Search Results (360)

This study examined the influence of the follicular (FP) and luteal phases (LP) of the menstrual cycle on sweat rate, estimated sweat sodium concentration, heart rate, hydration status, fluid intake, and perceived exertion in first-division university female football players. A small sample of eight athletes completed two monitored training sessions, one in each estimated-menstrual phase, following a repeated-measures field-based design under habitual training conditions. Sweat rate was determined using pre- to post-exercise body mass changes and microfluidic sweat patches, while estimated sweat sodium concentration was obtained via wearable colorimetric sensors. Heart rate was continuously monitored, hydration status was assessed using urine specific gravity, fluid intake was recorded, and perceived exertion was evaluated using the Borg CR-10 scale. Sweat rate was significantly higher during LP compared with FP (0.83 ± 0.20 vs. 0.55 ± 0.25 L·h⁻¹, p = 0.026), alongside greater estimated sweat sodium concentration (695 ± 305 vs. 404 ± 159 mg·L⁻¹, p = 0.031) and higher perceived exertion (4.63 ± 1.41 vs. 3.13 ± 0.83, p = 0.021). Fluid intake was also significantly greater during LP (0.99 ± 0.19 vs. 0.49 ± 0.25 L, p < 0.001). No significant differences were observed for urine specific gravity, mean heart rate, or total body mass change (p > 0.05). These findings suggest that the luteal phase may be associated with higher thermoregulatory and perceptual responses during football training, highlighting the potential importance of menstrual cycle-informed hydration and training management strategies in female athletes. Full article

Endurance performance is regulated through dynamic interactions between physiological capacity, nutritional status, and psychological control processes. While traditional endurance models have emphasized metabolic and cardiorespiratory determinants, growing evidence indicates that energy availability also influences cognitive function, perceived effort, and decision-making during prolonged exercise. This narrative review synthesizes current literature on the interplay between nutritional strategies and psychological regulation in endurance sports, with particular emphasis on low energy availability, carbohydrate availability, mental fatigue, and pacing behavior. Acute and chronic reductions in energy availability are associated not only with endocrine and metabolic disturbances but also with amplified perceived exertion, impaired executive functioning, reduced effort tolerance, and altered risk-related decision-making, even in the absence of overt physiological failure. Carbohydrate availability emerges as a central modulator operating through both peripheral mechanisms (substrate supply and glycogen preservation) and central neurocognitive pathways influencing perception, motivation, and fatigue regulation. Hydration status, caffeine ingestion, and gastrointestinal tolerance further interact with perceptual and cognitive processes to shape real-time pacing and endurance sustainability. Integrating sport nutrition and sport psychology provides a unifying framework for understanding endurance regulation as a multilevel process linking metabolic state to perceptual experience and behavioral decision-making. From an applied perspective, optimizing endurance performance requires maintenance of adequate long-term energy availability, strategic carbohydrate periodization aligned with training demands, and systematic monitoring of perceived effort alongside physiological load. Future research should prioritize interdisciplinary, ecologically valid designs combining metabolic, perceptual, and cognitive measurements, supported by wearable and data-driven technologies capable of capturing real-time endurance regulation. Bridging nutritional and psychological mechanisms within a unified conceptual model offers a stronger scientific basis for improving performance sustainability while safeguarding athlete health in modern endurance sport. Full article

Background: Aging is associated with increased adiposity, sarcopenia risk, and metabolic vulnerability. Digital tools may enhance adherence to nutritional strategies, but their impact on detailed body composition remains insufficiently explored. Methods: This 6-month prospective controlled longitudinal intervention study included 60 middle-aged and older adults. All participants received a smart watch and smart scale for self-monitoring. The control group attended evaluations only at baseline and study completion, while the intervention group received monthly follow-up and remote feedback. Body composition was assessed using multi-frequency BIA. Statistical analyses included paired tests, effect sizes, correlations, and linear mixed-effects models. Results: Significant reductions were observed in BMI (p < 0.001), fat mass (p = 0.003), and visceral fat (p = 0.003; Cohen’s d = 0.41). The sarcopenic index improved (p = 0.001), while skeletal muscle mass remained stable. ECW increased significantly (p = 0.010). Age was inversely associated with the magnitude of improvement. Mixed-effects modeling confirmed a time-dependent reduction in visceral fat independent of age and sex. Conclusions: A 6-month digitally assisted nutritional monitoring program was associated with favorable changes in adiposity, muscle quality, and hydration status. Multi-frequency BIA provides valuable integrative markers for monitoring nutritional interventions in aging populations. Full article

Background: Roux-en-Y gastric bypass (RYGB) is a highly effective treatment for severe obesity, achieving substantial weight loss and metabolic improvement. Beyond weight, assessing body composition and functional markers is essential. Phase angle (PA), obtained through bioelectrical impedance, is a relevant indicator of cellular integrity and nutritional status. The rise of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide (GLP-1 and GLP-1/GIP) agonists makes comparison with surgical outcomes increasingly important. This study aimed to evaluate changes in fat mass, lean mass, hydration, and PA after RYGB and compare these findings with evidence from pharmacological therapies. Methods: A retrospective observational study was conducted in 15 patients (18–50 years, BMI > 35 kg/m²) at Quirón Salud Hospital Torrevieja. Body composition was assessed using multifrequency bioelectrical impedance (TANITA BC-980) before surgery and at 3 and 12 months. All patients received structured nutritional follow-up. Repeated-measures ANOVA and the Friedman test were applied. Results: After 12 months, weight decreased by 40.06 ± 11.86 kg; fat mass by 30.43 ± 10.81 kg; and fat-free mass by 9.64 ± 5.31 kg. PA declined 11% during the first 3 months and then stabilized. Women lost more fat mass; men lost more lean mass. Conclusions: RYGB combined with nutritional support produces high-quality weight loss with relative preservation of lean tissue and stabilization of PA, which proves valuable for postoperative monitoring. Full article

Accurate dry weight assessment is crucial for hemodialysis (HD) fluid management, yet traditional clinical methods often lack precision. A significant scientific gap exists in the availability of a standardized multimodal framework for integrating objective tools, leaving clinicians without clear guidance on combining results from multiple devices. To address this gap, this narrative review provides a qualitative clinical synthesis of bioimpedance spectroscopy (BIS), lung ultrasound (LUS), and inferior vena cava diameter (IVCD). A structured literature search was conducted across PubMed, Scopus, and CINAHL for English-language studies published between 2012 and 2024. Studies focusing on dry weight assessment using these tools in adult HD patients were included, and findings from 22 core studies were synthesized narratively. BIS and LUS are valuable tools for identifying fluid overload. BIS assesses systemic fluid distribution across compartments, whereas LUS allows non-invasive detection of extravascular lung water. In contrast, IVCD primarily reflects intravascular volume status. While the integrated use of these tools shows potential clinical utility, individual methods, particularly IVCD, require further validation owing to interpatient variability. A multimodal approach that integrates these objective methods with clinical judgment offers a comprehensive evaluation of dry weight. Integrating these assessment strategies may improve outcomes and decision-making in nephrology care. Full article

Preconception care is globally recognized as essential for optimizing pregnancy outcomes; however, in Japan, comprehensive data on medication-related potential exposure to pregnancy-contraindicated medications among women of reproductive age remain limited. We conducted a retrospective cross-sectional descriptive study using data from Japan’s National Database of Health Insurance Claims (fiscal year 2022) to assess the potential exposure to pregnancy-contraindicated medications among women of reproductive age. Outpatient prescriptions for oral medications dispensed to women aged 15–49 years were analyzed. In total, 270 medications classified as contraindicated during pregnancy were identified, of which 75 were also contraindicated for women planning pregnancy. Of these, 58 active ingredients were restricted in both phases. Notably, 212 medications were uniquely contraindicated during pregnancy, highlighting the broader contraindication profiles during fetal development than during the preconception period. Despite these contraindications, high prescription volumes were observed for medications such as loxoprofen sodium hydrate, sodium valproate, and metformin hydrochloride among women of reproductive age. These findings illustrate a high baseline utilization of pregnancy-contraindicated medications among women of reproductive age. As most women in this demographic are neither pregnant nor actively planning conception, these volumes primarily reflect standard care rather than inappropriate prescribing. In conclusion, pharmacists serve as an important supplementary safety net by routinely confirming pregnancy status to prevent inadvertent exposure. Full article

Background/Objectives: Malnutrition and altered body composition are frequent in chronic heart failure (HF) and are associated with worse functional status and prognosis. Bioelectrical impedance analysis (BIA) is increasingly used in nutritional assessment, although its interpretation may be confounded by fluid overload. This study aimed to evaluate the association between BIA-derived parameters and clinical and biochemical markers of disease severity in ambulatory patients with chronic heart failure. Methods: This cross-sectional study included adult outpatients with chronic HF consecutively assessed in a specialised HF unit. Nutritional evaluation comprised anthropometry, handgrip strength, rectus femoris muscle ultrasound and BIA. Phase angle (PA) and hydration-related parameters were analysed in relation to New York Heart Association (NYHA) functional class and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels. Multivariable regression models adjusted for relevant clinical and BIA variables were applied. Results: A total of 115 patients were included (mean age 68.2 ± 12.6 years; 71.3% men). Mean PA was 4.6 ± 1.1°. Lower PA was independently associated with greater dyspnoea severity (p = 0.026) and higher NT-proBNP concentrations (p = 0.014). Higher total body water was positively associated with symptom burden (p = 0.013) and NT-proBNP levels (p < 0.001) and showed good discriminatory performance for identifying patients in the highest NT-proBNP quartile. Conclusions: In ambulatory patients with chronic HF, BIA-derived parameters reflecting cellular integrity and hydration status are independently associated with clinical and biochemical markers of disease severity. BIA may provide complementary information in nutritional assessment, although hydration-related confounding should be carefully considered. Future longitudinal studies should determine whether these bioimpedance-derived parameters can improve risk stratification and nutritional assessment in chronic heart failure. Full article

Postharvest dehydration is a major determinant of cucumber freshness and marketability, yet early reductions in internal water status are difficult to detect using conventional quality assessment methods. This study presents a non-destructive, physiology-informed deep learning approach that links cucumber surface color and texture patterns to internal hydration level for automated freshness classification. A time-resolved dataset comprising 4160 RGB images of cucumber fruits was paired with gravimetrically determined relative water content (RWC), used as an objective indicator of internal hydration status. Based on RWC, fruits were classified into four freshness categories: Very Fresh (≥98%), Moderately Fresh (95–98%), Low Freshness (90–95%), and Spoiled (<90%). A custom convolutional neural network (CNN) was trained using standardized RGB images and evaluated on an independent test set. The model achieved an overall classification accuracy of 91.35% and a Cohen’s Kappa coefficient of 0.875, indicating strong agreement between predicted and actual freshness classes. Classification performance was highest for the extreme freshness states, with F1-scores exceeding 0.94 for Very Fresh and Spoiled fruits, while intermediate classes showed greater overlap, reflecting the gradual nature of postharvest water loss. Model interpretability analyses revealed that the CNN consistently focused on physiologically meaningful surface color and texture features associated with dehydration. Overall, these findings highlight the potential of physiology-informed deep learning to advance non-destructive freshness assessment in cucumbers, offering a realistic pathway toward hydration-based sorting, improved shelf-life management, and intelligent quality monitoring in modern postharvest supply chains. Full article

Background: Short bowel syndrome (SBS) is the leading cause of chronic intestinal failure and is frequently associated with long-term dependence on parenteral nutrition (PN) and intravenous fluids. Teduglutide, a glucagon-like peptide-2 (GLP-2) analogue, promotes intestinal adaptation and has been demonstrated to reduce parenteral support requirements. However, real-world data from the Greek population are scarce. Methods: We conducted a non-interventional, multicenter, retrospective cohort study across 5 centers in Greece, including adult patients with SBS receiving teduglutide therapy. Demographic and clinical characteristics, parenteral nutrition and intravenous fluid requirements, body mass index (BMI), laboratory parameters, and adverse events were recorded at baseline and during follow-up at weeks 4, 12, 26, and 52. Results: Eight adult patients with SBS were included (75% female), with a median age of 53 years (range 19–71). Over 52 weeks of treatment, mean parenteral nutrition requirements decreased by approximately 45% compared with baseline (from 1430 to 788 kcal/day), while mean intravenous hydration requirements decreased by approximately 80% (from 5170 to 1000 mL/week). Complete independence from parenteral nutrition was achieved in 2 of 8 patients (25%). Nutritional status improved, with a 10.6% increase in mean BMI at Week 52. Teduglutide was generally well tolerated; mild adverse events occurred in 3 of 8 patients, were predominantly gastrointestinal, and did not lead to treatment discontinuation. Conclusions: This study provides data from the Greek population and supports the effectiveness and favorable safety profile of teduglutide in adult patients with SBS and chronic intestinal failure. Further prospective studies are warranted to better define predictors of response and optimize long-term management strategies. Full article

Objectives: Procalcitonin (PCT) is used increasingly in emergency settings to guide evaluation of febrile illnesses, but its role in pediatric infectious diarrhea, particularly as a marker of severity, remains unclear. The study objective evaluates whether PCT correlates with clinical severity and outcomes in pediatric infectious diarrhea presenting to the emergency department (ED). Methods: This prospective study enrolled 105 children with infectious diarrhea presenting to a tertiary pediatric ED. Serum PCT, C-reactive protein, clinical features, hydration status, treatment decisions (including hospitalization and antibiotic use), and outcomes were analyzed. PCT cutoffs (<0.25, <0.5, and <1.0 ng/mL) were evaluated for their associations with Salmonella infection and severity measures, including dehydration, hospitalization, length of stay, and antibiotic use. Results: Thirty-five patients (33.3%) had Salmonella enteritidis. PCT levels did not differ significantly between Salmonella-positive and negative cases (median 0.49 vs. 0.46 ng/mL; p = 0.84), and PCT demonstrated poor diagnostic performance (AUC 0.49). In contrast, PCT was strongly associated with markers of severity. Compared with lower PCT levels, children with PCT ≥ 0.25 ng/mL were more frequently hospitalized (92.1% vs. 52.6%; p < 0.001) and had longer hospital stays (4.41 vs. 3.00 days; p < 0.001). Higher PCT levels were also associated with more dehydration, higher CRP (all p < 0.001), and greater antibiotic use (66.7% vs. 23.7%; p < 0.001). PCT thresholds of 0.25–0.5 ng/mL consistently identified children at increased risk for admission and higher treatment intensity. Conclusions: PCT should not be used as a diagnostic marker for Salmonella enteritidis. Instead, it reflects the host inflammatory response and is strongly associated with clinical severity in children with acute infectious diarrhea evaluated in the ED. The incorporation of PCT thresholds into ED assessment may support early severity-based risk stratification and inform decisions regarding admission and treatment intensity. Full article

Dromedary camels possess unique anatomical, physiological, and metabolic adaptations that enable survival in arid environments; however, these same adaptations make them highly sensitive to nutritional imbalance under modern feeding conditions. This review synthesizes current knowledge on nutritional pathologies and metabolic disorders in camels, emphasizing the links between diet composition, foregut fermentation, mineral status, and systemic health. Imbalances in energy and carbohydrates predispose camels to subacute and acute acidosis, negative energy balance, and ketosis-like syndromes, particularly when rapidly fermentable feeds are introduced without adequate fiber or water. Protein and nitrogen disorders, including ammonia toxicity and impaired urea recycling, arise from mismatches between degradable protein, fermentable energy, hydration, and mineral availability. Widespread deficiencies of phosphorus, copper, cobalt, zinc, selenium, and vitamins A and E remain major constraints, leading to pica, poor microbial fermentation, oxidative stress, immunosuppression, reproductive failure, and skeletal disorders. Nutritional disturbances frequently extend beyond the gastrointestinal tract, forming a gut–liver–kidney metabolic axis characterized by hepatic dysfunction, renal compromise, and systemic oxidative stress. The review also addresses gastrointestinal impaction, foreign-body ingestion, toxic plant consumption, and feeding on human food waste as emerging nutritional challenges, particularly in peri-urban systems. Advances in diagnostic ultrasonography, feed evaluation techniques, probiotics, mineral–vitamin supplementation, and omics-based approaches are discussed as tools for improving early diagnosis and precision nutrition. Despite growing research interest, the lack of camel-specific feeding standards and reliance on cattle-based recommendations remain critical gaps. This review highlights the need for species-specific nutrient requirement models, sustainable rangeland management, and integrative research to support the health, resilience, and productivity of camels under changing environmental and production systems. Full article

Water scarcity, rapid soil moisture loss, and high evaporative demand severely limit vegetable production in arid regions such as Qatar. Sustainable soil amendments that enhance water retention and stabilize plant water status are therefore critical for improving productivity. This study evaluated a biodegradable hydrogel synthesized from date-palm leaf cellulose using a sodium alginate crosslinking method and assessed its effects on soil hydro-physical properties and tomato (Solanum lycopersicum L.) performance under arid conditions. A pot experiment was conducted under semi-controlled conditions using a single-factor randomized complete design with three hydrogel rates (0, 1, and 2% w/w) and three replications, with one plant per pot. All treatments received the same seasonal irrigation depth, scheduled when soil moisture declined to approximately 60–65% of field capacity. The hydrogel exhibited rapid hydration behavior, reaching equilibrium within 30–60 min with a swelling ratio of 5.659 g g⁻¹, corresponding to a water uptake of 465.9%, and SEM analysis revealed a porous internal structure favorable for water retention. At 1 and 2% application rates, hydrogel significantly reduced bulk density, increased total porosity and field capacity, and maintained higher soil moisture across irrigation cycles. Tomato plants grown in hydrogel-amended pots showed substantial gains in fresh biomass and root length, together with higher chlorophyll content, leaf nitrogen concentration, and relative water content. Water use efficiency improved significantly at 1% hydrogel, whereas the 2% rate showed a positive but non-significant trend. Overall, the results demonstrate that hydrogels derived from date-palm waste can enhance soil water retention, plant physiological status, and tomato productivity, offering a locally relevant strategy to improve agricultural resilience in arid environments. Full article

Background: Ramadan fasting involves daily abstinence from food and water between dawn and sunset, but human studies cannot readily disentangle the effects of fasting timing, circadian alignment, and hydration status on metabolic regulation. Objective: To determine whether fasting timing or hydration status exerts a stronger influence on metabolic outcomes in diet-induced obese rats under controlled Ramadan-like conditions. Methods: Forty diet-induced obese rats were assigned to four Ramadan-like fasting groups differing by timing and hydration: dry morning (DM), wet morning (WM), dry night (DN), or wet night (WN) fasting, in addition to healthy control (HC) and obese control (OC) groups (n = 8 each). Because rats are nocturnal, morning fasting restricted food during the inactive (light) phase, whereas night fasting restricted food during the active (dark) phase. Body weight, glucose, insulin, HOMA-IR, lipid profile, adipokines, and electrolytes were assessed after four weeks. Results: Morning fasting significantly reduced body-weight gain (F(5,42) = 10.72, p < 0.0001; η² = 0.56) and improved insulin sensitivity, reflected by lower insulin (F(5,30) = 2.98, p = 0.027; η² = 0.33) and HOMA-IR (F(5,30) = 3.76, p = 0.0092; η² = 0.39), independent of hydration status. Serum glucose differed across groups (F(5,42) = 5.82, p = 0.00036). After body-weight adjustment, total cholesterol and triglycerides were reduced in fasting groups, whereas hydration primarily influenced fluid and electrolyte parameters without materially altering core metabolic outcomes. Conclusions: Under controlled conditions, fasting timing exerted a stronger influence on metabolic regulation than hydration status. Fasting aligned with the inactive circadian phase was associated with more favorable metabolic outcomes, highlighting circadian alignment as a key determinant of fasting-related metabolic adaptation in obesity. Full article

The cosmetic and personal care industry is increasingly shifting toward plant-derived ingredients that combine multifunctional biological activity with favorable safety and sustainability profiles. Trigonella foenum-graecum L. (fenugreek), a leguminous plant traditionally used in food and medicine, has recently attracted growing attention as a potential cosmetic and cosmeceutical ingredient. This review provides a comprehensive and critical synthesis of current knowledge on fenugreek in the context of skin and hair care applications. First, the phytochemical profile of fenugreek relevant to cosmetics is examined, with emphasis on polyphenols and flavonoids, steroidal saponins, alkaloids (notably trigonelline), and mucilage-rich galactomannans. The biological activities of these constituents are then discussed in relation to key cutaneous and scalp mechanisms, including antioxidant defense, anti-inflammatory and antimicrobial effects, anti-glycation and dermal matrix protection, skin hydration and barrier support, as well as hair growth promotion and scalp health. Particular attention is given to recent in vitro, ex vivo, and emerging clinical evidence supporting anti-aging, moisturizing, and hair-care claims. Current formulation strategies and green extraction technologies enabling the incorporation of fenugreek-derived ingredients into topical products are reviewed, alongside considerations of safety, toxicity, and regulatory status under EU cosmetic legislation. Finally, existing research gaps are identified, highlighting the need for standardized extracts, robust clinical validation, and advanced omics-based approaches. This review highlights fenugreek’s strong potential as a versatile plant-based ingredient in cosmetics, despite remaining understudied in topical applications. Full article

Wildland firefighting involves prolonged, high-intensity physical work performed under hot, variable, and operationally demanding conditions, placing firefighters at substantial risk of heat-related illness. This paper synthesizes current evidence on the mechanisms, contributing factors, and management of heat stress in wildland firefighting, with a specific focus on physiologically and operationally relevant considerations aligned with NIOSH, NFPA, and USFS guidelines. Heat stress is conceptualized as a cumulative process resulting from the interaction of metabolic heat production, environmental heat load, protective clothing, and individual susceptibility. Key environmental contributors include high ambient temperatures, humidity, and solar and fire-related radiant heat, while occupational demands such as sustained heavy work, extended shift durations, limited recovery, and the thermal burden of personal protective equipment further exacerbate risk. Individual factors—including fitness, hydration status, acclimatization, fatigue, and underlying health conditions—modify heat tolerance and vulnerability. This review highlights evidence-based exposure management strategies tailored to wildland fire operations, including work–rest cycles, heat acclimatization protocols, and practical cooling interventions, and addresses the operational constraints that shape their implementation. This paper further emphasizes the role of standardized training programs in prevention, early symptom recognition, and rapid response. Together, these integrated approaches provide a focused framework for reducing heat-related morbidity and enhancing wildland firefighter safety. Full article