Search Results (4,050)

Breast implants are among the most frequently used long-term implantable medical devices in aesthetic and reconstructive surgery. In addition to correcting anatomical deficits, they have significant psychosocial effects, influencing body image, self-esteem, and quality of life, particularly in patients undergoing postmastectomy reconstruction. This review provides a comprehensive overview of the historical development, biological interactions, material characteristics, and clinical outcomes of breast implants. Early reconstructive attempts using foreign materials and injectable substances were associated with severe complications, underscoring the need for safer technologies. The introduction of silicone gel implants in the 1960s marked a pivotal advancement, followed by the development of saline-filled devices and highly cohesive silicone gels with enhanced mechanical stability. Key surgical considerations, including incision type and implant placement plane (subglandular, submuscular, dual-plane, and subfascial), are discussed in relation to aesthetic outcomes and complication risk. Emphasis is placed on the implant–tissue interface and the foreign body response (FBR), a process involving protein adsorption, immune cell activation, fibrous capsule formation, and potential chronic inflammation. Persistent inflammatory stimulation, often associated with bacterial biofilm formation, contributes to capsular contracture, the most common long-term complication. Additional adverse events include implant rupture, silicone gel bleed, granulomatous reactions, infection, hematoma, implant malposition, and rare but clinically significant conditions such as breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). The review also summarizes implant classification according to construction, filling material, shape, and surface topography, highlighting the influence of surface characteristics on host response and clinical outcomes. Advances in biomaterials, cohesive gel formulations, and surface engineering aim to enhance biocompatibility and long-term safety, supported by standardized mechanical and biological testing protocols. Full article

Railway traction power supply systems (TPSSs) are evolving from passive grid-fed infrastructures into active energy systems with local photovoltaic (PV) generation capacity, energy storage systems (ESSs), and converter-based regulation. Unlike conventional microgrids, TPSSs feature single-phase, highly dynamic traction loads; short-duration regenerative braking bursts; and strict constraints on voltage quality, stability, and protection. These characteristics make the energy management of distributed PV-storage-integrated TPSSs a distinct research problem. This review examines the field from three coupled perspectives: supply architecture, power electronic interfaces, and energy management strategies. First, representative integration architectures are classified into substation-side, wayside-distributed, and hybrid multi-port schemes. Second, converter interfaces and flexible traction substations are analyzed as the enabling layer for coordinated control of PV, ESS, the utility grid, and traction feeders. Third, major energy management strategies, including rule-based, optimization-based, hierarchical multi-timescale, and uncertainty-aware methods, are compared. The review further discusses power quality, stability, protection, and battery degradation constraints that shape practical deployments. Finally, research gaps and future directions are identified to further the development of more robust, railway-specific, and implementation-oriented PV-storage energy management. Full article

A systematic first-principles density functional theory (DFT) study was performed using the Perdew–Burke–Ernzerhof (PBE) generalized gradient approximation (GGA) functional combined with ultrasoft pseudopotentials (USPPs), as implemented in the CASTEP code. The PBE-GGA functional was chosen because it provides a well-balanced description of both metallic and covalent bonding characteristics at the Fe/Ti₃SiC₂ interface. To elucidate the interfacial bonding mechanisms and heterogeneous nucleation behavior of Ti₃SiC₂ particles in iron-based composites. The structural stability, work of adhesion, interfacial energy, and electronic properties of the Fe(111)/Ti₃SiC₂(0001) interface were comprehensively investigated. A total of eighteen interface models were constructed, encompassing six distinct Ti₃SiC₂(0001) terminations: C(TiC), C(TiSi), TiC(TiC), TiC(TiSi), TiSi, and Si, and three stacking sequences (OT, MT, and HCP). The results demonstrate that the C(TiC)-terminated interface with HCP stacking exhibits the highest work of adhesion (9.25 J·m⁻²) and the lowest interfacial energy, thus representing the most thermodynamically stable configuration. Analysis of the partial density of states (PDOS) and charge density difference reveals that this exceptional stability originates from strong covalent bonding between Fe 3d and C 2p orbitals at the interface, accompanied by pronounced charge accumulation in the interfacial region. Furthermore, the work of adhesion of this interface substantially exceeds that of the fcc-Fe/fcc-Fe melt interface, confirming the high potency of Ti₃SiC₂ particles as heterogeneous nucleation substrates for Fe grains. These findings provide an atomistic framework for understanding the enhanced nucleation and robust interfacial cohesion observed in Fe/Ti₃SiC₂ composite coatings, and offer theoretical guidance for the design of advanced iron-based MAX phase composites. Full article

Background/Objectives: The airway epithelium plays a central role in host defense, inflammatory signaling, and disease progression across infectious, inflammatory, and genetic respiratory disorders. Human nasal epithelial organoids have emerged as accessible and patient-specific in vitro platforms with increasing translational relevance. This systematic review aimed to critically evaluate the current evidence on nasal epithelial organoid models, focusing on donor characteristics, culture methodologies, differentiation strategies, and translational applications. Methods: A systematic search of PubMed/MEDLINE, Embase, Scopus, Ovid MEDLINE, and Cochrane Library was conducted for studies published between 1990 and April 2026. The review followed PRISMA guidelines and was structured according to the PICOTS framework. Eligible studies included in vitro experimental investigations using human-derived nasal epithelial organoids in infectious, inflammatory, or precision medicine contexts. Risk of bias was assessed using the QUIN tool. Results: Seventeen studies met the inclusion criteria. Applications clustered into three principal domains: infectious disease modeling, inflammatory and epithelial remodeling research, and cystic fibrosis precision medicine. Most studies employed expandable three-dimensional Matrigel-embedded organoids or organoid-derived air–liquid interface systems. Infection-focused studies demonstrated variant-specific viral replication dynamics and epithelial immune responses, while inflammatory models reproduced disease-associated differentiation and remodeling phenotypes. Cystic fibrosis oriented studies showed that organoid swelling and electrophysiological assays correlate with CFTR functional rescue and, in selected cases, clinical response. Methodological heterogeneity across protocols and outcome reporting precluded quantitative synthesis. Conclusions: Human nasal epithelial organoids represent versatile translational platforms bridging accessible patient-derived tissue and advanced airway disease modeling. Although variability in culture protocols and functional benchmarks limits standardization, these models hold significant promise for mechanistic investigation, therapeutic stratification, and precision medicine applications. Full article

Vertical electric sources serve as an effective method for identifying deep hydrocarbon reservoirs. This involves the ability to generate transverse magnetic fields, concentrate currents at reservoir interfaces, and effectively emphasize resistivity anomalies in late-time domains. Marine geological conditions are often complex, marked by rugged topography and intricate structures. This complexity results in highly complicated electromagnetic response features, presenting significant challenges for data interpretation. This research employs the Time-Domain Finite Element Method (TDFEM) using unstructured meshes to accurately discretize complex geological models. Through the formulation of TDFEM equations, we successfully performed three-dimensional forward modeling of VED transient electromagnetic (VSTEM) responses in intricate geological environments. An analysis was conducted on the diffusion mechanisms and spatial distribution characteristics of VSTEM fields located beneath the seabed. A comparative analysis was conducted on the resolution capabilities of different fields stimulated by horizontal and VED sources. The findings show that the Ex provides enhanced boundary identification for the lateral extent of targets, whereas the Ez displays the greatest anomaly contrast, highlighting its exceptional results in anomaly detection. We investigated how complex seabed topography and geological structures affect the resolution of hydrocarbon targets. The research indicates that complex topography significantly influences electromagnetic fields; however, the proposed method can still effectively identify resistive hydrocarbon reservoirs, even in intricate model scenarios, thus confirming its reliability in challenging marine environments. Full article

Carbon fiber-reinforced polymer (CFRP) composites are widely employed in the aerospace industry due to their excellent properties such as high specific strength and corrosion resistance. However, the delamination and tearing of composites are prone to occur in the machining of CFRP, which significantly affect its performance. The existing laser-assisted cutting model generally simplifies the machining process into high-temperature conventional cutting, and only reflects the thermal effect by modifying the material parameters. The core selective ablation characteristics of laser–CFRP interaction are completely ignored, and the unique mechanical behavior of bare fiber under a large cutting angle is not modeled, and the quantitative correlation between cutting force evolution and machining damage is lacking. In this study, an innovative method of partially exposing fibers is proposed to simulate laser-assisted machining. A micromechanical model is developed to analyze the removal mechanisms of different phases during CFRP processing, and a cutting force prediction model from the micro to macro scale is also established. At the micro-scale, a micromechanical model for fiber cutting in orthogonal machining of CFRP is constructed based on the elastic foundation beam theory. The results show that the proposed cutting force prediction model has high reliability, and the relative error between the predicted value and the experimental measured value is only 7.81%~8.99%. All experiments were repeated three times. Statistical analysis showed that the repeatability of the results was excellent. Compared with conventional cutting, laser-assisted cutting fundamentally changed the failure mode of the fiber from matrix-constrained crushing fracture to controllable free-end large-deflection bending fracture. This transformation leads to a smoother and more regular fiber fracture surface, which effectively inhibits fiber breakage, matrix tearing, and fiber–matrix interface debonding. Quantitative analysis confirms that under laser-assisted processing conditions, the matrix tearing length is positively linearly correlated with the cutting depth, cutting speed, and bare fiber length. Full article

This work presents a comprehensive analysis of a Palladium (Pd)-gated graphene nanoribbon field-effect transistor (GNRFET) as a high-sensitivity potential hydrogen sensor under idealized conditions, focusing on the structural and environmental control of multimetric sensitivity. Hydrogen adsorption is modeled through pressure-dependent work-function modulation and interface coverage, including competition with oxygen. For hydrogen gas at a pressure of $P_{{\mathrm{H}}_2}={10}^{-6}$ Torr without O₂, the sensor exhibits a maximum threshold voltage sensitivity of about 300 mV, which is reduced to roughly 40 mV under an oxygen partial pressure of 152 Torr, quantifying the impact of background gas on response. Band diagrams, transmission spectra, local density of states, and transfer characteristics are examined over wide ranges of H₂ pressure, temperature, gate length, and nanoribbon width. Sensitivity is evaluated using drain current change, threshold voltage shift, and average subthreshold swing variation. Results showed that the sensitivity based on current is high for ultralow hydrogen pressures, whereas it is low in higher levels of pressure compared to the sensitivity based on subthreshold. Also, uncertainty analysis revealed that the threshold voltage metric remains largely geometry-independent and thus tolerant to fabrication variations. Full article

Titanium matrix composites (TMCs) are increasingly vital in aerospace for their high specific strength and wear resistance, with compositional gradient design serving as a key strategy to mitigate thermophysical mismatches between ceramic and metal phases. This study utilized laser-directed energy deposition with concurrent wire-powder feeding (LDED-WP) to fabricate TiC/Ti6Al4V gradient composites, employing a laser power of 2700 W, wire feed rates of 110–150 cm/min, and calibrated powder feed rates ranging from 50.22 to 497.13 g/h. Along the build direction, the TiC content was progressively increased from 10 wt.% to 60 wt.%. Investigations into microstructural evolution revealed that the reinforcement morphology transitions from chain-like eutectic TiC to dendritic primary TiC, while the lamellarα-Ti width refines significantly from 4.07 ± 1.15 μm to 0.45 ± 0.29 μm. EBSD analysis confirmed that higher TiC concentrations weaken the characteristic <001> solidification texture, reducing intensity from 11.24 to 7.64. Furthermore, KAM analysis highlighted that thermal expansion and elastic modulus mismatches trigger substantial geometrically necessary dislocation (GND) accumulation at interfaces. Consequently, Vickers hardness improved by 164% along the gradient, peaking at 950 HV. Although the composite achieved an ultimate tensile strength of 630 MPa, the elongation was limited to 2.4% due to crack nucleation in TiC-rich regions and interfacial instability. Full article

The development of non-enzymatic glucose sensors for beverage analysis remains challenging due to insufficient active sites, poor conductivity, and limited stability in complex matrices. A nickel-carbon nanotube composite (Ni/CNT−600) was synthesized via in situ solvothermal deposition followed by pyrolysis at 600 °C under an inert atmosphere. The optimized Ni/CNT−600 featured uniform anchoring of Ni nanoparticles on CNTs through strong Ni–C and Ni–O–C interfacial bonds, validated by various characteristic techniques. The Ni/CNT−600 sensor exhibited exceptional sensitivity (538.48 μA mM⁻¹ cm⁻²) and an ultralow detection limit (0.003 μM) in 0.1 M NaOH at +0.65 V, surpassing many reported metal-based and enzymatic sensors. It demonstrated remarkable selectivity against key interferents (e.g., ascorbic acid, uric acid). In real beverage samples (orange juice, grape juice, cola, green tea, milk), recovery rates ranged from 95.6% to 112.8%. This work demonstrates a well-defined Ni-CNT synergistic interface that contributes to enhanced non-enzymatic glucose sensing performance, effectively addressing matrix complexity in beverages. Full article

Electrical discharge machining (EDM) is an efficient method for processing silicon carbide (SiC) substrates. However, the chemical modification mechanism of SiC substrates in the EDM process remains not fully elucidated. To clarify the material removal mechanism of SiC substrates in EDM, this study investigated the behaviors of SiC substrates under different discharge conditions through experimental analysis and interface temperature field simulation. Results indicate that the SiC substrates sequentially exhibit characteristic morphologies of surface oxidation, thermal decomposition, and fracture as discharge energy increases. A discolored layer composed of amorphous SiO₂ is formed on the SiC surface in low-discharge energy. Crystalline silicon and graphitic carbon are generated from the thermal decomposition of SiC substrates in high-discharge energy. Excessively high discharge energy induces the breakdown of SiC substrates. A critical temperature threshold is identified that delineates the initiation of prominent thermal oxidation on the SiC surface. Temperature field simulations further reveal the correlation between EDM parameters and interfacial temperature variations, along with the mechanisms of material removal driven by thermal diffusion. This study deepens the fundamental understanding of the EDM removal mechanism of SiC substrates and is expected to provide a scientific basis for the efficient material removal of SiC substrates. Full article

Presently, there is little to no literature that investigates the effect of electron beams on para-aramid (Kevlar^®) fiber polymer (KFRP) composites. Therefore, we assessed the effect of homogeneous low-potential electron beam irradiation (HLEBI) on Kevlar-reinforced recyclable thermoplastic (TP) polypropylene (PP) (KFRPP). Samples were assembled in an interlayered configuration of four-sized KF plies between five PP sheets [PP1-KF1-PP2-KF2-PP3-KF2-PP2-KF1-PP1] designated [PP]₅[KF]₄, which were hot-pressed at 493 K at 4 MPa for 7 min. Experimental results show when an HLEBI setting of 250 kV cathode potential (V_c) at an 86 kGy dose is applied to finished sample surfaces, the Charpy impact strength (a_uc) at median fracture probability (P_f of 0.50) is increased 59% from 72.5 kJ/m² when untreated to 115.6 kJ/m² thereafter, while a 170 kV–129 kGy setting increased a_uc about 15%, to 83.3 kJ/m², when compared to the untreated sample. Scanning electron microscopy (SEM) showed the 250 kV–86 kGy HLEBI increases KF/PP adhesion with increased consolidation and KF bundling, while the electron spin resonance (ESR) showed HLEBI generates dangling bonds (DBs) in KF and PP, which is evidence of the strengthening KF/PP interface. X-ray photoelectron spectroscopy (XPS) of the N1s spectrum of Kevlar fiber from the fracture region of the untreated sample showed a dominant peak at 399.5 eV with 82.7% area, which is characteristic of the Kevlar backbone N–(C=O)–, indicating poor adhesion with fiber pullout. However, the dominant peak was shifted in the 250 kV–86 kGy sample to that of strongly bonded imines, –C=N–, at 398.6 eV and 36.8%, indicating strong bonds generated at the KF/PP interface. Together, the N1s, C1s and O1s spectra indicate increased polar groups, reduced weak Van der Waals forces, and the generation of a strong active nitrogen-containing interphase, acting to reduce fiber pullout to increase the impact strength of the [PP]₅[KF]₄ composite system. Full article

Introduction: Post-infectious bronchiolitis obliterans (PIBO) is a rare and severe chronic lung disease. Our goal was to characterize respiratory epithelium in children with PIBO, which remains unexplored, using an ex vivo model culture. Methods: Proximal bronchial biopsies from children with PIBO and reconstituted bronchial epithelium from PIBO patients (n = 3) and controls (n = 17) were analyzed using an air–liquid interface culture model. Epithelial cell composition, barrier integrity, and mediator production, including mucins, inflammatory and antiviral responses, were assessed in this pathological and functional approach. Results: Epithelial thickness was assessed in PIBO biopsies. Ex vivo reconstituted PIBO epithelia appeared to exhibit comparable cohesion and cell composition to controls. Mucin expression and secretion were likewise similar between groups. PIBO epithelial might have displayed reduced IL-33 transcript levels and decreased TSLP secretion, whereas IFN-λ1, IFN-λ2-3 and IFN-β secretion could have been elevated. No differences were detected in remodeling markers (MMP-9 and YKL-40). Conclusions: In summary, ex vivo model of PIBO epithelia suggested that the epithelium may preserve structural characteristics and mucin production, without evidence of remodeling. However, PIBO epithelial cells may have a distinct immune profile, with lower alarmin expression and higher interferon secretion. This could indicate a tendency toward enhanced antiviral response rather than structural changes. These preliminary results need to be confirmed in larger cohorts. Full article

Flexible supercapacitors (SCs) have attracted considerable attention for wearable electronics, and developing high-performance electrolytes is critical for their practical application. While hydrogels have been widely investigated as solid electrolytes, studies on double-network (DN) hydrogel electrolytes specifically addressing the electrode–electrolyte interface stability under mechanical deformation remain relatively scarce. A major obstacle is maintaining a stable electrode–electrolyte interface under large mechanical deformation. Drawing inspiration from the mucus of a snail, which effectively adheres to various surfaces in challenging conditions, we present a self-healing xanthan gum/hydrophobically associated polyacrylamide/NaCl (XG/HPAAm/NaCl) hydrogel polymer electrolyte (HPE) that facilitates the creation of flexible SCs with improved mechanical and electrochemical properties. The optimized 2 wt% XG/HPAAm/0.4 M NaCl DN HPE exhibits a high ionic conductivity of 4.0 S/m, a tensile strength of 0.43 MPa, and an elongation at break of 11.7 mm/mm, along with a high adhesive energy of 254.7 J/m². The tough HPE was coated with a mixed adhesive of 502 cyanoacrylate glue and triethyl citrate (TEC) to create a surface coating resembling “mucus”, onto which activated carbon (AC)-modified carbon cloth (CC) electrodes (CC/AC) were affixed on both sides to construct the flexible SCs. Investigations into the HPE’s characteristics and the SCs’ electrochemical performance at various bending angles reveal that the “mucus-coating” HPE exhibits strong electrode adhesion and significantly improved electrochemical performance. The assembled flexible SC delivers a high specific capacitance of 249.3 F/g at 0.30 A/g, retains 73.4% of its initial capacitance after 20,000 cycles, and maintains 86.9% capacitance retention under 180° bending, outperforming SCs assembled with original HPEs in both performance and stability. This approach provides a versatile method for improving the interfacial properties between electrodes and HPEs, paving the way for innovative applications in robust, self-healing, and flexible devices. Full article

Drag-reducing coating technology is a core approach to enhancing the performance of ice and snow sports equipment. By regulating the interfacial characteristics between the equipment surface and the ice or snow medium, it significantly reduces frictional resistance during motion, thereby optimizing athletes’ speed performance and control precision. This paper aims to review the current research status and challenges in this technological field. The review first elaborates on the fundamental principles of applying drag-reducing coatings to key equipment such as skis, sleds, and ice skates, covering current mainstream coating material systems, key preparation processes, and comprehensive performance evaluation methods. Furthermore, integrating multidisciplinary advances in surface engineering, fluid dynamics, and materials science, this review specifically examines how these disciplines can be harnessed to address the unique tribological challenges of snow/ice interfaces. It focuses on cutting-edge research directions such as micro-nano-structured coatings driven by biomimetic design concepts and smart coatings with environmental responsiveness. By synthesizing existing research achievements and potential technological bottlenecks, this paper aims to provide a systematic, theoretical basis and innovative ideas for the future development of a new generation of high-performance, intelligent ice and snow sports equipment. Full article

The key transformation of 2D Ti₃C₂ MXene nanosheets into 0D Ti₃C₂ MXene quantum dots (Ti₃C₂ QDs) restructures the landscape of surface-active sites and tunable band gaps, enabling visiblelight-driven photocatalytic activity. Interestingly, the evolution of these fascinating Ti₃C₂ QDs retains ordered structural characteristics like the parent 2D Ti₃C₂ MXene nanosheets with controlled surface chemistry even after the facile hydrothermal process. In particular, evidence of tailoring of Ti₃C₂ QDs smaller than 10 nm reinforces the charge carrier separation and suppresses recombination under the strong association of quantum confinement and edge effects. Thus, the physical effects of Ti₃C₂ QDs effectively control the limitations of semiconductors, such as charge carrier recombination, slow charge carrier separation, and transportation in the resultant photocatalyst, for the implementation of promising toxic matter degradation and clean H₂ production. Special considerations are given to the regulation of charge carrier generation and separation for stable photocatalytic performance, such as appropriate band gap formation, localized surface plasmonic behavior, and Schottky barrier formation at the semiconductor interface. Specifically, pure Ti₃C₂ QDs with a size smaller than 10 nm exhibit a band gap of 2.16 eV, which has been found to be a powerful way to enable semiconductor-like photoresponse behavior. Overall, the above features make Ti₃C₂ QDs the preferred choice for facilitating effective charge carrier dynamics for the optimization of chemical stability in optoelectronic applications. The paper concludes with challenges and future perspectives to guide the 0D Ti₃C₂ QDs practical applicability in light-driven and sustainable environmental applications. Full article