20,314 Results Found

Mediation analysis has a long history and its use in applied research has been increasing. Studying mediators can help improve our understanding of mechanisms relating independent and dependent variables. The objective of this paper is to compare dif...

Mediation analysis is a widely used statistical technique for identifying the mechanisms underlying the relationship between an exposure and an outcome. However, accurate power analysis and sample size determination for mediation models that involve...

A mediation effect refers to the effect transmitted by a mediator intervening in the relationship between an exposure variable and a response variable. Mediation analysis is widely used to identify significant mediators and to make inferences on thei...

In this study, we examine whether digitalization, measured by internet, fixed telephone, and mobile phone usage, has helped to lower carbon dioxide (CO₂) emissions. The correlation between ICT and CO₂ emissions is assessed via panel data analysis usi...

This study analyzes the relationship between economic inequality, social capital, and crime across Mexican municipalities in 2020, adopting a mediation approach and an exploratory territorial analysis. Using data from the National Council for the Eva...

The spread of the pandemic has posed unprecedented challenges for Chinese enterprises, particularly in the new energy sector, where numerous companies have been forced to halt their development plans and suspend projects, awaiting opportunities to re...

Mediation analysis plays an increasingly crucial role in identifying potential causal pathways between exposures and outcomes. However, there is currently a lack of developed mediation approaches for high-dimensional survival data, particularly when...

Many important exposure–response relationships, such as diet and weight, can be influenced by intermediates, such as the gut microbiome. Understanding the role of these intermediates, the mediators, is important in refining cause–effect t...

Background: Persistent gut microbiota (GM) imbalance has been associated with metabolic disease development. This study evaluated the mediating role of waist circumference in the association between GM and insulin resistance (IR) in children. Methods...

Modern mediation analysis techniques supplement the primary intention-to-treat analysis with the aim to shed light onto the treatment mechanism. We investigate to what extent the anatomic marker vitreomacular adhesion resolution (VMAR) mediates visio...

Background/Objectives: The relationship between lipid profiles, telomere length (TL), and cancer risk remains unclear. Methods: This study employed two-sample Mendelian randomization (MR) with mediation analysis to investigate their causal relationsh...

Background: This study examined the interplay between sociocultural internalization, perfectionism, and eating disorder (ED) symptoms. We pursued two complementary aims: (1) to identify latent profiles of women based on adaptive/maladaptive perfectio...

The aims of this study were: (a) to explore the relationships between adaptive defense mechanisms (ADMs), maladaptive defense mechanisms (MADMs), stress, recovery, resilience, and sport burnout; and (b) to examine resilience, stress, and recovery as...

Family caregiving is a public health issue because of caregivers’ significant contribution to the health and social care systems, as well as the substantial impact that giving and receiving care has on the health and quality of life of care rec...

The purpose of this investigation was to study the relationship between sleep quality, problematic smartphone use (PSU) and bedtime procrastination, as well as to assess gender and age differences. A total of 313 participants, aged 18–60 (M = 3...

Studies investigating the association between urinary Polycyclic Aromatic Hydrocarbons (PAHs) and asthma in children provided inhomogeneous results. We aimed to use Mediation Analysis to discover whether a link between urinary PAHs and lung function...

Maternal nutrition and health status in the peri-pregnancy period are closely related to offspring health. Currently, population studies are unable to provide quantitative relationships and effective measures of peri-pregnancy high-fat diet and offsp...

The EU Ecolabel, established in 1992, aims to promote sustainable consumption, yet a significant gap persists between consumers’ positive environmental attitudes and their actual purchasing behavior of ecolabeled products. This study examines t...

Background: Myeloproliferative neoplasms (MPN), a group of chronic hematologic neoplasms, are driven by inflammatory mechanisms that influence disease initiation and progression. Emerging evidence highlights the gut microbiome and plasma metabolome a...

Clinicians have an increasing number of evidence-based interventions to treat pain in youth. Mediation analysis offers a way of investigating how interventions work, by examining the extent to which an intermediate variable, or mediator, explains the...

Nurses often work under high stress and heavy workloads, making it critical to understand factors that influence their motivation, psychosocial safety climate (PSC), and work engagement (WE). Objectives: To assess nurses’ levels of motivation,...

Regional regulatory policies (RPs) are a major factor in the prevention and control of chronic diseases (PCCDs) through the implementation of various measures. This study aimed to explore the impacts of RPs on PCCDs, with a focus on the mediating rol...

It has been widely reported that younger and older drivers have an excess risk of causing a road crash. Two casual hypotheses may coexist: the riskier driving behaviors and age-related mechanisms in extreme age groups (direct path) and the different...

There is growing evidence showing that people with disabilities face more frequently socioeconomic inequities than their non-disabled peers. This study aims to examine to what extent socioeconomic consequences of disability contribute to poorer acces...

Causal mediation analysis of environmental mixtures is challenging because exposures are correlated and mediation effects depend on joint exposure intervention. We compared Bayesian kernel machine regression causal mediation analysis (BKMR-CMA) with...

Background/Objective: The purpose of this study was to determine whether the effects of pain education combined with physiotherapy could be explained by changes in psychological well-being and self-efficacy in individuals with chronic low back pain (...

Background/Objectives: Declining fertility rates pose a major demographic and public health challenge across Europe, including Croatia. Although health literacy and psychological well-being may influence reproductive decision-making, their relationsh...

University life is a critical period for personality development and psychological well-being. This study, which investigated the relationships between the Big Five personality traits, social support, and psychological well-being, particularly the me...

Mass vaccination campaigns have been implemented worldwide to counteract the SARS-CoV-2/COVID-19 pandemic, however their effectiveness could be challenged by vaccine hesitancy. The tremendous rise in the use of social media have made them acquire a l...

Compared to recent generations, workers today generally experience poorer quality employment across both contractual (e.g., wages, hours) and relational (e.g., participation in decision-making, power dynamics) dimensions within the worker–emplo...

The interaction between teachers and students is critical to the learning process. Student success and learner satisfaction have consistently improved in educational situations where instructors and students connect frequently and meaningfully. The C...

Background: Hyperuricemia has long been linked to the progression of chronic kidney disease (CKD), although the role of serum uric acid (sUA) reduction in kidney preservation remains uncertain. Sodium-glucose cotransporter 2 (SGLT2) inhibitors lower...

Background: Pressure injuries (PIs) remain a major and escalating global patient safety concern, affecting 12.8% of hospitalized patients worldwide and contributing to rising prevalence and mortality rates from 5.63 to 8.18 and 0.31 to 0.47 per 100,0...

Medical mediation (MM) is a collaborative tool for resolving ethically complex disputes in healthcare. Background/Objectives: Though widely recognized in international clinical ethics, it has only been recently introduced in Greece. The objective of...

Background/Objective: Food insecurity is increasingly recognised as a concern among university students. Less is known about the interrelationships between food insecurity, psychological distress, and disordered eating risk in this population. This s...

Background: Whether the etiology of underlying liver disease represents a prognostic factor in patients with hepatocellular carcinoma (HCC) treated with lenvatinib is still a matter of debate. This study investigates whether the viral etiology of HCC...

This study identifies and characterises the Socratic mediation patterns enacted by MIA, an AI-based conversational agent used in distance higher education. A deductive content analysis was conducted on 737 conversations using six categories: explorat...

Love addiction is a dysfunctional relational modality that takes on the addiction characteristics and which, for the individuals who suffer from it, can have a negative and pervasive impact on various areas of functioning. The objective of this resea...

The purpose of this research was to analyze how different effects of the COVID pandemic, expressed through pandemic accentuated occupational stress, perceived job insecurity, occupational safety and health perception and perceived organizational effe...

Background/Objectives: Out-of-hospital cardiac arrest (OHCA) outcomes remain poor and vary widely across communities with socioeconomic deprivation. This study examines whether delays in emergency medical services (EMS) activation, the earliest link...

In this study, we employ the novel method of quantile mediation analysis to explore dynamic relationships among hydropower energy consumption, economic growth, and carbon dioxide emissions in Taiwan during the period between 1990 and 2020. The empiri...

Prostate Cancer (PCa) is the most commonly diagnosed cancer and the second leading cause of cancer death among men. In Louisiana (LA), Black men are disproportionately diagnosed at later stages compared to White men. This study explores environmental...

Objectives: This study investigated the sequential mediating roles of protein intake and handgrip strength (HGS) in the association between socioeconomic status (SES) and 10-year atherosclerotic cardiovascular disease (ASCVD) risk within the social d...

Background: Comorbid occurrence of tinnitus and emotional symptoms of anxiety and depression is highly prevalent. The Ginkgo biloba extract EGb 761^® has been shown to be effective in reducing neuropsychiatric symptoms in patients with dementia and ti...

Background/Objectives: While some dietary indices have been developed to assess diet quality and chronic disease risk, their comparative effectiveness within the same population remains unclear due to methodological limitations in observational studi...

Abusive leadership is particularly prevalent in nursing and it can have multiple adverse effects on performance at work. However, little research has examined whether and under what conditions abusive leadership may be detrimental to nurses’ ex...

Older adults with disabilities face compounded vulnerabilities due to both functional limitations and socioeconomic disadvantage. In South Korea, where public welfare systems remain fragmented and cultural values emphasize independence and productivi...

Background: Global takeaway fast-food consumption (TFC) has surged. This study aimed to investigate the association between TFC frequency and diastolic blood pressure (DBP) and to explore the potential mediating roles of metabolic and inflammatory ma...

Background: Hepatocellular carcinoma (HCC) is a primary malignant liver tumor characterized by a low survival rate and high mortality. This study aimed to investigate the causal effect of immune cell phenotypes, plasma metabolites, and HCC in East As...

Seafarers inhabit acoustically hostile environments continuously across deployment rotations of four to six months, yet how shipboard noise relates to operational-safety risk is poorly characterised. We surveyed 242 maritime cadets with sea-service e...