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Search Results (514)

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Keywords = life expectancy of materials

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24 pages, 8197 KiB  
Article
Reuse of Decommissioned Tubular Steel Wind Turbine Towers: General Considerations and Two Case Studies
by Sokratis Sideris, Charis J. Gantes, Stefanos Gkatzogiannis and Bo Li
Designs 2025, 9(4), 92; https://doi.org/10.3390/designs9040092 (registering DOI) - 6 Aug 2025
Abstract
Nowadays, the circular economy is driving the construction industry towards greater sustainability for both environmental and financial purposes. One prominent area of research with significant contributions to circular economy is the reuse of steel from decommissioned structures in new construction projects. This approach [...] Read more.
Nowadays, the circular economy is driving the construction industry towards greater sustainability for both environmental and financial purposes. One prominent area of research with significant contributions to circular economy is the reuse of steel from decommissioned structures in new construction projects. This approach is deemed far more efficient than ordinary steel recycling, due to the fact that it contributes towards reducing both the cost of the new project and the associated carbon emissions. Along these lines, the feasibility of utilizing steel wind turbine towers (WTTs) as part of a new structure is investigated herein, considering that wind turbines are decommissioned after a nominal life of approximately 25 years due to fatigue limitations. General principles of structural steel reuse are first presented in a systematic manner, followed by two case studies. Realistic data about the geometry and cross-sections of previous generation models of WTTs were obtained from the Greek Center for Renewable Energy Sources and Savings (CRES), including drawings and photographic material from their demonstrative wind farm in the area of Keratea. A specific wind turbine was selected that is about to exceed its life expectancy and will soon be decommissioned. Two alternative applications for the reuse of the tower were proposed and analyzed, with emphasis on the structural aspects. One deals with the use of parts of the tower as a small-span pedestrian bridge, while the second addresses the transformation of a tower section into a water storage tank. Several decision factors have contributed to the selection of these two reuse scenarios, including, amongst others, the geometric compatibility of the decommissioned wind turbine tower with the proposed applications, engineering intuition about the tower having adequate strength for its new role, the potential to minimize fatigue loads in the reused state, the minimization of cutting and joining processes as much as possible to restrain further CO2 emissions, reduction in waste material, the societal contribution of the potential reuse applications, etc. The two examples are briefly presented, aiming to demonstrate the concept and feasibility at the preliminary design level, highlighting the potential of decommissioned WTTs to find proper use for their future life. Full article
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18 pages, 7274 KiB  
Article
Functional Compression Fabrics with Dual Scar-Suppressing and Antimicrobial Properties: Microencapsulation Design and Performance Evaluation
by Lihuan Zhao, Changjing Li, Mingzhu Yuan, Rong Zhang, Xinrui Liu, Xiuwen Nie and Bowen Yan
J. Funct. Biomater. 2025, 16(8), 287; https://doi.org/10.3390/jfb16080287 - 5 Aug 2025
Abstract
Pressure therapy combined with silicone has a significant effect on scar hyperplasia, but limitations such as long-term wearing of compression garments (CGs) can easily cause bacterial infection, cleanliness, and lifespan problems of CGs caused by the tedious operation of applying silicone. In this [...] Read more.
Pressure therapy combined with silicone has a significant effect on scar hyperplasia, but limitations such as long-term wearing of compression garments (CGs) can easily cause bacterial infection, cleanliness, and lifespan problems of CGs caused by the tedious operation of applying silicone. In this study, a compression garment fabric (CGF) with both inhibition of scar hyperplasia and antibacterial function was prepared. A polydimethylsiloxane (PDMS)-loaded microcapsule (PDMS-M) was prepared with chitosan quaternary ammonium salt (HACC) and sodium alginate (SA) as wall materials and PDMS as core materials by the complex coagulation method. The PDMS-Ms were finished on CGF and modified with (3-aminopropyl)triethoxysilane (APTES) to obtain PDMS-M CGF, which was further treated with HACC to produce PDMS-M-HACC CGF. X-ray Photoelectron Spectroscopy(XPS) and Fourier transform infrared spectroscopy (FTIR) analysis confirmed the formation of covalent bonding between PDMS-M and CGF. The PDMS-M CGF exhibited antibacterial rates of 94.2% against Gram-negative bacteria Escherichia coli (E. coli, AATCC 6538) and of 83.1% against Gram-positive bacteria Staphylococcus aureus (S. aureus, AATCC 25922). The antibacterial rate of PDMS-M-HACC CGF against both E. coli and S. aureus reached 99.9%, with wash durability reaching grade AA for E. coli and approaching grade A for S. aureus. The finished CGF maintained good biocompatibility and showed minimal reduction in moisture permeability compared to unfinished CGF, though with decreased elastic recovery, air permeability and softness. The finished CGF of this study is expected to improve the therapeutic effect of hypertrophic scars and improve the quality of life of patients with hypertrophic scars. Full article
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25 pages, 906 KiB  
Review
Evolution and Prognostic Variables of Cystic Fibrosis in Children and Young Adults: A Narrative Review
by Mădălina Andreea Donos, Elena Țarcă, Elena Cojocaru, Viorel Țarcă, Lăcrămioara Ionela Butnariu, Valentin Bernic, Paula Popovici, Solange Tamara Roșu, Mihaela Camelia Tîrnovanu, Nicolae Sebastian Ionescu and Laura Mihaela Trandafir
Diagnostics 2025, 15(15), 1940; https://doi.org/10.3390/diagnostics15151940 - 2 Aug 2025
Viewed by 232
Abstract
Introduction: Cystic fibrosis (CF) is a genetic condition affecting several organs and systems, including the pancreas, colon, respiratory system, and reproductive system. The detection of a growing number of CFTR variants and genotypes has contributed to an increase in the CF population which, [...] Read more.
Introduction: Cystic fibrosis (CF) is a genetic condition affecting several organs and systems, including the pancreas, colon, respiratory system, and reproductive system. The detection of a growing number of CFTR variants and genotypes has contributed to an increase in the CF population which, in turn, has had an impact on the overall statistics regarding the prognosis and outcome of the condition. Given the increase in life expectancy, it is critical to better predict outcomes and prognosticate in CF. Thus, each person’s choice to aggressively treat specific disease components can be more appropriate and tailored, further increasing survival. The objective of our narrative review is to summarize the most recent information concerning the value and significance of clinical parameters in predicting outcomes, such as gender, diabetes, liver and pancreatic status, lung function, radiography, bacteriology, and blood and sputum biomarkers of inflammation and disease, and how variations in these parameters affect prognosis from the prenatal stage to maturity. Materials and methods: A methodological search of the available data was performed with regard to prognostic factors in the evolution of CF in children and young adults. We evaluated articles from the PubMed academic search engine using the following search terms: prognostic factors AND children AND cystic fibrosis OR mucoviscidosis. Results: We found that it is crucial to customize CF patients’ care based on their unique clinical and biological parameters, genetics, and related comorbidities. Conclusions: The predictive significance of more dynamic clinical condition markers provides more realistic future objectives to center treatment and targets for each patient. Over the past ten years, improvements in care, diagnostics, and treatment have impacted the prognosis for CF. Although genotyping offers a way to categorize CF to direct research and treatment, it is crucial to understand that a variety of other factors, such as epigenetics, genetic modifiers, environmental factors, and socioeconomic status, can affect CF outcomes. The long-term management of this complicated multisystem condition has been made easier for patients, their families, and physicians by earlier and more accurate identification techniques, evidence-based research, and centralized expert multidisciplinary care. Full article
(This article belongs to the Special Issue Advances in the Diagnosis of Inherited/Genetic Diseases)
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14 pages, 1717 KiB  
Article
Development of Floor Structures with Crumb Rubber for Efficient Floor Impact Noise Reduction
by Ji-Hoon Park and Chan-Hoon Haan
Acoustics 2025, 7(3), 47; https://doi.org/10.3390/acoustics7030047 - 29 Jul 2025
Viewed by 294
Abstract
Korea has a high population density, considering the size of its territory. Therefore, the importance of convenient and comfortable apartment buildings and high-rise residential–commercial complex buildings has been rising. In addition, because of the improvement in the standard of living along with continuous [...] Read more.
Korea has a high population density, considering the size of its territory. Therefore, the importance of convenient and comfortable apartment buildings and high-rise residential–commercial complex buildings has been rising. In addition, because of the improvement in the standard of living along with continuous national economic growth, the interest in well-being and the expectation of a quiet life with a comfortable and pleasant residential environment have also been increasing. However, Koreans have a lifestyle involving sitting on the floor, so floor impact noise has been occurring more and more frequently. Because of this, neighborly disputes have been a serious social problem. And lately, damage and disputes from noise between floors have been increasing much more. The present work, therefore, used waste tire chips as a resilient material for reducing floor impact noise in order to recycle waste tires effectively. Also, a compounded resilient material, which combines EPS (expanded polystyrene), a flat resilient material on the upper part, with waste tire chips for the lower part, was developed. After constructing waste tire chips at a standardized test building, experiments with both light-weight and heavy-weight floor impact noise were performed. The tests confirmed that waste tire chips, when used as a resilient material, can effectively reduce both light-weight and heavy-weight floor impact noise. Full article
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22 pages, 935 KiB  
Article
The Experiences of Hungarian Minority Parents of Children with Severe Disability from Romania
by Karolina Eszter Kovács and Beáta Andrea Dan
Educ. Sci. 2025, 15(8), 938; https://doi.org/10.3390/educsci15080938 - 22 Jul 2025
Viewed by 606
Abstract
This study explored the experiences of Hungarian minority parents of children with severe disabilities from Romania. Examining individual life paths and becoming a parent is difficult in all aspects, but the issue of parental responsibility for raising a child with a severe disability [...] Read more.
This study explored the experiences of Hungarian minority parents of children with severe disabilities from Romania. Examining individual life paths and becoming a parent is difficult in all aspects, but the issue of parental responsibility for raising a child with a severe disability suggests a much more complex approach. Participants were parents (female = 8; male = 3) who were purposively sampled from an urban setting (Bihor area) and whose children attended SEN schools in the same area. Data were collected using semi-structured interviews and were thematically analysed. It turned out from the interviews that the challenges parents of children with severe disabilities encounter at home, school, and in society are accumulated emotional stress and exhaustion; however, they also face material challenges. The analysis also revealed that the parents were unsure of what was expected of them in making educational or habilitation–rehabilitation decisions on behalf of their children. The parents’ difficulty with decision-making and their unpreparedness put them under serious stress, often characterized by depressive life stages. The findings reveal the need for ongoing professional development and the establishment of organizational–community networks. Parents of children with disabilities face serious, unresolved challenges that are difficult to overcome. In order to overcome these challenges, we need to develop policies that take the needs of parents into consideration. Full article
(This article belongs to the Special Issue Special and Inclusive Education: Challenges, Policy and Practice)
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36 pages, 1973 KiB  
Article
A Comparative Life Cycle Assessment of an Electric and a Conventional Mid-Segment Car: Evaluating the Role of Critical Raw Materials in Potential Abiotic Resource Depletion
by Andrea Cappelli, Nicola Stefano Trimarchi, Simone Marzeddu, Riccardo Paoli and Francesco Romagnoli
Energies 2025, 18(14), 3698; https://doi.org/10.3390/en18143698 - 13 Jul 2025
Viewed by 603
Abstract
Electric passenger vehicles are set to dominate the European car market, driven by EU climate policies and the 2035 ban on internal combustion engine production. This study assesses the sustainability of this transition, focusing on global warming potential and Critical Raw Material (CRM) [...] Read more.
Electric passenger vehicles are set to dominate the European car market, driven by EU climate policies and the 2035 ban on internal combustion engine production. This study assesses the sustainability of this transition, focusing on global warming potential and Critical Raw Material (CRM) extraction throughout its life cycle. The intensive use of CRMs raises environmental, economic, social, and geopolitical concerns. These materials are scarce and are concentrated in a few politically sensitive regions, leaving the EU highly dependent on external suppliers. The extraction, transport, and refining of CRMs and battery production are high-emission processes that contribute to climate change and pose risks to ecosystems and human health. A Life Cycle Assessment (LCA) was conducted, using OpenLCA software and the Ecoinvent 3.10 database, comparing a Peugeot 308 in its diesel and electric versions. This study adopts a cradle-to-grave approach, analyzing three phases: production, utilization, and end-of-life treatment. Key indicators included Global Warming Potential (GWP100) and Abiotic Resource Depletion Potential (ADP) to assess CO2 emissions and mineral resource consumption. Technological advancements could mitigate mineral depletion concerns. Li-ion battery recycling is still underdeveloped, but has high recovery potential, with the sector expected to expand significantly. Moreover, repurposing used Li-ion batteries for stationary energy storage in renewable energy systems can extend their lifespan by over a decade, decreasing the demand for new batteries. Such innovations underscore the potential for a more sustainable electric vehicle industry. Full article
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19 pages, 2167 KiB  
Review
Grain Boundary Engineering for Reversible Zn Anodes in Rechargeable Aqueous Zn-Ion Batteries
by Yu-Xuan Liu, Jun-Zhe Wang, Lei Cao, Hao Wang, Zhen-Yu Cheng, Li-Feng Zhou and Tao Du
Metals 2025, 15(7), 784; https://doi.org/10.3390/met15070784 - 11 Jul 2025
Viewed by 338
Abstract
Rechargeable aqueous zinc-ion batteries (AZIBs) have garnered significant research attention in the energy storage field owing to their inherent safety, cost-effectiveness, and environmental sustainability. Nevertheless, critical challenges associated with zinc anodes—including dendrite formation, hydrogen evolution corrosion, and mechanical degradation—substantially impede their practical implementation. [...] Read more.
Rechargeable aqueous zinc-ion batteries (AZIBs) have garnered significant research attention in the energy storage field owing to their inherent safety, cost-effectiveness, and environmental sustainability. Nevertheless, critical challenges associated with zinc anodes—including dendrite formation, hydrogen evolution corrosion, and mechanical degradation—substantially impede their practical implementation. Grain boundary engineering (GBE) emerges as an innovative solution for zinc anode optimization through the precise regulation of grain boundary density, crystallographic orientation, and chemical states in metallic materials. This study comprehensively investigates the fundamental mechanisms and application prospects of GBE in zinc-based anodes, providing pivotal theoretical insights and technical methodologies for designing highly stable electrode architectures. The findings are expected to promote the development of aqueous zinc batteries toward a high energy density and long cycle life. Full article
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36 pages, 2504 KiB  
Article
Long-Term Durability of CFRP Strips Used in Infrastructure Rehabilitation
by Karunya Kanagavel and Vistasp M. Karbhari
Polymers 2025, 17(13), 1886; https://doi.org/10.3390/polym17131886 - 7 Jul 2025
Viewed by 484
Abstract
Prefabricated unidirectional carbon fiber reinforced polymer (CFRP) composite strips are extensively used as a means of infrastructure rehabilitation through adhesive bonding to the external surface of structural concrete elements. Most data to date are from laboratory tests ranging from a few months to [...] Read more.
Prefabricated unidirectional carbon fiber reinforced polymer (CFRP) composite strips are extensively used as a means of infrastructure rehabilitation through adhesive bonding to the external surface of structural concrete elements. Most data to date are from laboratory tests ranging from a few months to 1–2 years providing an insufficient dataset for prediction of long-term durability. This investigation focuses on the assessment of the response of three different prefabricated CFRP systems exposed to water, seawater, and alkaline solutions for 5 years of immersion in deionized water conducted at three temperatures of 23, 37.8 and 60 °C, all well below the glass transition temperature levels. Overall response is characterized through tensile and short beam shear (SBS) testing at periodic intervals. It is noted that while the three systems are similar, with the dominant mechanisms of deterioration being related to matrix plasticization followed by fiber–matrix debonding with levels of matrix and interface deterioration being accelerated at elevated temperatures, their baseline characteristics and distributions are different emphasizing the need for greater standardization. While tensile modulus does not degrade appreciably over the 5-year period of exposure with final levels of deterioration being between 7.3 and 11.9%, both tensile strength and SBS strength degrade substantially with increasing levels based on temperature and time of immersion. Levels of tensile strength retention can be as low as 61.8–66.6% when immersed in deionized water at 60 °C, those for SBS strength can be 38.4–48.7% at the same immersion condition for the three FRP systems. Differences due to solution type are wider in the short-term and start approaching asymptotic levels within FRP systems at longer periods of exposure. The very high levels of deterioration in SBS strength indicate the breakdown of the materials at the fiber–matrix bond and interfacial levels. It is shown that the level of deterioration exceeds that presumed through design thresholds set by specific codes/standards and that new safety factors are warranted in addition to expanding the set of characteristics studied to include SBS or similar interface-level tests. Alkali solutions are also shown to have the highest deteriorative effects with deionized water having the least. Simple equations are developed to enable extrapolation of test data to predict long term durability and to develop design thresholds based on expectations of service life with an environmental factor of between 0.56 and 0.69 for a 50-year expected service life. Full article
(This article belongs to the Section Polymer Composites and Nanocomposites)
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26 pages, 20735 KiB  
Article
The Study of the Effect of Blade Sharpening Conditions on the Lifetime of Planar Knives During Industrial Flatfish Skinning Operations
by Paweł Sutowski, Bartosz Zieliński and Krzysztof Nadolny
Materials 2025, 18(13), 3191; https://doi.org/10.3390/ma18133191 - 6 Jul 2025
Viewed by 384
Abstract
Users of technical blades expect new generations of tools to feature reduced power requirements for process and maximized tool life. The second aspect is reflected in the reduction in costs associated with the purchase of tools and in the reduction in process line [...] Read more.
Users of technical blades expect new generations of tools to feature reduced power requirements for process and maximized tool life. The second aspect is reflected in the reduction in costs associated with the purchase of tools and in the reduction in process line downtime due to tool replacement. Meeting these demands is particularly challenging in cutting operations involving heterogeneous materials, especially when the processed raw material contains inclusions and impurities significantly harder than the material itself. This situation occurs, among others, during flatfish skinning operations analyzed in this paper, a common process in the fish processing industry. These fish, due to their natural living environment and behavior, contain a significant proportion of hard inclusions and impurities (shell fragments, sand grains) embedded in their skin. Contact between the tool and hard inclusions causes deformation, wrapping, crushing, and even chipping of the cutting edge of planar knives, resulting in non-uniform blade wear, which manifests as areas of uncut skin on the fish fillet. This necessitates frequent tool changes, resulting in higher tooling costs and longer operating times. This study provides a unique opportunity to review the results of in-service pre-implementation tests of planar knives in the skinning operation conducted under industrial conditions. The main objective was to verify positive laboratory research results regarding the extension of technical blade tool life through optimization of sharpening conditions during grinding. Durability test results are presented for the skinning process of fillets from plaice (Pleuronectes platessa) and flounder (Platichthys flesus). The study also examined the effect of varying cooling and lubrication conditions in the grinding zone on the tool life of technical planar blades. Sharpening knives under flood cooling conditions and using the hybrid method (combining minimum quantity lubrication and cold compressed air) increased their service life in the plaice skinning process (Pleuronectes platessa) by 12.39% and 8.85%, respectively. The increase in effective working time of knives during flounder (Platichthys flesus) skinning was even greater, reaching 17.7% and 16.3% for the flood cooling and hybrid methods, respectively. Full article
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117 pages, 10736 KiB  
Review
Design Principles and Engineering Strategies for Stabilizing Ni-Rich Layered Oxides in Lithium-Ion Batteries
by Alain Mauger and Christian M. Julien
Batteries 2025, 11(7), 254; https://doi.org/10.3390/batteries11070254 - 4 Jul 2025
Viewed by 940
Abstract
Nickel-rich layered oxides such as LiNixMnyCozO2 (NMC), LiNixCoyAlzO2 (NCA), and LiNixMnyCozAl(1–xyz)O2 (NMCA), where x [...] Read more.
Nickel-rich layered oxides such as LiNixMnyCozO2 (NMC), LiNixCoyAlzO2 (NCA), and LiNixMnyCozAl(1–xyz)O2 (NMCA), where x ≥ 0.6, have emerged as key cathode materials in lithium-ion batteries due to their high operating voltage and superior energy density. These materials, characterized by low cobalt content, offer a promising path toward sustainable and cost-effective energy storage solutions. However, their electrochemical performance remains below theoretical expectations, primarily due to challenges related to structural instability, limited thermal safety, and suboptimal cycle life. Intensive research efforts have been devoted to addressing these issues, resulting in substantial performance improvements and enabling the development of next-generation lithium-ion batteries with higher nickel content and reduced cobalt dependency. In this review, we present recent advances in material design and engineering strategies to overcome the problems limiting their electrochemical performance (cation mixing, phase stability, oxygen release, microcracks during cycling). These strategies include synthesis methods to optimize the morphology (size of the particles, core–shell and gradient structures), surface modifications of the Ni-rich particles, and doping. A detailed comparison between these strategies and the synergetic effects of their combination is presented. We also highlight the synergistic role of compatible lithium salts and electrolytes in achieving state-of-the-art nickel-rich lithium-ion batteries. Full article
(This article belongs to the Special Issue Batteries: 10th Anniversary)
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15 pages, 715 KiB  
Systematic Review
Oral Health and Healthy Ageing: A Systematic Review of Longitudinal Studies
by Lujain Sahab, Jonathon Timothy Newton and Wael Sabbah
Dent. J. 2025, 13(7), 303; https://doi.org/10.3390/dj13070303 - 4 Jul 2025
Viewed by 456
Abstract
Background: The global rise in life expectancy and the resulting shift toward ageing populations pose significant public health and socioeconomic challenges. As healthy ageing becomes a priority, understanding the factors that support well-being in older age is essential. Oral health is increasingly [...] Read more.
Background: The global rise in life expectancy and the resulting shift toward ageing populations pose significant public health and socioeconomic challenges. As healthy ageing becomes a priority, understanding the factors that support well-being in older age is essential. Oral health is increasingly recognised as a critical determinant of overall health and has been linked to chronic conditions. Objectives: To conduct a systematic review of longitudinal studies examining the relationship between oral health and healthy ageing. Materials and Methods: Two independent reviewers conducted searches in three databases (MEDLINE, EMBASE, and LILACS) up to April 2025, following a defined search strategy. Grey literature was explored using Open Grey and Google Scholar. The quality and the risk of bias of the included studies were evaluated using the Newcastle Ottawa Quality Assessment Scale (NOS) for longitudinal studies. The review protocol was registered with the International Prospective Register of Systematic Reviews (CRD420251029090). Results: Four longitudinal studies reporting the association between oral health and healthy ageing were recognised and included. All selected studies were considered of good quality according to the NOS. The studies varied in defining and measuring healthy ageing, the follow-up period, the sample size, and the measure of oral health; therefore, it was not possible to perform a meta-analysis. The studies included in the review demonstrated a positive relationship between the number of natural teeth and healthy ageing. Discussion: Despite variations in the definition of healthy ageing and the application of different oral health indicators, the review identified significant associations between the number of natural teeth and trajectories of healthy ageing. Conclusions: This review recognised significant longitudinal associations between oral health measures (number of teeth) and trajectories of healthy ageing. The findings emphasise the need to incorporate oral health into research and policy related to healthy ageing. Full article
(This article belongs to the Special Issue Dentistry in the 21st Century: Challenges and Opportunities)
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19 pages, 737 KiB  
Review
Sex-Related Differences in Chronic Pain: A Narrative Review by a Multidisciplinary Task Force
by Maurizio Marchesini, Diego Fornasari, Silvia Natoli, Elena Vegni and Arturo Cuomo
Medicina 2025, 61(7), 1172; https://doi.org/10.3390/medicina61071172 - 28 Jun 2025
Viewed by 1085
Abstract
Background and Objectives: Chronic pain (CP), defined as pain persisting for over 3 months, is a significant cause of global disability and affects more than 20% of individuals in Western countries, including Italy. Substantial evidence indicates a higher prevalence of CP among women, [...] Read more.
Background and Objectives: Chronic pain (CP), defined as pain persisting for over 3 months, is a significant cause of global disability and affects more than 20% of individuals in Western countries, including Italy. Substantial evidence indicates a higher prevalence of CP among women, who also experience greater sensitivity, increased frequency, and a longer duration of pain. The impact of CP on quality of life, daily functioning, and employment is profound, particularly for women. However, chronic pain research has insufficiently addressed sex and gender differences, contributing to suboptimal and inequitable care. This neglect limits the development of personalized treatment strategies and, when combined with an aging population and women’s longer life expectancy, highlights an increasing societal and economic burden. Materials and Methods: The authors conducted a narrative review of studies examining biological, psychological, or social determinants of sex-related differences in CP perception or treatment. Each thematic area was reviewed by at least two authors, who critically appraised the literature. Their analyses were refined through iterative group discussions to develop concise, evidence-informed recommendations for personalized and equitable pain management. Results: Sex differences in CP arise from a range of factors, including biological mechanisms such as hormonal and genetic influences, psycho-social factors such as depression and anxiety, and socio-economic determinants, such as income and education levels. These factors also affect sex-specific outcomes of analgesic treatments currently available. Identifying these risk factors and tailoring treatment strategies to sex differences can significantly improve CP management. Such a personalized approach is essential for advancing precision medicine in CP management. Even in the absence of molecular or genomic biomarkers, adopting a biopsychosocial model that considers sex and gender differences, symptoms, physiological indicators, medical history, lifestyle, and psychological aspects may substantially enhance patient outcomes. Conclusions: This review provides a comprehensive analysis of sex differences in CP perception, stressing the importance of individualized, interdisciplinary approaches in pain management. Addressing both the biological and psycho-social contributors to pain in men and women is critical for guiding healthcare professionals in implementing precision pain medicine strategies, ultimately fostering more equitable and effective care. Full article
(This article belongs to the Special Issue Treatment in Patients with Chronic Pain Syndrome)
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20 pages, 4670 KiB  
Article
Vascular Flora on Croatian Historic Structures: Drivers of Biodeterioration and Conservation Implications
by Alessia Cozzolino, Riccardo Motti and Ivana Vitasović-Kosić
Plants 2025, 14(12), 1773; https://doi.org/10.3390/plants14121773 - 10 Jun 2025
Viewed by 503
Abstract
Biodeterioration, the alteration of materials by living organisms, affects approximately two-thirds of the world’s cultural heritage. When organisms colonize the surfaces, they induce physical and chemical changes that can lead to significant damage. Despite its relevance, this phenomenon remains understudied in Croatia. This [...] Read more.
Biodeterioration, the alteration of materials by living organisms, affects approximately two-thirds of the world’s cultural heritage. When organisms colonize the surfaces, they induce physical and chemical changes that can lead to significant damage. Despite its relevance, this phenomenon remains understudied in Croatia. This study aims to assess the deteriogenic vascular flora colonizing Croatian historical structures, including castles, towers, and archaeological remains, in relation to several environmental and anthropogenic factors: distance from the sea (0–1, 1–10, 10–65, and 65–165 km), elevation (0–50, 50–150, 150–300, and 300–600 m a.s.l.), exposure (north, south, east, west), and the state of conservation of the site (absent, low, good, excellent). Vegetation cover and floristic diversity, assessed using the Shannon Index, were primarily influenced by elevation and conservation status. As expected, vegetation cover decreased significantly, by 67.75%, from sites classified as ‘Absent’ to those with ‘Excellent’ conservation status (p < 0.001). To explain the observed differences in vegetation cover across the four altitudinal ranges, an analysis of plant life forms was carried out, revealing a wide variability and statistically significant patterns also related to the type and frequency of maintenance interventions. The potential risk posed by vascular plants was evaluated using the Hazard Index (HI), which revealed significant differences only for elevation and distance from the sea. The highest risk levels were recorded at mid-elevations (150–300 m), where the Hazard Index reached its maximum value (HI = 158). Exposure did not show a significant effect on biodeterioration processes. These findings provide new insights into plant-driven biodeterioration in Croatia and highlight the need for targeted conservation strategies to protect the country’s cultural heritage. Full article
(This article belongs to the Special Issue Advances in Vegetation History and Archaeobotany)
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13 pages, 3783 KiB  
Article
Harvesting Reactor Pressure Vessel Beltline Material from the Decommissioned Zion Nuclear Power Plant Unit 1
by Thomas M. Rosseel, Mikhail A. Sokolov, Xiang (Frank) Chen and Randy K. Nanstad
Metals 2025, 15(6), 634; https://doi.org/10.3390/met15060634 - 5 Jun 2025
Viewed by 428
Abstract
The decommissioning of the Zion Nuclear Power Plant (NPP) provided a unique opportunity to harvest and study service-aged reactor pressure vessel (RPV) beltline materials. This work, conducted through the U.S. Department of Energy’s Light Water Reactor Sustainability (LWRS) Program, aims to improve the [...] Read more.
The decommissioning of the Zion Nuclear Power Plant (NPP) provided a unique opportunity to harvest and study service-aged reactor pressure vessel (RPV) beltline materials. This work, conducted through the U.S. Department of Energy’s Light Water Reactor Sustainability (LWRS) Program, aims to improve the understanding of radiation-induced embrittlement to support extended nuclear plant operations. Material segments containing the Linde 80 flux, wire heat 72105 (WF-70) beltline weld and the A533B Heat B7835-1 base metal, obtained from the intermediate shell region with a peak fluence of 0.7 × 1019 n/cm2 (E > 1.0 MeV), were extracted, cut into blocks, and machined into test specimens for mechanical and microstructural characterization. The segmentation process involved oxy-propane torch-cutting, followed by precision machining using wire saws and electrical discharge machining (EDM). A chemical composition analysis confirmed the expected variations in alloying elements, with copper levels being notably higher in the weld metal. The harvested specimens enable a detailed evaluation of through-wall embrittlement gradients, a comparison with the existing surveillance data, and the validation of predictive embrittlement models. This study provides critical data for assessing long-term reactor vessel integrity, informing aging-management strategies, and supporting regulatory decisions to extend the life of nuclear plants. This article is a revised and expanded version of a paper entitled, “Current Status of the Characterization of RPV Materials Harvested from the Decommissioned Zion Unit 1 Nuclear Power Plant”, PVP2017-65090, which was accepted and presented at the ASME 2017 Pressure Vessels and Piping Conference, Waikoloa, HI, USA, 16–20 July 2017. Full article
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14 pages, 3509 KiB  
Article
Enhancing the Outcomes of Temporalis Fascia Tympanoplasty Using Autologous Platelet-Rich Plasma and Gel: A Randomized Controlled Trial
by Nejc Steiner, Domen Vozel, Nina Bozanic Urbancic, Kaja Troha, Andraz Lazar, Veronika Kralj-Iglic and Saba Battelino
J. Pers. Med. 2025, 15(6), 233; https://doi.org/10.3390/jpm15060233 - 4 Jun 2025
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Abstract
Objectives: This study aimed to investigate the impact of platelet-rich plasma (PRP) and platelet-rich gel (PRG) on tympanic membrane closure rates, hearing improvement, and quality of life following tympanoplasty. Methods: Seventy-two patients with chronic tympanic membrane perforations were enrolled in a double-blinded, randomized [...] Read more.
Objectives: This study aimed to investigate the impact of platelet-rich plasma (PRP) and platelet-rich gel (PRG) on tympanic membrane closure rates, hearing improvement, and quality of life following tympanoplasty. Methods: Seventy-two patients with chronic tympanic membrane perforations were enrolled in a double-blinded, randomized controlled trial at a single tertiary referral center. All patients underwent tympanoplasty using a temporalis fascia graft and were randomly assigned to one of two groups: one group received standard tympanoplasty alone, while the other received intraoperative application of autologous PRP and PRG, in addition to the standard procedure. Results: The PRP group demonstrated a significantly higher rate of complete tympanic membrane closure compared to the control group (32/36; 88.9% vs. 24/36; 66.7%; p < 0.05). Bone conduction hearing remained unchanged in both groups, while air conduction hearing improved significantly from pre- to post-treatment in each group. However, the difference in air conduction improvement between the PRP group and the control group was not statistically significant (PRP group: Mdn = −8.25; control group: Mdn = −12.20; U = 618; z = −0.54; p = 0.30). Quality of life improved in both the PRP and control groups; however, the difference between the groups was not statistically significant (PRP group: 10.44 ± 10.46; control group: 10.47 ± 8.22; 95% CI [−4.45; 4.40]; t(66) = −0.01; p = 0.16). Conclusions: Our findings suggest that intraoperative application of autologous PRP and PRG may improve tympanoplasty outcomes, particularly in cases with lower expected success rates or when performing minimally invasive transcanal procedures under local anesthesia. However, variability in PRP preparation, application methods, and graft materials across studies limits direct comparisons. Standardized protocols and further controlled studies are necessary to clarify PRP’s clinical value in tympanoplasty. Full article
(This article belongs to the Special Issue Personalized Medicine in Otolaryngology: Novel Prognostic Markers)
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