Search Results (122)

The implementation of FLASH Radiotherapy (FLASH-RT), characterized by ultra-high dose rates (UHDRs) frequently exceeding ${10}^6$ Gy/s in microsecond pulses, imposes stringent requirements on real-time dosimetry. Conventional ionization chambers suffer severe ion recombination and space-charge limitations under these conditions. This review summarizes the state of SSD technologies—including conventional standard silicon diodes, advanced SiC diodes, Low-Gain Avalanche Detectors (LGADs), and pixel detectors—and compares their performance, linearity, and dynamic range in UHDR environments. Particular attention is devoted to operational modes (integrating vs. counting), saturation mechanisms, and readout electronics, which frequently dominate detector behavior at FLASH conditions. We discuss the experimental results from recent UHDR beamlines and highlight emerging concepts that will shape future clinical translation. Full article

To achieve a substantial enhancement in thermodynamic efficiency, Generation IV nuclear reactors are designed to operate at significantly elevated temperatures compared to conventional reactors. Moreover, they typically employ a fast neutron spectrum, characterized by higher neutron energy and flux. This combination results in a considerably more intense radiation environment within the core relative to traditional thermal neutron reactors. Therefore, the measurement of neutron flux in the core of Generation IV nuclear reactors faces the challenge of a high-temperature and high-radiation environment. Conventional neutron flux monitoring equipment—including fission chambers, gas ionization chambers, scintillator detectors, and silicon or germanium semiconductor detectors—faces considerable challenges in Generation IV reactor conditions. Under high temperatures and intense radiation, these sensors often experience severe performance degradation, significant signal distortion, or complete obliteration of the output signal by noise. This inherent limitation renders them unsuitable for the aforementioned applications. Consequently, significant global research efforts are focused on developing neutron detectors capable of withstanding high-temperature and high-irradiation environments. The objective is to enable accurate neutron flux measurements both inside and outside the reactor core, which are essential for obtaining key operational parameters. In summary, the four different types of neutron detectors have different performance characteristics and are suitable for different operating environments. This review focuses on 4H-SiC, diamond detectors, high-temperature fission chambers, and self-powered neutron detectors. It surveys recent research progress in high-temperature neutron flux monitoring, analyzing key technological aspects such as their high-temperature and radiation resistance, compact size, and high sensitivity. The article also examines their application areas, current development status, and offers perspectives on future research directions. Full article

Accurate real-time dosimetry is key in megavoltage radiotherapy; however, many detectors require external biasing or complex instrumentation. This study evaluated thin-film CdTe solar cells operating in photovoltaic (zero-bias) mode as medical dosimeters. Superstrate ITO/CdS/CdTe/Cu/Au devices were fabricated and irradiated with 6-MV photons from a clinical linear accelerator to 20 kGy cumulative dose. Electrical and dosimetric properties were assessed based on AM 1.5 current–voltage measurements, external quantum efficiency (EQE), dose linearity, dose-rate dependence, field-size dependence, percentage depth dose (PDD), and one-month reproducibility. With increasing dose (5–20 kGy), the open-circuit voltage and fill factor decreased by ~2–3%, the short-circuit current density by ~10%, retaining ~87% initial efficiency. Series and shunt resistances were stable, while EQE decreased uniformly (~5%), indicating degradation mainly from increased nonradiative recombination. Dose–signal linearity remained intact, and post-irradiation sensitivity loss was corrected with a single calibration factor. Dose-rate dependence was minor; low reverse bias (~3–7 V) enhanced response without nonlinearity. Field-size and PDD responses agreed with ionization chamber data within ~1%, and weekly stability was within ~1%. Parallel stacking of two cells increased signal nearly linearly. CdTe solar-cell detectors thus enable zero-bias, real-time, stable, and scalable dosimetry and strongly agree with reference standards. Full article

Online radiation dose monitoring is critical for the safe operation of accelerators. Although commercial dose monitors are well-developed, integrating an ionization chamber directly within a small-sized Betatron magnet remains challenging. In this study, we designed an air ionization chamber tailored for real-time dose monitoring in a small-sized Betatron. We selected aluminum for the chamber wall based on structural and integration requirements, designed the cavity geometry, and developed the associated charge collection and sampling circuits. Using a standard reference PTW ionization chamber, we calibrated the output voltage of the chamber against X-ray dose rates and conducted stability tests. The results show that there is a very good linear relationship between the output voltage of the ionization chamber and the X-ray dose rate. The relative standard deviation of the dose rate data within a 10 min working cycle is 3.25%, and the dose rate data shows good consistency with the standard reference ionization chamber. The ionization chamber can ensure operational safety for a small-sized Betatron and offer guidance for similar applications. Full article

There are many types of probes available on the market for measuring ambient dose equivalent rates (ADERs), which makes intercomparison exercises essential to ensure data comparability and reliability. This study evaluated the performance of four widely used and similarly priced probes—the Reuter-Stokes ionization chamber, the RX04L from BITT, the MIRA from ENVINET, and the LB9360 from Berthold. The Reuter-Stokes ionization chamber was also taken as reference. Measurements were continuously conducted in Bilbao, northern Spain, during the period 2017–2021 under background conditions as well as during episodes of heavy rainfall and extreme temperatures. Results show that the BITT proportional counter exhibited the highest consistency with the Reuter-Stokes chamber under all meteorological conditions, and excellent stability even during extreme conditions. The Berthold probe displayed similar trends, but systematically overestimated dose rates, while the Geiger–Müller-based detector showed acceptable agreement under rainfall, but clear instability during temperature extremes. These findings highlight the importance of probe selection in environmental radioactivity networks as well as the use of reliable instruments for integration into modernized radiological surveillance systems. Full article

Alanine dosimetry based on Electron Paramagnetic Resonance (EPR) spectroscopy has been a reliable reference and transfer dosimetry method in high-dose applications, valued for its high precision, accuracy and long-term stability. Additional characteristics, such as dose-rate independence up to 10¹⁰ Gy/s under electron beam (e-beam) irradiation, electron energy independence and tissue equivalence, position alanine EPR as a promising candidate to address dosimetric challenges arising in e-beam Flash Radiotherapy (RT), where radiation energy is delivered at Ultra-High Dose-Rates (UHDR) ≥ 40 Gy/s. At such dose-rates, reliable real-time monitoring dosimeters such as ionization chambers in conventional RT, suffer from ion recombination, compromising accuracy in dose determination. Several studies are currently focused on developing real-time beam monitoring systems dedicated specifically for e-beam Flash RT. This creates a need for standardized reference dosimetry methods to validate beam parameters determined by these systems under investigation. This review provides an overview of the potential and limitations of the alanine EPR dosimetry method for control, validation and verification of e-beam Flash RT beam parameters at doses less than 10 Gy, where the method has shown low sensitivity and increased uncertainty. It further discusses strategies to optimize alanine EPR measurements to enhance sensitivity and accuracy at these dose levels. Improved measurement procedures will ensure reliable and accurate e-beam Flash RT accelerator commissioning, performance checks, patient safety and treatment efficacy across all therapeutic dose ranges. Full article

Radiotherapy employs high-energy X-rays to precisely target tumor tissues while minimizing damage to the surrounding healthy structures. Although its clinical efficacy is well established, the immunomodulatory effects of ionizing radiation remain complex and context-dependent. This study investigated the biological effects of radiotherapeutic doses on immune cells by evaluating lymphocyte viability, phenotypic profiles, and cytokine expression levels. Peripheral blood mononuclear cells (PBMCs) were isolated from six healthy donors and irradiated with 0, 2, or 6 Gy using a 6 MV linear accelerator (LINAC). Dose validation with an ionization chamber demonstrated strong agreement between estimated and measured values (intraclass correlation coefficient = 1, 95% CI). Immune subsets, including T cells (CD3+), helper T cells (CD3+CD4+), cytotoxic T cells (CD3+CD8+), regulatory T cells (CD3+CD4+Foxp3+), and natural killer (CD3-CD56+) cells, along with intracellular cytokines interleukin-12 (IL-12) and interferon-gamma (IFN-γ), were analyzed via flow cytometry at multiple time points. The results showed a significant, dose-dependent decline in overall lymphocyte viability (p < 0.01) compared to control. Cytotoxic T cells were the most radiosensitive, followed by helper and regulatory T cells, while NK cells were the most radioresistant. IL-12 expression initially increased post-irradiation, while IFN-γ levels remained variable. These findings demonstrate that radiation induces distinct alterations in immune phenotypes and cytokine profiles, which may shape the immune response. Immune profiling following irradiation may therefore provide valuable insights for optimizing combination strategies that integrate radiotherapy and immunotherapy in cancer treatment. Full article

This paper introduces a novel Lateral Extraction Enhanced Desorption Electrospray Ionization (LEE-DESI) source. This source is specifically designed to tackle the crucial issue of electric field interference in dual-channel ambient ionization mass spectrometry (AIMS). By incorporating dual-channel spraying-based desorption and extraction into a 3D-printed chamber with optimized spatial parameters, the system effectively reduces cross-channel interference while boosting ionization efficiency. The desorption spray is responsible for desorbing analytes from untreated samples, and the extraction spray further ionizes more neutral droplets through charge transfer, which substantially enhances sensitivity. Compared with traditional DESI, the LEE-DESI source demonstrates improved detection limits, reproducibility, and operational simplicity, as validated using Rhodamine B, L-arginine, and Angiotensin I, as well as drug standards including methadone, ketamine, and fentanyl. This highlights its potential for high-throughput analysis of complex matrices in proteomics, metabolomics, and biomedical applications. Full article

In view of the great need for quality assurance in radiotherapy, this paper proposes a stitching-based detector (SBD) technique and a set of intelligent algorithms that can reconstruct the information of projected particle beams. The reconstructed information includes the intensity, sigma value, and location of the maximum intensity of the beam under test. To verify the effectiveness of the proposed technique and algorithms, this research study adopts the pencil beam scanning (PBS) form of proton beam therapy (PBT) as an example. Through the SBD technique, it is possible to utilize 128 × 128 ionization chambers, which constitute an ionization plate of 25.6 cm², with an acceptable number of 4096 analog-to-digital converters (ADCs) and a resolution of 0.25 mm. Through simulation, the proposed SBD technique and intelligent algorithms are proven to exhibit satisfactory and practical performance. By using two kinds of maximum intensity definitions, sigma values ranging from 10 to 120, and two definitions in an erroneous case, the maximum error rate is found to be 3.95%, which is satisfactorily low. Through analysis, this research study discovers that most errors occur near the symmetrical and peripheral boundaries. Furthermore, lower sigma values tend to aggravate the error rate because the beam becomes more like an ideal particle, which leads to greater imprecision caused by symmetrical sensor structures as its sigma is reduced. However, because proton beams are normally not projected onto the border region of the sensed area, the error rate in practice can be expected to be even lower. Although this research study adopts PBS PBT as an example, the proposed SBD technique and intelligent algorithms are applicable to any type of particle beam reconstruction in the field of radiotherapy, as long as the particles under analysis follow a Gaussian distribution. Full article

Conventional detectors based on ionization chambers, semiconductors, or thermoluminescent materials generally cannot be used to verify the in vivo dose delivered during brachytherapy treatments with γ-ray sources. However, certain adaptations and alternative methods, such as the use of miniaturized detectors or other specialized techniques, have been explored to address this limitation. One approach to solving this problem involves the use of dosimetric materials based on efficient scintillation crystals, which can be placed in the patient’s body using a long optical fiber inserted intra-cavernously, either in front of or next to the tumor. Scintillation crystals with a density close to that of tissue can be used in any location, including the respiratory tract, as they do not interfere with dose distribution. However, in many cases of radiation therapy, the detector may need to be positioned behind the target. In such cases, the use of heavy, high-density, and high-Z_eff scintillators is strongly preferred. The delivered radiation dose was registered using the radioluminescence response of the crystal scintillator and recorded with a compact luminescence spectrometer connected to the scintillator via a long optical fiber (so-called fiber-optic dosimeter). This proposed measurement method is completely non-invasive, safe, and can be performed in real time. To complete the abovementioned task, scintillation detectors based on YAG:Ce (ρ = 4.5 g/cm³; Z_eff = 35), LuAG:Ce (ρ = 6.75 g/cm³; Z_eff = 63), and GAGG:Ce (ρ = 6.63 g/cm³; Z_eff = 54.4) garnet crystals, with different densities ρ and effective atomic numbers Z_eff, were used in this work. The results obtained are very promising. We observed a strong linear correlation between the dose and the scintillation signal recorded by the detector system based on these garnet crystals. The measurements were performed on a specially prepared phantom in the brachytherapy treatment room at the Oncology Center in Bydgoszcz, where in situ measurements of the applied dose in the 0.5–8 Gy range were performed, generated by the ¹⁹²Ir (394 keV) γ-ray source from the standard Fexitron Elektra treatment system. Finally, we found that GAGG:Ce crystal detectors demonstrated the best figure-of-merit performance among all the garnet scintillators studied. Full article

Background: We present the implementation of an in vivo dosimetry program that enhances treatment setups, ensuring high accuracy that is needed globally. This approach proves valuable in smaller departments by helping to detect and prevent errors. Evaluation studies have shown that in vivo dosimetry is a reliable method for assessing the overall accuracy of treatment delivery. Methods: Comprehensive development and validation of an in vivo dosimetry program using silicon diodes, ionization chambers, and calibrated electrometers for accurate radiation in dose measurements for treatments involving Co-60 or 6 MV X-ray beams. Results: The outcomes demonstrated that all diodes were dependable, with deviations of less than 1% (0.89 ± 0.10 cGy). Calibration curves were generated, showing dose variations of only 0.13% in the diode readings. The overall analysis revealed a mean deviation of up to 1%. Conclusions: These results provide a thorough assessment for patients’ treatment and facilitate timely interventions when needed, helping to ensure that dose variations stay within acceptable limits. Full article

This study presents a comprehensive dosimetric characterization and commissioning of a grid-type collimator manufactured via 3D printing using PLA-W composite filament, following an international protocol for small-field dosimetry. PLA doped with high concentrations of tungsten (>90% w/w) enables the fabrication of miniaturized collimators (<1 cm) with complex geometries, suitable for non-conventional radiotherapy applications. However, accurate assessment of spatial dose modulation is challenged by penumbra overlap between closely spaced beamlets, limiting the application of conventional instrumentation and protocols. To address this, absolute and relative dose distributions were evaluated for various radiation field configurations (number of beamlets) in both lateral and depth directions. Measurements were performed according to the IAEA TRS-483 protocol, using micro-ionization chambers and diode detectors. Additionally, long-term stability assessments were carried out to evaluate both the structural integrity and modulation performance of the printed grid over time. Point dose measurements using the same detectors were repeated after one year, and 2D surface dose distributions measured with EBT3 films were compared to SRS MapCHECK measurements two years later. The generated radiation field size of the central beamlet (FWHM) differed by less than 0.2% (15.8 mm) from the physical projection size (15.6 mm) and the lateral transmission due simultaneous beamlets resulted in FWHM variations of less than 3.8%, confirming manufacturing precision and collimator capability. Output factor measurements increased with the number of beamlets, from 0.75 for a single beamlet to 0.82 for the full beamlets configuration. No significant changes were observed in the depth of maximum dose across the different beamlets configurations (1.20 ± 0.20 cm). On the other hand, the long-term evaluations show no relevant changes in the FWHM or VPR, confirming the performance and reliability of the system. These results support the clinical feasibility and lasting performance stability of in-house manufactured grid collimators using PLA-W filaments and accessible 3D printing technology. Full article

This study concerns the effects of the addition of crystalline nanocellulose (CNC) and ionizing radiation on the properties of cornstarch–poly(vinyl alcohol) (PVA) films. Moreover, ESR spectroscopy and gas chromatography were used for a comparison of the reactivity of CNC and two micro-sized celluloses (microfibrinal (MFC) and microcrystalline (MCC)) under the influence of irradiation. This showed that the highest reactivity of CNC was related to the lowest sizes of the particles (observed by SEM). A series of starch/PVA/CNC films characterized by a starch/PVA ratio equal to 40:60 and a CNC addition in a range from 0.5 wt% to 10.0 wt% with 30 wt% of glycerol were prepared by solution casting. The films were irradiated in a gamma chamber (in a vacuum) or in an e-beam (in the air) using a dose of 25 kGy. The mechanical properties, contact angle to water, swelling and solubility in water, moisture absorption in a humid atmosphere, and the gel content of the films were determined. The functional properties of the films strongly depended on the addition of CNC. The films formed with 1.0 wt% of CNC had the best mechanical properties and the lowest surface and bulk hydrophilicity, which could be improved further after irradiation. The results can be related to the increased homogeneity and modified distribution of the nanoparticles in the films after irradiation (as shown by SEM). Degradation is a predominant process that occurs due to irradiation; however, the crosslinking processes also have some role. The protective effect of CNC against degradation was discovered by diffuse reflectance spectroscopy. Full article

Various models of ionization and fission chambers for ionizing radiation detection, designed to operate under harsh conditions such as those found in fusion reactors or particle accelerators, have been experimentally characterized and numerically simulated. These models were calibrated using a photon beam in the X-ray spectrum. Irradiations were performed at the Biomedical Research Center of the University of Granada (CIBM) with a bipolar metal-ceramic X-ray tube operating at a voltage of 150 kV and a dose rate ranging from 0.05 to 2.28 Gy/min. All detectors under study featured identical external structures but varied in detection volume, anode configuration, and filling gas composition. To assess inter- and intra-model response variations, the tested models included 12 micro-ionization chambers (CRGR10/C5B/UG2), 3 micro-fission chambers (CFUR43/C5B-U5/UG2), 8 micro-fission chambers (CFUR43/C5B-U8/UG2), and 3 micro-fission chambers (CFUR44/C5B-U8/UG2), all manufactured by Photonis (Merignac, France). The experimental setup was considered suitable for the tests, as the leakage current was below 20 pA. The optimal operating voltage range was determined to be 130–150 V, and the photon sensitivities for the chambers were measured as 29.8 ± 0.3 pA/(Gy/h), 43.0 ± 0.8 pA/(Gy/h), 39.2 ± 0.3 pA/(Gy/h), and 96.0 ± 0.9 pA/(Gy/h), respectively. Monte Carlo numerical simulations revealed that the U layer in the fission chambers was primarily responsible for their higher sensitivities due to photoelectric photon absorption. Additionally, the simulations explained the observed differences in sensitivity based on the filling gas pressure. The detectors demonstrated linear responses to dose rates and high reproducibility, making them reliable tools for accurate determination of ionizing photon beams across a range of applications. Full article

This study describes a sensor system for continuous monitoring of volatile organic compounds (VOCs) emitted from small industrial facilities in urban centers, such as automobile paint facilities and printing facilities. Previously, intermittent measurements were made using expensive flame ionization detector (FID)-type instruments that were impossible to install, resulting in a lack of continuous management. This paper develops a low-cost sensor system for full-time management and consists of multi-sensor systems to increase the spatial resolution in the pipe. To improve the accuracy and reliability of this system, a new reinforced adaptive neuro fuzzy inference system (RANFIS) model with enhanced preprocessing based on the adaptive neuro fuzzy inference system (ANFIS) model is proposed. For this purpose, a smart sensor module consisting of low-cost metal oxide semiconductors (MOSs) and photo-ionization detectors (PIDs) is fabricated, and an operating controller is configured for real-time data acquisition, analysis, and evaluation. In the front part of the RANFIS, interquartile range (IQR) is used to remove outliers, and gradient analysis is used to detect and correct data with abnormal change rates to solve nonlinearities and outliers in sensor data. In the latter stage, the complex nonlinear relationship of the data was modeled using the ANFIS to reliably handle data uncertainty and noise. For practical verification, a toluene evaporation chamber with a sensor system for monitoring was built, and the results of real-time data sensing after training based on real data were compared and evaluated. As a result of applying the RANFIS model, the RMSE of the MQ135, MQ138, and PID-A15 sensors were 3.578, 11.594, and 4.837, respectively, which improved the performance by 87.1%, 25.9%, and 35.8% compared to the existing ANFIS. Therefore, the precision within 5% of the measurement results of the two experimentally verified sensors shows that the proposed RANFIS-based sensor system can be sufficiently applied in the field. Full article