Search Results (258)

This paper presents a conceptual and methodological framework for using Geographical Information Systems (GIS) to “deep map” cultural heritage sites along Ireland’s Wild Atlantic Way, with a focus on the 1588 Spanish Armada wrecks in County Kerry and archaeological landscapes in County Sligo’s “Yeats Country.” Drawing on interdisciplinary dialogues from the humanities, social sciences, and geospatial sciences, it illustrates how digital spatial technologies can excavate, preserve, and sustain intangible cultural knowledge embedded within such palimpsestic landscapes. Using MAXQDA 24 software to mine and code historical, literary, folkloric, and environmental texts, the study constructed bespoke GIS attribute tables and visualizations integrated with elevation models and open-source archaeological data. The result is a richly layered cartographic method that reveals the spectral and affective dimensions of heritage landscapes through climate, memory, literature, and spatial storytelling. By engaging with “deep mapping” and theories such as “Spectral Geography,” the research offers new avenues for sustainable heritage conservation, cultural tourism, and public education that are sensitive to both ecological and cultural resilience in the West of Ireland. Full article

Microglia, as the immune guardians of the central nervous system (CNS), have the ability to maintain neural homeostasis, respond to environmental changes, and remodel the synaptic landscape. However, persistent microglial activation can lead to chronic neuroinflammation, which can alter neuronal signaling pathways, resulting in accelerated cognitive decline. Phosphoinositol 3-kinase (PI3K) has emerged as a critical driver, connecting inflammation to neurodegeneration, serving as the nexus of numerous intracellular processes that govern microglial activation. This review focuses on the relationship between PI3K signaling and microglial activation, which might lead to cognitive impairment, inflammation, or even neurodegeneration. The review delves into the components of the PI3K signaling cascade, isoforms, and receptors of PI3K, as well as the downstream effects of PI3K signaling, including its effectors such as protein kinase B (Akt) and mammalian target of rapamycin (mTOR) and the negative regulator phosphatase and tensin homolog (PTEN). Experiments have shown that the overproduction of certain cytokines, coupled with abnormal oxidative stress, is a consequence of poor PI3K regulation, resulting in excessive synapse pruning and, consequently, impacting learning and memory functions. The review also highlights the implications of autonomously activated microglia exhibiting M1/M2 polarization driven by PI3K on hippocampal, cortical, and subcortical circuits. Conclusions from behavioral studies, electrophysiology, and neuroimaging linking cognitive performance and PI3K activity were evaluated, along with new approaches to therapy using selective inhibitors or gene editing. The review concludes by highlighting important knowledge gaps, including the specific effects of different isoforms, the risks associated with long-term pathway modulation, and the limitations of translational potential, underscoring the crucial role of PI3K in mitigating cognitive impairment driven by neuroinflammation. Full article

This paper investigates the cultural landscapes established by nineteenth-century German immigrants in South Australia and the southern Riverina of New South Wales, with particular attention to settlement patterns, architectural traditions and toponymic transformation. German immigration to Australia, though numerically modest compared to the Americas, significantly shaped local communities, especially due to religious cohesion among Lutheran migrants. These settlers established distinct, enduring rural enclaves characterized by linguistic, religious and architectural continuity. The paper examines three manifestations of these cultural landscapes. A rich toponymic landscape was created by imposing on natural landscape features and newly founded settlements the names of the communities from which the German settlers originated. It discusses the erosion of German toponyms under wartime nationalist pressures, the subsequent partial reinstatement and the implications for cultural memory. The study traces the second manifestation of a cultural landscapes in the form of nucleated villages such as Hahndorf, Bethanien and Lobethal, which often followed the Hufendorf or Straßendorf layout, integrating Silesian land-use principles into the Australian context. Intensification of land use through housing subdivisions in two communities as well as agricultural intensification through broad acre farming has led to the fragmentation (town) and obliteration (rural) of the uniquely German form of land use. The final focus is the material expression of cultural identity through architecture, particularly the use of traditional Fachwerk (half-timbered) construction and adaptations such as pug-and-pine walling suited to local materials and climate. The paper examines domestic forms, including the distinctive black kitchen, and highlights how environmental and functional adaptation reshaped German building traditions in the antipodes. Despite a conservation movement and despite considerable documentation research in the late twentieth century, the paper shows that most German rural structures remain unlisted and vulnerable. Heritage neglect, rural depopulation, economic rationalization, lack of commercial relevance and local government policy have accelerated the decline of many of these vernacular buildings. The study concludes by problematizing the sustainability of conserving German Australian rural heritage in the face of regulatory, economic and demographic pressures. With its layering of intangible (toponymic), structural (buildings) and land use (cadastral) features, the examination of the cultural landscape established by nineteenth-century German immigrants adds to the body of literature on immigrant communities, settler colonialism and landscape research. Full article

Background: Thyroid neoplasms exhibit a diverse molecular landscape, and the 2022 WHO classification emphasizes the critical role of molecular profiling in thyroid cancer management; however, comprehensive mutational data from fine-needle aspiration cytology (FNAC) samples using targeted next-generation sequencing (NGS) are still limited, necessitating further investigation to guide clinical practice. Purpose: To characterize the mutational landscape of thyroid neoplasms using targeted NGS of FNAC samples and to assess the clinical implications of molecular profiling. Materials and Methods: This retrospective study included 952 patients with thyroid carcinomaneoplasms who underwent surgery at Sun Yat-sen Memorial Hospital from 2021 to 2023. Preoperative ultrasound, FNAC, and targeted NGS were performed. NGS panels covering 18, 88, and pan-cancer genes were used to analyze FNAC samples. Molecular alterations were correlated with clinical and pathological features. Results: The most frequent mutation was BRAF^V600E (84.45%), followed by RET (6.41%), BRCA1/2 (4.41%) and RAS (4.41%). Patients were categorized into BRAF-like (830 cases), RAS-like (36 cases), high-risk mutations (25 cases), and other mutations (28 cases). High-risk mutations were associated with older age and larger tumor size. BRAF-like tumors had a higher lymph node metastasis rate (58.77%) compared to RAS-like tumors (33.33%). Tumor mutation burden varied significantly among different thyroid neoplasm subtypes. Conclusions: Molecular profiling using targeted NGS of FNAC samples provides valuable insights into the genetic landscape of thyroid neoplasms and has significant clinical implications for diagnosis and personalized treatment strategies. Further validation with paired tumor and plasma samples is warranted. Full article

This article offers a critical reading of the fishing neighbourhood of Paramos, located on the northern coast of Portugal, through a methodological approach that combines documentary photography and cognitive cartography. The study investigates the relationships between identity, landscape, and power within a territory marked by spatial fragmentation, symbolic exclusion, and functional indeterminacy. By means of a structured visual essay supported by field observation and interpretive maps, Paramos is examined as a liminal urban enclave whose ambiguities reveal tensions between memory, informal appropriation, and control devices. Drawing on authors such as Lefebvre, Augé, Hayden, Domingues, Foucault, and Latour, the article argues that the photographic image, used as a critical tool, can unveil hidden territorial logics and contribute to a more inclusive and situated spatial discourse. Full article

With the rapid proliferation of Android smartphones, mobile malware threats have escalated significantly, underscoring the need for more accurate and adaptive detection solutions. This work proposes an innovative deep learning hybrid model that combines Convolutional Neural Networks (CNNs) with Bidirectional Long Short-Term Memory (BiLSTM) networks for learning both local features and sequential behavior in Android applications. To improve the relevance and clarity of the input data, Mutual Information is applied for feature selection, while Bayesian Optimization is adopted to efficiently optimize the model’s parameters. The designed system is tested on standard Android malware datasets and achieves an impressive detection accuracy of 99.3%, clearly outperforming classical approaches such as Support Vector Machines (SVMs), Random Forest, CNN, and Naive Bayes. Moreover, it delivers strong outcomes across critical evaluation metrics like F1-score and ROC-AUC. These findings confirm the framework’s high efficiency, adaptability, and practical applicability, making it a compelling solution for Android malware detection in today’s evolving threat landscape. Full article

This article analyzes the significance of the ruins and remnants of the Soviet Army in Borne Sulinowo, a former secret Soviet military base in Western Pomerania (Poland), as a source of inspiration for performance artists. This study draws from a variety of theoretical frameworks, including performance art theory, new materialism, and the thing theory. Additionally, it draws from the ideas of Carl Lavery, Richard Gough, Ann Laura Stoler, and Georg Simmel. This text delves into the notion that the transient character of performance art mirrors the fleeting nature of power, particularly in the context of the dissolution of the Soviet regime. Following the Polish reacquisition of the site in the early 1990s, artists such as Władysław Kaźmierczak and Brian Connolly transformed found objects and the decaying environment into performance art. This article analyzes performances such as Kaźmierczak’s кoнец фильма (The End of the Movie) and Connolly’s Frieze Frame. It discusses how these works captured the emotional and intellectual responses to the remnants of military occupation. The performances demonstrate the interplay between decay, memory, and historical consciousness, employing the ruins as a medium for reflecting on the collapse of Soviet influence in Poland and the shifting geopolitical landscape. Full article

Urban pluvial flooding (UPF) is an increasingly critical issue due to rapid urbanization and intensified precipitation driven by climate change that yet remains understudied in the Caribbean. This study analyzes the effects of UPF resulting from the transformation of a natural karstic landscape into an urbanized area considering a sub-watershed in Chetumal, Southern Mexican Caribbean, as a case study. Hydrographic numerical modeling was conducted using the IBER 2.5.1 software and the SCS-CN method to estimate surface runoff for a critical UPF event across three stages: (i) 1928—natural condition; (ii) 1998—semi-urbanized (78% coverage); and (iii) 2015—urbanized (88% coverage). Urbanization led to the orthogonalization of the drainage network, an increase in the sub-watershed area (20%) and mainstream length (33%), flow velocities rising 10–100 times, a 52% reduction in surface roughness, and a 32% decrease in the potential maximum soil retention before runoff occurs. In urbanized scenarios, 53.5% of flooded areas exceeded 0.5 m in depth, compared to 16.8% in non-urbanized conditions. Community-based knowledge supported flood extent estimates with 44.5% of respondents reporting floodwater levels exceeding 0.50 m, primarily in streets. Only 43.1% recalled past flood levels, indicating a loss of societal memory, although risk perception remained high among directly affected residents. The reported UPF effects perceived in the area mainly related to housing damage (30.2%), mobility disruption (25.5%), or health issues (12.9%). Although UPF events are frequent, insufficient drainage infrastructure, altered runoff patterns, and limited access to public shelters and communication increased vulnerability. Full article

Artificial Intelligence (AI) is transforming smart healthcare by enhancing diagnostic precision, automating clinical workflows, and enabling personalized treatment strategies. This review explores the current landscape of AI in healthcare from two key perspectives: capability types (e.g., Narrow AI and AGI) and functional architectures (e.g., Limited Memory and Theory of Mind). Based on capabilities, most AI systems today are categorized as Narrow AI, performing specific tasks such as medical image analysis and risk prediction with high accuracy. More advanced forms like General Artificial Intelligence (AGI) and Superintelligent AI remain theoretical but hold transformative potential. From a functional standpoint, Limited Memory AI dominates clinical applications by learning from historical patient data to inform decision-making. Reactive systems are used in rule-based alerts, while Theory of Mind (ToM) and Self-Aware AI remain conceptual stages for future development. This dual perspective provides a comprehensive framework to assess the maturity, impact, and future direction of AI in healthcare. It also highlights the need for ethical design, transparency, and regulation as AI systems grow more complex and autonomous, by incorporating cross-domain AI insights. Moreover, we evaluate the viability of developing AGI in regionally specific legal and regulatory frameworks, using South Korea as a case study to emphasize the limitations imposed by infrastructural preparedness and medical data governance regulations. Full article

This work presents a comprehensive mathematical framework for symmetrized neural network operators operating under the paradigm of fractional calculus. By introducing a perturbed hyperbolic tangent activation, we construct a family of localized, symmetric, and positive kernel-like densities, which form the analytical backbone for three classes of multivariate operators: quasi-interpolation, Kantorovich-type, and quadrature-type. A central theoretical contribution is the derivation of the Voronovskaya–Santos–Sales Theorem, which extends classical asymptotic expansions to the fractional domain, providing rigorous error bounds and normalized remainder terms governed by Caputo derivatives. The operators exhibit key properties such as partition of unity, exponential decay, and scaling invariance, which are essential for stable and accurate approximations in high-dimensional settings and systems governed by nonlocal dynamics. The theoretical framework is thoroughly validated through applications in signal processing and fractional fluid dynamics, including the formulation of nonlocal viscous models and fractional Navier–Stokes equations with memory effects. Numerical experiments demonstrate a relative error reduction of up to 92.5% when compared to classical quasi-interpolation operators, with observed convergence rates reaching $\mathcal{O}\left(n^{-1.5}\right)$ under Caputo derivatives, using parameters $\lambda =3.5$, $q=1.8$, and $n=100$. This synergy between neural operator theory, asymptotic analysis, and fractional calculus not only advances the theoretical landscape of function approximation but also provides practical computational tools for addressing complex physical systems characterized by long-range interactions and anomalous diffusion. Full article

The aim of the work is to analyze the survival strategy of Taxus baccata L., one of the promising plants for landscaping and the creation of woodlands, in the changing ecological conditions of the steppe zone of the Donetsk ridge. In order to achieve this goal, we used biomechanics methods, which help to understand the relationship between the physical and mechanical properties of living tissues and the overall stability of trees during interactions with environmental factors such as temperature, snow and ice storms, cyclic freeze–thaw processes, wind loads, and others. The work was based both on experimental studies on the estimation of the tissue elasticity modulus in response to temperature changes, the mechanical stability of plants, the field collection of materials, and studies on the modeling of forest stand conditions of English yew. As a result of the conducted experiments, it was established for the first time that at the absolute wood moisture content of 77 ± 5.1%, the density of wood tissues in the conditions of Donetsk is 907 ± 43 kg m⁻³. The modulus of elasticity of living tissues depending on the temperature factor varied in the following range: 8.8 ± 0.31 GN m⁻² (T = 288 K), 11.5 ± 0.55 GN m⁻² (T = 255 K) and 6.9 ± 0.47 GN m⁻² (t = 308 K). It was revealed that during the local thawing of skeletal branches and tables, the mechanical resistance of T. baccata is reduced by 20–22% and this critically affects the overall plant resistance. It was established for the first time that T. baccata in the conditions of the steppe zone has an adaptive strategy of preserving the integrity of the organism under the action of environmental factors with limited loads. The secret lies in the formation of the shape memory effect, under the influence of critical loads. The plant, thus, chooses not migration, not death, but adaptation to changes in environmental conditions, which can become a serious factor in the use of T. baccata in the landscaping of urban areas and the creation of artificial forests. Full article

Staphylococcus lugdunensis is a coagulase-negative staphylococcus known for its significant pathogenic potential, often causing severe infections such as endocarditis and bacteremia, with virulence comparable to S. aureus. Despite general susceptibility to most antibiotics, the emergence of oxacillin-resistant strains is increasingly concerning. This study conducted whole-genome sequencing on 20 S. lugdunensis isolates from Chang Gung Memorial Hospital to explore their genetic diversity, antimicrobial resistance mechanisms, and mobile genetic elements. The lugdunin biosynthetic operon, essential for antimicrobial peptide production, was present in multilocus sequence typing (MLST) types 1, 3, and 6 but absent in STs 4, 27, and 29. Additionally, IS256 insertion elements, ranging from 7 to 17 copies, were identified in four strains and linked to multidrug resistance. CRISPR-Cas systems varied across STs, with type III-A predominant in ST1 and ST6 and type IIC in ST4, ST27, and ST29; notably, ST3 lacked CRISPR systems, correlating with a higher diversity of SCCmec elements and an increased potential for horizontal gene transfer. Phage analysis revealed stable phage–host associations in ST1, ST6, and ST29, whereas ST4 displayed a varied prophage profile. Phenotypic resistance profiles generally aligned with genomic predictions, although discrepancies were observed for aminoglycosides and clindamycin. These findings highlight the complex genetic landscape and evolutionary dynamics of S. lugdunensis, emphasizing the need for genomic surveillance to inform clinical management and prevent the spread of resistant strains. Full article

As urbanization has accelerated, rail transit has evolved from being a mere means of transportation to a public area that houses the city’s cultural memory and serves as a crucial portal for the public to understand the culture of the city. As an urban public space with huge passenger flow, the metro (or subway) cultural space has also become a public cultural space, serving communal welfare and representing the image of the city. It is currently attracting more and more attention from the academic community. Wuhan, located in central China, has many subway lines and its engineering construction has set several national firsts, which is a typical sample of urban subway development in China. In this study, we use Python 3.13.0 crawler technology to capture the public’s comments on cultural space of Wuhan metro in social media and adopt SnowNLP sentiment score and LDA thematic clustering analysis to explore the overall quality, distinct characteristics, and deficiencies of Wuhan metro cultural space construction, and propose targeted design optimization strategies based on this study. The main findings are as follows: (1) The metro cultural space is an important window for the public to perceive the city culture, and the public in general shows positive perception of emotions: among the 16,316 data samples, 47.7% are positive comments, 17.8% are neutral comments, and 34.5% are negative comments. (2) Based on the frequency of content in the sample data for metro station exit and entrance space, metro train space, metro concourse and platform space, they are ranked as weak cultural spaces (18%), medium cultural spaces (33%), and strong cultural spaces (49%) in terms of the public’s perception of urban culture. (3) At present, there are certain deficiencies in Wuhan metro cultural space: the circulation paths in concourses and platforms are overly dominant, leaving little space for rest or interaction; the cultural symbols of metro train space are fragmented; the way of articulation between cultural and functional space in the metro station exit and entrance space is weak, and the space is single in form. (4) Wuhan metro cultural space needs to be based on locality landscape expression, functional zoning reorganization, innovative scene creation to optimize the visual symbol system and behavioral symbol system in the space, to establish a good image of the space, and to strengthen the public’s cultural identity and emotional resonance. Full article

Across the centuries, trees have been recognised as one of the oldest lifeforms on earth, witnessing and subject to the passage of time on a scale that far exceeds human life, telling us who we are in the world. This paper explores the intricate nature of human interactions with trees across a broad chronological and conceptual range, and the cultural, symbolic, and ecological meaning of “iconic” trees, drawing upon a selection of case studies to explore and analyse the relationship between the tree as a living organism and its cultural, textual, and mnemonic meaning. In conducting this, it reflects upon the cultural geographies of presence and absence, and the role of emblematic trees as places of memory and structures of belief. The relationship between human life and the life of trees is shown to be symbiotic; multiple cultural values and symbolic forms are ascribed to trees, and those same trees shape the physical, ecological, and human environment. The social and cultural construction of the landscape and sites of memory is presented as a key component in the formation of narratives and mentalities that define the relationship between humans and iconic trees, material and imagined. Physical, ecological, and cultural erosion, it is suggested, have the capacity of memorialising forgetfulness and creating a space in which the absence of presence and the presence of absence co-exist. The iconic image of the fallen tree, in its presence and absence, exposes the extent to which trees are also human objects, constructed and understood in human terms, and subject to a range of personal, political, and pragmatic impulses. A tree can be iconic not simply because of what it was but because of what it was believed to be, integrating a physical, historical, memory, and ecological or cultural space into our relationship with the natural world. Full article

Monastic life presents a contrast to many aspects of modern existence (the rule of ideology, consumerism, various forms of negativity, dominance of the virtual, forgetfulness). The following essay explores this contrast and its presence throughout the long history of monasticism, with a focus on early Northern and Western monasticism on the one hand, and the modern Benedictine tradition on the other. The counter-cultural dimensions of monastic life range from special landscapes and sacred space to the function of time, and from the transcendental role of prayer to the earthy nature of hard work. Not only do the traditions of monastic scholarship and the books gathered in monastic libraries help preserve the memory and reinforce the special counter-culture of monasteries, but the monasteries remain to this day places of healing and sources of hope. The poem “Pilgrimage” composed in 1929 by Austin Clarke captures the character of monastic life not only as something contrary, but as an essential way of life, which has survived from the founding of medieval Clonmacnoise up until today. Full article