric study). The results indicate that eugenol impacts fungal growth, and this corresponds with increased ROS levels and diminished PM fluidity in the C. albicans WT strain. C. albicans strains deprived of ergosterol (erg11Δ/Δ) exhibited lowered ROS level and no change in PM fluidity in response to the tested eugenol extracts, but they affected its growth and caused PM permeabilization and Cdr1p delocalization. These conclusions indicate that mode of action of eugenol can be related to disruption of PM structure by both ergosterol-dependent and -independent mechanisms. Ergosterol can play a crucial role in maintaining the PM integrity during treatment with lower concentrations of eugenol. Full article

The Multi-Mode Model (MMM) is a physics-based anomalous transport model integrated into TRANSP for predicting electron and ion thermal transport, electron and impurity particle transport, and toroidal and poloidal momentum transport. While MMM provides valuable predictive capabilities, its computational cost, although manageable for standard simulations, is too high for real-time control applications. MMMnet, a neural network-based surrogate model, is developed to address this challenge by significantly reducing computation time while maintaining high accuracy. Trained on TRANSP simulations of DIII-D discharges, MMMnet incorporates an updated version of MMM (9.0.10) with enhanced physics, including isotopic effects, plasma shaping via effective magnetic shear, unified correlation lengths for ion-scale modes, and a new physics-based model for the electromagnetic electron temperature gradient mode. A key advancement is MMMnet’s ability to predict all six transport coefficients, providing a comprehensive representation of plasma transport dynamics. MMMnet achieves a two-order-of-magnitude speed improvement while maintaining strong correlation with MMM diffusivities, making it well-suited for real-time tokamak control and scenario optimization. Full article

Achieving decoupling between tourism economic growth and tourism carbon emissions is of paramount importance. This study innovatively integrates the geographically weighted regression (GWR) model—a tool for analyzing spatial heterogeneity—into the Tapio decoupling framework to examine the dynamic decoupling relationship between tourism growth and carbon emissions. It further investigates the driving factors behind decoupling evolution, their interactions, and precisely characterizes the mechanisms, directions, pathways, and intensities of these drivers. Key findings reveal an M-shaped fluctuation trend in tourism carbon emissions within the study area, with significant variations in emission shares across different tourism sectors and transportation modes. Spatially, carbon emissions exhibit heterogeneity and negative autocorrelation, where inter-regional disparities diminish while intra-regional disparities intensify. The tourism economic system in the Yangtze River Economic Belt (YREB) transitioned through weak decoupling, expansive negative decoupling, and strong decoupling states, eventually stabilizing at weak decoupling. Regional decoupling states varied markedly, suggesting that some areas require exploration of new low-carbon development paradigms. For sustainable tourism development, policy-makers should prioritize the decoupling relationship between tourism emissions and economic growth. Region-specific policies must be formulated to facilitate low-carbon transitions, promote industrial upgrading, and enhance inter-regional collaboration—ultimately advancing sustainable tourism under carbon neutrality goals. Full article

Background: Armed conflicts impose complex logistical and behavioral challenges on healthcare systems, particularly in managing acute conditions such as ST-elevation myocardial infarction (STEMI) and ischemic stroke. Although both diagnoses require timely intervention, their clinical pathways differ significantly. Few studies have systematically compared their management during active warfare, particularly within the warzone. Methods: This retrospective cohort study was conducted at Soroka University Medical Center (SUMC), the sole tertiary hospital in southern Israel and the main referral center for cardiovascular and neurological emergencies in the region. We included all adult patients (≥18 years) admitted with new-onset STEMI or ischemic stroke during three-month periods of wartime (October–December 2023) and matched routine periods in 2021 and 2022. Patients with in-hospital events, inter-hospital transfers, or foreign citizenship were excluded. Data on demographics, comorbidities, arrival characteristics, treatment timelines, and outcomes were extracted from electronic medical records. Categorical variables were compared using Chi-squared or Fisher’s exact test, and continuous variables using t-tests or Mann–Whitney U tests, as appropriate. Multivariable logistic and linear regression models were adjusted for age, sex, Charlson Comorbidity Index (CCI), and mode of arrival. Interaction terms assessed whether wartime modified the associations differently for STEMI and stroke. Results: A total of 410 patients were included (193 with STEMI and 217 with stroke). Patients with STEMI were significantly more likely to arrive by self-transport during the war (38, 57.6% vs. 32, 25.2%, p < 0.001) and had higher rates of late arrival beyond 12 h (19, 28.8% vs. 13, 10.2%, p = 0.002). These findings support the conclusion that patients were more prone to delayed and unstructured presentations during a crisis. In contrast, patients with stroke showed a reduction of 354 min in symptom-to-door times during the war [median 246 (30–4320 range) vs. 600 min (12–2329 range), p = 0.026]. Regression models revealed longer delays for stroke vs. STEMI in routine settings [β = 543.07 min (239.68–846.47 95% CI), p < 0.001], along with significantly lower in-hospital (OR = 0.39, 95% CI= 0.15–0.97, p = 0.05) and 30-day mortality (OR = 0.43, 95% CI= 0.19–0.94, p = 0.04). However, these differences were no longer significant during wartime. Patients with STEMI showed a trend toward lower 180-day mortality during the war (OR = 0.33, 95% CI = 0.09–0.99; p = 0.07), although this difference did not reach statistical significance. Conclusions: During wartime, patients with stroke arrived earlier and in greater numbers, while patients with STEMI showed reduced admissions and delayed, self-initiated transport. Despite these shifts, treatment timelines and short-term outcomes were maintained. These diagnosis-specific patterns highlight the importance of reinforcing EMS access for STEMI and preserving centralized protocol-based coordination for stroke during crises. Full article

Atmospheric aerosols are recognized as a major air pollutant with significant impacts on human health, air quality, and climate. Yet, the chemical composition and seasonal variability of aerosols remain underexplored in several Western Mediterranean regions. This study presents a year-long investigation of PM_2.5 and PM₁₀ in Tetouan, Northern Morocco, where both local emissions and regional transport influence air quality. PM_2.5 and PM₁₀ samples were collected and analysed for total mass and comprehensive chemical characterization, including organic carbon (OC), elemental carbon (EC), water-soluble ions (WSIs), and sugar tracers (levoglucosan, arabitol, and glucose). Concentration-weighted trajectory (CWT) modelling and air mass back-trajectory analyses were used to assess potential source regions and transport pathways. PM_2.5 concentrations ranged from 4.2 to 41.8 µg m⁻³ (annual mean: 18.0 ± 6.4 µg m⁻³), while PM₁₀ ranged from 11.9 to 66.3 µg m⁻³ (annual mean: 30.8 ± 9.7 µg m⁻³), with peaks in winter and minima in spring. The PM_2.5-to-PM₁₀ ratio averaged 0.59, indicating a substantial accumulation of particle mass within the fine fraction, especially during the cold season. Carbonaceous aerosols dominated the fine fraction, with total carbonaceous aerosol (TCA) contributing ~52% to PM_2.5 and ~34% to PM₁₀. Secondary organic carbon (SOC) accounted for up to 90% of OC in PM_2.5, reaching 7.3 ± 3.4 µg m⁻³ in winter. WSIs comprised ~39% of PM_2.5 mass, with sulfate, nitrate, and ammonium as major components, peaking in summer. Sugar tracers exhibited coarse-mode dominance, reflecting biomass burning and biogenic activity. Concentration-weighted trajectory and back-trajectory analyses identified the Mediterranean Basin and Iberian Peninsula as dominant source regions, in addition to local urban emissions. Overall, this study attempts to fill a critical knowledge gap in Southwestern Mediterranean aerosol research by providing a comprehensive characterization of PM_2.5 and PM₁₀ chemical composition and their seasonal dynamics in Tetouan. It further offers new insights into how a combination of local emissions and regional transport shapes the aerosol composition in this North African urban environment. Full article

Air pollution poses growing challenges to public health and urban mobility in Southeast Asia. This study investigates how air quality crises affect travel mode choices in Chiang Rai, Thailand, a secondary city experiencing seasonal PM2.5 smog episodes. A structured online survey was conducted with 406 respondents, collecting paired data on travel behaviors during non-air quality crisis (N-AQC) and air quality crisis (AQC) periods. Using a multinomial logit model (MNL), key socioeconomic and trip-related variables were analyzed to estimate mode choice probabilities. The results reveal significant behavioral shifts during an air quality crisis, with private car usage increasing from 30.30% to 34.70% and motorcycle usage decreasing from 50.20% to 42.90%. Multinomial logit models attained correct classification rates of 67.5% and 63.8%, with pseudo R² values exceeding 0.50 for both periods. These findings highlight how environmental stress alters travel behavior, especially among younger and low-income populations. The study contributes new insights from a Southeast Asian urban context, emphasizing the need for adaptive transport policies, protective infrastructure, and equity-focused interventions to promote sustainable mobility during an environmental crisis. Full article

Objective: The development of natural and new P-gp modulators to reverse tumor multidrug resistance (MDR). Methods: Test compounds were prepared from the plant Metaplexis japonica, and their ability to reverse P-glycoprotein (P-gp)-mediated MDR was investigated in HepG2/Dox cells. Their effects on P-gp expression and function and their interaction modes with P-gp were also investigated. Results: Natural product 3β,12β,14β, 17β,20(S)-pentahydroxy-5α-pregnan-12β-O-(E)-cinnamate (1) and its new semisynthetic derivative 3β12β,14β,17β,20(S)-pentahydroxy-5α-pregnan-3β-O-nicotinate-12β-O-(E)-cinnamate (1a) were obtained. At non-cytotoxic concentrations of 5 or 10 μM, they significantly reversed the resistance of HepG2/Dox cells to P-gp substrate drugs doxorubicin, paclitaxel, and vinblastine, with reversal folds of 7.1, 118.5, and 198.3 (1), and 18.8, 335.8, and 140.0 (1a), respectively, at 10 μM. Cell apoptosis and expression of caspase 9 were both triggered by the combination of 10 μM of compound 1 or 1a and 500 nM of paclitaxel (p < 0.001). Compound 1 or 1a did not affect P-gp expression, but it did significantly suppress the efflux of Rhodamine 123 out of HepG2/Dox cells (p < 0.001). On the Caco-2 cell monolayer, 1 and 1a were shown to be non-substrates of P-gp, with efflux ratios of 0.83 and 0.89. Molecular docking revealed their strong binding energies (−8.2 and −8.4 kcal/mol) with P-gp, and their direct binding to P-gp was confirmed by their dissociation constants (5.53 µM for 1 and 3.72 µM for 1a), determined using surface plasmon resonance. Conclusions: Compounds 1 and 1a are potential P-gp modulators; they may reverse P-gp-MDR through interacting with P-gp to interfere with substrate binding and transporting, and have the potential to improve the efficacy of paclitaxel or vinblastine drugs for combating P-gp-mediated MDR in tumor cells. Full article

As cities grow, they increase in complexity, requiring the effective use of land resources. Cycling is generally regarded as an alternative transport mode to support the development of the cities of tomorrow. In response to urbanization, in many cities worldwide, a common concern associated with investing in cycling networks is the resulting use after such investment. This study uses a continuous longitudinal dataset of daily cycling counts from January 2018 to June 2024 to assess bicycle volumes across three of New Zealand’s largest cities. The results reveal that the relationship between distance and cycle count is not uniform across space, with some areas showing a negative effect between distance and cycling, and others showing a positive one. A global OLS model hides these complexities, as shown in the geographically weighted regression (GWR) model. The coefficients for distance (−0.49) and precipitation (−95.23) in the global OLS are higher, and do not reveal the non-uniformity between cities, wheras themultiple GWR coefficients for distance range between −0.57 and −0.47 and precipitation between −33.47 and −97.63. The results reveal that cycling volume demonstrates lower sensitivity to changes in distance compared to variations in weather conditions. At the city level, there are notable intercity differences in sensitivity. The variability in the coefficients across locations suggests that, although distance and precipitation have general effects, local factors, such as infrastructure quality, topography, weather adaptation measures, and cultural attitudes toward cycling, play a critical role in modulating these relationships. The findings highlight the complexity of spatial interactions and emphasize the need for localized interventions when planning cycling networks. Full article

For the last few decades, the use of High-Speed Trains (HSTs) has been growing rapidly in various parts of the world. Despite rapid global expansion, many HST projects fail due to demand overestimation and cost overruns. This study analyzes factors influencing HST demand in Indonesia, aiming to identify impactful determinants from user perspectives. Employing a quantitative cross-sectional approach, this research utilized questionnaires distributed to users of different modes of transportation in the Jakarta–Bandung area, including trains, buses, travel services, and private cars. Structural Equation Modeling (SEM) via Lisrel software was used to analyze the data. The results indicate that Transit-Oriented Developments (TOD) and new urban areas significantly increase HST demand by facilitating urban growth and development. Additionally, supporting infrastructure and external factors such as road accessibility, parking availability, shuttle services, and environmental integration are pivotal in shaping commuter preferences. Although factors such as safety, comfort, and reliability are important, they alone may not be adequate to persuade consumers to use high-speed trains for their travel. Full article

Urban areas are facing increasing traffic congestion, pollution, and infrastructure strain. Traditional urban transportation systems are often fragmented. They require users to plan, pay, and travel across multiple disconnected services. Mobility-as-a-Service (MaaS) integrates these services into a single digital platform, simplifying access and improving the user experience. This review critically examines the role of MaaS in fostering sustainable mobility ecosystems. MaaS aims to enhance user-friendliness, service variety, and sustainability by adopting a customer-centric approach to transportation. The findings reveal that successful MaaS systems consistently align with multimodal transport infrastructure, equitable access policies, and strong public-private partnerships. MaaS enhances the management of routes and traffic, effectively mitigating delays and congestion while concurrently reducing energy consumption and fuel usage. In this study, the authors examine MaaS as a new mobility paradigm for a sustainable transportation system in smart cities, observing the challenges and opportunities associated with its implementation. To assess the environmental impact, a sustainability index is calculated based on the use of different modes of transportation. Significant findings indicate that MaaS systems are proliferating in both quantity and complexity, increasingly integrating capabilities such as real-time multimodal planning, dynamic pricing, and personalized user profiles. Full article