Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (35)

Search Parameters:
Keywords = multi-view slicing

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
35 pages, 55325 KB  
Article
Lightweight Real-Time Strawberry Volume Estimation Based on Instance Segmentation and Principal-Axis Slicing
by Xiang Zhang, Quan Gao, Yuhai Long, Guangchuan Zhang and Yun He
Agriculture 2026, 16(13), 1443; https://doi.org/10.3390/agriculture16131443 - 1 Jul 2026
Viewed by 403
Abstract
Real-time strawberry volume estimation is a pivotal technology for automated harvesting and precision grading. However, conventional contact methods are prone to damaging fruits, while existing vision-based approaches struggle to balance high accuracy with low computational overhead. To address these challenges, this study proposes [...] Read more.
Real-time strawberry volume estimation is a pivotal technology for automated harvesting and precision grading. However, conventional contact methods are prone to damaging fruits, while existing vision-based approaches struggle to balance high accuracy with low computational overhead. To address these challenges, this study proposes a two-stage real-time volume estimation framework coupling a red-green-blue-depth (RGB-D) sensor with an “Instance segmentation–Principal-axis slicing” framework. First, to precisely extract target contours in complex backgrounds, we designed Deformable Feature Aware-YOLO (DFA-YOLO) based on the YOLO11-seg architecture. This model enhances the geometric perception of irregular fruit edges and effectively overcomes the challenges of background noise and multi-scale variations, providing high-precision masks for subsequent spatial mapping. Subsequently, a principal-axis-slicing algorithm extracts the mask’s centroid and principal axis, perpendicularly slicing the mask into infinitesimal micro-slices. By computing and accumulating the pixel-space volume of these slices, the system converts them into precise 3D physical volumes based on RGB-D depth mapping. The entire system was deployed on an NVIDIA Jetson Orin edge computing platform and validated in a greenhouse. Experimental results demonstrate that the estimated volume highly agrees with the true volume, achieving a coefficient of determination (R2) of 0.945 and a mean absolute percentage error (MAPE) of 9.0%. Under typical operating conditions (1–5 targets per field of view), the system maintains an overall frame rate of 8–15 FPS, requiring only 55 ms for single-fruit estimation. This method exhibits favorable stability and lightweight efficiency under the tested greenhouse conditions, offering a reliable solution for real-time non-destructive crop phenotypic monitoring in computationally constrained agricultural environments. Full article
(This article belongs to the Topic Digital Agriculture, Smart Farming and Crop Monitoring)
Show Figures

Figure 1

30 pages, 1397 KB  
Article
GAN-Based Cross-Modality Brain MRI Synthesis: Paired Versus Unpaired Training and Comparison with Diffusion and Transformer Models
by Behnam Kiani Kalejahi, Sebelan Danishvar and Mohammad Javad Rajabi
Biomimetics 2026, 11(3), 175; https://doi.org/10.3390/biomimetics11030175 - 2 Mar 2026
Cited by 3 | Viewed by 1631
Abstract
Incomplete or faulty MRI sequences are common in clinical practice and can impair AI-based analyses that rely on complete multi-contrast data. The relative effectiveness of classical generative adversarial networks (GANs) versus modern diffusion and transformer-based models for clinically usable MRI synthesis remains unclear. [...] Read more.
Incomplete or faulty MRI sequences are common in clinical practice and can impair AI-based analyses that rely on complete multi-contrast data. The relative effectiveness of classical generative adversarial networks (GANs) versus modern diffusion and transformer-based models for clinically usable MRI synthesis remains unclear. This study evaluates cross-modality MRI synthesis using the BraTS 2019 brain tumour dataset, focusing on T1-to-T2 translation. We assess paired and unpaired CycleGAN models and compare them with two stronger but computationally intensive baselines, a conditional denoising diffusion probabilistic model (DDPM) and a transformer-enhanced GAN, using identical data splits and preprocessing pipelines. Inter-modality correlation was evaluated to estimate the achievable similarity between modalities. Conceptually, modality synthesis may be viewed as a representation-learning approach that compensates for missing imaging information by reconstructing clinically relevant features from available contrasts. Paired CycleGAN achieved correlations of r0.920.93  and SSIM 0.900.92, approaching natural T1–T2 correlation (r0.95) while maintaining very fast inference (<50 ms/slice). Unpaired CycleGAN achieved r0.740.78 and SSIM 0.820.85, producing clinically interpretable reconstructions without voxel-level supervision. DDPM achieved the highest fidelity (SSIM 0.930.95, r0.94) but required substantially greater computational resources, while transformer-enhanced GAN performance was intermediate. Qualitative analysis showed that CycleGAN and DDPM best preserved tumour and tissue boundaries, whereas unpaired CycleGAN occasionally over-smoothed subtle lesions. These findings highlight the trade-off between fidelity and efficiency in cross-modality MRI synthesis, suggesting paired CycleGAN for time-sensitive clinical workflows and diffusion models as a computationally expensive accuracy upper bound. Full article
Show Figures

Figure 1

30 pages, 146632 KB  
Article
Form Meets Flow: Linking Historic Corridor Morphology to Multi-Scale Accessibility and Pedestrian Interface on Beishan Street, West Lake
by Dongxuan Li, Jin Yan, Shengbei Zhou, Yingning Shen, Hongjun Peng, Zhuoyuan Du, Xinyue Gao, Yankui Yuan, Ming Du and Jun Wu
Buildings 2026, 16(5), 889; https://doi.org/10.3390/buildings16050889 - 24 Feb 2026
Viewed by 619
Abstract
Historic linear corridors in living-heritage settings concentrate identity, everyday mobility, and visitor experience. Balancing authenticity, adaptability, and publicness therefore benefits from evidence that jointly characterizes long-term physical change, network accessibility, and eye-level interface conditions. Existing assessments often focus on façades or single time [...] Read more.
Historic linear corridors in living-heritage settings concentrate identity, everyday mobility, and visitor experience. Balancing authenticity, adaptability, and publicness therefore benefits from evidence that jointly characterizes long-term physical change, network accessibility, and eye-level interface conditions. Existing assessments often focus on façades or single time slices, leaving limited evidence that relates decades of built-fabric reconfiguration (changes in building footprints, street edges, and open-space fragmentation) to multi-scale accessibility and pedestrian-facing qualities. We propose an integrated and interpretable workflow for the Beishan Street corridor in the West Lake World Heritage core (Hangzhou) over 1929–2024. Scale-sensitive morphological metrics, multi-radius network measures (integration and centrality), and street-view semantic segmentation are aligned at corridor-segment resolution and examined together with segment-level functional intensity derived from POIs using transparent linear models. The results indicate a long-term shift from a lakeshore-led to a road-led spatial logic, followed by post-2000 stabilization near saturation. Average integration increases, while the high-integration tail becomes thinner. In connector-removal scenarios, the eastern segment shows a relative accessibility decline, and a central hinge node emerges as a vulnerability hotspot (bottleneck) where through-movement concentrates. Eye-level profiles differ by segment: the west exhibits maximal canopy and lower sky visibility, the center shows stronger continuous walls around compounds with intermittent forecourt openings, and the east is characterized by compact residential heritage frontage with low vegetation. Segment-level associations suggest that address and wayfinding density tends to co-occur with clearer frontages, wider sky cones, and stronger tree cover. Transportation-related and access/passage facilities tend to co-occur with higher ground-plane legibility, measured as wider and more continuous road and sidewalk surfaces. Medical and government clusters tend to co-occur with lower sky openness. Recommended actions include the following: (1) mesh-aware protection of key connectors and the hinge, (2) segment-specific targets for façade share and ground cues with planned punctuations, (3) tailored interface standards for institutional clusters, (4) scalable address and wayfinding systems, and (5) event staging that preserves effective roadway and sidewalk capacity. Full article
(This article belongs to the Special Issue Advanced Study on Urban Environment by Big Data Analytics)
Show Figures

Figure 1

29 pages, 111557 KB  
Article
Early Wildfire Smoke Detection with a Multi-Resolution Framework and Two-Stage Classification Pipeline
by Gihwan Jung, Tae-Hyuk Ahn and Byungseok Min
Fire 2026, 9(2), 92; https://doi.org/10.3390/fire9020092 - 19 Feb 2026
Cited by 1 | Viewed by 1823
Abstract
Early wildfire smoke detection is critical for preventing small ignitions from escalating into large-scale fires, yet early-stage smoke plumes are often faint, low-contrast, and spatially small. When full-resolution frames are resized to satisfy fixed-input detector architectures and enable efficient batched GPU inference, these [...] Read more.
Early wildfire smoke detection is critical for preventing small ignitions from escalating into large-scale fires, yet early-stage smoke plumes are often faint, low-contrast, and spatially small. When full-resolution frames are resized to satisfy fixed-input detector architectures and enable efficient batched GPU inference, these subtle cues are further diminished, leading to missed detections and unreliable scores near deployment thresholds. Existing remedies such as multi-scale inference, slicing/tiling, or super-resolution could improve sensitivity, but typically incur substantial overhead from multiple forward passes or added network components, limiting real-time use on resource-constrained platforms. To mitigate these challenges, we propose a composite multi-resolution detection framework that improves sensitivity to small smoke regions while maintaining single-pass inference. Motivated by the fact that most operational wildfire monitoring systems rely on Unmanned Aerial Vehicle (UAV) platforms and mountain-top Closed-Circuit Television (CCTV) systems surveillance, their wide-field imagery typically contains a large sky region above the horizon where early smoke is most likely to first become visible. Accordingly, crop placement is guided by a skyline prior that prioritizes this high-probability sky band while retaining the remaining scene for global context. A dynamic compositing stage stacks a global view with a high-resolution, sky-aligned band into a standard square detector input, preserving context with minimal added cost. Detections from the two views are reconciled via coordinate restoration and non-maximum suppression. For deployment, a lightweight second-stage classifier selectively re-evaluates low-confidence detections to stabilize decisions near a fixed operating threshold without retraining the detector. Compared to the baseline detector, our approach improves detection performance on the Early Smoke dataset, achieving gains of +4.6 percentage points in AP @0.5:0.95, +3.4 percentage points in AP @0.5, +2.9 percentage points in precision, +5.3 percentage points in recall, and +4.3 percentage points in F1-score. Full article
Show Figures

Figure 1

37 pages, 2122 KB  
Article
US-ATHC: Unsupervised Multi-Class Glioma Segmentation via Adaptive Thresholding and Clustering
by Jihan Alameddine, Céline Thomarat, Xavier Le-Guillou, Rémy Guillevin, Christine Fernandez-Maloigne and Carole Guillevin
Biomedicines 2026, 14(2), 397; https://doi.org/10.3390/biomedicines14020397 - 9 Feb 2026
Viewed by 828
Abstract
Background/Objectives: Accurate segmentation of gliomas in 3D volumetric MRI is critical for diagnosis, treatment planning, and surgical navigation. However, the scarcity of expert annotations limits the applicability of supervised learning approaches, motivating the development of unsupervised methods. This study presents US-ATHC (Unsupervised Segmentation [...] Read more.
Background/Objectives: Accurate segmentation of gliomas in 3D volumetric MRI is critical for diagnosis, treatment planning, and surgical navigation. However, the scarcity of expert annotations limits the applicability of supervised learning approaches, motivating the development of unsupervised methods. This study presents US-ATHC (Unsupervised Segmentation using Adaptive Thresholding and Hierarchical Clustering), a fully unsupervised two-step pipeline for both global tumor detection and multi-class subregion segmentation. Methods: In the first step, a global tumor mask is extracted by combining adaptive thresholding (Sauvola) with morphological processing on individual MRI slices. The resulting candidates are fused across axial, coronal, and sagittal views using a strict 3D consistency criterion. In the second step, the global mask is refined into a three-class segmentation (active tumor, edema, and necrosis) using optimized affinity propagation clustering. Results: The method was evaluated on the BraTS 2021 dataset, demonstrating accurate tumor and subregion segmentation that outperformed both classical clustering techniques and state-of-the-art deep learning models. External validation on the Gliobiopsy dataset from the University Hospital of Poitiers confirmed robustness and practical applicability in real-world clinical settings. Conclusions: US-ATHC establishes an unsupervised paradigm for glioma segmentation that balances accuracy with computational efficiency. Its annotation-independent nature makes it suitable for scenarios with scarce labeled data, supporting integration into clinical workflows and large-scale neuroimaging studies. Full article
(This article belongs to the Special Issue Medical Imaging in Brain Tumor: Charting the Future)
Show Figures

Figure 1

15 pages, 2011 KB  
Article
Analysis of Calcium Patterns in the Thoracic Aorta and Clinical Outcomes of TAVR Patients Presenting with Porcelain Aorta
by Caterina Campanella, Stephanie Voss, Julia Schreyer, Nazan Puluca, Andrea Amabile, Felix Wirth, Markus Krane and Hendrik Ruge
J. Clin. Med. 2025, 14(2), 503; https://doi.org/10.3390/jcm14020503 - 14 Jan 2025
Cited by 1 | Viewed by 2359
Abstract
Background/Objectives: In the presence of porcelain aorta (PA), transcatheter aortic valve replacement (TAVR) has become a class I therapeutic indication for the treatment of severe aortic valve stenosis. To date, few studies have analyzed the clinical outcomes of TAVR in PA patients. [...] Read more.
Background/Objectives: In the presence of porcelain aorta (PA), transcatheter aortic valve replacement (TAVR) has become a class I therapeutic indication for the treatment of severe aortic valve stenosis. To date, few studies have analyzed the clinical outcomes of TAVR in PA patients. We aim to analyze the calcification patterns of the thoracic aorta in PA patients and to evaluate their clinical implications for TAVR procedures. Methods: This study included 161 patients who had PA confirmed through pre-operative CT and underwent TAVR between 11/2014 and 12/2022. The primary outcome was to perform a multi-slice CT (MSCT) analysis assessing the calcification in the proximal, middle, and distal thoracic aortic segments. Each segment was divided into quadrants for scoring calcifications on a scale from 1 (<25%) to 4 (>75%). The cohort was categorized into circular or noncircular calcification group. The secondary clinical outcomes were defined according to VARC-3 criteria. Results: The study cohort included 161 patients (median age, 77.2 years; IQR, 70.1–82.6 years). The median EuroSCORE II and STS predicted risk of mortality were 3.10% [1.80–5.58] and 2.70% [1.70–4.30], respectively. In 75% of patients (n = 121/161), TAVR was performed via transfemoral access. Circular calcifications were found in 8.1% of patients, while noncircular calcifications were present in 91.9%. Significant calcifications were primarily in the right quadrant of the proximal segment (33.54%), superior quadrant of the middle segment (39.75%), and left quadrant of the distal segment (73.29%). The 30-day mortality rate was 3.11% and periprocedural ischemic stroke rate 3.38%. Conclusions: Most TAVR patients with PA exhibited noncircular calcification. The most extensive calcifications were primarily in areas relevant to surgical manipulation. Patients with PA displayed low short-term mortality and relatively few stroke events. In view of these findings, TAVR constitutes a valid treatment option for patients with PA and aortic stenosis. Full article
Show Figures

Figure 1

26 pages, 12239 KB  
Article
Deep Learning-Based Intelligent Diagnosis of Lumbar Diseases with Multi-Angle View of Intervertebral Disc
by Kaisi (Kathy) Chen, Lei Zheng, Honghao Zhao and Zihang Wang
Mathematics 2024, 12(13), 2062; https://doi.org/10.3390/math12132062 - 1 Jul 2024
Cited by 5 | Viewed by 3111
Abstract
The diagnosis of degenerative lumbar spine disease mainly relies on clinical manifestations and imaging examinations. However, the clinical manifestations are sometimes not obvious, and the diagnosis of medical imaging is usually time-consuming and highly relies on the doctor’s personal experiences. Therefore, a smart [...] Read more.
The diagnosis of degenerative lumbar spine disease mainly relies on clinical manifestations and imaging examinations. However, the clinical manifestations are sometimes not obvious, and the diagnosis of medical imaging is usually time-consuming and highly relies on the doctor’s personal experiences. Therefore, a smart diagnostic technology that can assist doctors in manual diagnosis has become particularly urgent. Taking advantage of the development of artificial intelligence, a series of solutions have been proposed for the diagnosis of spinal diseases by using deep learning methods. The proposed methods produce appealing results, but the majority of these approaches are based on sagittal and axial images separately, which limits the capability of different deep learning methods due to the insufficient use of data. In this article, we propose a two-stage classification process that fully utilizes image data. In particular, in the first stage, we used the Mask RCNN model to identify the lumbar spine in the spine image, locate the position of the vertebra and disc, and complete rough classification. In the fine classification stage, a multi-angle view of the intervertebral disc is generated by splicing the sagittal and axial slices of the intervertebral disc up and down based on the key position identified in the first stage, which provides more pieces of information to the deep learning methods for classification. The experimental results reveal substantial performance enhancements with the synthesized multi-angle view, achieving an F1 score of 96.67%. This represents a performance increase of approximately 15% over the sagittal images at 84.48% and nearly 14% over the axial images at 83.15%. This indicates that the proposed paradigm is feasible and more effective in identifying spinal-related degenerative diseases through medical images. Full article
(This article belongs to the Special Issue Algorithms and Models for Bioinformatics and Biomedical Applications)
Show Figures

Figure 1

12 pages, 454 KB  
Article
Robust Tensor Learning for Multi-View Spectral Clustering
by Deyan Xie, Zibao Li, Yingkun Sun and Wei Song
Electronics 2024, 13(11), 2181; https://doi.org/10.3390/electronics13112181 - 3 Jun 2024
Cited by 2 | Viewed by 1834
Abstract
Tensor-based multi-view spectral clustering methods are promising in practical clustering applications. However, most of the existing methods adopt the 2,1 norm to depict the sparsity of the error matrix, and they usually ignore the global structure embedded in each single [...] Read more.
Tensor-based multi-view spectral clustering methods are promising in practical clustering applications. However, most of the existing methods adopt the 2,1 norm to depict the sparsity of the error matrix, and they usually ignore the global structure embedded in each single view, compromising the clustering performance. Here, we design a robust tensor learning method for multi-view spectral clustering (RTL-MSC), which employs the weighted tensor nuclear norm to regularize the essential tensor for exploiting the high-order correlations underlying multiple views and adopts the nuclear norm to constrain each frontal slice of the essential tensor as the block diagonal matrix. Simultaneously, a novel column-wise sparse norm, namely, 2,p, is defined in RTL-MSC to measure the error tensor, making it sparser than the one derived by the 2,1 norm. We design an effective optimization algorithm to solve the proposed model. Experiments on three widely used datasets demonstrate the superiority of our method. Full article
(This article belongs to the Special Issue Multi-Modal Learning for Multimedia Data Analysis and Applications)
Show Figures

Figure 1

13 pages, 1668 KB  
Article
AcquisitionFocus: Joint Optimization of Acquisition Orientation and Cardiac Volume Reconstruction Using Deep Learning
by Christian Weihsbach, Nora Vogt, Ziad Al-Haj Hemidi, Alexander Bigalke, Lasse Hansen, Julien Oster and Mattias P. Heinrich
Sensors 2024, 24(7), 2296; https://doi.org/10.3390/s24072296 - 4 Apr 2024
Viewed by 2216
Abstract
In cardiac cine imaging, acquiring high-quality data is challenging and time-consuming due to the artifacts generated by the heart’s continuous movement. Volumetric, fully isotropic data acquisition with high temporal resolution is, to date, intractable due to MR physics constraints. To assess whole-heart movement [...] Read more.
In cardiac cine imaging, acquiring high-quality data is challenging and time-consuming due to the artifacts generated by the heart’s continuous movement. Volumetric, fully isotropic data acquisition with high temporal resolution is, to date, intractable due to MR physics constraints. To assess whole-heart movement under minimal acquisition time, we propose a deep learning model that reconstructs the volumetric shape of multiple cardiac chambers from a limited number of input slices while simultaneously optimizing the slice acquisition orientation for this task. We mimic the current clinical protocols for cardiac imaging and compare the shape reconstruction quality of standard clinical views and optimized views. In our experiments, we show that the jointly trained model achieves accurate high-resolution multi-chamber shape reconstruction with errors of <13 mm HD95 and Dice scores of >80%, indicating its effectiveness in both simulated cardiac cine MRI and clinical cardiac MRI with a wide range of pathological shape variations. Full article
Show Figures

Figure 1

21 pages, 9395 KB  
Article
Wetland Classification, Attribute Accuracy, and Scale
by Kate Carlson, Barbara P. Buttenfield and Yi Qiang
ISPRS Int. J. Geo-Inf. 2024, 13(3), 103; https://doi.org/10.3390/ijgi13030103 - 20 Mar 2024
Cited by 9 | Viewed by 3564
Abstract
Quantification of all types of uncertainty helps to establish reliability in any analysis. This research focuses on uncertainty in two attribute levels of wetland classification and creates visualization tools to guide analysis of spatial uncertainty patterns over several scales. A novel variant of [...] Read more.
Quantification of all types of uncertainty helps to establish reliability in any analysis. This research focuses on uncertainty in two attribute levels of wetland classification and creates visualization tools to guide analysis of spatial uncertainty patterns over several scales. A novel variant of confusion matrix analysis compares the Cowardin and Hydrogeomorphic wetland classification systems, identifying areas and types of misclassification for binary and multivariate categories. The specific focus on uncertainty in the paper refers to categorical consistency, that is, agreement between the two classification systems, rather than comparing observed data to ground truth. Consistency is quantified using confusion matrix analysis. Aggregation across progressive focal windows transforms the confusion matrix into a multiscale data pyramid for quick determination of where attribute uncertainty is highly variant, and at what spatial resolutions classification inconsistencies emerge. The focal pyramids summarize precision, recall, and F1 scores to visualize classification differences across spatial scales. Findings show that the F1 scores appear most informative on agreement about wetlands misclassification at both coarse and fine attribute scales. The pyramid organizes multi-scale uncertainty in a single unified framework and can be “sliced” to view individual focal levels of attribute consistency. Results demonstrate how the confusion matrix can be used to quantify the percentage of a study area in which inconsistencies occur reflecting wetland presence and type. The research provides confusion metrics and display tools to focus attention on specific areas of large data sets where attribute uncertainty patterns may be complex, thus reducing land managers’ workloads by highlighting areas of uncertainty where field checking might be appropriate, and improving analytics by providing visualization tools to quickly see where such areas occur. Full article
Show Figures

Figure 1

19 pages, 54513 KB  
Article
A Satellite-Drone Image Cross-View Geolocalization Method Based on Multi-Scale Information and Dual-Channel Attention Mechanism
by Naiqun Gong, Liwei Li, Jianjun Sha, Xu Sun and Qian Huang
Remote Sens. 2024, 16(6), 941; https://doi.org/10.3390/rs16060941 - 7 Mar 2024
Cited by 11 | Viewed by 7522
Abstract
Satellite-Drone Image Cross-View Geolocalization has wide applications. Due to the pronounced variations in the visual features of 3D objects under different angles, Satellite-Drone cross-view image geolocalization remains an unresolved challenge. The key to successful cross-view geolocalization lies in extracting crucial spatial structure information [...] Read more.
Satellite-Drone Image Cross-View Geolocalization has wide applications. Due to the pronounced variations in the visual features of 3D objects under different angles, Satellite-Drone cross-view image geolocalization remains an unresolved challenge. The key to successful cross-view geolocalization lies in extracting crucial spatial structure information across different scales in the image. Recent studies improve image matching accuracy by introducing an attention mechanism to establish global associations among local features. However, existing methods primarily focus on using single-scale features and employ a single-channel attention mechanism to correlate local convolutional features from different locations. This approach inadequately explores and utilizes multi-scale spatial structure information within the image, particularly lacking in the extraction and utilization of locally valuable information. In this paper, we propose a cross-view image geolocalization method based on multi-scale information and a dual-channel attention mechanism. The multi-scale information includes features extracted from different scales using various convolutional slices, and it extensively utilizes shallow network features. The dual-channel attention mechanism, through successive local and global feature associations, effectively learns depth discriminative features across different scales. Experimental results were conducted using existing satellite and drone image datasets, with additional validation performed on an independent self-made dataset. The findings indicate that our approach exhibits superior performance compared to existing methods. The methodology presented in this paper exhibits enhanced capabilities, especially in the exploitation of multi-scale spatial structure information and the extraction of locally valuable information. Full article
(This article belongs to the Section AI Remote Sensing)
Show Figures

Figure 1

32 pages, 1867 KB  
Review
Opportunities and Difficulties in the Repurposing of HDAC Inhibitors as Antiparasitic Agents
by Tapas Kumar Mohapatra, Reena Rani Nayak, Ankit Ganeshpurkar, Prashant Tiwari and Dileep Kumar
Drugs Drug Candidates 2024, 3(1), 70-101; https://doi.org/10.3390/ddc3010006 - 18 Jan 2024
Cited by 9 | Viewed by 4242
Abstract
Ongoing therapy for human parasite infections has a few known drugs but with serious side effects and the problem of drug resistance, impelling us to discover novel drug candidates with newer mechanisms of action. Universally, this has boosted the research in the design [...] Read more.
Ongoing therapy for human parasite infections has a few known drugs but with serious side effects and the problem of drug resistance, impelling us to discover novel drug candidates with newer mechanisms of action. Universally, this has boosted the research in the design and development of novel medicinal agents as antiparasitic drugs with a novel mode of action. Histone deacetylase inhibitors (HDACis) are used in a vast variety of diseases due to their anti-inflammatory properties. Drug repurposing strategies have already approved HDACis as cancer therapeutics and are now under investigation for many parasitic infections. Along with the expression of the gene, histone deacetylase (HDAC) enzymes also act as a slice of great multi-subunit complexes, targeting many non-histones, changing systemic and cellular levels signaling, and producing different cell-based specified effects. Zinc (Zn2+)- and nicotinamide adenine dinucleotide (NAD+)-dependent HDACs of parasites play pivotal roles in the alteration of gene expression of parasites. Some of them are already known to be responsible for the survival of several parasites under odd circumstances; thus, targeting them for therapeutic interventions will be novel for potential antiparasitic targets. This point of view outlines the knowledge of both class-I and class-II HDACis and sirtuin inhibitors that emerged to be the key players in the treatment of human parasitic disorders like Leishmaniasis, Schistosomiasis, Malaria, Trypanosomiasis, and Toxoplasmosis. This review also focuses on repurposing opportunities and challenges in HDAC inhibitors that are preceded by their clinical development as potent new antiparasitic drugs. Full article
(This article belongs to the Collection Anti-Parasite Drug Discovery)
Show Figures

Figure 1

19 pages, 4007 KB  
Article
Multi-Slice Generation sMRI and fMRI for Autism Spectrum Disorder Diagnosis Using 3D-CNN and Vision Transformers
by Asrar G. Alharthi and Salha M. Alzahrani
Brain Sci. 2023, 13(11), 1578; https://doi.org/10.3390/brainsci13111578 - 10 Nov 2023
Cited by 27 | Viewed by 6047
Abstract
Researchers have explored various potential indicators of ASD, including changes in brain structure and activity, genetics, and immune system abnormalities, but no definitive indicator has been found yet. Therefore, this study aims to investigate ASD indicators using two types of magnetic resonance images [...] Read more.
Researchers have explored various potential indicators of ASD, including changes in brain structure and activity, genetics, and immune system abnormalities, but no definitive indicator has been found yet. Therefore, this study aims to investigate ASD indicators using two types of magnetic resonance images (MRI), structural (sMRI) and functional (fMRI), and to address the issue of limited data availability. Transfer learning is a valuable technique when working with limited data, as it utilizes knowledge gained from a pre-trained model in a domain with abundant data. This study proposed the use of four vision transformers namely ConvNeXT, MobileNet, Swin, and ViT using sMRI modalities. The study also investigated the use of a 3D-CNN model with sMRI and fMRI modalities. Our experiments involved different methods of generating data and extracting slices from raw 3D sMRI and 4D fMRI scans along the axial, coronal, and sagittal brain planes. To evaluate our methods, we utilized a standard neuroimaging dataset called NYU from the ABIDE repository to classify ASD subjects from typical control subjects. The performance of our models was evaluated against several baselines including studies that implemented VGG and ResNet transfer learning models. Our experimental results validate the effectiveness of the proposed multi-slice generation with the 3D-CNN and transfer learning methods as they achieved state-of-the-art results. In particular, results from 50-middle slices from the fMRI and 3D-CNN showed a profound promise in ASD classifiability as it obtained a maximum accuracy of 0.8710 and F1-score of 0.8261 when using the mean of 4D images across the axial, coronal, and sagittal. Additionally, the use of the whole slices in fMRI except the beginnings and the ends of brain views helped to reduce irrelevant information and showed good performance of 0.8387 accuracy and 0.7727 F1-score. Lastly, the transfer learning with the ConvNeXt model achieved results higher than other transformers when using 50-middle slices sMRI along the axial, coronal, and sagittal planes. Full article
Show Figures

Figure 1

29 pages, 1495 KB  
Review
Radiation Doses in Cardiovascular Computed Tomography
by Bartłomiej Kędzierski, Piotr Macek, Barbara Dziadkowiec-Macek, Krystian Truszkiewicz, Rafał Poręba and Paweł Gać
Life 2023, 13(4), 990; https://doi.org/10.3390/life13040990 - 11 Apr 2023
Cited by 25 | Viewed by 11889
Abstract
We discussed the contemporary views on the effects of ionising radiation on living organisms and the process of estimating radiation doses in CT examinations and the definitions of the CTDI, CTDIvol, DLP, SSDE, ED. We reviewed the reports from large analyses on the [...] Read more.
We discussed the contemporary views on the effects of ionising radiation on living organisms and the process of estimating radiation doses in CT examinations and the definitions of the CTDI, CTDIvol, DLP, SSDE, ED. We reviewed the reports from large analyses on the radiation doses in CT examinations of the coronary arteries prior to TAVI procedures, including the CRESCENT, PROTECTION, German Cardiac CT Registry studies. These studies were carried out over the last 10 years and can help confront the daily practice of performing cardiovascular CT examinations in most centres. The reference dose levels for these examinations were also collected. The methods to optimise the radiation dose included tube voltage reduction, ECG-monitored tube current modulation, iterative and deep learning reconstruction techniques, a reduction in the scan range, prospective study protocols, automatic exposure control, heart rate control, rational use of the calcium score, multi-slices and dual-source and wide-field tomography. We also present the studies that indicated the need to raise the organ conversion factor for cardiovascular studies from the 0.014–0.017 mSv/mGy*cm used for chest studies to date to a value of 0.0264–0.03 mSv/mGy*cm. Full article
(This article belongs to the Section Physiology and Pathology)
Show Figures

Figure 1

23 pages, 9974 KB  
Article
Synthetic Data Generation for Automatic Segmentation of X-ray Computed Tomography Reconstructions of Complex Microstructures
by Athanasios Tsamos, Sergei Evsevleev, Rita Fioresi, Francesco Faglioni and Giovanni Bruno
J. Imaging 2023, 9(2), 22; https://doi.org/10.3390/jimaging9020022 - 19 Jan 2023
Cited by 23 | Viewed by 4498
Abstract
The greatest challenge when using deep convolutional neural networks (DCNNs) for automatic segmentation of microstructural X-ray computed tomography (XCT) data is the acquisition of sufficient and relevant data to train the working network. Traditionally, these have been attained by manually annotating a few [...] Read more.
The greatest challenge when using deep convolutional neural networks (DCNNs) for automatic segmentation of microstructural X-ray computed tomography (XCT) data is the acquisition of sufficient and relevant data to train the working network. Traditionally, these have been attained by manually annotating a few slices for 2D DCNNs. However, complex multiphase microstructures would presumably be better segmented with 3D networks. However, manual segmentation labeling for 3D problems is prohibitive. In this work, we introduce a method for generating synthetic XCT data for a challenging six-phase Al–Si alloy composite reinforced with ceramic fibers and particles. Moreover, we propose certain data augmentations (brightness, contrast, noise, and blur), a special in-house designed deep convolutional neural network (Triple UNet), and a multi-view forwarding strategy to promote generalized learning from synthetic data and therefore achieve successful segmentations. We obtain an overall Dice score of 0.77. Lastly, we prove the detrimental effects of artifacts in the XCT data on achieving accurate segmentations when synthetic data are employed for training the DCNNs. The methods presented in this work are applicable to other materials and imaging techniques as well. Successful segmentation coupled with neural networks trained with synthetic data will accelerate scientific output. Full article
(This article belongs to the Special Issue Industrial Machine Learning Application)
Show Figures

Figure 1

Back to TopTop