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Keywords = near-wall treatment

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20 pages, 3890 KiB  
Article
Numerical Analysis of Pressure Drops in Single-Phase Flow Through Channels of Brazed Plate Heat Exchangers with Dimpled Corrugated Plates
by Lorenzo Giunti, Francesco Giacomelli, Urban Močnik, Giacomo Villi, Adriano Milazzo and Lorenzo Talluri
Appl. Sci. 2025, 15(15), 8431; https://doi.org/10.3390/app15158431 (registering DOI) - 29 Jul 2025
Viewed by 194
Abstract
The presented research examines the performance characteristics of Brazed Plate Heat Exchangers through computational fluid dynamics (CFD), focusing on pressure drop calculations for single-phase flow within full channels of plates featuring dimpled corrugation. This work aims to bridge gaps in the literature, particularly [...] Read more.
The presented research examines the performance characteristics of Brazed Plate Heat Exchangers through computational fluid dynamics (CFD), focusing on pressure drop calculations for single-phase flow within full channels of plates featuring dimpled corrugation. This work aims to bridge gaps in the literature, particularly regarding the underexplored behavior near the ports for the studied technology and establishing a framework for future conjugate heat transfer studies. A methodology for the domain generation was developed, integrating a preliminary forming simulation to reproduce the complex plate geometry. Comprehensive sensitivity analyses were conducted to evaluate the influence of different parameters and identify the optimal settings for obtaining reliable results. The findings indicate that the kε realizable turbulence model with enhanced wall treatment offers superior accuracy in predicting pressure drops, with errors within ±4.4%. Additionally, leveraging the information derived from CFD, a strategy to estimate contributions from different channel sections without a direct reliance on those simulations was developed, offering practical implications for plate design. Full article
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20 pages, 2271 KiB  
Article
Single and Combined Effects of Meropenem, Valproic Acid, and Ketoprofen on Adult Zebrafish Behavior, Oxidative Stress, and Acetylcholinesterase Activity
by Ionut-Alexandru Chelaru, Roxana Strungaru-Jijie, Mircea Nicoara, Diana Mirila, Alin Ciobica and Dorel Ureche
Pharmaceuticals 2025, 18(8), 1096; https://doi.org/10.3390/ph18081096 - 24 Jul 2025
Viewed by 302
Abstract
Background: Pharmaceutical compounds frequently co-occur in environmental waters, but studies on their combined effects on animals and humans remain limited. The present study investigated the individual and combined short-term effects of ketoprofen (Kp, a nonsteroidal anti-inflammatory drug inhibiting cyclooxygenase-2), valproic acid (VPA, [...] Read more.
Background: Pharmaceutical compounds frequently co-occur in environmental waters, but studies on their combined effects on animals and humans remain limited. The present study investigated the individual and combined short-term effects of ketoprofen (Kp, a nonsteroidal anti-inflammatory drug inhibiting cyclooxygenase-2), valproic acid (VPA, an anticonvulsant acting as a voltage-gated sodium channel modulator), and meropenem (Mp, a β-lactam antibiotic) at environmentally relevant concentrations on zebrafish behavior, acetylcholinesterase (AChE) activity, and oxidative status. Methods: Adult zebrafish were exposed for 4 days to Kp, VPA, Mp, and their binary and ternary mixtures. Behavioral effects were assessed using 3D novel tank and social behavior tests, while the oxidative stress response was assessed through malondialdehyde (MDA) content, superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities. Results: Zebrafish exposed to Mp showed a notable increase in immobility, whereas those exposed to VPA and Mp + Kp exhibited a significant augmentation of average velocity and counter-clockwise rotations. All treated groups exhibited a notable increase in the time spent near the walls (thigmotaxis), and except for the control and Mp-exposed zebrafish, the other groups mostly stayed in the bottom tank zone (geotaxis). Kp, VPA + Kp, and VPA + Mp + Kp treatments impaired social behavior, with zebrafish displaying less interest in conspecifics. Biochemical analysis demonstrated that both the individual drugs and their combination caused oxidative stress, characterized by decreased GPx activity and increased SOD activity and MDA levels. Moreover, AChE activity was more strongly inhibited in zebrafish exposed to the binary and ternary mixtures than to individual drugs. Conclusions: The results indicate that acute exposure to individual and/or combined pharmaceuticals induces behavioral changes, oxidative damage, and AChE inhibition in zebrafish, highlighting the need to assess the effects of pharmaceutical mixtures for comprehensive ecosystem risks evaluation. Full article
(This article belongs to the Section Medicinal Chemistry)
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21 pages, 5135 KiB  
Article
Assessing the Heat Transfer Modeling Capabilities of CFD Software for Involute-Shaped Plate Research Reactors
by Cezary Bojanowski, Ronja Schönecker, Katarzyna Borowiec, Kaltrina Shehu, Julius Mercz, Frederic Thomas, Yoann Calzavara, Aurelien Bergeron, Prashant Jain, Christian Reiter and Jeremy Licht
Energies 2025, 18(14), 3692; https://doi.org/10.3390/en18143692 - 12 Jul 2025
Viewed by 343
Abstract
The ongoing efforts to convert High-Performance Research Reactors (HPRRs) using Highly Enriched Uranium (HEU) to Low-Enriched Uranium (LEU) fuel require reliable thermal–hydraulic assessments of modified core designs. The involute-shaped fuel plates used in several major HPRRs present unique modeling challenges due to their [...] Read more.
The ongoing efforts to convert High-Performance Research Reactors (HPRRs) using Highly Enriched Uranium (HEU) to Low-Enriched Uranium (LEU) fuel require reliable thermal–hydraulic assessments of modified core designs. The involute-shaped fuel plates used in several major HPRRs present unique modeling challenges due to their compact core geometries and high heat flux conditions. This study evaluates the capability of three commercial CFD tools, STAR-CCM+, COMSOL, and ANSYS CFX, to predict cladding-to-coolant heat transfer using Reynolds-Averaged Navier–Stokes (RANS) methods within the thermal–hydraulic regimes of involute-shaped plate reactors. Broad sensitivity analysis was conducted across a range of reactor-relevant parameters using two turbulence models (kϵ and kω SST) and different near-wall treatment strategies. The results were benchmarked against the Sieder–Tate correlation and experimental data from historic studies. The codes produced consistent results, showing good agreement with the empirical correlation of Sieder–Tate and the experimental measurements. The findings support the use of these commercial CFD codes as effective tools for assessing the thermal–hydraulic performance of involute-shaped plate HPRRs and guide future LEU core development. Full article
(This article belongs to the Section B4: Nuclear Energy)
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20 pages, 2486 KiB  
Article
An Experimental Study on the Novel Ozone-Electro-Fenton Coupled Reactor for Treating Ofloxacin-Containing Industrial Wastewater
by Yifeng Han, Lifen Zhang, Keyan Liu, Jinliang Tao and Feng Wei
Water 2025, 17(11), 1649; https://doi.org/10.3390/w17111649 - 29 May 2025
Viewed by 457
Abstract
Industrial organic wastewater, with its complex composition, high biological toxicity, and recalcitrance, has become a major challenge in water pollution control. This is especially true for antibiotic-containing wastewater, such as ofloxacin wastewater, for which there is an urgent need to develop effective treatment [...] Read more.
Industrial organic wastewater, with its complex composition, high biological toxicity, and recalcitrance, has become a major challenge in water pollution control. This is especially true for antibiotic-containing wastewater, such as ofloxacin wastewater, for which there is an urgent need to develop effective treatment technologies. Conventional treatment processes are insufficiently efficient, while individual advanced oxidation processes (AOPs) have drawbacks such as poor oxidation selectivity and catalyst deactivation. To address these issues, researchers have explored the coupling of different AOPs and found that such combinations can enhance the oxidation performance, achieve complementary advantages, reduce the equipment costs, and offer great development potential. An experiment was conducted to evaluate the performance of an Ozone-Electro-Fenton coupled process in treating ofloxacin industrial wastewater. The results demonstrated that under the same conditions, after four hours of treatment, the coupled process achieved a 70% reduction in the UV absorption peak of the wastewater, compared to less than 20% for individual processes, indicating a significant synergistic effect. Further optimization of the ozone aeration structure revealed that with a hole size of 0.5 mm, single-layer aeration holes, and six holes, the COD removal rate reached 96% after six hours, the ozone utilization improved to 85%, and the gas holdup stabilized at 4.6%. Under these conditions, the mixture of ozone and air bubbles formed mixed bubbles. Influenced by the electric field and electrode plate wall effects, the bubble residence time was prolonged. The bubble size was approximately 2.8 mm, the gas flow horizontal velocity was about 18.5 m/s, and after a horizontal displacement of 0.17 mm in the wastewater, the lateral velocity became zero. The ratio of the distance between the bubble center and the wall to the equivalent bubble diameter was approximately 3.45. The bubbles were subject to a strong wall effect, which extended their residence time. This not only facilitated the removal of small bubbles from the electrode plates but also enhanced the ion diffusion near the plates, thereby boosting pollutant degradation. This study shows that the Ozone-Electro-Fenton coupled process is highly effective in degrading ofloxacin industrial wastewater, offering an innovative solution for treating other antibiotic-containing wastewater. Future research will focus on further optimizing the process, improving its adaptability to complex matrix wastewater, and validating it at the pilot scale to promote its engineering application. Full article
(This article belongs to the Section Wastewater Treatment and Reuse)
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24 pages, 6650 KiB  
Article
Wire Arc Additive Manufacturing of Scalmalloy® (Al-Mg-Sc-Zr): Thermal Management Effects on Direct Age-Hardening Response
by Leandro João da Silva, Douglas Bezerra de Araújo, Ruham Pablo Reis, Frank Palm and Américo Scotti
Coatings 2025, 15(2), 237; https://doi.org/10.3390/coatings15020237 - 17 Feb 2025
Viewed by 966
Abstract
The thermal history of a part deposited via wire arc additive manufacturing (WAAM) and hence its as-built properties can vary significantly depending on the thermal management applied, especially for metallurgically complex materials. Thus, this work aimed to assess the feasibility of processing thin-walled [...] Read more.
The thermal history of a part deposited via wire arc additive manufacturing (WAAM) and hence its as-built properties can vary significantly depending on the thermal management applied, especially for metallurgically complex materials. Thus, this work aimed to assess the feasibility of processing thin-walled Scalmalloy® (Al-Mg-Sc-Zr) structures by WAAM while examining the effects of arc energy and heat dissipation on their response to direct age-hardening heat treatment (without solution annealing). As a complement, the geometry, porosity, and processing time of such parts were also analyzed. The walls were built via the cold metal transfer (CMT) deposition process with different arc energy levels in combination with near-immersion active cooling (NIAC) settings (as thermal management solution), as well as with natural cooling (NC), resulting overall in both low surface waviness and porosity levels. Based on hardness testing, the resultant Scalmalloy® direct-aging response (relative increase in hardness after direct age-hardening from WAAM as-built state) depended more on the arc energy per unit length of deposit applied. In contrast, the other thermal management approaches (NIAC or NC) helped in maintaining Sc in a supersaturated solid solution during deposition. Thus, Scalmalloy® strengthening was demonstrated as feasibly triggered by means of a post-WAAM direct age-hardening heat treatment solely. Additionally, in comparison with a thermally equivalent (same interpass temperature) condition based on NC, the NIAC technique allowed the achievement of such a positive result on direct-aging response with much shorter WAAM processing times, therefore improving productivity. Full article
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16 pages, 4414 KiB  
Article
Effect of Alternating Magnetic Field Treatment on the Friction/Wear Resistance of 20Cr2Ni4A Under Lubricated Conditions
by Sufyan Akram, Mose Bevilacqua, Anatolii Babutskyi and Andreas Chrysanthou
Metals 2025, 15(1), 69; https://doi.org/10.3390/met15010069 - 14 Jan 2025
Viewed by 717
Abstract
High-strength nickel–chromium steel (20Cr2Ni4A) is typically used in bearing applications. Alternating magnetic field treatment, which is based on the use of a magnetiser, and which is fast and cost-effective in comparison to conventional processes, was applied to the material to improve its wear [...] Read more.
High-strength nickel–chromium steel (20Cr2Ni4A) is typically used in bearing applications. Alternating magnetic field treatment, which is based on the use of a magnetiser, and which is fast and cost-effective in comparison to conventional processes, was applied to the material to improve its wear resistance. The results of pin-on-disc wear testing using a AISI 52100 alloy counter pin revealed a decrease in the specific wear rate of the treated samples by 58% and a reduction in the value of the coefficient of friction by 28%. X-ray diffraction analysis showed a small increase in the amount of martensite and higher surface compressive residual stresses by 28% leading to improved hardness. The observed changes were not induced thermally. The volume expansion by the formation of martensite was achieved at near room temperature and led to a further increase in compressive residual stresses. The significance of this study is that the improvement in the properties was achieved at a current density value that was two orders of magnitude higher than the threshold for phase transformation and dislocation movement. The reasons for the effect of the alternating magnetic field treatment on the friction and wear properties are discussed in terms of the contribution of the magnetic field to the austenite-to-martensite phase transformation and the interaction between the magnetic domain walls and dislocations. Full article
(This article belongs to the Special Issue Advances in Electromagnetic Processing of Metallic Materials)
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27 pages, 9883 KiB  
Article
Assessment of RANS Models for Milli-Channel Turbulent Flow in Drip Irrigation Emitter
by Qi Feng, Qingzheng Li, Yaojun Li, Xuefeng Qiu, Jiandong Wang and Xingfa Huang
Agronomy 2025, 15(1), 81; https://doi.org/10.3390/agronomy15010081 - 30 Dec 2024
Viewed by 1074
Abstract
Accurate numerical simulation of turbulent flow within the milli-channels of drip irrigation emitters has long been a significant challenge. This paper presents a comprehensive Reynolds-Averaged Navier–Stokes (RANS) modeling-based analysis of the flow dynamics within the labyrinth milli-channel of a tooth-shaped emitter, with partial [...] Read more.
Accurate numerical simulation of turbulent flow within the milli-channels of drip irrigation emitters has long been a significant challenge. This paper presents a comprehensive Reynolds-Averaged Navier–Stokes (RANS) modeling-based analysis of the flow dynamics within the labyrinth milli-channel of a tooth-shaped emitter, with partial experimental validation. The objective was to assess the performances of four RANS turbulence models: RNG k-ε (RNG), Realizable k-ε (RKE), SST k-ω (SST), and baseline k-ω (BSL), alongside three near-wall treatments: scalable wall function (SWF), enhanced wall treatment (EWT), and y+-insensitive wall treatment (YIWT) for emitter flow analysis. The results showed that the RNG and RKE, coupled with EWT, are preferred options for predicting the flow rate—pressure loss relationship of the emitter, with relative errors of 2.08% and 1.02% in the discharge exponent and 5.66% and 7.58% in the flow rate coefficient, respectively. Although both RNG and RKE using SWF are viable for hydraulic performance prediction under high-flow rate conditions, the deviation of predicted flow rate reaches up to 25.46% under low-flow rate conditions. The SST and BSL models, which employ IYPT, captured induced vortices at channel corners; however, they underestimated emitter flow rates. Furthermore, computations using SWF failed to capture the asymptotic characteristics of flow parameters in the near-wall region, resulting in an overestimation of turbulent kinetic energy and turbulence intensity. Additionally, the magnitude of wall shear stress in the channel corners fell below the threshold required for self-cleaning, underscoring the necessity for optimizing channel structures to enhance the anti-clogging performance of the emitter. Full article
(This article belongs to the Section Precision and Digital Agriculture)
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20 pages, 3282 KiB  
Article
A Near-Wall Methodology for Large-Eddy Simulation Based on Dynamic Hybrid RANS-LES
by Michael Tullis and D. Keith Walters
Entropy 2024, 26(12), 1095; https://doi.org/10.3390/e26121095 - 14 Dec 2024
Viewed by 1096
Abstract
Attempts to mitigate the computational cost of fully resolved large-eddy simulation (LES) in the near-wall region include both the hybrid Reynolds-averaged Navier–Stokes/LES (HRL) and wall-modeled LES (WMLES) approaches. This paper presents an LES wall treatment method that combines key attributes of the two, [...] Read more.
Attempts to mitigate the computational cost of fully resolved large-eddy simulation (LES) in the near-wall region include both the hybrid Reynolds-averaged Navier–Stokes/LES (HRL) and wall-modeled LES (WMLES) approaches. This paper presents an LES wall treatment method that combines key attributes of the two, in which the boundary layer mesh is sized in the streamwise and spanwise directions comparable to WMLES, and the wall-normal mesh is comparable to a RANS simulation without wall functions. A mixing length model is used to prescribe an eddy viscosity in the near-wall region, with the mixing length scale limited based on local mesh size. The RANS and LES regions are smoothly blended using the dynamic hybrid RANS-LES (DHRL) framework. The results are presented for the turbulent channel flow at two Reynolds numbers, and comparison to the DNS results shows that the mean and fluctuating quantities are reasonably well predicted with no apparent log-layer mismatch. A detailed near-wall meshing strategy for the proposed method is presented, and estimates indicate that it can be implemented with approximately twice the number of grid points as traditional WMLES, while avoiding the difficulties associated with analytical or numerical wall functions and modified wall boundary conditions. Full article
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19 pages, 13821 KiB  
Article
Structure and Electrocatalytic Properties of Sulfur-Containing Multi-Walled Carbon Nanotubes on a Titanium Substrate Modified by a Helium Ion Beam
by Petr M. Korusenko, Egor V. Knyazev, Alexander S. Vinogradov, Ksenia A. Kharisova, Sofya S. Filippova, Ulyana M. Rodionova, Oleg V. Levin and Elena V. Alekseeva
Nanomaterials 2024, 14(23), 1948; https://doi.org/10.3390/nano14231948 - 4 Dec 2024
Cited by 1 | Viewed by 1239
Abstract
In this work, a set of analytical techniques, including scanning electron microscopy (SEM), Raman scattering spectroscopy, X-ray photoelectron spectroscopy (XPS), energy-dispersive X-ray microanalysis (EDX) and cyclic voltammetry (CV), were used to study the impact of high-energy He+ ion irradiation on the structural [...] Read more.
In this work, a set of analytical techniques, including scanning electron microscopy (SEM), Raman scattering spectroscopy, X-ray photoelectron spectroscopy (XPS), energy-dispersive X-ray microanalysis (EDX) and cyclic voltammetry (CV), were used to study the impact of high-energy He+ ion irradiation on the structural and electrochemical characteristics of sulfur-containing multi-walled carbon nanotubes (S-MWCNTs) placed on a titanium substrate. The results indicate that the ion beam treatment of the S-MWCNT system led to an increase in the level of imperfections on the surface structures of the nanotubes due to the formation of point defects on their outer walls and the appearance of oxygen-containing functional groups, including SOx groups, near these defects. At the same time, a significant increase in the sulfur concentration (by 6.4 times) was observed on the surface of the S-MWCNTs compared to the surface of unirradiated nanotubes. This was due to the redeposition of sulfur atoms near the point defects under the action of the ion beam, followed by the subsequent formation of direct S–C chemical bonds. Electrochemical studies demonstrated that the irradiated S-MWCNTs/Ti system exhibit enhanced catalytic activity, with improved oxygen reduction reaction (ORR) performance and a substantial increase in anodic current during the oxidation reaction of hydrogen peroxide under alkaline conditions, highlighting their potential for advanced electrocatalytic applications. Full article
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21 pages, 11094 KiB  
Article
Non-Condensation Turbulence Models with Different Near-Wall Treatments and Solvers Comparative Research for Three-Dimensional Steam Ejectors
by Yiqiao Li, Hao Huang, Dingli Duan, Shengqiang Shen, Dan Zhou and Siyuan Liu
Energies 2024, 17(22), 5586; https://doi.org/10.3390/en17225586 - 8 Nov 2024
Cited by 2 | Viewed by 1150
Abstract
Steam ejectors are important energy-saving equipment for solar thermal energy storage; however, a numerical simulation research method has not been agreed upon. This study contributes to a comprehensive selection of turbulence models, near-wall treatments, geometrical modeling (2-D and 3-D), solvers, and models (condensation [...] Read more.
Steam ejectors are important energy-saving equipment for solar thermal energy storage; however, a numerical simulation research method has not been agreed upon. This study contributes to a comprehensive selection of turbulence models, near-wall treatments, geometrical modeling (2-D and 3-D), solvers, and models (condensation and ideal-gas) in the RANS equations approach for steam ejectors through validation with experiments globally and locally. The turbulence models studied are k-ε Standard, k-ε RNG, k-ε Realizable, k-ω Standard, k-ω SST, Transition SST, and linear Reynolds Stress. The near-wall treatments assessed are Standard Wall Functions, Non-equilibrium Wall Functions, and Enhanced Wall Treatment. The solvers compared are pressure-based and density-based solvers. The root causes of their distinctions in terms of simulation results, applicable conditions, convergence, and computational cost are explained and compared. The complex phenomena involving shock waves, choking, and vapor condensation captured by different models are discussed. The internal connections of their performance and flow phenomena are analyzed from the mechanism perspective. The originality of this study is that both condensation and 3-D asymmetric effects on the simulation results are considered. The results indicate that the k-ω SST non-equilibrium condensation model coupling the low-Re boundary conditions has the most accurate prediction results, best convergence, and fit for the widest range of working conditions. A 3-D asymmetric condensation model with a density-based solver is recommended for simulating steam ejectors accurately. Full article
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22 pages, 6213 KiB  
Article
Simulation of the Neutral Atmospheric Flow Using Multiscale Modeling: Comparative Studies for SimpleFoam and Fluent Solver
by Zihan Zhao, Lingxiao Tang and Yiqing Xiao
Atmosphere 2024, 15(10), 1259; https://doi.org/10.3390/atmos15101259 - 21 Oct 2024
Cited by 1 | Viewed by 1025
Abstract
The reproduced planetary boundary layer (PBL) wind is commonly applied in downscaled simulations using commercial CFD codes with Reynolds-averaged Navier–Stokes (RANS) turbulence modeling. When using the turbulent inlets calculated by numerical weather prediction models (NWP), adjustments of the turbulence eddy viscosity closures and [...] Read more.
The reproduced planetary boundary layer (PBL) wind is commonly applied in downscaled simulations using commercial CFD codes with Reynolds-averaged Navier–Stokes (RANS) turbulence modeling. When using the turbulent inlets calculated by numerical weather prediction models (NWP), adjustments of the turbulence eddy viscosity closures and wall function formulations are concerned with maintaining the fully developed wind profiles specified at the inlet of CFD domains. The impact of these related configurations is worth discussing in engineering applications, especially when commercial codes restrict the internal modifications. This study evaluates the numerical performances of open-source OpenFOAM 2.3.0 and commercial Fluent 17.2 codes as supplementary scientific comparisons. This contribution focuses on the modified turbulence closures to incorporate turbulent profiles produced from mesoscale PBL parameterizations and the modified wall treatments relating to the roughness length. The near-ground flow features are evaluated by selecting the flat terrains and the classical Askervein benchmark case. The improvement in near-ground wind flow under the downscaled framework shows satisfactory performance in the open-source CFD platform. This contributes to engineers realizing the micro-siting of wind turbines and quantifying terrain-induced speed-up phenomena under the scope of wind-resistant design. Full article
(This article belongs to the Section Atmospheric Techniques, Instruments, and Modeling)
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18 pages, 4354 KiB  
Article
Modeling of Tensile Stress Distribution Considering Anisotropy of Mechanical Properties of Thin-Walled AlSi10Mg Samples Obtained by Selective Laser Melting
by Sergey N. Grigoriev, Nikita Yu. Nikitin, Aleksander Frolov, Petr Shapovalov, Anton Medeltsev, Mikhail Voronov, Roman Khmyrov, Idarmach Idarmachev and Pavel Peretyagin
J. Manuf. Mater. Process. 2024, 8(5), 235; https://doi.org/10.3390/jmmp8050235 - 20 Oct 2024
Viewed by 1810
Abstract
The work that is being presented demonstrates that there is a critical point at which the engineering stress–strain diagram’s elastic–plastic region transitions to yield and fracture stresses. This transition is demonstrated using thin-walled specimens made using selective laser melting technology from high-strength aluminum [...] Read more.
The work that is being presented demonstrates that there is a critical point at which the engineering stress–strain diagram’s elastic–plastic region transitions to yield and fracture stresses. This transition is demonstrated using thin-walled specimens made using selective laser melting technology from high-strength aluminum alloys (AlSi10Mg) that have undergone preliminary heat treatment. It was discovered that the strain-hardening coefficient, which was determined in the section from yield strength to fracture strength, and the critical point have a highly statistically significant association (0.83 by Spearman and 0.93 by Pearson). It was possible to derive a regression equation that connected the strain-hardening coefficient with the crucial transition point. The type of stress distribution in the elastic–plastic region changes (the Weibull distribution changes to a normal distribution) as the plasticity of the thin-walled samples increases. Additionally, the contribution of the probability density of the stress distribution described by the Cauchy distribution increases in a mode near the point at which the probability density of the fracture increases. Full article
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18 pages, 7375 KiB  
Review
Bioengineering Approaches and Novel Biomaterials to Enhance Sternal Wound Healing after Cardiac Surgery: A Crosstalk between Innovation and Surgical Practice
by Chiara Ferrisi, Francesco Loreni, Antonio Nenna, Omar Giacinto, Mario Lusini and Massimo Chello
J. Funct. Biomater. 2024, 15(9), 254; https://doi.org/10.3390/jfb15090254 - 31 Aug 2024
Cited by 1 | Viewed by 2227
Abstract
Median sternotomy and steel wires for sternal closure are the standard approach for cardiac surgery. An incomplete repair associated with chest wall motion, especially in the presence of predisposing factors, can lead to life-threatening deep sternal wound infection, also known as mediastinitis, in [...] Read more.
Median sternotomy and steel wires for sternal closure are the standard approach for cardiac surgery. An incomplete repair associated with chest wall motion, especially in the presence of predisposing factors, can lead to life-threatening deep sternal wound infection, also known as mediastinitis, in 2–5% of cases. Despite current antibiotic and surgical treatments, mediastinitis is associated with a 10–40% mortality rate and a significant increase in morbidity and hospital stay. High mortality and difficult treatment appear to be due to bacterial biofilm, a self-produced extracellular polymeric product that incorporates host tissue and is responsible for the failure of immune defenses and standard antimicrobial therapies. Nanostructures are an effective strategy to enhance the healing process, as they establish a favorable environment for the neosynthesis of the extracellular matrix, supporting tissue development. Synthetic polymers have been proven to exhibit suitable biodegradable and mechanical properties, and their biofunctionalization to enhance cell attachment and interaction with the extracellular matrix is being widely investigated. The use of antibiotic treatments suspended in poly-D,L-lactide and polyethylene oxide and electrospun into nanofibers, or in sponges, has been shown to inhibit bacterial biofilm production. Additionally, growth factors can be incorporated into 3D bioresorbable scaffolds with the aim of constituting a structural and biological framework to organize and expedite the healing process. Therefore, these combined approaches may change the treatment of mediastinitis in the near future. Full article
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19 pages, 62520 KiB  
Article
Investigation of Point-Contact Strategies for CFD Simulations of Pebble-Bed Reactor Cores
by Nolan Goth, Thien Nguyen and William David Pointer
Appl. Sci. 2024, 14(16), 7343; https://doi.org/10.3390/app14167343 - 20 Aug 2024
Viewed by 1732
Abstract
This study numerically investigated the effects of various contact strategies on the thermal hydraulic behavior within a structured bed of 100 explicitly modeled pebbles. Four contact strategies and two thermal hydraulic conditions were considered. The strategies to avoid contact singularities include decreasing the [...] Read more.
This study numerically investigated the effects of various contact strategies on the thermal hydraulic behavior within a structured bed of 100 explicitly modeled pebbles. Four contact strategies and two thermal hydraulic conditions were considered. The strategies to avoid contact singularities include decreasing the pebble diameter, increasing the pebble diameter, bridging the pebble surfaces near the contact region, and capping the pebble surfaces near the contact region. One strategy, Strategy 3a, which involves bridging with a cylinder equal to 10% of the pebble diameter, was selected as the baseline strategy because it addressed the contact singularity while minimizing the geometric changes that affect the bed porosity. The two thermal hydraulic conditions were full-power operation (Case 1) and pressurized loss of forced cooling or PLOFC (Case 2). Simulations of the conjugate heat transfer within the structured bed were performed using the Reynolds-averaged Navier–Stokes approach with the realizable k-ϵ turbulence model and two-layer all y+ wall treatment. The thermal-fluid quantities of interest were compared between the contact strategies for each case. In Case 1, the hydraulic behavior was sensitive to the contact strategy, with large differences in the pressure drop (30%) and volume-average velocity (4%). The thermal behavior was not sensitive, with less than a 0.5% difference across the strategies. To better understand the separate effects of each heat transfer mode, Case 2 was divided into the following subcases: conduction (Case 2a); conduction/radiation (Case 2b); and conduction/radiation/convection (Case 2c). Case 2a represents an early phase of the PLOFC transient. Case 2b represents an intermediate phase of the PLOFC transient, with the pebble temperatures sufficiently high for the radiative heat transfer to be non-negligible. Case 2c represents a late phase of the PLOFC transient after the establishment of the natural circulation of the heat transfer fluid. For Case 2, large differences in the contact strategy were observed only in Case 2a with only conduction. The difference in the maximum pebble temperature was 23% in Case 2a, 2% in Case 2b, and 0.3% in Case 2c. Full article
(This article belongs to the Special Issue CFD Analysis of Nuclear Engineering)
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12 pages, 2059 KiB  
Article
The Study of Myo-Inositol’s Anxiolytic Activity on Zebrafish (Danio rerio)
by Maria Derkaczew, Bartosz Kędziora, Małgorzata Potoczna, Piotr Podlasz, Krzysztof Wąsowicz, Marcin Jóźwik and Joanna Wojtkiewicz
Nutrients 2024, 16(13), 1997; https://doi.org/10.3390/nu16131997 - 23 Jun 2024
Viewed by 2438
Abstract
Introduction: Myo-inositol (MI) is the most abundant inositol found in nature. To date MI supplementation is reported to be effective in the treatment of polycystic ovary syndrome, it is also suggested to alleviate the symptoms of diabetes and neurodegenerative disorders, but to date [...] Read more.
Introduction: Myo-inositol (MI) is the most abundant inositol found in nature. To date MI supplementation is reported to be effective in the treatment of polycystic ovary syndrome, it is also suggested to alleviate the symptoms of diabetes and neurodegenerative disorders, but to date no statistically significant effects of inositol on depressive and anxiety symptoms were proven. In the study of anxiolytic effects in zebrafish, we often use the thigmotaxis index measuring the ratio of the amount of time the animal spends near the walls compared to the entire arena. Aim: The objective of this paper was to examine the effect of MI on zebrafish embryos’ locomotor activity, as well as its potential anxiolytic activity in zebrafish larvae. Material and methods: In the first part of the experiment, the embryos were incubated with 5, 10, 20, and 40 mg/mL MI. 1-day post fertilization, embryo mobility was evaluated and burst activity was calculated. In the next part of the study, the behavior of 5-day-old larvae was tested. Results: Tests on embryo movement showed an increase in burst activity in the MI group at concentrations of 40 mg/mL (p < 0.0001) and a slight decrease in the group at concentrations of 10 mg/mL (p < 0.05). MI in the light/dark challenge had no impact on the thigmotaxis index. Conclusions: MI was shown to not affect stress reduction in zebrafish larvae. Further research on the potential of MI and other stereoisomers is needed. Full article
(This article belongs to the Special Issue Dietary Supplements in Human Health and Disease)
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