Search Results (3,152)

Background/Objectives: People aged 65 years and older who live alone and have limited functional abilities need support in many circumstances and for a variety of activities. This study was conducted to explore the available formal and informal help for seniors, using findings from the “Inclusive Ageing in Place” (IN-AGE) study. Methods: This descriptive study was carried out in 2019 in three Italian regions, i.e., Lombardy in the north, Marche in the centre, and Calabria in the south, and involved 120 older people who lived at home, either alone or with a personal/private care assistant (PCA). Using a mixed-methods approach revealed both qualitative (thematic/content analysis of narratives) and quantitative (quantifications of statements) results. Results: This study identified several needs of seniors in different circumstances concerning basic and instrumental activities of daily living (ADL and IADL), health, and mobility in/outside the home. The seniors reported that support was provided primarily by their families, followed by friends and neighbours. Public home services were considered insufficient. The participants also reported using mobility aids and instances of self-sufficiency. Conclusions: These results highlight the need to improve support services for frail seniors and to better integrate formal and informal caregiving to facilitate ageing in place and promote the well-being of older people. Adequate interventions should be implemented for both older people and their family caregivers, who play a central role in care. Full article

In modern society, adolescents experiencing mental health problems are increasing. This study aims to identify barriers to mental health care at the individual, family, school, and staff levels among at-risk adolescents, employing a mixed-methods approach. Given the ethical and practical constraints of engaging at-risk adolescents directly, the study quantitatively analyzed responses to the AMPQ-III-I survey from 47 runaway adolescents, while conducting interviews with eight school nurses serving as proxy informants. The at-risk adolescents were found to be in a state of mental health crisis characterized by somatization, self-harm, excessive digital media use, and peer imitation. Within the family environment, they experienced communication gaps with adults, concerns about mental health stigma, and the risk of disengagement from home and school. Despite experiencing physical and emotional difficulties that hindered their ability to focus on academic work, schools tended to deprioritize mental health, and these adolescents reported notably low utilization of professional counseling. School nurses, although well-positioned to identify at-risk adolescents, expressed barriers such as excessive workload and a lack of communication among teachers. These findings suggest that, to support the growing and intensifying population of at-risk adolescents, an urgent shift in awareness and the alleviation of barriers within the family–school–staff ecosystem is required. Full article

The increasing use of low-density polyethylene (LDPE) has prompted growing interest in its application as a replacement for conventional aggregates in concrete. This study investigated the effects of replacing sand with 10%, 20%, and 30% LDPE granules in concrete. Compressive strength, splitting tensile strength, flexural strength, modulus of elasticity, slump, and density tests were performed. The results showed a gradual decrease in compressive strength (from 26.91 MPa in the reference mix to 16.56 MPa with 30% LDPE), tensile strength (from 2.46 MPa to 1.84 MPa), and flexural strength (from 3.37 MPa to 2.59 MPa). Decreases were also observed in modulus of elasticity, slump, and density values. However, LDPE-substituted concretes increased their axial and lateral strain capacities, showing improvement in ductility and deformation ability. Experimental results demonstrated a delicate balance between mechanical strength and sustainability benefits. It was demonstrated that low rates of LDPE substitution could balance performance with environmental advantages. The experimental results presented in this study were combined with previous research to create a dataset. Based on this dataset, exponential models predicting the properties of LDPE-substituted concrete and mortar were proposed. The proposed exponential models outperformed existing linear models in prediction accuracy, yielding coefficient of determination (R²) values up to 0.981 and significantly reduced mean absolute percentage error (MAPE) values, ranging from 1% to 17% depending on the dataset. Full article

Background/Objectives: Advanced age in Parkinson’s disease (PD) is linked to worse motor function, more severe symptoms, and impaired activities of daily living (ADLs). Lee Silverman Voice Treatment (LSVT)^® BIG may be suitable for older patients, as it can be adapted to individual abilities. This study evaluated whether age affects the effectiveness of LSVT^® BIG on gait speed, motor symptoms, ADLs, and quality of life (QoL) in PD. Methods: In this retrospective, single-center cohort study, 22 patients with PD were divided into an older group (≥65 years; n = 16) and a younger group (<65 years; n = 6). All participants completed 16 one-hour, face-to-face LSVT^® BIG sessions. Gait speed was assessed with the 10-m walk test; motor symptoms with Movement Disorders Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) Part III; ADLs with MDS-UPDRS Part II; and QoL with the Parkinson’s Disease Questionnaire-39 Summary Index. Two-way mixed-design analysis of variance with aligned rank transformation was used for statistical analysis. Results: Significant improvements were observed for all outcomes (gait speed, motor symptoms, ADLs, and QoL) after the intervention. A significant effect of age group was found for gait speed, with younger patients walking faster overall. No significant interaction between timepoint and group was observed for any measure. Conclusions: LSVT^® BIG appears to improve gait speed, motor symptoms, ADLs, and QoL in patients with PD, regardless of age, suggesting it is an effective intervention for both older and younger patients. Full article

The study develops and empirically evaluates a forecasting-orientated structural model in which future Bitcoin historical volatility is modelled as being associated with market sentiment and blockchain fundamentals through market uncertainty. Market Sentiment (MS) is specified as a behavioural construct, Blockchain Fundamentals (BF) as network conditions, and Market Uncertainty (MU) as an endogenous regime construct that consolidates signals shaping historical volatility at t+1. Using 262 weekly observations from January 2021 to January 2026, the analysis applies partial least squares structural equation modelling (PLS-SEM) with formative constructs and a forward-dated volatility target to preserve temporal ordering. Paths are evaluated with bootstrapping, effect sizes, and mediation analysis, while predictive performance is assessed using PLSpredict, the cross-validated predictive ability test (CVPAT), benchmark-based comparison, and Diebold-Mariano (DM) tests. MU emerges as the dominant predictor of Future Historical Volatility, denoted as HV(t+1) in the structural model (β = 0.864, p-value < 0.001; f² = 2.036). The effect of BF is largely indirect, with 91.02% of the total effect transmitted via uncertainty, indicating indirect-only mediation. The model explains substantial variation in HV(t+1) (R² = 0.791) and shows predictive relevance (Q² predict = 0.287), while the benchmark-based results indicate mixed but competitive forecasting performance relative to persistence-based and econometric alternatives. These findings are consistent with a regime-based interpretation of Bitcoin volatility and highlight the explanatory and predictive relevance of an integrated behavioural-network-uncertainty architecture. Full article

Heritage-led urban redevelopment is increasingly adopted to advance cultural continuity and social vitality; however, its long-term sustainability is often compromised due to the absence of user-oriented assessment methods. Conventional Post-Occupancy Evaluation (POE) approaches are limited in their ability to capture experiential, social, and participatory dimensions of architectural and urban spaces. This study examines the potential of Virtual Reality (VR) as a participatory POE tool for sustainable heritage redevelopment through the case study of Souq Al Muharraq in Bahrain. A convergent mixed-method approach is employed, integrating immersive VR 360-degree walkthroughs, structured questionnaires, qualitative semi-structured interviews, and expert evaluation. The findings reveal significant discrepancies between design intentions and lived experience, specifically in thermal comfort, circulation, social usability, and informal spatial practices. The study demonstrates that VR supports a user-centered and experiential approach aligned with Sustainable Development Goals (SDGs) 9, 11, and 16. It further proposes a sustainable and cost-efficient framework for architecture and urban projects’ evaluation by enabling early and post-user-centered evaluation of projects to reduce costly revisions and the creation of inclusive, adaptive, and resilient architecture and urban spaces. Full article

Candida albicans is the causal agent of invasive candidiasis, which might be lethal in immunocompromised patients. Biofilm formation is considered a key virulence factor of C. albicans and is associated with its elevated resistance to antifungals. C. albicans and bacteria like E. coli are frequently found to form mixed biofilms on biotic or abiotic surfaces, rendering them more refractory to existing antifungals. To investigate how E. coli endogenous indole interplaying with exogenous IAA exerts modulatory effects on dual-species biofilm with C. albicans, an E. coli strain deficient in the indole biosynthetic gene tnaA was constructed, and the enzyme TnaA inhibitor was administered to block the indole production in E. coli monoculture and/or E. coli–C. albicans dual culture. Phenotypic assay revealed that indole deficiency attenuated E. coli mono-species biofilm by 12% (tnaA∆ versus WT E. coli), and the lack of indole in the E. coli cell-free culture filtrate abolished the ability to promote C. albicans biofilms, evidenced by the fact that the treatment with WT E. coli culture supernatants exhibited a 1.7-fold promotive effect, while treatment with tnaA∆ displayed no significant difference from the broth control towards C. albicans biofilms. Furthermore, impaired E. coli indole production might disrupt E. coli–C. albicans biofilm, as examined by confocal laser scanning microscopy (CLSM). Moreover, indole-3-acetic acid (IAA) was found to exhibit more potent biofilm-modulatory activity than indole by CLSM imaging with dual biofilms of WT E. coli–C. albicans, in contrast to those of E. coli tnaA∆–C. albicans post-supplemented with exogenous IAA. This study provides evidence for indole as a signaling molecule mediating bacterial–fungal communication during mixed-biofilm formation. Indole and its derivatives, particularly in combination with existing antifungals, have potential in the development of anti-biofilm strategies to eradicate refractory fungal infections. Full article

Synthetic polymers are widely used in stone conservation, yet their long-term biological stability remains insufficiently evaluated. This study investigates the microbial susceptibility of three commonly used acrylic consolidants, Paraloid B-72, B-66, and B-44, applied to deteriorated limestone. Bacteria, fungi, and actinomycetes were isolated from a deteriorated limestone false door and screened for acid production. From each microbial group, only the strong acid-producing isolates were selected for further investigation, including evaluation of their ability to utilize the three Paraloid resins as sole carbon sources and their deterioration potential on limestone cubes before and after consolidation. Deterioration was assessed by weight loss, compressive strength testing, stereomicroscopy, scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). All selected strong acid-producing isolates demonstrated the ability to grow on the tested polymers, confirming their biodegradation potential. Mixed microbial cultures caused greater weight loss and compressive strength reduction than single isolates, attributed to synergistic metabolic interactions. Among the consolidants, Paraloid B-72 showed the highest susceptibility to microbial attack, while Paraloid B-66 exhibited comparatively greater resistance, attributed to the steric hindrance of its isobutyl side groups and higher surface hydrophobicity. FTIR and XRD analyses confirmed ester bond hydrolysis, progressive gypsum formation, and structural alteration of the limestone substrate. These findings demonstrate that acrylic consolidants commonly used in stone conservation are not biologically inert and may actively contribute to biodeterioration under microbial colonization, highlighting the need for developing bio-resistant conservation materials. Full article

Unsafe behaviors among construction workers constitute a major contributing factor to construction accidents, making it critically important to explore their underlying mechanisms and temporal dynamics from a cognitive perspective. This study employed an exploratory sequential mixed-methods approach. Initially, grounded theory was used to conduct three-level coding of in-depth interview data from 35 construction workers, resulting in the development of a cognitive theory model of unsafe behavior among construction workers comprising two main categories: ‘ perceptual recognition’ and ‘cognitive response’. Subsequently, a questionnaire was designed based on this model, and a 10-day longitudinal survey was conducted among 300 workers. Multi-group structural equation modelling was employed to analyze the temporal variation in the relationship between cognitive ability and unsafe behavior. The results indicate that: workers’ cognitive abilities can be decomposed into four dimensions—perceiving danger, identifying hazards, perceptual response, and decision-making response—and further summarized into two higher-order factors: perceptual recognition and cognitive response; (2) cognitive abilities are significantly negatively correlated with unsafe behavior; (3) this relationship exhibits significant temporal variations, with the inhibitory effect on Day 5 (path coefficient −0.95) being stronger than that on Day 1 (−0.88) and Day 10 (−0.50); furthermore, the ‘cognitive response → decision-making response’ path also shows significant differences between Day 5 and Day 10. The study reveals the pattern of fluctuations over time in the inhibitory effects of workers’ cognitive ability on unsafe behavior, providing a theoretical basis for construction companies to implement dynamic and targeted safety interventions. Full article

As agricultural marketization deepens, market risks have become a key factor affecting rural household livelihoods, while the trend toward differentiation among rural households has further exacerbated heterogeneity in resource allocation strategies and risk-coping capabilities across different groups. Based on field survey data from 763 rural households in the border areas of Yunnan Province, this study employs a combination of the Target MOTAD model and OLS regression to analyze the optimal production mix, resource utilization efficiency, and determinants of agricultural income for different types of farming households. Empirical results indicate that capital shortages are the primary factor constraining the full utilization of agricultural resources and farmers’ income growth; non-agricultural households, through proactive risk management, demonstrate significantly stronger risk resilience than agricultural households; and differences in the income structures of these two types of households drive them to adopt differentiated risk response strategies. Based on these findings, this study proposes the following optimization pathways: First, enhance rural households’ ability to accumulate capital to overcome the bottlenecks of resource idleness and income growth; second, promote moderate-scale agricultural operations to improve resource utilization efficiency; third, implement differentiated risk response strategies based on the heterogeneous characteristics of farming households. This research provides theoretical references and practical foundations for optimizing resource allocation among rural households in Yunnan’s border regions and enhancing agricultural risk-response capabilities. Full article

Dispersion stabilization of nanoparticles for catalytic reactions is an important issue. However, dispersing agents should be carefully selected not to hinder catalytic performance. In the present study, physisorption of cyclic poly(ethylene glycol) (c-PEG) onto platinum nanoparticles (PtNPs) was investigated in comparison with unmodified PtNPs (PtNPs/No PEG), PtNPs mixed with linear PEG (PtNPs/HO-PEG-OH), and PtNPs chemisorbed with HS-PEG-OMe (PtNPs/HS-PEG-OMe). DLS showed a significant increase in the particle size for PtNPs/c-PEG and PtNPs/HS-PEG-OMe compared to PtNPs/No PEG and PtNPs/HO-PEG-OH. ζ-potential measurements revealed values around −30 mV for PtNPs/No PEG and PtNPs/HO-PEG-OH, whereas PtNPs/c-PEG and PtNPs/HS-PEG-OMe approached 0 mV, which indicated that c-PEG and HS-PEG-OMe adsorb onto PtNPs to form a shielding layer. Moreover, PtNPs/c-PEG and PtNPs/HS-PEG-OMe were stable in a phosphate-buffered saline (PBS) solution, but PtNPs/No PEG and PtNPs/HO-PEG-OH immediately aggregated. This suggests that high dispersion stability by c-PEG is comparable to ordinary surface modification using HS-PEG-OMe. Furthermore, the catalytic ability of PtNPs/c-PEG and PtNPs/HS-PEG-OMe was compared in various reactions. As a result, physisorbed PtNPs/c-PEG showed suitable catalytic activities, whereas chemisorbed PtNPs/HS-PEG-OMe was significantly hampered by the blocking of the catalytic sites with thiol in some reactions. Thus, physisorption of c-PEG endows PtNPs with dispersion stability and maintains the catalytic ability, leading to an alternative way of modifying metal nanoparticles. Full article

Hazard perception (HP) is a critical component of road safety; however, the HP abilities of adolescent bicyclists (aged 13–16 years) and their associations with decision-making (DM) across different hazard types remain underexplored. This study investigated grade-related differences in HP and DM among adolescent bicyclists using a video-based hazard prediction task. A total of 115 middle school students who ride bicycles on a regular basis were recruited. A 3 (grade: 7th, 8th, and 9th) × 2 (hazard type: environmental prediction hazards/EPs, behavioural prediction hazards/BPs) mixed experimental design was employed. Participants answered two HP questions (What is the hazard? What happens next?) and one DM question (What would you do?). Students in the ninth and eighth grades had higher scores on BP hazards in the “what happens next” and DM questions than did their peers in the seventh grade. Although students in the ninth grade made more safe decisions on the EP hazards than their peers in the seventh and eighth grades, their scores on the “what happens next” question were similar on EP hazards. Importantly, students in the ninth grade scored significantly higher on DM than on HP for EP hazards, while students in the eighth grade scored significantly higher on DM than on HP for BP hazards. These findings demonstrate that both HP and DM accuracy improve with grade level and that the relations between HP and DM varies by hazard type. The results underscore the necessity for targeted, hazard-specific training programmes to improve cycling safety among adolescents. Full article

Self-efficacy—one’s belief in their ability to take the actions necessary to succeed—is a critical determinant of student success and retention, particularly during the transitional first two years of undergraduate study. Learning communities that incorporate peer mentors have been identified as promising structures for fostering self-efficacy, yet the mechanisms by which intentional peer mentoring within structured career development contexts shapes students’ self-efficacy beliefs remain underexplored. This study examined the following research questions: (1) How does participation in a career-focused Learning community course shape first- and second-year STEM students’ sense of self-efficacy regarding academic and career decision-making? (2) In what ways do peer mentors and peer support networks within the learning community contribute to students’ self-efficacy development? (3) How do students describe feeling empowered—or not—to pursue their career goals as a result of this experience? Using a mixed-methods design that combined pre- and post-course surveys, semi-structured focus groups, and phenomenological one-on-one interviews, we investigated the self-efficacy development of first- and second-year STEM students (N = 53) enrolled in a semester-long learning community course at a large, predominantly White public institution in the Midwest. Of these, 25 students completed both the pre- and post-course Career Self-Efficacy surveys and were included in matched statistical analyses. Three major findings emerged: (1) the learning community class environment created a space where self-efficacy was prioritized and developed; (2) peer support groups and peer mentors positively impacted students’ self-efficacy; and (3) students felt empowered by the experience in pursuing their chosen career goals. These findings have practical implications for the design of learning communities in STEM, highlighting the value of intentional peer mentoring structures and career-focused activities as tools for promoting student confidence, retention, and long-term academic success. Full article

The nonfluent/agrammatic variant of primary progressive aphasia (nfav-PPA) and primary progressive apraxia of speech (PPAOS) are neurodegenerative syndromes that raise diagnostic challenges related to several issues. First, there are two divergent conceptions, one stipulating that (i) nfav-APP and PPAOS are distinct entities, and the other (ii) that PPAOS has to be integrated into the nfav-APP spectrum. A second related issue concerns the consideration of phonological dimensions, lying at the language interface with speech, which could potentially help overcome the nfva-PPA/PPAOS controversy. Third, there is a lack of internationally validated clinical tests assessing apraxia of speech and syntactic abilities with sufficient specificity and sensitivity. This narrative review discusses these issues taking into account clinical, neurocognitive and neurobiological dimensions. It proposes a conceptual-integrative framework conciliating competing nfav-APP/PPAOS accounts while suggesting a graded continuum with subdivisions, related to neurodegenerative expansion throughout language/speech production systems, ranging from syntactic to phonological to phonetic-articulatory impairments. A second controversy in the field of PPA arises from divergent conceptions of semantic PPA (sv-PPA), defined by primary damage to verbal semantics, and of semantic dementia (SD) characterized by multimodal semantic impairments. The current consensus criteria of PPA have deconstructed the initial SD conception by absorbing it into sv-PPA, hence leaving mixed and some non-verbal semantic phenotypes nosologically orphaned. Again, the article proposes a conceptual and integrative model, built on findings from clinical research and cognitive neuroscience, suggesting a graded continuum with subdivisions spanning from verbal to different non-verbal semantic impairments including social-semantic/behavioral phenotypes. Full article

Motor imagery electroencephalography (MI-EEG) decoding remains challenging in cross-subject scenarios due to pronounced inter-subject variability and signal non-stationarity, which often lead to performance degradation on unseen subjects. Existing prototype-based and domain adaptation methods typically rely on global feature alignment or single-level class representation, limiting their ability to capture both channel-wise spatial variability and high-level semantic structure. To address these limitations, we propose a dual-stage prototype representation framework for cross-subject MI-EEG decoding. The framework models spatial and semantic variability in a hierarchical manner by introducing channel prototypes and feature prototypes, enabling more consistent representations across subjects. Furthermore, a prototype-guided pairwise similarity learning strategy is employed to enhance intra-class compactness and inter-class separability in the embedding space. To mitigate cross-subject distribution shifts, we integrate a lightweight statistical perturbation method (StyleMix) with Wasserstein-based domain alignment, helping reduce subject-specific distribution variations. Experiments on the BCI Competition IV 2a and 2b datasets show that the proposed method achieves competitive performance under the evaluated target-assisted few-shot setting, reaching average accuracies of 79.12% and 87.31%, respectively, and improving over the strongest baseline by up to 2.99 percentage points. Full article