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Article

445 Views

22 Pages

Multiplex Immunofluorescence Assay with Opal Reagents for Identifying Mononuclear Cell Subsets in Kidney Allograft Rejection Types

Ernest Kwame Adjepong-Tandoh,
Jin-Myung Kim,
Hye Eun Kwon,
Youngmin Ko,
Joo Hee Jung,
Young Hoon Kim,
Heounjeong Go,
Haeyon Cho,
Sang-Yeob Kim and
Hyunwook Kwon
+ 1 author

Int. J. Mol. Sci.2025, 26(23), 11569;https://doi.org/10.3390/ijms262311569

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28 November 2025

Antibody-mediated rejection (ABMR) remains a leading cause of kidney allograft failure, yet the mechanistic roles of innate immune cell subsets such as monocytes and natural killer (NK) cells remain incompletely understood. In this retrospective coho...

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Article

476 Views

17 Pages

Tissue Microarray-Based Digital Spatial Profiling of Benign Breast Lobules and Breast Cancers: Feasibility, Biological Coherence, and Cross-Platform Benchmarks

Mark E. Sherman,
Jodi C. Carter,
Robert A. Vierkant,
Melody Stallings-Mann,
Laura Pacheco-Spann,
Stacey J. Winham,
Celine M. Vachon,
Chen Wang,
Matthew R. Jensen and
Derek C. Radisky
+ 4 authors

Cancers2025, 17(23), 3797;https://doi.org/10.3390/cancers17233797

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27 November 2025

Background: Discovering risk biomarkers in small benign breast disease (BBD) biopsies is constrained by scarce tissue and microanatomic heterogeneity of terminal duct lobular units (TDLUs). We tested whether tissue-sparing tissue microarray (TMA)&nda...

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8 Citations

3,367 Views

12 Pages

Application of Immunoprofiling Using Multiplexed Immunofluorescence Staining Identifies the Prognosis of Patients with High-Grade Serous Ovarian Cancer

Shin-Wha Lee,
Ha-Young Lee,
Sung Wan Kang,
Min Je Kim,
Young-Jae Lee,
Chang Ohk Sung and
Yong-Man Kim

Int. J. Mol. Sci.2021, 22(17), 9638;https://doi.org/10.3390/ijms22179638

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6 September 2021

Immunoprofiling has an established impact on the prognosis of several cancers; however, its role and definition in high-grade serous ovarian cancer (HGSOC) are mostly unknown. This study is to investigate immunoprofiling which could be a prognostic f...

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