Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Article Types

Countries / Regions

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Search Results (2,849)

Search Parameters:
Keywords = mechanical switches

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
16 pages, 2574 KB  
Article
Addressing a Special Case of Zero-Crossing Range Adjustment Detection in a Passive Autoranging Circuit for the FBG/PZT Photonic Current Transducer
by Burhan Mir, Grzegorz Fusiek and Pawel Niewczas
Sensors 2025, 25(20), 6311; https://doi.org/10.3390/s25206311 (registering DOI) - 12 Oct 2025
Abstract
This paper analyses a special case in evaluating the passive autoranging (AR) technique that dynamically extends the measurement range of a fiber Bragg grating/piezoelectric transducer (FBG/PZT) operating with a current transformer (CT) to realize a dual-purpose metering and protection photonic current transducer (PCT). [...] Read more.
This paper analyses a special case in evaluating the passive autoranging (AR) technique that dynamically extends the measurement range of a fiber Bragg grating/piezoelectric transducer (FBG/PZT) operating with a current transformer (CT) to realize a dual-purpose metering and protection photonic current transducer (PCT). The technique relies on shorting serially connected burden resistors operating with the CT, using MOSFET switches that react to a changing input current to extend measurement range. The rapid changes in the voltage at the FBG/PZT transducer that are associated with the MOSFET switching are then used on the FBG interrogator side to select the correct measurement range. However, when the MOSFET switching in the AR circuit occurs near the zero-crossing of the input current, the rapid changes in the voltage presented to the FBG/PZT no longer occur, rendering the correct range setting at the interrogator side problematic. The basic switching detection algorithm based on voltage derivative (dV/dt) thresholds proposed in the previous research is not sufficiently sensitive in these conditions, leading to incorrect range selection. To address this, a new detection algorithm based on temporal slope differencing around the zero-crossing is proposed as an additional detection mechanism for these special cases. Thus, the improved hybrid algorithm additionally computes the derivative dV/dt at the FBG/PZT voltage signal within a focused 6 ms temporal window centered around the zero-crossing point, a 3 ms window before and after each zero-crossing instance. It then compares the difference between these two values to a predefined threshold. If the difference exceeds the threshold, a switching event is identified. This method reliably detects even subtle switching events near zero crossings, enabling the accurate reconstruction of the burden current. The performance of the improved algorithm is validated through simulations and experimental results involving zero-crossing switching scenarios. Results indicate that the proposed algorithm improves MOSFET switching detection and facilitates reliable waveform reconstruction without requiring additional hardware. Full article
(This article belongs to the Special Issue Optical Sensing in Power Systems)
Show Figures

Figure 1

22 pages, 5131 KB  
Article
Predictive Torque Control for Induction Machine Fed by Voltage Source Inverter: Theoretical and Experimental Analysis on Acoustic Noise
by Bouyahi Henda and Adel Khedher
Acoustics 2025, 7(4), 63; https://doi.org/10.3390/acoustics7040063 (registering DOI) - 11 Oct 2025
Abstract
Induction motors piloted by voltage source inverters constitute a major source of acoustic noise in industry. The discrete tonal bands generated by induction motor stator current spectra controlled by the fixed Pulse Width Modulation (PWM) technique have damaging effects on the electronic noise [...] Read more.
Induction motors piloted by voltage source inverters constitute a major source of acoustic noise in industry. The discrete tonal bands generated by induction motor stator current spectra controlled by the fixed Pulse Width Modulation (PWM) technique have damaging effects on the electronic noise source. Nowadays, the investigation of new advanced control techniques for variable speed drives has developed a potential investigation field. Finite state model predictive control has recently become a very popular research focus for power electronic converter control. The flexibility of this control shows that the switching times are generated using all the information on the drive status. Predictive Torque Control (PTC), space vector PWM and random PWM are investigated in this paper in terms of acoustic noise emitted by an induction machine fed by a three-phase two-level inverter. A comparative study based on electrical and mechanical magnitudes, as well as harmonic analysis of the stator current, is presented and discussed. An experimental test bench is also developed to examine the effect of the proposed PTC and PWM techniques on the acoustic noise of an induction motor fed by a three-phase two-level voltage source converter. Full article
Show Figures

Figure 1

12 pages, 3323 KB  
Article
Effects of Laser Shock Processing on the Mechanical Properties of 6061-T6 Aluminium Alloy Using Nanosecond and Picosecond Laser Pulses
by Martha Guadalupe Arredondo Bravo, Gilberto Gomez-Rosas, Miguel Morales, David Munoz-Martin, Juan Jose Moreno-Labella, Jose Manuel Lopez Lopez, Jose Guadalupe Quiñones Galvan, Carlos Rubio-Gonzalez, Francisco Javier Casillas Rodriguez and Carlos Molpeceres
Materials 2025, 18(20), 4649; https://doi.org/10.3390/ma18204649 - 10 Oct 2025
Viewed by 16
Abstract
Laser shock processing (LSP) is a surface treatment technique used to enhance mechanical properties such as hardness, corrosion resistance, and wear resistance. This study investigates the effects of LSP on a 6061-T6 aluminium alloy using four treatment conditions: nanosecond (ns-LSP), picosecond (ps-LSP), and [...] Read more.
Laser shock processing (LSP) is a surface treatment technique used to enhance mechanical properties such as hardness, corrosion resistance, and wear resistance. This study investigates the effects of LSP on a 6061-T6 aluminium alloy using four treatment conditions: nanosecond (ns-LSP), picosecond (ps-LSP), and a combination of nanosecond–picosecond (nsps-LSP) and picosecond–nanosecond (psns-LSP) pulses. Two laser systems were employed: a Q-switched Nd:YAG laser (850 mJ/pulse, 6 ns, 1064 nm, 10 Hz), and an Ekspla Atlantic 355-60 laser (0.110 mJ/pulse, 13 ps, 1064 nm, 1 kHz). All treatments induced compressive residual stresses up to 1 mm in depth. Additionally, improvements in microhardness were observed, particularly at deeper layers in the combined nsps-LSP treatment. Surface roughness was measured and compared. Among all configurations, the nsps-LSP treatment produced the highest compressive residual stresses (−428 MPa) and greater microhardness at depth. These results suggest that the combined nsps-LSP treatment represents a promising approach to enhance the mechanical performance of metallic components. Full article
(This article belongs to the Special Issue Advances in Laser Processing Technology of Materials—Second Edition)
Show Figures

Figure 1

17 pages, 8553 KB  
Article
High-Intensity Focused Pressure Wave Generation via Q-Switched Er:YAG Laser with a Water Layer Formed by the Coupled Lens for Optoacoustic Conversion
by Dominik Šavli, Aleš Babnik, Daniele Vella and Matija Jezeršek
Appl. Sci. 2025, 15(19), 10860; https://doi.org/10.3390/app151910860 - 9 Oct 2025
Viewed by 151
Abstract
We demonstrate coating-free optoacoustic generation and focusing of ultrasound using a mechanically Q-switched (MQS) erbium-doped yttrium aluminum garnet (Er:YAG) source (~100 ns, ≤20 mJ) combined with a concave water interface that simultaneously serves as converter and acoustic lens. Axial, lateral, and focal-point measurements [...] Read more.
We demonstrate coating-free optoacoustic generation and focusing of ultrasound using a mechanically Q-switched (MQS) erbium-doped yttrium aluminum garnet (Er:YAG) source (~100 ns, ≤20 mJ) combined with a concave water interface that simultaneously serves as converter and acoustic lens. Axial, lateral, and focal-point measurements mapped the pressure field while varying beam diameter (2w = 5–15 mm) and pulse energy (E = 10–20 mJ). The maximum focal positive pressure (Pmax = 7 MPa) occurs at an intermediate diameter (~10 mm), whereas the tightest lateral/axial confinement and strongest spectral enhancement arise at larger diameters (14–15 mm) with fc = ~5 MHz and −6 dB bandwidth up to 7 MHz. Pressure increases nearly monotonically with energy. For equal fluence, larger diameters yield higher focal pressures due to greater focusing gain. Small beams (2w ≈ 5–7 mm) show shorter apparent time-of-flight (TOF) and waveform broadening, consistent with early shock-like emission from locally vaporizing region. These results provide practical rules for tuning amplitude, spectrum, and confinement, enabling sub-millimeter focusing for contamination-sensitive and therapeutic applications. Full article
(This article belongs to the Section Optics and Lasers)
Show Figures

Figure 1

9 pages, 1056 KB  
Article
Photoprotective Switching Reveals a Thermal Achilles’ Heel in Breviolum minutum at 41 °C
by Hadley England, Emma F. Camp and Andrei Herdean
J. Mar. Sci. Eng. 2025, 13(10), 1937; https://doi.org/10.3390/jmse13101937 - 9 Oct 2025
Viewed by 90
Abstract
Non-photochemical quenching (NPQ) is a key photoprotective mechanism in Symbiodiniaceae, enabling photosystem II (PSII) to dissipate excess excitation energy under stress. The balance between regulated (ΦNPQ) and unregulated (ΦNO) energy dissipation influences thermal tolerance, yet the temperature thresholds at [...] Read more.
Non-photochemical quenching (NPQ) is a key photoprotective mechanism in Symbiodiniaceae, enabling photosystem II (PSII) to dissipate excess excitation energy under stress. The balance between regulated (ΦNPQ) and unregulated (ΦNO) energy dissipation influences thermal tolerance, yet the temperature thresholds at which this balance shifts remain poorly defined. Here, we used the Phenoplate, a high-throughput fluorometric platform integrating rapid light curves with controlled temperature ramping, to examine short-term thermal responses in Breviolum minutum across 6–71 °C. We identified a sharp transition at 41 °C where ΦNPQ collapsed and was replaced by ΦNO, indicating loss of regulated photoprotection. This switch coincided with a pronounced drop in PSII effective quantum yield (ΦII) and substantial reductions in cell density, marking a thermal Achilles’ heel in the photoprotective capacity of this species. Despite this regulatory breakdown, a fraction of cells persisted for at least three days post-exposure. These results demonstrate that B. minutum maintains regulated photoprotection up to a discrete threshold, beyond which unregulated becomes the dominant pathway and survival is compromised. Identifying such thermal inflection points in coral symbionts provides mechanistic insight into their vulnerability under acute heat stress and may inform early-warning indicators for coral bleaching susceptibility. Full article
Show Figures

Figure 1

26 pages, 5816 KB  
Article
Disturbance-Free Switching Control Strategy for Grid-Following/Grid-Forming Modes of Energy Storage Converters
by Geling Jiang, Siyu Kan, Yuhang Li and Xiaorong Zhu
Electronics 2025, 14(19), 3963; https://doi.org/10.3390/electronics14193963 - 9 Oct 2025
Viewed by 163
Abstract
To address the problem of transient disturbance arising during the grid-following (GFL) and grid-forming (GFM) mode switching of energy storage converters, this paper proposes a dual-mode seamless switching control strategy. First, we conduct an in-depth analysis of the mechanism behind switching transients, identifying [...] Read more.
To address the problem of transient disturbance arising during the grid-following (GFL) and grid-forming (GFM) mode switching of energy storage converters, this paper proposes a dual-mode seamless switching control strategy. First, we conduct an in-depth analysis of the mechanism behind switching transients, identifying that sudden changes in current commands and angle-control misalignment are the key factors triggering oscillations in system power and voltage frequency. To overcome this, we design a virtual synchronous generator (VSG) control angle-tracking technique based on the construction of triangular functions, which effectively eliminates the influence of periodic phase-angle jumps on tracking accuracy and achieves precise pre-synchronization of the microgrid phase in GFM mode. Additionally, we employ a current-command seamless switching technique involving real-time latching and synchronization of the inner-loop current references between the two modes, ensuring continuity of control commands at the switching instant. The simulation and hardware-in-the-loop (HIL) experimental results show that the proposed strategy does not require retuning of the parameters after switching, greatly suppresses voltage and frequency fluctuations during mode transition, and achieves smooth, rapid, seamless switching between the GFL and GFM modes of the energy storage converter, thereby improving the stability of microgrid operation. Full article
Show Figures

Figure 1

17 pages, 1706 KB  
Article
Cross-Attention Enhanced TCN-Informer Model for MOSFET Temperature Prediction in Motor Controllers
by Changzhi Lv, Wanke Liu, Dongxin Xu, Huaisheng Zhang and Di Fan
Information 2025, 16(10), 872; https://doi.org/10.3390/info16100872 - 8 Oct 2025
Viewed by 174
Abstract
To address the challenge that MOSFET temperature in motor controllers is influenced by multiple factors, exhibits strong temporal dependence, and involves complex feature interactions, this study proposes a temperature prediction model that integrates Temporal Convolutional Networks (TCNs) and the Informer architecture in parallel, [...] Read more.
To address the challenge that MOSFET temperature in motor controllers is influenced by multiple factors, exhibits strong temporal dependence, and involves complex feature interactions, this study proposes a temperature prediction model that integrates Temporal Convolutional Networks (TCNs) and the Informer architecture in parallel, enhanced with a cross-attention mechanism. The model leverages TCNs to capture local temporal patterns, while the Informer extracts long-range dependencies, and cross-attention strengthens feature interactions across channels to improve predictive accuracy. A dataset was constructed based on measured MOSFET temperatures under various operating conditions, with input features including voltage, load current, switching frequency, and multiple ambient temperatures. Experimental evaluation shows that the proposed method achieves a mean absolute error of 0.2521 °C, a root mean square error of 0.3641 °C, and an R2 of 0.9638 on the test set, outperforming benchmark models such as Times-Net, Informer, and LSTM. These results demonstrate the effectiveness of the proposed approach in reducing prediction errors and enhancing generalization, providing a reliable tool for real-time thermal monitoring of motor controllers. Full article
Show Figures

Figure 1

31 pages, 2573 KB  
Article
Hardware Design of DRAM Memory Prefetching Engine for General-Purpose GPUs
by Freddy Gabbay, Benjamin Salomon, Idan Golan and Dolev Shema
Technologies 2025, 13(10), 455; https://doi.org/10.3390/technologies13100455 - 8 Oct 2025
Viewed by 183
Abstract
General-purpose graphics computing on processing units (GPGPUs) face significant performance limitations due to memory access latencies, particularly when traditional memory hierarchies and thread-switching mechanisms prove insufficient for complex access patterns in data-intensive applications such as machine learning (ML) and scientific computing. This paper [...] Read more.
General-purpose graphics computing on processing units (GPGPUs) face significant performance limitations due to memory access latencies, particularly when traditional memory hierarchies and thread-switching mechanisms prove insufficient for complex access patterns in data-intensive applications such as machine learning (ML) and scientific computing. This paper presents a novel hardware design for a memory prefetching subsystem targeted at DDR (Double Data Rate) memory in GPGPU architectures. The proposed prefetching subsystem features a modular architecture comprising multiple parallel prefetching engines, each handling distinct memory address ranges with dedicated data buffers and adaptive stride detection algorithms that dynamically identify recurring memory access patterns. The design incorporates robust system integration features, including context flushing, watchdog timers, and flexible configuration interfaces, for runtime optimization. Comprehensive experimental validation using real-world workloads examined critical design parameters, including block sizes, prefetch outstanding limits, and throttling rates, across diverse memory access patterns. Results demonstrate significant performance improvements with average memory access latency reductions of up to 82% compared to no-prefetch baselines, and speedups in the range of 1.240–1.794. The proposed prefetching subsystem successfully enhances memory hierarchy efficiency and provides practical design guidelines for deployment in production GPGPU systems, establishing clear parameter optimization strategies for different workload characteristics. Full article
Show Figures

Figure 1

15 pages, 3325 KB  
Article
Impact of SiN Passivation on Dynamic-RON Degradation of 100 V p-GaN Gate AlGaN/GaN HEMTs
by Marcello Cioni, Giacomo Cappellini, Giovanni Giorgino, Alessandro Chini, Antonino Parisi, Cristina Miccoli, Maria Eloisa Castagna, Aurore Constant and Ferdinando Iucolano
Electron. Mater. 2025, 6(4), 14; https://doi.org/10.3390/electronicmat6040014 - 7 Oct 2025
Viewed by 202
Abstract
In this paper, the impact of SiN passivation on dynamic-RON degradation of AlGaN/GaN HEMTs devices is put in evidence. To this end, samples showing different SiN passivation stoichiometry are considered, labeled as Sample A and Sample B. For dynamic-RON tests, two [...] Read more.
In this paper, the impact of SiN passivation on dynamic-RON degradation of AlGaN/GaN HEMTs devices is put in evidence. To this end, samples showing different SiN passivation stoichiometry are considered, labeled as Sample A and Sample B. For dynamic-RON tests, two different experimental setups are employed to investigate the RON-drift showing up during conventional switch mode operation by driving the DUTs under both (i) resistive load and (ii) soft-switching trajectory. This allows to discern the impact of hot carriers and off-state drain voltage stress on the RON parameter drift. Measurements performed with both switching loci shows similar dynamic-RON response, indicating that hot carriers are not involved in the degradation of tested devices. Nevertheless, a significant difference was observed between Sample A and Sample B, with the former showing an additional RON-degradation mechanism, not present on the latter. This additional drift is totally ascribed to the SiN passivation layer and is confirmed by the different leakage current measured across the two SiN types. The mechanism is explained by the injection of negative charges from the Source Field-Plate towards the AlGaN surface that are captured by surface/dielectric states and partially depletes the 2DEG underneath. Full article
Show Figures

Figure 1

17 pages, 3752 KB  
Article
Operating State Analysis of Asymmetric Reactive Power Compensator via Data Mining
by Yunfei Chen and Yi Zhang
Symmetry 2025, 17(10), 1676; https://doi.org/10.3390/sym17101676 - 7 Oct 2025
Viewed by 175
Abstract
Given the inadequacies in the management of reactive power compensation equipment in distribution networks and insufficient power data mining, existing studies pay little attention to asymmetric reactive power compensation equipment and face pain points such as difficult quantification of nonlinear relationships and challenging [...] Read more.
Given the inadequacies in the management of reactive power compensation equipment in distribution networks and insufficient power data mining, existing studies pay little attention to asymmetric reactive power compensation equipment and face pain points such as difficult quantification of nonlinear relationships and challenging evaluation of mechanical switches. First, this paper proposes a data mining-based diagnostic method for the operating status of asymmetric reactive power compensation equipment: it preprocesses data via singular value decomposition and matrix approximation. Second, it classifies load types with K-means clustering, defines “health degree” by introducing mutual information and a reliability coefficient, constructs dual switching criteria, and defines the switching qualification rate. Third, the TOPSIS method is employed for dual-index comprehensive evaluation, and equipment status levels are classified with statistical analysis. Finally, the case analysis demonstrates that the proposed method is accurate, applicable, and easy to implement, which can serve as a basis for equipment troubleshooting and maintenance, thereby filling the relevant research gap. Full article
(This article belongs to the Section Engineering and Materials)
Show Figures

Figure 1

16 pages, 1895 KB  
Article
Modernization of Hoisting Operations Through the Design of an Automated Skip Loading System—Enhancing Efficiency and Sustainability
by Keane Baulen Size, Rejoice Moyo, Richard Masethe, Tawanda Zvarivadza and Moshood Onifade
Mining 2025, 5(4), 62; https://doi.org/10.3390/mining5040062 - 4 Oct 2025
Viewed by 212
Abstract
This study presents the design and validation of an automated skip loading system for vertical shaft hoisting operations, aimed at addressing inefficiencies in current manual systems that contribute to consistent underperformance in meeting daily production targets. Initial assessments revealed a task completion rate [...] Read more.
This study presents the design and validation of an automated skip loading system for vertical shaft hoisting operations, aimed at addressing inefficiencies in current manual systems that contribute to consistent underperformance in meeting daily production targets. Initial assessments revealed a task completion rate of 91.6%, largely due to delays and inaccuracies in manual ore loading and accounting. To resolve these challenges, an automated system was developed using a bin and conveyor mechanism integrated with a suite of industrial automation components, including a programmable logic controller (PLC), stepper motors, hydraulic cylinders, ultrasonic sensors, and limit switches. The system is designed to transport ore from the draw point, halt when one ton is detected, and activate the hoisting process automatically. Digital simulations demonstrated that the automated system reduced loading time by 12% and increased utilization by 16.6%, particularly by taking advantage of the 2 h post-blast idle period. Financial evaluation of the system revealed a positive Net Present Value (NPV) of $1,019,701, a return on investment (ROI) of 69.7% over four years, and a payback period of 2 years and 11 months. The study concludes that the proposed solution significantly improves operational efficiency and recommends further enhancements to the hoisting infrastructure to fully optimize performance. Full article
(This article belongs to the Special Issue Mine Automation and New Technologies, 2nd Edition)
Show Figures

Figure 1

22 pages, 3445 KB  
Article
Decoding the Impacts of Mating Behavior on Ovarian Development in Mud Crab (Scylla paramamosain, Estampador 1949): Insights from SMRT RNA-seq
by Chenyang Wu, Sadek Md Abu, Xiyi Zhou, Yang Yu, Mhd Ikhwanuddin, Waqas Waqas and Hongyu Ma
Biology 2025, 14(10), 1362; https://doi.org/10.3390/biology14101362 - 4 Oct 2025
Viewed by 358
Abstract
Pubertal molting represents a pivotal transition in the life cycle of crustaceans, marking the shift from somatic growth to reproductive development. In mud crabs, mating is known to facilitate this process, yet the molecular mechanisms remain poorly understood. Here, we applied full-length transcriptome [...] Read more.
Pubertal molting represents a pivotal transition in the life cycle of crustaceans, marking the shift from somatic growth to reproductive development. In mud crabs, mating is known to facilitate this process, yet the molecular mechanisms remain poorly understood. Here, we applied full-length transcriptome sequencing to characterize changes in gene expression and alternative splicing (AS) across post-mating ovarian development. AS analysis revealed extensive transcript diversity, predominantly alternative first exon (AF) and alternative 5′ splice site (A5) events, enriched in genes linked to chromatin remodeling, protein regulation, and metabolism, underscoring AS as a fine-tuning mechanism in ovarian development. Comparative analyses revealed profound molecular reprogramming after mating. In the UM vs. M1 comparison, pathways related to serotonin and catecholamine signaling were enriched, suggesting early neuroendocrine regulation. Serotonin likely promoted, while dopamine inhibited, oocyte maturation, indicating a potential “inhibition–activation” switch. In the UM vs. M3 comparison, pathways associated with oxidative phosphorylation, ATP biosynthesis, and lipid metabolism were upregulated, reflecting heightened energy demands during vitellogenesis. ECM-receptor interaction, HIF-1, and IL-17 signaling pathways further pointed to structural remodeling and tissue regulation. Enhanced antioxidant defenses, including upregulation of SOD2, CAT, GPX4, and GSTO1, highlighted the importance of redox homeostasis. Together, these findings provide the first comprehensive view of transcriptional and splicing dynamics underlying post-mating ovarian maturation in Scylla paramamosain, offering novel insights into the molecular basis of crustacean reproduction. Full article
(This article belongs to the Section Marine Biology)
Show Figures

Figure 1

18 pages, 8209 KB  
Article
A Direct-Drive Rotary Actuator Based on Modular FSPM Topology for Large-Inertia Payload Transfer
by Jianlong Zhu, Zhe Wang, Minghao Tong, Longmiao Chen and Linfang Qian
Energies 2025, 18(19), 5272; https://doi.org/10.3390/en18195272 - 4 Oct 2025
Viewed by 332
Abstract
This paper proposes a novel direct-drive rotary actuator based on a modular five-phase outer-rotor flux-switching permanent magnet (FSPM) machine to overcome the limitations of conventional actuators with gear reducers, such as mechanical complexity and low reliability. The research focused on a synergistic design [...] Read more.
This paper proposes a novel direct-drive rotary actuator based on a modular five-phase outer-rotor flux-switching permanent magnet (FSPM) machine to overcome the limitations of conventional actuators with gear reducers, such as mechanical complexity and low reliability. The research focused on a synergistic design of a lightweight, high-torque-density motor and a precise control strategy. The methodology involved a structured topology evolution to create a modular stator architecture, followed by finite element analysis-based electromagnetic optimization. To achieve precision control, a multi-vector model predictive current control (MPCC) scheme was developed. This optimization process contributed to a significant performance improvement, increasing the average torque to 13.33 Nm, reducing torque ripple from 9.81% to 2.36% and obtaining a maximum position error under 1 mil. The key result was experimentally validated using an 8 kg inertial load, confirming the actuator’s feasibility for industrial deployment. Full article
Show Figures

Figure 1

28 pages, 4335 KB  
Perspective
Time-Restricted Eating, ANGPTL4, and Reduction in Residual Cardiovascular Risk
by Alejandro Gugliucci
J. Clin. Med. 2025, 14(19), 7026; https://doi.org/10.3390/jcm14197026 - 3 Oct 2025
Viewed by 576
Abstract
Atherosclerotic cardiovascular disease treatment is being reevaluated, since a residual cardiovascular risk (RCR) persists even in patients who achieve optimal LDL-C values. Underlying causes are metabolic dysfunction, lipoprotein(a), inflammation, and triglyceride-rich lipoproteins and their remnants. Dietary treatment options like time-restricted eating (TRE) are [...] Read more.
Atherosclerotic cardiovascular disease treatment is being reevaluated, since a residual cardiovascular risk (RCR) persists even in patients who achieve optimal LDL-C values. Underlying causes are metabolic dysfunction, lipoprotein(a), inflammation, and triglyceride-rich lipoproteins and their remnants. Dietary treatment options like time-restricted eating (TRE) are becoming more widely acknowledged for their potential advantages in metabolic health and weight control, as a treatment of atherosclerosis expanding beyond LDL-C medication. Beyond weight loss, TRE (which restricts meals to a window of 6 to 8 h) appears as the most accessible treatment, and has been shown to improve blood pressure, lipid profiles, and glucose regulation through mechanisms like metabolic switching and circadian synchronization. We hypothesize, and will present our arguments, that a key mechanism underlying the cardiovascular and weight-related benefits of TRE is its impact on the circadian regulation of angiopoietin-like protein 4 (ANGPTL4) activity within adipose tissue. Additionally, lipolysis is accelerated by ANGPTL4 activation. TRE, via its actions on ANGPTL4, therefore not only inhibits adipose fatty acid uptake but stimulates their release as well. Additionally, TRE may increase intravascular very low-density lipoprotein (VLDL) catabolism by muscle due to the reduced exposure of lipoprotein lipase (LPL) to competing chylomicrons, known to slow the rate of VLDL catabolism. During the prolonged fasting, VLDL residence time is thus shortened, limiting the exposure to endothelium and hepatic lipases and thus reducing the amount of atherogenic remnant particles. Larger, longer-term randomized controlled studies in a variety of groups are required to further clarify TRE’s function in RCR prevention and therapy. As knowledge of triglyceride lipoprotein (TRL) metabolism expands, a comprehensive strategy for the management of RCR emerges, and a broader spectrum of LPL regulator-based therapeutics is created. Consequently, it is advisable to prioritize further research into the influence of TRE on LPL modulation via ANGPTL4 and ANGPTL8, which provides a natural, accessible, and low-cost alternative. Full article
(This article belongs to the Section Endocrinology & Metabolism)
Show Figures

Graphical abstract

19 pages, 2189 KB  
Article
Dissecting the Interplay Between NRF2 and BACH1 at CsMBEs
by Maria-Armineh Tossounian, Alexander Zhyvoloup, Rakesh Chatterjee and Jerome Gouge
Antioxidants 2025, 14(10), 1203; https://doi.org/10.3390/antiox14101203 - 3 Oct 2025
Viewed by 713
Abstract
BACH1 (BTB And CNC Homology 1) and NRF2 (Nuclear Factor Erythroid 2-related Factor 2) are transcription factors that regulate antioxidant and iron metabolism genes by competing for binding to cis-regulatory Maf-binding elements (CsMBEs) as heterodimers with small Maf proteins (sMafs). To dissect the [...] Read more.
BACH1 (BTB And CNC Homology 1) and NRF2 (Nuclear Factor Erythroid 2-related Factor 2) are transcription factors that regulate antioxidant and iron metabolism genes by competing for binding to cis-regulatory Maf-binding elements (CsMBEs) as heterodimers with small Maf proteins (sMafs). To dissect the mechanisms underlying this competition, we developed a chimeric tethering system where the DNA-binding domains of BACH1 or NRF2 were covalently linked to sMafG via a flexible, cleavable linker. This design enables efficient heterodimer formation on DNA and circumvents kinetic barriers to partner exchange in the solution. The site-specific fluorescent labelling of proteins allowed for the tracking of complex compositions by electrophoretic mobility shift assays. Both BACH1/sMafG and NRF2/sMafG heterodimers bind CsMBEs with similar affinities. Notably, DNA binding by BACH1 was impaired in a C574-dependent, redox-sensitive manner and promoted the exchange of heterodimer partners. Competition assays demonstrated that BACH1 and NRF2 can displace each other from preformed DNA-bound complexes, with greater efficiency when presented as preassembled heterodimers with sMafG. These findings reveal a redox-sensitive mechanism for regulating transcriptional switches at CsMBEs and highlight how preformed heterodimers facilitate the rapid displacement at target promoters. Full article
(This article belongs to the Special Issue Antioxidant Systems, Transcription Factors and Non-Coding RNAs)
Show Figures

Graphical abstract

Back to TopTop