Search Results (5,224)

The Hadamengou gold deposit, hosted in the Precambrian metamorphic basement, is a super-large gold deposit occurring along the northern margin of the North China Craton. Despite extensive investigation, the genesis of the gold mineralization is poorly understood and remains highly debated. This study integrates a comprehensive dataset, including fluid inclusion microthermometry and C-H-O-S-Pb isotopes, to better constrain the genesis and ore-forming mechanism of the deposit. Hydrothermal mineralization can be divided into pyrite–potassium feldspar–quartz (Stage I), quartz–gold–pyrite–molybdenite (Stage II), quartz–gold–polymetallic sulfide (Stage III), and quartz–carbonate stages (Stage IV). Four types of primary fluid inclusions are identified, including pure CO₂-type, composite CO₂-H₂O-type, aqueous-type, and solid-daughter mineral-bearing-type inclusions. Microthermometric and compositional data reveal that the fluids were mesothermal to hypothermal, H₂O-dominated, and CO₂-rich fluids containing significant N₂ and low-to-moderate salinity, indicative of a magmatic–hydrothermal origin. Fluid inclusion assemblages further imply that the ore-forming fluids underwent fluid immiscibility, causing CO₂ effusion and significant changes in physicochemical conditions that destabilized gold bisulfide complexes. The hydrogen–oxygen isotopic compositions, moreover, support a dominant magmatic water source, with increasing meteoric water input during later stages. The carbon–oxygen isotopes are also consistent with a magmatic carbon source. Sulfur and lead isotopes collectively imply that ore-forming materials were derived from a hybrid crust–mantle magmatic reservoir, with minor contribution from the country rocks. By synthesizing temporal–spatial relationships between magmatic activity and ore formation, and the regional tectonic evolution, we suggest that the Hadamengou is an intrusion-related magmatic–hydrothermal lode gold deposit. It is genetically associated with multi-stage magmatism induced by crust–mantle interaction, which developed within the extensional tectonic regimes. Full article

This study evaluates and compares the protective effects of several type II taste receptor (T2R) agonists against LPS (lipopolysaccharide)-induced inflammatory damage in BEAS-2B cells, focusing on their action via an α-gustducin (encoded by GNAT3)-dependent signaling pathway that leads to NF-κB inhibition. To investigate gene expression, mRNA levels of target inflammatory cytokines and T2R subtypes were quantified by qRT-PCR. Cytotoxicity assessment of LPS and bitter agonists was conducted using the CCK-8 assay. The activation status of the NF-κB pathway was examined by Western blot analysis of total and phosphorylated forms of p65 and IκB. Finally, the specific and essential role of GNAT3 was definitively validated through siRNA-mediated gene knockdown. LPS treatment induced significant upregulation of IL-6 and IL-8 mRNA, along with increased phosphorylation of p65 and IκB in BEAS-2B cells. A direct, parallel comparison of the bitter taste agonists PTC (phenylthiourea), QN (quinine), CPD (carisoprodol), and LK (chloroquine) revealed their capacity to upregulate specific T2R subtypes, suppressing inflammatory mediator release and NF-κB activation. Critically, upon GNAT3 silencing, the inhibitory effects of all tested agonists on p-p65/p65 and p-IκB/IκB ratios were significantly attenuated, without altering total p65 or IκB abundance. This provides direct genetic evidence that GNAT3 is specifically required for mediating the anti-inflammatory effects elicited by these T2R agonists. Multiple bitter receptor agonists exert anti-inflammatory effects on airway epithelial cells in a GNAT3-dependent manner. Our study advances the field by systematically comparing agonist efficacy and establishing the indispensable role of GNAT3 within the anti-inflammatory signaling cascade triggered by T2R agonists, thereby revealing a refined mechanistic insight and potential therapeutic target for inflammatory lung diseases. Full article

In response to the significant threat posed by low-frequency P-band anti-stealth radar to aircraft stealth capabilities, this paper examines the inverse design of electromagnetic parameters for a single-layer, thin P-band radar absorbing material. An efficient computational model is constructed by integrating impedance boundary conditions with the characteristic basis function method. The NSGA-II genetic algorithm is employed to accomplish multi-objective co-optimization of electromagnetic parameters and material thickness. Results demonstrate that the optimized single-layer RAM, with a relative permittivity of μ_r = 3.3078 + j3.9018 and permeability of ε_r = 2.3522 + j6.9519, exhibits outstanding P-band absorption characteristics within a thickness constraint of only 1 mm. Applying this RAM to aircraft wing components’ leading/trailing edges, intake duct cavities, and lip areas effectively suppresses edge diffraction and cavity scattering. The target achieves a maximum forward average RCS reduction of −13.97 dB and a maximum rearward average RCS reduction of −5.03 dB, maintaining stable performance within a pitch angle range of 0° ± 5°. Full article

Waste textiles may contain heavy metals, which can originate from dyes, mordants, or other chemical treatments used during manufacturing. To explore the impact of heavy metals on the adsorption properties of activated carbon derived from discarded textiles through pyrolysis and to mitigate heavy metal migration, this study investigated the adsorption behavior of copper-impregnated pyrolytic carbon toward typical pollutants—methylene blue and lead—in simulated dyeing wastewater. Aqueous copper nitrate was used to impregnate the waste pure cotton textiles (WPCTs) to introduce copper species as precursors for creating additional active sites. The study systematically examined adsorption mechanisms, single and binary adsorption systems, adsorption kinetics, adsorption isotherms, adsorption thermodynamics, and the influence of pH. Key findings and conclusions are as follows: Under optimal conditions, the copper-containing biochar (Cu-BC) demonstrated maximum adsorption capacities of 36.70 ± 1.54 mg/g for Pb(II) and 104.93 ± 8.71 mg/g for methylene blue. In a binary adsorption system, when the contaminant concentration reached 80 mg/L, the adsorption capacity of Cu-BC for Pb(II) was significantly enhanced, with the adsorption amount increasing by over 26%. However, when the Pb(II) concentration reached 40 mg/L, it inhibited the adsorption of contaminants, reducing the adsorption amount by 20%. SEM, XRD, Cu LMM, FTIR and XPS result analysis proves that the adsorption mechanism of methylene blue involves π–π interactions, hydrogen bonding, electrostatic interactions, and pore filling. For Pb(II) ions, the adsorption likely occurs via electrostatic interactions, complexation with functional groups, and pore filling. This study supplements the research content on the copper adsorption mechanism supported by biochar for heavy metal adsorption research and broadens the application scope of biochar in the field of heavy metal adsorption. Full article

Understanding thrombosis in acute coronary syndromes (ACSs) has evolved through advances in biomarkers, intracoronary imaging, and emerging analytical tools, improving diagnostic accuracy and risk stratification in high-risk patients. This narrative review provides an integrative overview of contemporary evidence from clinical trials, meta-analyses, and international guidelines addressing circulating biomarkers, intracoronary imaging modalities—including optical coherence tomography (OCT), intravascular ultrasound (IVUS), and near-infrared spectroscopy (NIRS)—artificial intelligence–based analytical approaches, and emerging antithrombotic therapies. High-sensitivity cardiac troponins and natriuretic peptides remain the most robust and guideline-supported biomarkers for diagnosis and prognostic assessment in ACS, whereas inflammatory markers and multimarker strategies offer incremental prognostic information but lack definitive validation for routine therapeutic guidance. Intracoronary imaging with IVUS or OCT is supported by current guidelines to guide percutaneous coronary intervention in selected patients with ACS and complex coronary lesions, leading to improved procedural optimization and clinical outcomes compared with angiography-guided strategies. Beyond procedural guidance, OCT enables detailed plaque characterization and mechanistic insights into ACS, while NIRS provides complementary information on lipid-rich plaque burden, primarily for risk stratification based on observational evidence. Artificial intelligence represents a rapidly evolving tool for integrating clinical, laboratory, and imaging data, with promising results in retrospective and observational studies; however, its clinical application in thrombosis management remains investigational due to the lack of outcome-driven randomized trials. In the therapeutic domain, factor XI inhibitors have demonstrated favorable safety profiles with reduced bleeding and preserved antithrombotic efficacy in phase II and early phase III studies, but their definitive role in ACS management awaits confirmation in large, outcome-driven randomized trials. Overall, the integration of biomarkers, intracoronary imaging, and emerging analytical and pharmacological strategies highlights the potential for more individualized cardiovascular care. Nevertheless, careful interpretation of existing evidence, rigorous validation, and alignment with guideline-directed practice remain essential before widespread clinical adoption. Full article

Background/Objectives: Multimodal large language models (LLMs) may directly interpret medical images, including thyroid ultrasounds (USs). Whether these models can reliably assess thyroid nodules—where subtle echogenic and morphological details are critical—remains uncertain. The American College of Radiology (ACR) TI-RADS system provides a structured framework for benchmarking artificial intelligence. This study evaluates GPT-5.0’s ability to interpret thyroid US images according to TI-RADS criteria and contextualizes its performance relative to expert radiologist assessment, using FNA cytology as the reference standard. Methods: This retrospective study included 100 patients (mean age 49.8 ± 12.6 years; 72 women) with cytology-confirmed diagnoses: Bethesda II (benign) or Bethesda V–VI (malignant). Each nodule had longitudinal and transverse US images acquired with high-frequency linear probes. A board-certified radiologist (>10 years’ experience) and GPT-5.0 independently assessed TI-RADS features (composition, echogenicity, shape, margin, echogenic foci) and assigned final categories. Agreement was analyzed using Cohen’s κ, and diagnostic performance was calculated using TR4–TR5 as positive for malignancy. Results: Agreement was substantial for composition (κ = 0.62), shape (κ = 0.70), and margin (κ = 0.68); moderate for echogenicity (κ = 0.48); and poor for echogenic foci (κ = 0.12). GPT-5.0 demonstrated a systematic, risk-averse tendency to up-classify nodules, leading to increased TR4–TR5 assignments. Overall, the TI-RADS agreement was 58% (κ = 0.31). The radiologist showed superior diagnostic performance (sensitivity 89%, specificity 85%) compared with GPT-5.0 (sensitivity 67%, specificity 49%), largely driven by false-positive TR4 classifications among benign nodules. Conclusions: GPT-5.0 recognizes several high-level TI-RADS features but struggles with microcalcifications and tends to overestimate malignancy risk within a risk-stratification framework, limiting its standalone clinical use. Ultrasound-specific training and domain adaptation may enable meaningful adjunctive roles in thyroid nodule assessment. Full article

Video super-resolution (VSR) has advanced rapidly in enhancing video quality and restoring compressed content, yet leading methods often remain too costly for real-world use. We present LIF-VSR, a lightweight, near-real-time framework built with an efficiency-first philosophy, comprising economical temporal propagation, a new neighboring-frame fusion strategy, and three streamlined core modules. For temporal propagation, a uni-directional recurrent architecture transfers context through a compact inter-frame memory unit, avoiding the heavy compute and memory of multi-frame parallel inputs. For fusion and alignment, we discard 3D convolutions and optical flow, instead using (i) a deformable convolution module for implicit feature-space alignment, and (ii) a sparse attention fusion module that aggregates adjacent-frame information via learned sparse key sampling points, sidestepping dense global computation. For feature enhancement, a cross-attention mechanism selectively calibrates temporal features at far lower cost than global self-attention. Across public benchmarks, LIF-VSR achieves competitive results with only 3.06 M parameters and a very low computational footprint, reaching 27.65 dB on Vid4 and 31.61 dB on SPMCs. Full article

Multimessenger constraints tightly bound the gravitational-wave speed to be luminal, posing a strong filter for modified gravity. This paper develops a symmetry-selected Palatini framework with torsion in which exact luminality at quadratic order is achieved by construction rather than by parameter tuning. Two ingredients shape the observable sector: (i) a scalar PT projector that keeps scalar densities real and parity-even, and (ii) projective invariance implemented via a non-dynamical Stueckelberg compensator that enters only through its gradient. Under an explicit posture (A1–A6), we establish three structural results: (C1) algebraic uniqueness of torsion to a pure-trace form aligned with the compensator gradient; (C2) bulk equivalence, modulo improvements, among a rank-one determinant route, a closed-metric deformation, and a PT-even CS/Nieh–Yan route; and (C3) a coefficient-locking identity that enforces $K=G$ for tensor modes on admissible domains; hence, $c_T=1$ with two propagating polarizations. Beyond leading order, the framework yields a distinctive, falsifiable next-to-leading correction $\delta c_T^2\left(k\right)=b{k}^2/{\Lambda }^2$ (for $k\ll \Lambda$), predicting slope 2 in log–log fits across frequency bands (PTA/LISA/LVK). The analysis is formulated to be reproducible, with a public repository providing figure generators, coefficients, and tests that directly validate (C1)–(C3). Full article

The Wufeng–Longmaxi (WF–LMX) shale gas reservoirs at depths > 3500 m in the Lu203–Yang101 well block, southern Sichuan Basin, possess great exploration potential, but their reservoir characteristics and high-production mechanisms remain unclear. In this study, we employed multi-scale analyses—including core geochemistry, X-ray diffraction (XRD), scanning electron microscopy (SEM), low-pressure N₂ adsorption, and nuclear magnetic resonance (NMR)—to characterize the macro- and micro-scale characteristics of these deep shales. By comparing with shallower shales in adjacent areas, we investigated differences in pore structure between deep and shallow shales and the main controlling factors for high gas-well productivity. The results show that the Long 11 sub-member shales are rich in organic matter, with total organic carbon (TOC) content decreasing upward. The mineral composition is dominated by quartz (averaging ~51%), which slightly decreases upward, while clay content increases upward. Porosity ranges from 1% to 7%; the Long11-1-3 sublayers average 4–6%, locally >6%. Gas content correlates closely with TOC and porosity, highest in the Long11-1 sublayer (6–10 m³/t) and decreasing upward, and the central part of the study area has higher gas content than adjacent areas. The micro-pore structure exhibits pronounced stratigraphic differences: the WF Formation top and Long11-1 and Long11-3 sublayers are dominated by connected round or bubble-like organic pores (50–100 nm), whereas the Long11-2 and Long11-4 sublayers contain mainly smaller isolated organic pores (5–50 nm). Compared to shallow shales nearby, the deep shales have a slightly lower proportion of organic pores, smaller pore sizes with more isolated pores, inorganic pores of mainly intraparticle types, and more developed microfractures, confirming that greater burial depth leads to a more complex pore structure. Type I high-quality reservoirs are primarily distributed from the top of the WF Formation to the Long11-3 sublayer, with a thickness of 15.6–38.5 m and a continuous thickness of 13–23 m. The Lu206–Yang101 area has the thickest high-quality reservoir, with a cumulative thickness of Type I + II exceeding 60 m. Shale gas-well high productivity is jointly controlled by multiple factors: an oxygen-depleted, stagnant deep-shelf environment, with deposited organic-rich, biogenic siliceous shales providing the material basis for high yields; abnormally high pore-fluid pressure with preserved abundant large organic pores and increased free gas content; and effective multi-stage massive fracturing connecting a greater reservoir volume, which is the key to achieving high gas-well production. This study provides a scientific basis for evaluating deep marine shale gas reservoirs in southern Sichuan and understanding the enrichment patterns for high productivity. Full article

Background and Objectives: Tear film instability and corneal surface irregularity are important sources of variability in keratometric and corneal topographic measurements, particularly affecting astigmatic magnitude and axis. Accurate preoperative biometry is crucial for optimal refractive outcomes in cataract surgery. Dry eye disease (DED) may compromise the reproducibility of keratometric parameters, leading to errors in intraocular lens (IOL) power calculation. This study aimed to evaluate the impact of DED on the reproducibility of keratometric measurements and to assess the effect of a four-week treatment with lipid-containing artificial tears on these parameters in cataract patients. Materials and Methods: This cross-sectional study included 116 patients scheduled for cataract surgery, of whom 65 (56.0%) had DED and 51 (44.0%) served as controls. All patients underwent two preoperative keratometric measurements 10–20 min apart (IOL1 and IOL2). The control group proceeded to surgery the next day, while surgery in the DED group was postponed. Patients with DED received preoperative therapy with lipid-containing artificial tears. Follow-up assessments occurred one month after therapy (keratometric measurement named IOL3) and eight weeks postoperatively. Clinical evaluation included slit-lamp examination, dry eye testing according to Dry eye Workshop II (DEWS II) criteria: Ocular surface Disease Index (OSDI), Tear Break-Up Time (TBUT), Schirmer I, Oxford staining, and meibomian gland assessment), ocular biometry, and postoperative spherical equivalent measurement using an auto ref-keratometer. Nonparametric statistical analyses were applied to evaluate associations between parameters. Results: In the DED group, corneal astigmatism showed a significant difference between IOL1 and IOL2 (Wilcoxon signed-rank test {Z = 2.43; p = 0.015}). Significant changes in predicted IOL power were observed between pretreatment and posttreatment values (t = 2.57; p = 0.013) and between IOL2 and IOL3 (t = 2.23; p = 0.029), indicating improved keratometric stability following tear film therapy. No additional significant correlations were identified. Conclusions: DED adversely affects the reproducibility of keratometric measurements and may compromise IOL power selection. Preoperative identification and treatment of DED, followed by repeated biometry after tear film stabilization, are strongly recommended to enhance refractive accuracy and optimize surgical outcomes in cataract patients. Full article

Background and Objectives: Inadvertent perioperative hypothermia is a common and clinically significant complication during laparoscopic surgery, leading to pain, agitation, shivering, and delayed recovery. This randomized controlled trial evaluated the effect of peri-induction active warming with an electric resistive blanket on postoperative pain and agitation—the primary outcomes—compared with passive insulation. Materials and Methods: This study was registered at ClinicalTrials.gov (Identifier: NCT06022926; date of registration: 15 August 2023) prior to the enrollment of the first patient. One hundred and thirty-two American Society of Anesthesiologists I–II adults undergoing laparoscopic cholecystectomy were randomly allocated (1:1) to two groups: one received active warming with a resistive carbon fiber underbody blanket (Group 1), and the other received passive insulation (Group 2). The tympanic core temperature was measured at four perioperative time points (TT1–TT4). Postoperative agitation (Riker Sedation–Agitation Scale, RSAS) and pain (Numerical Rating Scale, NRS) were assessed 20 min after extubation in the post-anesthesia care unit (PACU). Secondary outcomes included intraoperative and postoperative temperature, postoperative shivering, adverse events (bradycardia, tachycardia, hypotension, hypertension, postoperative nausea and vomiting, and respiratory depression), and the PACU length of stay. Results: Baseline core temperatures (TT1) were similar between the groups (36.5 ± 0.55 °C vs. 36.6 ± 0.54 °C; p = 1.00). However, mean core temperatures at TT2, TT3, and TT4 were significantly higher in the active warming group compared with the control group (TT2: 36.7 ± 0.53 °C vs. 36.5 ± 0.54 °C; TT3: 36.6 ± 0.49 °C vs. 36.4 ± 0.54 °C; TT4: 36.6 ± 0.51 °C vs. 36.2 ± 0.52 °C; all p < 0.001). Active warming markedly reduced postoperative agitation (RSAS ≥ 5: 3.1% vs. 19.4%, p = 0.004) and pain (NRS ≥ 4: 15.4% vs. 49.3%, p < 0.001). The incidence of shivering was lower (20.0% vs. 46.3%, p = 0.006), and the PACU stay was shorter (24 [23–28] min vs. 35 [30–40] min, p < 0.001) with active warming. No significant differences in adverse events were observed between groups. Logistic regression identified the intraoperative fentanyl dose as a predictor of agitation and identified shivering and the PACU duration as predictors of pain. Conclusions: Peri-induction active warming effectively maintained normothermia and improved recovery quality by reducing postoperative agitation, pain, shivering, and PACU stays without increasing adverse events. It should be considered a standard component of thermal management in short- and medium-duration laparoscopic surgeries. Full article

Background: Among the 15 human (h) carbonic anhydrase (CA; EC 4.2.1.1) isoforms, hCA IX and XII are particularly important due to their roles in tumor cell growth and survival, identifying them as promising targets for anticancer therapy. As a result, considerable effort has been directed toward the development of novel inhibitors that are highly selective for these isoforms. Methods: A library of twelve novel N-aryl-2-(4-sulfamoylphenyl)hydrazine-1-carbothioamides 3 along with two new N-aryl-2-(4-sulfamoylphenyl)hydrazine-1-carboxamide derivatives 5 were synthesized and their inhibition abilities were tested against four human carbonic anhydrase isozymes (hCA I, II, IX and XII) related to some global diseases including glaucoma, cancer and osteoporosis. Results: All compounds exhibited potent inhibition of the tested isoforms in the nanomolar range. Compound 3i showed the highest inhibition of hCA I activity but demonstrated poor selectivity toward the other isoforms. Compound 3h displayed superior selectivity for hCA II over hCA I (hCA I/II = 37) and exhibited 2.5-fold higher inhibitory activity compared to acetazolamide (AAZ). Among the tested compounds, 3l (K_i = 32.1 nM) demonstrated markedly improved selectivity for hCA IX over hCA I, II, and XII relative to the standard drug. Notably, compound 3a showed the most potent inhibition against hCA XII (K_i = 6.8 nM), comparable to AAZ, while exhibiting significantly greater selectivity over off-target isoforms and the other tumor-associated isozyme (hCA IX/XII = 20 versus hCA IX/XII = 4.5 for AAZ). Conclusions: The present study suggests potent lead compounds as selective hCA IX and XII inhibitors with anticancer activity. Full article

Pulmonary arterial hypertension (PAH) is a severe, progressive vasculopathy characterized by endothelial dysfunction, medial hypertrophy, and maladaptive vascular and cardiac remodelling that ultimately leads to right-heart failure and premature death. Despite advances in vasodilator therapies targeting endothelin, nitric oxide, and prostacyclin pathways, a substantial proportion of patients fail to achieve or maintain a low-risk profile, highlighting the need for disease-modifying strategies. Dysregulation of transforming growth factor-β (TGF-β) superfamily signalling, with excessive activin and growth differentiation factor activity and impaired bone morphogenetic protein signalling, plays a central role in PAH pathobiology. Sotatercept, a first-in-class activin signalling inhibitor, restores this imbalance by selectively trapping pro-proliferative ligands, thereby addressing a key molecular driver of pulmonary vascular remodelling. Evidence from pivotal phase II and III trials—PULSAR, STELLAR, ZENITH, and HYPERION—demonstrates that sotatercept significantly improves exercise capacity, haemodynamics, and risk status when added to background therapy. This review summarises the molecular mechanisms underlying sotatercept’s therapeutic effects, synthesises the current clinical evidence, and discusses its emerging role as a disease-modifying agent capable of promoting reverse pulmonary vascular remodelling within contemporary PAH management. Full article

Lentinula edodes (shiitake) is a major edible and medicinal mushroom and a key component of the horticultural mushroom industry in East Asia. During April–June 2024 cropping season, a widespread blue mold outbreak was observed on bag-cultivated shiitake in Xixia County, Henan Province, China. Affected cultivation rooms showed extensive blue-green sporulation on the exposed surfaces of substrate blocks and on developing and mature fruiting bodies, leading to rapid loss of marketability. To clarify the etiology of this disease, we coupled field surveys with morphological, molecular, and pathogenicity analyses. Fifty-five Penicillium isolates were obtained from symptomatic cultivation bags. Three representative isolates (LE06, LE15, and LE26) were characterized in detail. Colonies on PDA produced velutinous to floccose mycelia with blue-green conidial masses and terverticillate penicilli bearing smooth-walled, globose conidia. Sequencing of four loci—the internal transcribed spacer (ITS1-5.8S-ITS2), β-tubulin (benA), calmodulin gene (CaM), and RNA polymerase II second largest subunit (rpb2)—followed by multilocus phylogenetic analysis placed all three isolates in a well-supported clade with the ex-type CBS 227.28 of Penicillium bialowiezense. Inoculation of healthy shiitake cultivation bags with conidial suspensions (1 × 10⁶ conidia mL⁻¹) reproduced typical blue mold symptoms on substrate surfaces and fruiting bodies within 40 days post inoculation, whereas mock-inoculated controls remained symptomless. The pathogen was consistently reisolated from diseased tissues and showed identical ITS and benA sequences to the inoculated strains, thereby fulfilling Koch’s postulates. This is the first confirmed report of P. bialowiezense causing blue mold on shiitake, and it expands the known host range of this species. Our findings highlight the vulnerability of bag cultivation systems to airborne Penicillium contaminants and underscore the need for improved hygiene, environmental management, and targeted diagnostics in commercial shiitake production. Full article

Gabal (G.) Suwayqat El-Arsha contains two distinct phases of granitoids: I-type granodiorite and A-type monzogranite. Both of them experienced intense fractional crystallization that affected plagioclase, alkali feldspar, quartz, and, to a lesser degree, ferromagnesian minerals. EnMAP hyperspectral data were used to discriminate between the different granitoid types through spectral analysis, using various techniques, including the Sequential Maximum Angle Convex Cone (SMACC) method. Granodiorite has high SiO₂ (68.21–71.44 wt%), Al₂O₃ (14.29–14.92 wt%), Fe₂O₃ (1.99–3.32 wt%), and CaO (2.34–3.87 wt%), whereas monzogranite has even higher SiO₂ (73.58–75.87 wt%) and K₂O (4.28–4.88 wt%). Both granodiorite and monzogranite exhibit calc-alkaline, peraluminous to metaluminous, and medium- to high-K characteristics, with attendant enrichment of light REE and LILE and depletion of heavy REE and HFSE. A negative Eu anomaly may indicate early plagioclase fractionation, especially in the monzogranite. The I-type granodiorite is likely derived from a high-K, mafic protolith that partially melted during lithospheric delamination, leading to severe fractional crystallization in the upper crust in a post-collisional environment. In contrast, the monzogranite exhibits A-type characteristics and was likely emplaced in an anorogenic setting. Both granites were affected by several episodes of hydrothermal alteration, resulting in silicification, kaolinitization, sericitization, and chloritization. The intrusions studied here exhibit key similarities with those in the Wadi El-Hima area, including tectonic setting, petrogenetic type, Neoproterozoic age (Stage I collisional: ca. 650–620 Ma; Stage II post-collisional: ca. 630–590 Ma), and mineralogical assemblages (notably two-mica granites). These correlations suggest that both suites form part of a regionally extensive batholith composed of I- and A-type granites, stretching from north of the Marsa Alam Road (Umm Salatit–Homrit Waggat) southward to at least Wadi El-Hima. Full article