Fast-dissolving films (FDFs) were prepared from natural polysaccharides, such as pullulan, without heating, controlling the pH, or adding other materials. The release profiles of model drugs from the films were investigated. In the absence of a drug,...
Hydrogels have gained prominence as a class of biomaterials in biomedicine due to their excellent biocompatibility, biodegradability, and high water retention. Among them, hydrogels derived from natural polysaccharides sourced from plants, animals, a...
Many chronic diseases such as Alzheimer’s disease, diabetes, and cardiovascular diseases are closely related to in vivo oxidative stress caused by excessive reactive oxygen species (ROS). Natural polysaccharides, as a kind of biomacromolecule w...
Natural functional polysaccharides are biodegradable, safe, and bioactive macromolecules that contribute significantly to food security. This review provides a systematic overview of their classification, structural characteristics, and applications...
14 December 2022
Skincare is one of the most profitable product categories today. Consumers’ demand for skin-friendly products has stimulated the development of natural-ingredient-based cosmeceutical preparations over synthetic chemicals. Thus, natural polysacc...
Natural plant polysaccharides are renowned for their broad spectrum of biological activities, making them invaluable in both the pharmaceutical and food industries. Their safety, characterized by low toxicity and minimal side effects, coupled with th...
Polysaccharides are ubiquitous biomolecules found in nature that contain various biological and pharmacological activities that are employed in functional foods and therapeutic agents. Natural polysaccharides are obtained mainly by extraction and pur...
As natural oligo- and polysaccharides are important biomass resources and exhibit vital biological functions, non-natural oligo- and polysaccharides with a well-defined structure can be expected to act as new functional materials with specific nature...
Adipose tissue serves as a critical metabolic and endocrine organ, essential for maintaining systemic energy homeostasis and inter-organ communication. During the aging process, it undergoes significant structural remodeling and functional decline, c...
Ulcerative colitis (UC), a chronic inflammatory bowel disease, is closely associated with disturbances in the gut microbiota. Natural polysaccharides, owing to their unique “indigestibility” and prebiotic properties, represent a potential...
Natural polysaccharides are frequently used in the design of drug delivery systems due to their biocompatibility, biodegradability, and low toxicity. Moreover, they are diverse in structure, size, and charge, and their chemical functional groups can...
Naturally occurring polysaccharide sulfates are highly diverse, owning variations in the backbone structure, linkage pattern and stereochemistry, branching diversity, sulfate content and positions of sulfate group(s). These structural characteristics...
New promising manganese-containing nanobiocomposites (NCs) based on natural polysaccharides, arabinogalactan (AG), arabinogalactan sulfate (AGS), and κ-carrageenan (κ-CG) were studied to develop novel multi-purpose trophic low-dose organomineral fert...
The gut microbiota constitutes a complex ecosystem, comprising trillions of microbes that have co-evolved with their host over hundreds of millions of years. Over the past decade, a growing body of knowledge has underscored the intricate connections...
Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of morbidity and mortality worldwide, driven by dyslipidemia, chronic inflammation, oxidative stress, and endothelial dysfunction. Despite widespread use of lipid-lowering and ant...
Natural polysaccharides (NPs), as a class of bioactive macromolecules with multitarget synergistic regulatory potential, exhibit significant advantages in diabetes intervention. This review systematically summarizes the core hypoglycemic mechanisms o...
The prevention of disease and infection requires immune systems that operate effectively. This is accomplished by the elimination of infections and abnormal cells. Immune or biological therapy treats disease by either stimulating or inhibiting the im...
Bleeding is a potentially life-threatening emergency that can result in severe complications or death regardless of the cause of bleeding. The development of hemostatic materials has been a long-standing concern for emergency treatment in surgery and...
Polysaccharides are structurally diverse biopolymers composed of multiple monosaccharide units linked through glycosidic bonds. Their complexity, biodegradability, and functional versatility make them integral to biological systems as well as modern...
In recent years, natural polysaccharides have been considered as the ideal candidates for novel drug delivery systems because of their good biocompatibility, biodegradation, low immunogenicity, renewable source and easy modification. These natural po...
Removal of contaminants from discharge water is vital and demands urgent assistance with the goal to keep clean water. Adsorption is one of the most common, efficient, and low-priced methods used in water treatment. Various polysaccharide-based gels...
With the rapid development of modern society, many chronic diseases are increasing including diabetes, obesity, cardiovascular diseases, etc., which further cause an increased death rate worldwide. A high caloric diet with reduced natural polysacchar...
Hyperlipidemia is a chronic metabolic disease caused by the abnormal metabolism of lipoproteins in the human body. Its main hazard is to accelerate systemic atherosclerosis, which causes cerebrovascular diseases such as coronary heart disease and thr...
Natural polysaccharides have attracted considerable interest in pharmaceutical and biomedical applications. However, native polysaccharides often possess limitations, like poor solubility, inadequate mechanical strength, limited stability, and insuff...
Transdermal drug delivery is limited by the barrier function of the stratum corneum, which restricts the penetration of many therapeutic agents, whereas hypodermic injection provides efficient drug delivery but is associated with pain and reduced pat...
Disorders of skin wound healing and the repair of full-thickness skin defects remain significant clinical challenges. Natural polysaccharide-based hydrogels, with their excellent biocompatibility, tunable degradability, and multifunctional properties...
Acute skin damage caused by burns or cuts occurs frequently in people’s daily lives. Such wounds are difficult to heal normally and have persistent inflammation. Wound dressings not only improve the speed of wound healing, but also protect and...
Colorectal Cancer (CRC) is a prevalent global malignant tumor, and conventional therapies and drugs for CRC are limited by poor targeting and severe toxic side effects. Existing reviews on hydrogel-based CRC treatments mainly focus on synthetic mater...
Natural compounds are an important source of beneficial components that could be used in cancer therapy along with well-known cytostatic agents to enhance the therapeutic effect while targeting tumoral tissues. Therefore, nanoplatforms containing mes...
Efficient cutaneous wound healing relies on the phenotypic transition of macrophages toward an anti-inflammatory, pro-reparative M2-like state. Non-healing chronic wounds are pathologically characterized by the breakdown of this polarization balance....
Neurodegenerative diseases are a serious and widespread global public health burden amongst aging populations. The total estimated worldwide global cost of dementia was US$818 billion in 2015 and has been projected to rise to 2 trillion US$ by 2030....
Polysaccharide-based hydrogels have emerged as indispensable materials in tissue engineering and wound healing, offering a unique combination of biocompatibility, biodegradability, and structural versatility. Indeed, their three-dimensional polymeric...
Most of the existing hydrogel dressings have inadequacies in mechanical performance, biological activities, compatibility, or versatility, which results in the development of rapid, green, and cost-effective approaches for hydrogels in biochemical an...
Natural polysaccharides and their metabolites’ short chain fatty acids (SCFAs) have attracted much attention. Recently, they have shown great potential in attenuating systemic inflammation activities, especially in inflammatory bowel disease (IBD). I...
Natural polysaccharides exhibit beneficial immune modulatory effects, including immune stimulatory and anti-cancer activities. In this study, we examined the effect of Codium fragile polysaccharide (CFP) on natural killer (NK) cell activation, and it...
Natural polysaccharides, which are described in this study, are some of the most extensively used biopolymers in food, pharmaceutical, and medical applications, because they are renewable and have a high level of biocompatibility and biodegradability...
The inclusion of physiologically active molecules into a naturally occurring polymer matrix can improve the degradation, absorption, and release profile of the drug, thus boosting the therapeutic impact and potentially even reducing the frequency of...
Background: Liver fibrosis drives mortality in chronic liver disease, with effective and approved targeted therapies being an urgent unmet medical need. Natural polysaccharides are promising multitarget candidates, but a critical appraisal of the pre...
Numerous innovative advancements in dressing technology for wound healing have emerged. Among the various types of wound dressings available, hydrogel dressings, structured with a three-dimensional network and composed of predominantly hydrophilic co...
This study investigated the effects of natural polysaccharides—guar gum (GG) and xanthan gum (XG)—on the properties and structure of illitic clay. Clay samples were prepared using five different GG and XG solutions, with polysaccharide co...
The treatment of classical phenylketonuria is currently represented by many new methods of disease management. A promising method is the use of the enzyme L-phenylalanine ammonia-lyase (PAL) in various forms. The widespread use of enzyme preparations...
Polysaccharides are one of the most abundant natural polymers and their molecular structure influences many crucial characteristics—inter alia hydrophobicity, mechanical, and physicochemical properties. Vibrational spectroscopic techniques, suc...
Gelatin, a water-soluble protein, shows unique gellification properties, which determine the active commercial availability of gelatin hydrogels in modern alimentary, cosmetic, and pharmaceutical applications. The traditional sources of gelatin for i...
The art of dyeing fabrics is one of the oldest human activities. In order to improve the fastness properties of dyeing products, various additives are added to optimize the uniformity of fibers and surfaces and improve dye distribution. Unfortunately...
This review overviews the efficient hydrophobization method of hydrophilic natural polymers, which has been developed by means of glucan phosphorylase (GP)-induced enzymatic grafting of unnatural heteropolysaccharides, that is, partially 2-deoxygenat...
Infection with the novel coronavirus SARS-CoV-2, the cause of coronavirus disease (COVID-19), has emerged as a global pandemic, with a high toll on casualties, economic impact, and human lifestyle. Despite the recent approval of various vaccines agai...
As natural products, plant polysaccharides have been demonstrated to induce a variety of biological activities by numerous epidemiological investigations and interventional studies, including immunomodulation and antioxidant, antibacterial, antitumor...
Two novel natural flavonoid substituted polysaccharides (MBAP-1 and MBAP-2) were obtained from Tamarix chinensis Lour. and characterized by HPGPC, methylation, ultra-high-performance liquid chromatography-ion trap tandem mass spectrometry (UPLC-IT-MS...
This manuscript shows the use of natural polysaccharides such as starch and cellulose as a carbon source for fuel cells. To achieve this, two innovative methods of obtaining hydrogen have been shown: by adsorption and by enzyme. The carbonization pat...
The green synthesis of nanomaterials has emerged as a sustainable and environmentally friendly approach, gaining significant attention in recent years for its potential in a wide range of multifunctional applications. Among these materials, zinc oxid...
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