Search Results (3,219)

Data-driven quality control (QC) systems for the hot forming of steel parts increasingly rely on deep learning models deployed at the network edge, making multivariate sensor time series a critical asset for both local decisions and management information system (MIS) reporting. However, these models are vulnerable to adversarial perturbations and realistic signal disturbances, which can induce misclassification and distort key performance indicators (KPIs) such as first-pass yield (FPY), scrap-related losses, and latency service-level objectives (SLOs). To address this risk, this study introduces a Digital-Twin-Conditioned Diffusion Purification (DTCDP) framework that constrains latent diffusion-based denoising using process states from a lightweight digital twin of the hot-forming line. At each reverse-denoising step, the twin provides physics residuals that are converted into a scalar penalty, and the diffusion latent is updated with a guidance term. This directly bends the sampling trajectory toward reconstructions that adhere to process constraints while removing adversarial perturbations. DTCDP operates as an edge-side preprocessing module that purifies sensor sequences before they are consumed by existing long short-term memory (LSTM)-based QC models, while exposing purification metadata and physics-guidance diagnostics to the plant MIS. In a four-week production dataset comprising more than 40,000 bars, with white-box ℓ∞ attacks crafted on multivariate sensor time series using Fast Gradient Sign Method and Projected Gradient Descent at perturbation budgets of 1–3% of the physical range, combined with additional realistic disturbances, DTCDP improves the robust classification performance of an LSTM-based QC model from 61.0% to 81.5% robust accuracy, while keeping clean accuracy (≈93%) and FPY on clean data (≈97%) essentially unchanged. These results indicate that physics-aware, digital-twin-guided diffusion purification can enhance the adversarial robustness of edge QC in hot forming without compromising operational KPIs. Full article

We have developed a magnetic holographic memory using transparent bismuth-substituted rare-earth iron garnet as a next-generation optical memory. To realize this, a magnetic garnet with a large Faraday rotation angle and a moderately small extinction coefficient is required. In this study, we investigated the effect of Al or Ga substitution for the iron site of bismuth-substituted yttrium iron garnet (Bi/YIG) films on their magneto-optical properties. The Faraday rotation angle decreased with the amount of substitution, x, increase, for both Al- and Ga-substituted Bi/YIG, and a reversal of sign of rotation angle was only observed for Ga-substituted Bi/YIG, indicating a compensation composition. In the Al-substituted sample, due to small squareness, the residual Faraday rotation angle at zero magnetic field, |θ_R,res|, gradually decreased above x = 0.5, whereas in the Ga-substituted sample, the squareness ratio increased with increasing substitution up to x = 2.0, and thus showed a peak at x = 1.5. The Curie temperature and extinction coefficient were reduced with increasing substitution amount. As a result of a decrease in extinction coefficient, k, the high figure of merit, |θ_R,res|/(2πkλ) was obtained around x = 1.5~1.9 for Ga and x = 2.1 for Al, while it was smaller than that of Bi/RIG we usually used. Full article

Tree-related microhabitats (TreMs) are small features on living or dead trees that offer habitat, shelter, breeding sites, or food for many organisms, making them useful indicators of forest-dwelling species. Despite increasing research on TreMs in Europe, most published studies have focused on temperate regions, leaving a relative paucity of data from hemiboreal forests. In our research, we aimed to fill the knowledge gap, offering insight into the occurrence patterns and factors influencing TreM diversity in the hemiboreal region. We analyzed data from the National Forest Inventory in Latvia, comprising information on 168,839 trees across 5653 sample plots. The most common TreMs were bark loss (6.1% of trees), bryophytes (2.6%), and perennial polypores (2.6%). TreMs occurred more frequently on deciduous than on coniferous trees, on larger trees (diameter at breast height more than 60 cm), and on dead trees compared to living ones. Forest type and signs of recent cutting also had significant effects on TreM richness at both the tree and plot scales, whereas forest protection status was significant only at the plot scale. TreMs such as buttress-root concavities and ivy or liana cover, which are common in temperate Europe, had a low relative occurrence in our study. The occurrence of specific TreM forms was strongly tree-species dependent: exudates were much more common on live Picea abies (4.0%) than on other species, whereas Populus tremula had a higher occurrence of fruiting bodies of saproxylic fungi and slime moulds (2.0%). The highest occurrence of crown deadwood was observed on Quercus robur. Overall, dead trees play a particularly important role, providing both a higher total number of TreMs and certain TreM types more frequently. Given their high TreM richness, dead and large trees represent important structural components supporting biodiversity in hemiboreal forests. Full article

Background: Otitis media with effusion (OME) is a widespread condition that causes hearing impairment, particularly in pediatric populations. Existing non-absorbable tubes often require elective or unplanned removal surgery. Bioabsorbable polylactic acid (PLA) offers a promising alternative due to its inherent biocompatibility and tunable degradation characteristics. In this study, we designed, fabricated, and comprehensively evaluated a novel PLA middle-ear ventilation tube. Methods: Bioabsorbable PLA tubes were designed and fabricated based on commercial models. In vitro biocompatibility was assessed according to ISO 10993 guidelines. A guinea pig model was used to perform in vivo evaluations, including otoscopic examinations, auditory brainstem response (ABR) measurements, micro-computed tomography (micro-CT) imaging, and histological analyses. Results: The PLA tubes were successfully designed and fabricated, exhibiting dimensions comparable to those of commercially available products. In vitro testing confirmed their biocompatibility. In vivo observations revealed that the PLA segments remained stable, with no significant inflammation detected. ABR measurements revealed no adverse impacts on hearing function. Micro-CT imaging confirmed tube integrity and indicated initial signs of degradation over a 9-month period, as evidenced by radiographic morphology. Histological analyses indicated a favorable tissue response with minimal foreign body reaction. Conclusions: The developed PLA middle-ear ventilation tube represents a highly promising alternative to conventional non-absorbable tubes. It demonstrates excellent biocompatibility, preserves auditory function, and exhibits a controlled degradation profile. This preclinical study provides strong support for further investigation and subsequent clinical trials to validate its safety and efficacy in human patients. Full article

In inland waters, Atmospheric Correction (AC), including Adjacency Effect (AE) correction, is a major challenge for water quality retrieval using optical satellite data. This study evaluated three image pre-processing options for turbidity retrieval in the St. Lawrence River using Sentinel-2 (S2) and Landsat 8/9 (L8/9) imagery with the Light Gradient Boosting Machine (LightGBM) model: (1) No pre-processing, i.e., use of Top-of-Atmosphere (TOA) reflectance, (2) AC pre-processing, obtaining water-leaving reflectance (R_w) from AC for the Operational Land Imager lite (ACOLITE)’s Dark Spectrum Fitting (DSF) technique, and (3) AE pre-processing, correcting for the AE using T-Mart before obtaining R_w from DSF. Results demonstrated that AE pre-processing outperformed the other two options. For L8/9, AE pre-processing reduced the Root Mean Square Error (RMSE) and improved the median symmetric accuracy (ε) by 48.8% and 19.0%, respectively, compared with AC pre-processing, and by 48.5% and 50.7%, respectively, compared with No pre-processing. For S2, AE pre-processing performed better than AC pre-processing and also outperformed No pre-processing, reducing RMSE by 28.4% and ε by 50.8%. However, No pre-processing yielded the lowest absolute symmetric signed percentage bias (|β|) among all pre-processing options. Analysis indicated that AE pre-processing yielded superior performance within 0–300 m from shore than other options, where the AE influence is strongest. Turbidity maps generated using AE pre-processing were smoother and less noisy compared to the other pre-processing options, particularly in cloud-adjacent regions. Overall, our findings suggest that incorporating AE correction through T-Mart improves the performance of the LightGBM model for turbidity retrieval from both L8/9 and S2 imagery in the St. Lawrence River, compared to the alternative pre-processing options. Full article

Background/Objectives: The Seklers are a Hungarian-speaking regional population in Transylvania, Romania, with a long and complex history, yet comprehensive genome-wide studies remain limited. Our aim was to characterize the genetic background of multiple Sekler communities using high-density autosomal data and to place them in a broader Central and Eastern European context. Methods: Here we analyzed genome-wide autosomal SNP data obtained from 17 Sekler groups. Allele frequency- and haplotype-based approaches were applied to assess overall genetic structure, ancestry patterns, recent shared ancestry, and signals of demographic history. Results: Analyses based on overall allele-frequency patterns showed that Sekler groups fit into a single, coherent genetic cluster shared with Hungarians. No major differences were detected among the Sekler communities at this broader genomic level, and their genetic profiles were largely indistinguishable from one another. Using haplotype-based methods, most Sekler groups again formed a compact cluster. However, two villages, Deményháza and Nyárádszentimre, showed clear signs of increased within-group relatedness and subtle separation. These patterns might indicate that both communities experienced stronger local drift and reduced effective population size, while other Sekler groups showed no comparable deviation from the general regional pattern. Conclusions: Although a small number of villages display modest signs of localized demographic drift, our results support that the Seklers represent a regionally distinct and internally cohesive population, whose genetic structure is shaped mainly by common historical and linguistic ties, with minor village-level variation, forming a uniform part of the Hungarian-speaking population of the East-Central European region. Full article

To investigate the molecular characteristics of H3N2 canine influenza viruses circulating in Jiangsu, China, we isolated a H3N2 strain (A/Canine/Nanjing/CnNj01-2025) from a dog presenting with respiratory signs at the Veterinary Teaching Hospital of Nanjing Agricultural University. All eight gene segments were sequenced and compared with those of two human H3N2 strains and five avian H3N2 strains. Antigenicity and receptor-binding properties were also assessed. Phylogenetic analysis revealed that the canine isolate descended from the avian lineage and formed an independent evolutionary clade, while the human strains were more distantly related to the avian lineage. Glycosylation analysis of the HA protein revealed that the canine strain carried seven N-glycosylation sites, including a unique site at residue 97/81 (HA/H3 numbering), which serves as a molecular signature of the canine strain. Several amino-acid substitutions were identified in major antigenic sites, including D97/81N, A176/160T, N204/188D, V212/196I, and W237/222L. Analysis of internal genes showed that the canine strain harbored PB2 292T and 590S mammalian adaptation mutations, which are also present in human strains. Hemagglutination inhibition (HI) assays of the canine strain indicated moderate serologic cross-reactivity with a human H3N2 antiserum (16-fold reduction), whereas avian strains showed no cross-reactivity. Receptor-binding assays demonstrated that the virus retained predominant α-2,3 sialic acid binding, comparable to that of avian influenza viruses, and gained a modest affinity for human-type α-2,6 sialic acid receptors. Therefore, the canine H3N2 virus has undergone significant antigenic drift, developed partial serological cross-reactivity with human strains, and acquired detectable but limited binding affinity for human-type receptors. Overall, our findings suggest that the current canine H3N2 influenza virus exhibits distinct genetic and antigenic variations from human and avian strains. Continuous molecular and serological surveillance of canine influenza viruses is therefore warranted to monitor their evolutionary trends and assess the potential for cross-species transmission. Full article

Background: Preoperative anemia is common among patients undergoing arthroplasty and is associated with increased transfusion requirements and worse outcomes. Current perioperative pathways rely on iron studies to guide intravenous iron supplementation, but systemic inflammation triggered by surgery profoundly alters iron markers, risking misclassification of iron deficiency. This study evaluated whether adjusting iron indices for inflammatory markers improves diagnostic accuracy after total hip arthroplasty (THA). Methods: In this prospective cohort study, 20 patients undergoing elective primary THA at a single center were enrolled. Patients with preoperative inflammation were excluded. Serum iron, transferrin, transferrin saturation (TSAT), CRP, and albumin were measured preoperatively and on postoperative days (PODs) 1, 2, 3, and 90. Serum iron was adjusted for systemic inflammation using a validated regression equation incorporating CRP and albumin, and adjusted TSAT was calculated accordingly. Absolute iron deficiency was defined as serum iron < 10 µmol/L, and functional iron deficiency was defined as TSAT < 20%. Comparisons were made using Wilcoxon’s signed-rank test and ANOVA. Results: In the 20 included patients, a pronounced systemic inflammatory response was observed, with CRP peaking on POD 2 (median, 162 mg/L) and albumin falling to 32 g/L on POD 1 (both p < 0.001). Unadjusted serum iron and TSAT fell sharply, with nearly all patients classified as iron-deficient in the first three postoperative days. Adjustment for CRP and albumin significantly attenuated these declines: on POD 2, median iron was 8.2 µmol/L adjusted versus 2.0 µmol/L unadjusted (p < 0.001), and TSAT was 19% versus 4% (p < 0.001). Misclassification of iron deficiency fell by 40–50% with adjustment, and by POD 90, adjusted indices approximated baseline values. Conclusions: Systemic inflammation after THA markedly suppresses iron indices, leading to widespread misclassification of iron deficiency. Adjustment for CRP and albumin reduces this misclassification and provides a more accurate assessment of perioperative iron status. These findings complement existing evidence supporting intravenous iron supplementation by highlighting a diagnostic refinement that could improve patient selection for therapy. Full article

Effective monitoring and early warning of the instability of anti-slide piles in loess landslides depend on identifying the precursory signs of anti-slide pile failure. The acoustic emission (AE) characteristics of concrete anti-slide piles under cyclic loading were studied by using the model box test of the loess landslide–pile system. Cyclic graded loading simulates natural landslide sliding. The synergistic relationship between AE signal characteristics and pile bending moment is established, which reveals the evolution law from micro-damage to macro-damage. The results show that (1) AE ringing count and energy count change in the same way, first stable and then a sudden increase. The evolution of AE dominant frequency and amplitude experiences four stages: low frequency and low amplitude (initial damage), high frequency and low amplitude (stable development), medium frequency and high amplitude (accelerated development), and low frequency and high amplitude (failure). Each stage obviously corresponds to the change in bending moment. (3) The significant increase in the proportion of low-frequency AE energy effectively indicates that the landslide–pile system has entered the state of accelerated deformation and instability, which provides a quantifiable, real-time early warning criterion. This study verifies the feasibility and effectiveness of acoustic emission technology in anti-slide pile damage monitoring and landslide early warning and provides a new technical way for the precursor’s identification and early warning of anti-slide pile instability. Full article

Biometric authentication is widely regarded as more secure and reliable than conventional approaches like passwords and PINs. Nonetheless, many current systems rely on active user participation, such as fingerprint scanning or facial recognition, which can disrupt tasks, increase the likelihood of errors, and raise privacy concerns. To address these challenges, this study introduces a continuous, seamless authentication framework that utilizes vital signs for passive identity verification across various activities, including resting, walking, and running. The framework analyzes physiological indicators such as Heart Rate (HR), Heart Rate Variability (HRV), Skin Temperature, Peripheral Oxygen Saturation (${\mathrm{SpO}}_2$), and Breathing Rate to provide zero-effort authentication without requiring user intervention. Multiple machine learning algorithms, including Decision Tree, Random Forest, XGBoost, Gradient Boosting, and K-Nearest Neighbors, were implemented and compared to identify the most effective predictive model. The methodology involved data collection, preprocessing, model construction, evaluation, and comparison. Experimental results revealed that the XGBoost Classifier achieved the highest accuracy at 96%. Overall, the proposed framework demonstrates strong reliability, scalability, adaptability, and flexibility, making it suitable for practical deployment. By continuously verifying identity without interrupting user activity, it improves both security and usability, offering a modern and convenient alternative to traditional authentication methods. Full article

Bennett fractures are common intra-articular fractures of the base of the first metacarpal. Not optimal restoration of the articular surface often leads to osteoarthritis, with pain and limited movement. In patients with established and symptomatic TMC osteoarthritis, arthroplasty with MAIA^® prosthesis could be a valid option. In July 2024, a right-handed man of 68 years old fell on his hand. Radiographs showed a Bennett fracture in a setting of Eaton–Littler stage 3 osteoarthritis, already painful and disabling according to the patient. For correct pre-operative planning, a 3D model of the affected hand was produced. The patient underwent TMC arthroplasty with a MAIA^® prosthesis. Two months after surgery, the results reported no pain (VAS scale) and considerable functionality and mobility of the first ray (AROM, Kapandji score, and PRWHE were investigated). The mean pinch strength of the right hand was 7 kg and of the left hand 7.5 kg using a pinch meter. At one-year follow-up, no complications were reported: the implant did not show signs of loosening or subsidence. TMC arthroplasty in Bennett fractures could represent a safe procedure in patients with established TMC osteoarthritis; however, further studies are requested in order to clarify effectiveness and indications. Full article

The intraspecific taxonomy of snow sheep (Ovis nivicola) is one of the most controversial issues in Caprinae systematics. Although eight subspecies have been described using morphological traits, the validity of several taxa, particularly those in the eastern part of their geographical range, remains disputed. We investigated the phylogenetic relationships and genetic diversity of snow sheep in the Chukotka Autonomous Okrug using genome-wide single-nucleotide polymorphism (SNP) data (935 loci after filtering) and complete mitochondrial genomes from 57 individuals collected across the Russian Far East (Chukotka Autonomous Okrug, Kamchatka Krai, Magadan Oblast, and Republic of Sakha (Yakutia)). Post SNP-genotyping nuclear genomic studies using principal component analysis (PCA), ADMIXTURE, pairwise F_ST and Neighbor-Net revealed two clearly differentiated groups within Chukotka. One included individuals from the Koryak Mountains that are genetically indistinguishable from the Koryak subspecies (O. n. koriakorum) of northern Kamchatka. The other one encompassed individuals from the Anadyr Plateau and the Chukotka Mountains cluster with the Okhotsk subspecies (O. n. alleni) of the Kolyma Mountains. Bayesian phylogeny of complete mitochondrial genomes fully corroborated the nuclear results: Koryak Mountains samples formed a monophyletic clade, while Anadyr–Chukotka samples grouped with Kolyma Mountains individuals. Genetic diversity indices (_UH_E, A_R, F_IS) in both Chukotka groups were comparable to other studied populations and showed no signs of inbreeding depression. Our results provide important insights and can be used to develop science-based strategies for preserving the population-genetic diversity of snow sheep. Full article

In Serbia, Babesia canis is the predominant cause of canine babesiosis, while B. gibsoni and B. vulpes have been reported only sporadically. Limited awareness of these small Babesia species often leads to misdiagnosis and inappropriate treatment. International reports indicate that American Staffordshire Terriers (ASTs) and related breeds are particularly affected. This study examined 101 ASTs over a two-year period to determine the occurrence of small Babesia species and identify dog- and owner-related risk factors. Collected data included age, sex, body condition score (BCS), clinical signs, presence of scars, history of vector-borne diseases (VBD), living conditions, antiparasitic prophylaxis, and tick exposure. Molecular identification using PCR and Sanger sequencing revealed that 37 dogs were positive for Babesia spp.; among them, 36 were infected with B. gibsoni and one with B. vulpes. Significant risk factors associated with infection included the presence of scars, low BCS, history of VBDs, tick exposure, and living in rural areas. These findings demonstrate a notably high occurrence of B. gibsoni and the presence of B. vulpes in ASTs in Serbia. The results highlight the need for improved awareness, accurate molecular diagnostics, and targeted preventive and therapeutic measures. Additionally, observed risk factors suggest chronic infection and support transmission pathways linked to dog bites and tick exposure. Full article

This paper presents the findings of a dual-approach research study conducted for the Utah Department of Transportation to evaluate the effectiveness of variable message sign (VMS) treatments on Utah roadways. The study aimed to determine the impact of VMS treatments on mobility and safety for Utah’s unique road conditions and configurations. Two primary analyses were performed: a diversion rate analysis to assess the effectiveness of VMS messages on Utah freeways during incidents and a weather analysis to evaluate the effectiveness of VMS messages on driver speeds in Utah canyons during winter weather. The findings of the diversion rate analysis indicate that the activation of VMS messages during crash incidents increased diversion rates by 18 percent. The weather analysis showed that the activation of VMS messages warning drivers to slow down due to inclement weather conditions increased driver speeds by 0.23 mph (0.37 kph) during weather conditions, which was statistically significant, but holds little practical significance. The methodologies and findings of this study will assist departments of transportation and other interested parties in developing their VMS policies to more effectively influence driver behaviors. Full article

Global freshwater scarcity necessitates the exploitation of alternative water resources for aquaculture. Chloride-type saline-alkaline water, characterized by high salinity but moderate pH, is widely distributed in arid regions worldwide and represents a vast, underutilized resource. This study comprehensively evaluated the potential of the endemic Ili perch (Perca schrenkii) for aquaculture in such environments. Through acute stress experiments, we determined its 96 h median lethal salinity (LC₅₀) to be 12.396 ppt, with a safe concentration of 3.72 ppt. Physiological analysis revealed a critical salinity threshold of 13 ppt, beyond which osmoregulatory collapse (indicated by plasma Na⁺/K⁺ dysregulation and Na⁺-K⁺-ATPase suppression), oxidative damage (elevated malondialdehyde), and immune suppression occurred. In contrast, chronic 60-day exposure to salinities up to 7 ppt demonstrated successful long-term acclimation. Acclimated fish re-established ion homeostasis, as plasma ion levels normalized, and exhibited sustained antioxidant enzyme (SOD, CAT) and immune parameter (AKP, ACP, IgM) activities without signs of damage. Our findings establish P. schrenkii as a highly promising species for chloride-type saline-alkaline aquaculture. The study provides a physiological framework for its adaptation and offers evidence-based salinity guidelines for its sustainable cultivation, thereby contributing to the expansion of aquaculture into non-traditional water resources. Full article