In recent years, wild morel mushroom species have begun to be widely cultivated in China due to their high edible and medicinal values. To parse the medicinal ingredients, we employed the technique of liquid-submerged fermentation to investigate the secondary metabolites of
Morehella importuna
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In recent years, wild morel mushroom species have begun to be widely cultivated in China due to their high edible and medicinal values. To parse the medicinal ingredients, we employed the technique of liquid-submerged fermentation to investigate the secondary metabolites of
Morehella importuna. Two new natural isobenzofuranone derivatives (
1–
2) and one new orsellinaldehyde derivative (
3), together with seven known compounds, including one
o-orsellinaldehyde (
4), phenylacetic acid (
5), benzoic acid (
6), 4-hydroxy-phenylacetic acid (
7), 3,5-dihydroxybenzoic acid (
8),
N,
N′-pentane-1,5-diyldiacetamide (
9), and 1H-pyrrole-2-carboxylic acid (
10), were obtained from the fermented broth of
M. importuna. Their structures were determined according to the data of NMR, HR Q-TOF MS, IR, UV, optical activity, and single-crystal X-ray crystallography. TLC-bioautography displayed that these compounds possess significant antioxidant activity with the half DPPH free radical scavenging concentration of 1.79 (
1), 4.10 (
2), 4.28 (
4), 2.45 (
5), 4.40 (
7), 1.73 (
8), and 6.00 (
10) mM. The experimental results would shed light on the medicinal value of
M. importuna for its abundant antioxidants.
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