Search Results (32)

Background/Objectives: Fatigue is a common symptom in adults with cerebral palsy (CP), characterized by fluctuations across the day. This pilot study aimed to evaluate the feasibility, reliability, and validity of ecological momentary assessment (EMA) for capturing these temporal dynamics in adults with CP. Methods: Ten adults with CP (60% female, mean age = 44 years, Gross Motor Function Classification System levels I–III) and eight typically developed controls (62% female, mean age = 39 years) completed a 20-item EMA survey ten times daily for seven days using the SEMA³ smartphone application. Feasibility was evaluated through retention rates, response rates, and qualitative interviews. Intraindividual variability, within-person reliability, measurement reactivity, and convergent validity with the Fatigue Severity Scale (FSS) were examined using mixed-effects regression and multilevel measurement error autoregressive (MEAR) models. Results: No participants dropped out. Average response rates were 76% (CP) and 75% (control). The protocol was perceived as acceptable overall, though demanding by some participants. In the CP group, 61% of total variability in momentary fatigue was attributable to within-person fluctuations, and within-person reliability was 0.73 (SEM = 1.13). No evidence of reactivity to self-monitoring was found in fatigue ratings or qualitative interviews. FSS scores were positively associated with person-level average momentary fatigue, β = 0.51, p = 0.048. Conclusions: EMA is feasible in adults with CP and reveals substantial within-person fluctuations in fatigue. These findings provide initial proof-of-concept and inform methodological amendments for a future large-scale study of fatigue dynamics aiming to advance symptom management in this population. Full article

Background/Objective: This study aimed to determine the prevalence of neurological symptoms and findings in patients with Ankylosing Spondylitis (AS) and to evaluate their relationship with disease activity. Methods: A total of 86 patients diagnosed with AS underwent a structured neurological examination including assessment of mental status, cranial nerves, motor system, deep tendon reflexes, pathological reflexes, and cerebellar/extrapyramidal functions. Sensory deficits and motor weakness were recorded. Orthostatic hypotension was evaluated as a clinical marker of autonomic involvement. Insomnia symptoms and neuropathic pain features were assessed clinically. Disease activity was quantified using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Associations between neurological findings, BASDAI scores, and inflammatory parameters were analyzed. Results: Motor weakness was observed in 5% of patients. Sensory deficits were present in 31% and orthostatic hypotension in 23% of patients. Insomnia symptoms were reported by 51% and neuropathic pain features by 53% of participants. A highly significant association was found between insomnia and neuropathic pain (p < 0.001). BASDAI scores were significantly higher in patients with insomnia, orthostatic hypotension, and sensory deficits (p = 0.004, p = 0.014, and p < 0.001, respectively). No significant association was observed between Anti-Tumor Necrosis Factor therapy and sensory deficits, and no significant correlation was demonstrated between neurological findings and C-reactive protein/Erythrocyte Sedimentation Rate values (p > 0.05). Conclusions: Neurological symptoms are common in AS and are associated with higher disease activity, without parallel changes in inflammatory markers such as CRP and ESR. Systematic evaluation of these symptoms may facilitate earlier identification of subgroups with a higher disease burden and inform individualized follow-up and management strategies. Full article

Background/Objectives: Visuomotor interception requires aligning action with the future state of moving targets under sensory and motor delays. This constraint provides a tractable framework to examine how predictive and feedback-driven processes interact. This narrative review evaluates theoretical and empirical accounts of interception, with emphasis on how prediction and online control are integrated across behavioral and neural levels. Methods: We conducted a narrative synthesis of behavioral, eye-tracking, computational, and neurophysiological studies on visuomotor interception. Literature was identified through searches of PubMed, Web of Science, and Google Scholar using search terms including “visuomotor interception,” “predictive motor control,” “eye–hand coordination,” “time-to-contact,” “sensorimotor delay,” and related combinations. Studies published between 1986 and 2026 were considered, with emphasis on peer-reviewed empirical and theoretical work. Preprints were included only when directly relevant and are identified as such. The review compares internal model, ecological, and hybrid frameworks, and organizes evidence around spatial (“where”) and temporal (“when”) components of control. Results: Across paradigms, interception behavior is not well accounted for by purely predictive or reactive mechanisms. Instead, trajectories reflect a continuous interaction between anticipatory guidance and online correction. Spatial and temporal components show partial dissociation across tasks and manipulations. Available evidence supports the involvement of distributed circuits, including parietal, frontal, cerebellar, and subcortical systems, while indicating that eye movements play an active role in both information sampling and motor planning. Conclusions: Interception is best understood as the product of interacting biological, environmental, and learned constraints. Similar behavioral signatures can arise from distinct mechanisms, arguing against a unitary account. Progress requires integrating behavioral analyses with model-based and neural approaches to dissociate underlying computations. Full article

Whether the enactment effect benefits from motor information activation is a key concern in action memory; meanwhile, the degree of enactability may influence this activation. Accordingly, this study aims to examine the explanatory role of motor information reactivation in the enactment effect and to further clarify whether a certain degree of motor information activation is necessary for this effect to emerge. To this end, we manipulated the degree of enactability and separately investigated its impact on the enactment effect at the encoding stage (Experiment 1) and the retrieval stage (Experiment 2). Experiment 1 required participants to either silently read phrases or both silently read and physically enact the actions represented by the phrases during encoding. The research showed that an enactment effect was only observed for the high-enactability-phrases condition, but not for the low-enactability-phrases condition. Experiment 2 additionally required participants to either verbally recall (verbal retrieval) or verbally recall while simultaneously performing corresponding actions (enactment retrieval) during retrieval. The findings showed that under the verbal retrieval condition, the enactment effect was observed for the high-enactability-phrases condition but not for the low-enactability-phrases condition; under the enactment retrieval condition, the enactment effect was observed both for the high-enactability phrases and low-enactability-phrases conditions. Thus, motor information activation during encoding and retrieval is crucial for the enactment effect, which emerges only when motor information activation reaches a threshold, supporting and expanding motor information reactivation theory. Full article

Background/Objectives: Preterm newborns (NBs) are at increased risk of motor developmental impairments. Evidence on inflammatory and neurotrophic biomarkers measured in the neonatal period as predictors of motor outcomes is scarce and heterogeneous. This systematic review synthesised data on inflammatory biomarkers and neurotrophic factors in Preterm NB as predictors of motor development (MD) up to 24 months of corrected age. Methods: MEDLINE, SciELO, Web of Science and Embase were searched for longitudinal observational studies of Preterm NB (World Health Organization definition) that measured one or more inflammatory biomarkers and/or neurotrophic factors in blood, urine or saliva and applied validated neurodevelopmental scales up to 24 months. Non-original reports, populations outside scope and studies with incomplete data were excluded. Methodological quality of primary studies was assessed with the Newcastle–Ottawa Scale (NOS). The protocol was registered in PROSPERO (CRD42022365839). Results: Of 1475 records, eight studies met the eligibility criteria. Higher neonatal concentrations of interleukin-6 (IL-6), interleukin-8 (IL-8), tumour necrosis factor-alpha (TNF-α) and C-reactive protein (CRP) were generally associated with poorer motor performance, although null findings occurred in some cohorts. One study assessing neurotrophic factors reported elevated urinary brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic factor (GDNF) among infants with below-expected MD. Conclusions: Inflammatory biomarkers show promise as early indicators of adverse MD in Preterm NB, but heterogeneity in populations, biospecimens, sampling windows, assays and outcome scales limits comparability and precludes definition of risk thresholds. Larger, standardised cohorts are needed to clarify the prognostic value of inflammatory and neurotrophic biomarkers and to inform early risk stratification. Full article

Background/Objectives: This cross-sectional study examined how training age, chronological age, and biological maturity influence motor and perceptual–cognitive performance in youth soccer players, with relevance for health and well-being through sport participation. Methods: Forty-one male athletes (age = 14.86 ± 0.81 years) completed a two-day field-based assessment following a holistic framework integrating motor (sprinting, jumping, and agility) and perceptual–cognitive components (psychomotor speed, visuospatial working memory, and spatial visualization). Biological maturity was estimated using the maturity offset method. Results: Regression analyses showed that biological maturity and training age significantly predicted motor performance, particularly sprinting, jumping, and pre-planned agility, whereas chronological age was not a predictor. In contrast, neither maturity nor training experience influenced perceptual–cognitive skills. Among cognitive measures, only psychomotor speed significantly predicted reactive agility, emphasizing the role of rapid information processing in dynamic, game-specific contexts. Conclusions: Youth soccer training should address both physical and cognitive development through complementary strategies. Physical preparation should be tailored to maturity status to ensure safe and progressive loading, while systematic training of psychomotor speed and decision-making should enhance reactive agility and game intelligence. Integrating maturity and perceptual–cognitive assessments may support individualized development, improved performance, and long-term well-being. Full article

Background/Objectives: Rapid postural reactions are critical for preventing falls, yet the neural systems supporting these responses are not fully understood, particularly with respect to aging and neurological disorders. Understanding how the brain detects, interprets, and responds to balance disturbances is essential for developing new interventions. This scoping review aimed to synthesize evidence from neuroimaging studies to identify the cortical and subcortical mechanisms underlying reactive balance and to characterize how these mechanisms are altered by aging and pathology. Methods: A structured search of EMBASE, PubMed, and CINAHL (7 November 2024) identified studies examining neural activity during experimentally induced balance perturbations. Sixty-one studies met inclusion criteria (EEG n = 45; MRI n = 9; fNIRS n = 8; PET n = 1) and were analyzed for patterns of regional activation and age- or disease-related differences. Results: Evidence converges on a distributed network supporting reactive balance. Sensorimotor, premotor, supplementary motor, and prefrontal cortices show consistent involvement, while cerebellar, brainstem, and basal ganglia structures contribute to rapid, automatic responses. Aging and neurological conditions commonly heighten cortical activation, suggesting reduced automaticity and increased reliance on compensatory control. Conclusions: Reactive balance emerges from coordinated activity across cortico-subcortical systems that are altered by aging and pathology. Further research incorporating multimodal imaging approaches and more ecologically realistic perturbation paradigms is needed to clarify mechanistic pathways and inform precision-based fall-prevention strategies. Full article

Insights into motor cortex remodeling may enable the development of more effective rehabilitation strategies during the acute phase. We aim to assess the affected and unaffected motor/premotor/somatosensory cortex resting state functional connectivity (RSFC) and reactivity with continuous wave functional near-infrared spectroscopy (cw-fNIRS) in patients with ICH compared to age, sex, and comorbidity-matched subjects. We enrolled patients with acute–subacute hemispheric ICH (n = 37; two were excluded due to artifacts) and grouped them according to the side (right and left) of the stroke. Matched participants or patients with recent transient ischemic attack were enrolled as control subjects for the study (n = 44; five were excluded due to artifacts). RSFC was assessed in both affected and unaffected hemispheres by group-level seed-based (primary motor cortex, priMC) correlation analysis. FT-associated relative oxyhemoglobin (ΔHbO) changes were analyzed in affected and unaffected hemispheres with generalized linear model regression. In left hemispheric ICH, the resting state coherence between the affected priMC and the affected premotor cortex (preMC) increased (β = 0.83, 95% CI = 0.19, 1.47, p = 0.01). In contrast, in right hemispheric ICH, the coherence between the unaffected priMC and the affected preMC decreased (β = −0.6, 95% CI = −1.12, −0.09, p = 0.02). In the left hemispheric ICH, the left-hand FT was associated with increased ΔHbO over the affected preMC (β = 0.01, 95% CI = 0.003, 0.02, p = 0.01). In contrast, in right hemispheric ICH, the left-hand FT was associated with increased ΔHbO over the unaffected preMC (β = 0.02, 95% CI = 0.006, 0.04, p = 0.01). Left hemispheric preMC may be involved in motor cortex reorganization in acute ICH in either hemisphere. Further studies may be required to assess longitudinal changes in motor cortex reorganization to inform acute motor rehabilitation. Full article

Strobilurins are a prominent class of fungicides capable of entering aquatic environments via runoff and leaching from the soil. Findings from previous studies suggest that strobilurins are highly toxic in aquatic environments, and evidence of acute developmental toxicity and altered behavioral responses have been emphasized. The objective here was to determine the effects of a new strobilurin, metyltetraprole (MTP), on zebrafish using developmental endpoints, gene expression, and behavioral locomotor assays. We hypothesized that MTP would cause developmental toxicity and induce hyperactivity in zebrafish (Danio rerio). To test this, developing zebrafish embryos/larvae were exposed to environmentally relevant levels of MTP (0.1, 1, 10, and 100 µg/L) until 7 days post-fertilization. Survival percentages did not differ among the treatment groups. No change in reactive oxygen species production was detected, but two genes involved in the mitochondrial electron transport chain (mt-nd3 and uqcrc2) were altered in abundance following MTP exposure. Moreover, the highest concentration (100 µg/L) of MTP caused notable hyperactivity in the zebrafish in the visual motor response test. Overall, results from this study increase our knowledge regarding sub-lethal effects of MTP, helping inform risk assessment for aquatic environments. Full article

Background: Agility is crucial in game sports, requiring both motor and cognitive skills. Athletes must perceive and process information to adapt movements, yet traditional agility tests often lack cognitive and multidirectional demands. Additionally, modern test systems are mostly stationary. This study evaluated the novel and portable “Functional Agility Square Test” (FAST) for validity, reliability, and usefulness. Methods: To assess discriminant validity, 22 game sports (GS) and 22 non-game sports (NGS) athletes participated in one session. Test–retest reliability was examined with 36 GS athletes (20 female) across three sessions. Participants performed cognitive (FAST_COG), preplanned (FAST_MOT), and randomized (FAST_SAT) reactive change-of-direction tasks, each repeated three times per session. Results: Results showed significantly lower response times (RTs) in GS compared to NGS (p < 0.05). Mean RTs indicated moderate relative reliability (ICC 0.50–0.74), while medians showed moderate to good reliability (ICC 0.59–0.83). Usefulness was evident from the first session (FAST_MOT) or from the third session (FAST_SAT) based on median RTs. Conclusions: Thus, the FAST seems to be valid, reliable, and sensitive for GS-based agility assessment. Its portable setup enables ecologically valid field testing. Future research should further increase task complexity to better simulate game conditions. Full article

Background: Examining visual behavior during a motor learning paradigm can enhance our understanding of how infants learn motor skills. The aim of this study was to determine if infants who learned a contingency visually anticipated the outcomes of their behavior. Methods: 15 infants (6–9 months of age) participated in a contingency learning paradigm. When an infant produced a right leg movement, a robot provided reinforcement by clapping. Three types of visual gaze events were identified: predictive, reactive, and not looking. An exploratory analysis examined the trends in visual-motor behavior that can be used to inform future questions and practices in contingency learning studies. Results: All classically defined learners visually anticipated robot activation at greater than random chance (W = 21; p = 0.028). Specifically, all but one learners displayed a distribution of gaze timing identified as predictive (skewness: 0.56–2.42) with the median timing preceding robot activation by 0.31 s (range: −0.40–0.18 s). Conclusions: Findings suggest that most learners displayed visual anticipation withing the first minutes of performing the paradigm. Further, the classical definition of learning a contingency paradigm in infants can be sharpened to further the design of contingency learning studies and advance the processes infants use to learn motor skills. Full article

Traditional tactile brain–computer interfaces (BCIs), particularly those based on steady-state somatosensory–evoked potentials, face challenges such as lower accuracy, reduced bit rates, and the need for spatially distant stimulation points. In contrast, using transient electrical stimuli offers a promising alternative for generating tactile BCI control signals: somatosensory event-related potentials (sERPs). This study aimed to optimize the performance of a novel electrotactile BCI by employing advanced feature extraction and machine learning techniques on sERP signals for the classification of users’ selective tactile attention. The experimental protocol involved ten healthy subjects performing a tactile attention task, with EEG signals recorded from five EEG channels over the sensory–motor cortex. We employed sequential forward selection (SFS) of features from temporal sERP waveforms of all EEG channels. We systematically tested classification performance using machine learning algorithms, including logistic regression, k-nearest neighbors, support vector machines, random forests, and artificial neural networks. We explored the effects of the number of stimuli required to obtain sERP features for classification and their influence on accuracy and information transfer rate. Our approach indicated significant improvements in classification accuracy compared to previous studies. We demonstrated that the number of stimuli for sERP generation can be reduced while increasing the information transfer rate without a statistically significant decrease in classification accuracy. In the case of the support vector machine classifier, we achieved a mean accuracy over 90% for 10 electrical stimuli, while for 6 stimuli, the accuracy decreased by less than 7%, and the information transfer rate increased by 60%. This research advances methods for tactile BCI control based on event-related potentials. This work is significant since tactile stimulation is an understudied modality for BCI control, and electrically induced sERPs are the least studied control signals in reactive BCIs. Exploring and optimizing the parameters of sERP elicitation, as well as feature extraction and classification methods, is crucial for addressing the accuracy versus speed trade-off in various assistive BCI applications where the tactile modality may have added value. Full article

Rasmussen encephalitis (RE) is a rare and progressive form of chronic encephalitis that typically affects one hemisphere of the brain and primarily occurs in pediatric individuals. The current study aims to narratively review the literature about RE, including historical information, pathophysiology, and management of this condition. RE often occurs in individuals with normal development, and it is estimated that only a few new cases are identified each year in epilepsy centers. Approximately 10% of cases also occur in adolescents and adults. The hallmark feature of RE is drug-resistant focal seizures that can manifest as epilepsia partialis continua. Also, patients with RE usually develop motor and cognitive impairment throughout the years. Neuroimaging studies show progressive damage to the affected hemisphere, while histopathological examination reveals T-cell-dominated encephalitis with activated microglial cells and reactive astrogliosis. The current therapy guidelines suggest cerebral hemispherotomy is the most recommended treatment for seizures in RE, although significant neurological dysfunction can occur. Another option is pharmacological management with antiseizure medications and immunomodulatory agents. No significant progress has been made in understanding the pathophysiology of this condition in the last decades, especially regarding genetics. Notably, RE diagnosis still depends on the criteria established by Bien et al., and the accuracy can be limited and include genetically different individuals, leading to unexpected responses to management. Full article

Background: Within the social interoception field, little is known about the impact of interoception on autonomic system reactivity during synchronization tasks. The impact of social framing manipulation and Interoceptive Attentiveness (IA; defined as concentrated attention on the breath for a specific time interval) on autonomic responses during interpersonal synchronization was investigated in this research. Methods: Under two experimental interoceptive conditions—the concentration and no focus on the breath condition—participants completed two synchronization tasks. A social framing was given to participants by informing them that they needed to complete the tasks in unison to improve their collaboration abilities. Autonomic responses (electrodermal activity and cardiovascular indices) were collected throughout task performance. Results: Two orders of results were observed: high cognitive engagement was detected during the focus on the breath condition and for the social frame. This effect was specifically observed for the motor compared to the linguistic synchronization task. Meanwhile, a potential lack of emotional control was observed in the no focus on the breath condition when the synchronization tasks were not socially framed. Conclusions: Such results encourage the use of the hyperscanning paradigm to deepen the impact of IA in real-time and ecological interpersonal synchronization dynamics. Full article

Currently, there is no intervention model for autism spectrum disorder (ASD) that addresses all levels and factors of the International Classification of Functioning, Disability and Health (ICF, WHO). The most researched programs focus on naturalistic, developmental and behavioral approaches to socio-communication. Less attention has been paid to motor and environmental reactivity aspects (behavior/interest restriction and sensory reactivity). The evidence rationale for the Global Integration Method (MIG, “Método de Integração Global”), a model addressing sensorimotor reactivity in addition to socio-communication, is presented. MIG is an integrative, interdisciplinary, family-oriented intervention and naturalistic program that addresses all levels and moderating factors of ASD’s impact. MIG’s theoretical rationale is based on the predictive coding impairment and embodied cognition hypotheses. MIG incorporates both bottom-up (flexible therapeutic suit, social-motor synchronization) and top-down (schematic social information processing, narratives, imagery) strategies to promote the building and use of accurate, flexible and context-sensitive internal predictive models. MIG is based on the premises that predictive coding improves both socio-communication and environmental reactivity, and that the postural stabilization provided by the flexible therapeutic suit frees information processing resources for socio-cognitive learning. MIG builds on interdisciplinary, professionally and parentally mediated work based on behavioral principles of intensive training in a situated environment. Full article