Search Results (8,133)

Informal public transportation remains the backbone of urban mobility in many developing cities. While these systems offer flexible and affordable services, they are often associated with safety issues, unreliability, congestion, and environmental impacts. Consequently, transitioning travelers toward formal public transportation is a key objective for sustainable transport planning. This study investigates travelers’ willingness to shift from their current travel modes to a proposed Metro system in Alexandria, Egypt. The analysis uses stated preference data collected through interviews that presented respondents with multiple service scenarios. A correlated random parameters bivariate probit model with heterogeneity in means is estimated to capture interdependence between responses. The results reveal strong and statistically significant cross-equation error correlations, confirming that decisions are not independent and supporting the use of a joint modeling approach. Empirical results indicate that willingness to shift is influenced by socio-demographic characteristics, trip attributes, and current travel conditions. Female travelers are more sensitive to waiting time, while low-income and older individuals are less likely to shift across scenarios. Physical accessibility, especially walkability to and from stations, emerges as the most influential factor in encouraging adoption. These findings provide policymakers with actionable insights for designing inclusive, accessible, and sustainable public transportation systems. Full article

While environmental awareness is crucial for ecological governance, its sociocultural foundations across different macro-institutional contexts remain underexplored. This study compares the sociocultural correlates of environmental awareness in China and Singapore—two developmental states with state-centric governance but distinct institutional configurations. Integrating Sociocultural Theory and the Theory of Planned Behavior, this exploratory study analyzes World Values Survey data Wave 7 using ordered logistic and probit models. We identify three key patterns. First, both nations exhibit a pervasive “attitude-behavior gap,” with cognitive environmentalism significantly outpacing actual civic action. Second, universally, social trust is correlated with environmental attitudes, while political action and religiosity are positively linked to actual behavior. Third, distinct institutional mechanisms emerge: China reflects a “state-dependent environmentalism” where attitudes are associated with post-materialist values and institutional deterrence, and behavioral participation is strongly related to government trust. Conversely, Singapore displays an “institutionalized civic environmentalism,” where routine political action shows a strong positive association with environmental attitudes—an association neutralized in China. These findings demonstrate that pathways to ecological sustainability in developmental states are structurally divergent, necessitating context-specific governance interventions. Full article

Plant growth-promoting microorganisms (PGPMs) and microbial biocontrol agents have emerged as key tools for improving crop productivity while maintaining environmental sustainability. However, central questions remain regarding which factors determine their consistent field performance and how these factors interact under real agronomic conditions. Previous research has demonstrated that PGPMs enhance nutrient acquisition, regulate phytohormone balance, improve stress tolerance, and suppress plant pathogens through diverse biochemical and ecological mechanisms. Advances in omics technologies, genome mining, and synthetic microbial communities have further expanded understanding of their functional potential. Nevertheless, many studies rely on laboratory-scale experiments or short-term trials, with limited multi-season and cross-regional validation. This gap contributes to inconsistent field outcomes and restricts large-scale agricultural adoption. Long-term multi-season validation and reproducibility assessment remain essential priorities for improving reliability of microbial agricultural products. This review synthesizes recent advances in PGPM-based biofertilizers and microbial biocontrol technologies, critically examining their mechanisms of action, scalability constraints, formulation challenges, and regulatory limitations. It identifies major translational barriers, including context dependency, mechanistic uncertainties, reproducibility gaps, and insufficient systems-level integration. Full article

With the rapid development in data mining and learning analytics, integrating predictive analytics into educational data has become increasingly critical for supporting students’ learning trajectories. In many schooling systems, the academic tracks (such as Liberal Arts or Science) and the performance of junior high school students can substantially shape their subsequent university pathways and career planning. Despite the long-term impact of these decisions, academic track selections and the evaluation of students’ potential are often made without systematic and evidence-based guidance. Predictive computer applications can assist, but the training of accurate models and the selection of adequate features remain key challenges. This paper details our process of engineering such an application comprising two tasks based on 1357 real-world junior high school academic performance records. The first task applies a classification approach to predict students’ academic track orientation, while the second task employs a multi-output regression model to forecast students’ future academic performance in senior high school. Our approach shows that the stacking ensemble model achieved a classification accuracy of 85.76%, whereas the Bi-LSTM model with multi-head attention attained an overall R² exceeding 82% in performance forecasting; both models demonstrated strong and reliable predictive capability. Moreover, the proposed approach provides inherent interpretability by decomposing predictions at the subject level. Feature importance analysis reveals how different academic subjects contribute variably to both academic track decisions and future academic performance, offering actionable insights for academic counselling and future study planning. By bridging predictive modelling with students’ educational and career planning needs, this study advances the practical application of educational data mining and provides support for evidence-based academic guidance and future career choices in real-world contexts. Full article

Artificial Intelligence (AI) has transitioned from a specialized research area to a ubiquitous socio-technical infrastructure influencing sectors from healthcare and law to manufacturing and defense. In tandem with its transformative promise, AI has created an exponentially expanding ethics literature questioning, fairness, transparency, accountability, and justice. This review synthesizes publications and key policy developments between 2019 and 2025, bringing sectoral discourses together with cross-cutting frameworks. Grounded in a systematic scoping review methodology, we frame the field along four meta-dimensions: trust and transparency, bias and fairness, governance & regulation, and justice, while we investigate their expression across diverse sectors. Special attention is dedicated to healthcare (patient trust and algorithmic bias), education (integrity and authorship), media (misinformation), law (accountability), and the industrial sector (data integrity, intellectual property protection, and environmental safety). We ground abstract principles in concrete case studies to illustrate real-world harms and mitigation strategies. Furthermore, we incorporate pluralistic ethics (e.g., Ubuntu, Islamic perspectives), environmental ethics, and emerging challenges posed by Generative AI and neuro-AI interfaces. To bridge theory and practice, we propose an operational governance framework for organizations. We contend that success involves transitioning from principles toward ethics-by-design, pluralistic governance, sustainability, and adaptive oversight. This review is intended for scholars, practitioners, and policymakers who need a comprehensive and actionable framework for navigating the complex landscape of AI ethics. Full article

This study examines the role of Paradoxical Leadership (PL) in enhancing sustainable service performance in Egypt’s hotel industry, with Organizational Citizenship Behavior (OCB) serving as a key mediating mechanism. Moving beyond conventional performance frameworks, the research examines how the dual nature of PL behaviors encourages discretionary employee actions that advance social sustainability, employee well-being, responsible service delivery, and long-term organizational resilience. Employing a survey-based quantitative design, data were collected from 397 hotel employees in Egypt using a structured questionnaire assessing overall PL, its five core dimensions, and OCB. A structured questionnaire was used to measure overall PL, its five core dimensions, OCB, and sustainable service performance. The data were analyzed using SPSS Version 24 and WarpPLS 8, confirmatory factor analysis, reliability analysis, and regression-based mediation analysis to examine the relationships among the study variables. The findings reveal that PL positively influences sustainable service performance, while OCB not only enhances service outcomes but also significantly mediates the relationship between PL and performance. In addition, each dimension of PL—balancing self- and other-centeredness (SO), maintaining distance while fostering closeness (CD), treating employees uniformly while recognizing individuality (UI), preserving decision control while encouraging autonomy (CA), and enforcing work requirements while allowing flexibility (RF)—significantly strengthens employees’ citizenship behaviors. Full article

Antibiotic therapy represents one of the strongest ecological perturbations of the human gut microbiota, inducing rapid and often prolonged alterations in community structure, metabolic activity, and functional resilience. While the use of probiotics to mitigate antibiotic-associated dysbiosis is widely adopted in clinical practice, probiotic selection is still largely empirical and insufficiently grounded in biological compatibility with specific antibiotic pressures. In this conceptual review, antibiotics are reframed not merely as antimicrobial agents, but as ecological forces that shape microbial survival, quiescence, and recolonization dynamics. We propose a biologically informed framework that distinguishes genetic antibiotic resistance from functional or ecological insensitivity, highlighting how microbial traits, such as the absence or inaccessibility of the antibiotic target, metabolic state, sporulation, and cellular architecture, influence the persistence of probiotics during antibiotic exposure. By integrating the mechanisms of action of antibiotics with key physiological and structural features of probiotic microorganisms, we develop a conceptual framework aimed at rationalizing the compatibility of probiotics and antibiotics. This framework does not imply clinical efficacy but provides an interpretative tool to guide hypothesis generation, experimental validation, and the design of future targeted probiotic strategies. A more ecologically grounded approach to probiotic selection may ultimately improve microbiota support during antibiotic therapy and advance personalized microbiome modulation. Full article

Cancer is an alarming health concern and economic burden in both developed and developing countries. Recently, there has been a growing demand for new alternative medications with more effectiveness and fewer harmful effects. During the past decades, a set of chemotherapeutic agents has been developed to fight against a large spectrum of cancer types. Unfortunately, their use is associated with a high level of toxicity; they are expensive, also, and their deployment is restricted by the emergence of cellular resistance. Plant-based components are garnering attention due to their low toxicity, selectivity, efficiency, and ease of accessibility. Alkaloids are one of these targeted compounds. Indeed, they are a highly diverse group with basic heterocyclic nitrogen-containing alkaloids that exhibit potent anticancer effects against a large panel of solid and liquid tumors, such as lung, breast, leukemia, liver, and colon cancer. The main molecular mechanisms involved in alkaloids’ anticancer effect are the induction of apoptosis via the extrinsic and intrinsic pathways, DNA damage, and the inhibition of cell cycle progression. Amazingly, these auspicious compounds exhibited strenuous inhibitory effects against a whole range of key enzymes involved in cancer progression and metastasis, such as Cytochrome P450 (CYP450), Cyclooxygenase-2 (Cox-2), Lysine-Specific Demethylase 1 (LSD1), Poly [ADP-ribose] polymerase (PARP), and topoisomerase, mainly through two action modes, namely irreversible and reversible inhibition. Furthermore, several conventional extraction methods have been developed to extract bioactive compounds from natural matrices, such as Soxhlet and hot water extraction. However, these techniques have many drawbacks, as they require a large amount of organic solvents, which not only affect human health but also generate severe environmental issues. To overcome these limitations, multiple eco-extraction techniques have emerged as potential alternatives to traditional extraction methods such as ultrasonic extraction, microwave-assisted extraction, and supercritical fluid extraction. In fact, they are considered eco-friendly and efficient technologies with less time and solvent consumption. Overall, this review aims to provide an updated overview of the most prominent anticancer alkaloids that have not been well reviewed already, as well as the main green extraction techniques relevant to the extraction of antineoplastic alkaloids. Full article

Textile-to-textile recycling is strongly constrained by upstream pre-processing, where post-consumer clothing must be identified, separated, and prepared under high variability in materials, appearance, and contamination. This paper presents a Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-guided systematic literature review of intelligent and automated technologies for textile recycling pre-processing covering the interval between 2015 to 2025. After screening and quality assessment, 21 primary studies published between 2020 and 2025 were included. The literature is synthesized across three task families: (i) identificationof fiber/material, composition, or color; (ii) sorting, considered only when explicit separation strategies are defined to operationalize identification outcomes into routing actions or output streams; and (iii) contaminant detection and/or removal, targeting non-recyclable items. Results show that identification dominates the field (19/21 studies), supported by Red–Green–Blue (RGB) and red–green–blue plus depth (RGB-D) imaging and material-signature sensing, including near-infrared (NIR) spectroscopy, hyperspectral imaging (HSI), and Raman spectroscopy. In contrast, sorting as a defined separation stage is less frequent (4/21), and contaminant-related automation remains sparse (3/21). Most studies are validated in laboratory conditions, with limited semi-industrial evidence, highlighting a persistent perception-to-action gap. Overall, the review indicates that robust separation strategies, representative datasets, and end-to-end system integration remain key bottlenecks for scalable automated textile recycling pre-processing. Full article

The rapid expansion of mobile healthcare (mHealth) applications has transformed health-related e-commerce, creating new challenges for understanding and responding to user needs. This study proposes a data-driven framework to systematically identify and prioritize unmet user requirements from negative reviews of Chinese mHealth applications. Using a dataset of 31,124 user reviews collected between 2019 and 2025, the framework integrates sentiment analysis, topic modeling, and machine learning regression to uncover six key areas of user concern and examine their temporal evolution. Among several predictive models linking user concerns to app ratings, the k-nearest neighbors (KNN) model demonstrated superior performance. Subsequent SHAP-based interpretability analysis reveals that account authentication, system accessibility, and application stability have the most significant impact on user ratings, highlighting the critical roles of trust and technical reliability in health e-commerce. This research not only provides actionable insights for platform governance but also contributes a generalizable methodology for leveraging user-generated content to inform evidence-based management and policy decisions in mobile digital services. Full article

Authentic, situated learning experiences which mirror the collaborative nature of healthcare practice are essential in preparing students for their future professions. Feedback literacy may be thought of as the understanding, capacity, and disposition needed to make sense of information and use it to enhance work or learning strategies. This study explored how feedback literacy can be developed through situated, interprofessional peer-to-peer feedback within a community-based paediatric health screening programme. Using an exploratory Action Research qualitative design, the planning activities stage explored current practice, gathering student insights via interviews, reflections, and a workshop to co-design an Interprofessional Feedback Conversation Guide (IPFCG). The IPFCG was piloted, integrating structured feedback tools and protected time for peer exchange, within the community screening activity. Feedback regarding use of the IPFCG contributed to the gathering data stage, which was followed by the evaluation and reflection stage. Evaluation revealed four key themes: value, engagement, optimising relationships, and structuring conversations. Students valued receiving feedback from peers outside their discipline, actively engaged with the process, emphasised the importance of building rapport, and utilised structured dialogue. These findings highlight how authentic, field-based learning can foster feedback literacy, enhancing the development of professional identity. The interprofessional nature of the program reflects the complexity of modern healthcare and demonstrates how curriculum-integrated models of authentic learning can enhance student engagement and workplace readiness. This study contributes to the evolving conversation about embedding authenticity in higher education and offers a practical model for building collaborative communication within situated learning experiences at scale. Full article

This study aimed to systematically elucidate the antihyperlipidemic mechanism of paeoniflorin, and we adopted an integrated multi-omics strategy to screen the key molecular targets and regulatory pathways involved in its action, followed by experimental validation to verify the potential regulatory effects of paeoniflorin on the screened targets and metabolic processes. Rats with high-fat diet-induced hyperlipidemia received paeoniflorin treatment. Liver histopathology was evaluated using hematoxylin–eosin and Oil Red O staining. Serum levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total bile acids, activated partial thromboplastin time, prothrombin time, thrombin time, and fibrinogen were measured using a biochemical analyzer. Integrated multi-omics analyses were performed to investigate paeoniflorin’s lipid-lowering mechanism. Critical pathways and targets identified were validated using Western blotting. Paeoniflorin alleviated pathological liver damage in hyperlipidemic rats and improved blood lipid levels, coagulation function, and liver function markers. Multi-omics analyses verified that paeoniflorin downregulated the expression of TREM-1, TLR4, NF-κB, TNF-α, and IL-1β, thereby alleviating hepatic inflammation. Paeoniflorin also upregulated the expression of low-density lipoprotein receptors (LDLR), liver X receptor alpha (LXRα), and ATP-binding cassette subfamily G member 1 (ABCG1), while downregulating proprotein convertase subtilisin/kexin type 9 (PCSK9) expression, contributing to balanced cholesterol metabolism. Paeoniflorin normalized glycerophospholipid and branched-chain amino acid metabolism, which correlated with reduced inflammation and improved cholesterol metabolism. Paeoniflorin ameliorates hyperlipidemia through multitarget mechanisms, potentially by suppressing the TREM-1-TLR4-NF-κB signaling pathway to reduce inflammation and by regulating cholesterol metabolism via the PCSK9-LDLR and LXRα-ABCG1 pathways. Full article

Islands often suffer from relatively limited freshwater resources, and the effective utilization and distribution of water resources are a key issues for the sustainable development of island-based economies and societies. While island water security has been widely discussed, few studies trace the socio-technical construction of island water-supply systems across the stages of planning, construction, and operation. Integrating Actor-Network Theory with political ecology, this study investigates the water-supply infrastructure of Kinmen. Drawing on official archives, participant observation, and in-depth interviews, this research analyzes the collective actions mobilized to address Kinmen’s water scarcity following the lifting of martial law in 1992. These efforts jointly reshaped both water-supply practices and the infrastructural network. Over the past three decades, Kinmen’s water-supply system has transformed into a sophisticated technological network, integrating reservoirs, desalination plants, and advanced sewage infrastructure. The introduction of these technologies, which function as critical non-human actors within the system, marks a clear shift in how water is managed and distributed. However, the rapid expansion of water-intensive industries, especially tourism, liquor distilling, and cattle farming, has outpaced local ecological limits, precipitating the current water crisis. The study concludes that this shortage has been mitigated through the strategic integration of water sources, most notably the cross-strait pipeline from mainland China, which now provides more than 80 percent of the island’s water. This transition marks a profound shift in the island’s socio-technical and geopolitical network. Full article

Introduction: Olives have been used in traditional Mediterranean medicine for thousands of years to address the causes of inflammation, ageing and cognitive health. Traditional preparations of olive include olive oil and olive leaf extract, which are major components of diets that contribute to maintaining cognitive function and reducing neurodegenerative disease risk. Aims of the study: This systematic review aimed to synthesise experimental and limited human evidence on olive biophenols in neurodegenerative disease models, identify the most studied compounds, characterise their mechanisms of action, and evaluate key translational barriers. Materials and methods: Following PRISMA 2020 guidelines and registered with PROSPERO (CRD420251252252), primary studies investigating the effects of well-characterised olive biophenols in neurodegenerative relevant in vitro, in vivo, or human models were systematically reviewed. Each study was assessed for its design, experimental model, mechanistic outcomes and reported limitations. Risk of bias was evaluated using validated tools (SYRCLE/OHAT/ToxR) appropriate for preclinical and experimental study designs. Results: Among the 25 studies, 7 (28.0%) examined oleuropein or oleuropein aglycone, 10 (40.0%) focused on hydroxytyrosol or its derivatives, and 9 (36.0%) investigated oleocanthal. Most studies employed in vivo animal models (57.7%), predominantly transgenic mouse models of AD and toxin-induced PD models. Oleuropein-based studies reported inhibition of amyloid-β and α-synuclein aggregation with behavioural improvements. Hydroxytyrosol primarily exerted antioxidant and anti-inflammatory effects with modest cognitive benefits. Oleocanthal showed the most consistent anti-amyloid and anti-tau activity, including enhanced amyloid-β clearance across the blood–brain barrier. Most studies show a moderate risk of bias due to incomplete reporting, randomisation and blinding. Conclusions: Olive biophenols demonstrate consistent neuroprotective effects in preclinical models; however, translation to clinical application remains limited by pharmacokinetic constraints, methodological heterogeneity, and insufficient human evidence. Full article

Nighttime light (NTL), a crucial indicator of human activity intensity, has not been systematically analyzed for its interactive mechanisms with air pollution and climate change. This study first investigates the spatiotemporal evolution of China’s total nighttime light (TNTL) and average nighttime light (ANTL), alongside key indicators of meteorological parameters and air pollution, at the grid scale from 2000 to 2023. We then employ prefecture-level city data and a geographically and temporally weighted regression (GTWR) model to quantify the spatiotemporally heterogeneous associations of temperature (TMP), precipitation (PRE), fine particulate matter (PM_2.5), ozone (O₃), land use (LUL), topography, and socioeconomic factors with NTL. The results indicate that (1) China’s NTL exhibits a significant overall upward trend, with areas of increase or significant increase comprising 92.04% of the total study area. TNTL growth demonstrates regional heterogeneity, expanding by a factor of 4.91 in East China and 2.65 in Northeast China; (2) meteorological and air pollution indicators display spatiotemporal non-stationarity, with the synergistic effect between O₃ and PRE being the strongest; (3) among NTL drivers, LUL contributes most significantly (0.44), followed by TMP (0.14) > PM_2.5 (−0.33 × 10⁻¹) > O₃ (0.17 × 10⁻¹) > PRE (−0.33 × 10⁻⁶); (4) TMP and PRE may primarily influence NTL by altering ecological conditions and nighttime activity patterns. TMP shows a strong positive correlation with NTL in the junction zone of South, East, and Central China, whereas PRE predominantly exerts a negative influence; (5) air pollution exhibits distinct spatiotemporal effects: high PM_2.5 and O₃ generally correspond to lower NTL, though positive correlations persist in some areas due to industrial structures, highlighting the need for integrated policies that balance air quality management with sustainable urban planning; (6) the 2013 “Air Pollution Prevention and Control Action Plan” significantly strengthened the negative correlation between PM_2.5 and NTL in North China. However, O₃ concentrations increased by 28.9% after 2017, underscoring the challenge of coordinating VOC and NOx controls for long-term atmospheric sustainability. Full article