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Open AccessArticle

Microbial Kinetic Resolution of Aroma Compounds Using Solid-State Fermentation

Department of Chemistry, Wroclaw University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland
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Catalysts 2018, 8(1), 28; https://doi.org/10.3390/catal8010028
Received: 14 December 2017 / Revised: 12 January 2018 / Accepted: 13 January 2018 / Published: 16 January 2018
(This article belongs to the Special Issue Enzyme-Mediated Stereoselective Synthesis)
A novel microbial approach to the production of enantiomerically enriched and pure aroma compounds based on kinetic resolution via solid-state fermentation is proposed. Twenty-five filamentous fungi were screened for lipase activity and enantioselective hydrolysis of a volatile racemic ester (1-phenylethyl acetate (1)) and several racemic lactones (trans and cis whisky lactones (4, 5), γ-decalactone (7), δ-decalactone (8), (cis-3a,4,7,7a-tetrahydro-1(3H)-isobenzofuranone) (9)). Solid-state fermentation was conducted with linseed and rapeseed cakes. Kinetic resolution afforded enantiomerically enriched products with high enantiomeric excesses (ee = 82–99%). The results highlight the potential economic value of solid-state fermentation using agroindustrial side-stream feedstocks as an alternative to more expensive processes conducted in submerged fermentation. View Full-Text
Keywords: aroma compounds; kinetic resolution; solid-state fermentation; agro-industrial side stream; rapeseed cake; linseed cake; lactones; esters aroma compounds; kinetic resolution; solid-state fermentation; agro-industrial side stream; rapeseed cake; linseed cake; lactones; esters
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Boratyński, F.; Szczepańska, E.; Grudniewska, A.; Olejniczak, T. Microbial Kinetic Resolution of Aroma Compounds Using Solid-State Fermentation. Catalysts 2018, 8, 28.

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