Search Results (6,409)

Chronic arthritis following arthritogenic alphavirus infections presents symptoms resembling autoimmune rheumatic diseases, raising questions about the underlying mechanisms, including molecular mimicry and autoantibody production. This systematic review evaluated evidence supporting molecular mimicry and the potential role of autoantibodies as predictive biomarkers in alphavirus-induced chronic arthritis. A comprehensive search of PubMed, Scopus and Web of Science was conducted following PRISMA 2020 guidelines and PECO framework. Thirteen studies met the inclusion criteria: four computational studies assessing peptide homology between viral and human proteins, and nine clinical studies evaluating autoantibodies in chronic post-alphavirus arthritis. Computational analyses identified conserved alphavirus peptides with sequence and structural similarity to human proteins implicated in autoimmunity, supporting the hypothesis of molecular mimicry. However, most lacked experimental validation. Clinical studies showed variable detection of autoantibodies, rheumatoid factors, anti-cyclic citrullinated peptide, and antinuclear antibodies in chronic patients, though seropositivity rates were inconsistent and generally low. Only one study reported a significant association between autoantibody levels and disease chronicity. The findings suggest a potential autoimmune component in post-alphavirus arthritis driven by molecular mimicry, though current evidence remains inconclusive due to methodological heterogeneity and limited validation. Autoantibodies may contribute to pathogenesis but are not reliable predictors of chronicity. Future longitudinal studies with standardized assays and validation of computational findings in human models are needed. Full article

Taste masking in pharmaceutical products is a complex and subjective process that requires reliable evaluation methods. This review focuses on the electronic tongue (e-tongue), an emerging sensor-based technology designed to mimic human taste perception without the need for human panels. E-tongue systems provide objective data to support the development of palatable formulations. In this review, we discuss the principles, types of e-tongue devices, data processing approaches, and their applications in pharmaceutical research. By comparing e-tongue performance with human taste assessment, we highlight its potential as a complementary tool to traditional in vitro assays, accelerating formulation development and improving patient adherence. Full article

Articulated vehicles are essential for global freight transportation but are highly susceptible to instability phenomena such as jackknifing, trailer sway, and rollover, particularly under high-speed or emergency maneuvers. These challenges become even more critical in the context of autonomous driving, where stability must be guaranteed without human intervention. Conventional systems like Electronic Stability Control (ESC) and Roll Stability Control (RSC) provide reactive interventions but lack predictive capability, while other advanced methods often address isolated objectives. To overcome these limitations, this paper proposes a Model Predictive Control (MPC)-based control strategy that integrates trajectory tracking, yaw stability, and longitudinal speed regulation within a unified optimization framework, using differential braking as the primary actuator. A dynamic model of a tractor–semitrailer combination was developed, and the proposed controller was validated through high-fidelity simulations under varying operating conditions, including speeds exceeding the critical threshold of 31.04 m/s. Results demonstrate that the MPC-based system effectively mitigates instability, reduces articulation angle and yaw rate deviations, and maintains accurate path tracking while proactively managing vehicle speed. These findings highlight MPC’s potential as a cornerstone technology for safe and reliable autonomous operation of articulated vehicles. Future work will focus on experimental validation and multi-actuator coordination to further enhance performance. Full article

Lumbar shear forces are increasingly recognized as critical contributors to lower-back injury risk, yet most ergonomic assessment tools—most notably the Revised NIOSH Lifting Equation (RNLE)—do not directly estimate shear loading. This study develops and evaluates a family of linear mixed-effects regression models that statistically predict L4/L5 lumbar shear force exposure using traditional NIOSH lifting parameters combined with posture descriptors extracted from digital human models. A harmonized dataset of 106 peak-shear lifting postures was compiled from five controlled laboratory studies, with lumbar shear forces obtained from validated biomechanical simulations implemented in the Siemens JACK (Siemens software, Plano, TX, USA) platform. Twelve model formulations were examined, varying in fixed-effect structure and hierarchical random effects, to quantify how load magnitude, hand location, sex, and joint posture relate to simulated task-level anterior–posterior shear exposure at the lumbar spine. Across all models, load magnitude and horizontal reach emerged as the strongest and most stable predictors of shear exposure, reflecting their direct mechanical influence on anterior spinal loading. Hip and knee flexion provided substantial additional explanatory power, highlighting the role of whole-body posture strategy in modulating shear demand. Upper-limb posture and coupling quality exhibited minimal or inconsistent effects once load geometry and lower-body posture were accounted for. Random-effects analyses demonstrated that meaningful variability arises from individual movement strategies and task conditions, underscoring the necessity of mixed-effects modeling for representing hierarchical structure in lifting data. Parsimonious models incorporating subject-level random intercepts produced the most stable and interpretable coefficients while maintaining strong goodness-of-fit. Overall, the findings extend the NIOSH framework by identifying posture-dependent determinants of lumbar shear exposure and by demonstrating that simulated shear loading can be reliably predicted using ergonomically accessible task descriptors. The proposed models are intended as statistical predictors of task-level shear exposure that complement—rather than replace—comprehensive biomechanical simulations. This work provides a quantitative foundation for integrating shear-aware metrics into ergonomic risk assessment practices, supporting posture-informed screening of manual material-handling tasks in field and sensor-based applications. Full article

Sustainable management of indoor and outdoor air quality is essential for protecting public health, enhancing well-being, and supporting resilient urban environments. Low-cost air quality sensors enable continuous, real-time monitoring of key pollutants and, when combined with data analytics, provide scalable and cost-effective insights for smart building operation and environmental decision-making. This pilot study evaluates an indoor–outdoor air quality monitoring system deployed at the Faculty of Electrical Engineering and Information Technologies in Skopje, with a focus on: (i) PM2.5 and PM10 concentrations and their relationship with meteorological conditions and human occupancy; (ii) sensor responsiveness and reliability in an educational setting; and (iii) implications for sustainable building operation. From January to March 2025, two indoor sensors (a classroom and a faculty hall) and two outdoor rooftop sensors continuously measured PM2.5 and PM10 at one-minute intervals. All sensors were calibrated against a reference instrument prior to deployment, while meteorological data were obtained from a nearby station. Time-series analysis, Pearson correlation, and multiple regression were applied. Indoor particulate levels varied strongly with occupancy and ventilation status, whereas outdoor concentrations showed weak to moderate correlations with meteorological variables, particularly atmospheric pressure. Moderate correlations between indoor and outdoor PM suggest partial pollutant infiltration. Overall, this pilot study demonstrates the feasibility of low-cost sensors for long-term monitoring in educational buildings and highlights the need for adaptive, context-aware ventilation strategies to reduce indoor exposure. Full article

Accurate gait-phase detection is essential for rehabilitation monitoring, prosthetic control, and human–robot interaction. Artificial intelligence supports continuous, personalized mobility assessment by extracting clinically meaningful patterns from wearable sensors. A richer view of gait dynamics can be achieved by integrating additional signals, including inertial, plantar flex, footswitch, and EMG data, leading to more accurate and informative gait analysis. Motivated by these needs, this study investigates discrete gait-phase recognition for the right leg using a multi-subject IMU dataset collected from lower-limb sensors. IMU recordings were segmented into 128-sample windows across 23 channels, and each window was flattened into a 2944-dimensional feature vector. To ensure reliable ground-truth labels, we developed an automatic relabeling pipeline incorporating heel-strike and toe-off detection, adaptive threshold tuning, and sensor fusion across sensor modalities. These windowed vectors were then used to train a comprehensive suite of machine learning models, including Random Forests, Extra Trees, k-Nearest Neighbors, XGBoost, and LightGBM. All models underwent systematic hyperparameter tuning, and their performance was assessed through k-fold cross-validation. The results demonstrate that tree-based ensemble models provide accurate and stable gait-phase classification with accuracy exceeding 97% across both test sets, underscoring their potential for future real-time gait analysis and lower-limb assistive technologies. Full article

To meet the need for efficient and precise detection of people and obstacles in the actual operating environment of a gantry crane, a detection model based on an improved YOLOv5s was proposed which incorporates the parameter-free SimAM attention mechanism to enhance obstacle feature extraction capabilities, employs the EIoU loss function to optimize bounding box regression accuracy, and utilizes preprocessing techniques to improve input image quality. Training experiments on humans and simple simulated obstacles demonstrate that the improved model achieves significantly higher recognition accuracy and speed compared to the original YOLOv5 model. The improved model was applied to the recognition experiments of reducer obstacles under varying sizes, visibility levels, and distance conditions, and the comparative experiments were conducted with mainstream YOLO models, as well as different attention mechanisms and loss functions. The results show that the mAP@0.5 of the improved model achieves 0.884 with superior recognition performance and used lower computational resource requirements, providing a reliable solution for real-time obstacle detection in crane operation scenarios. Full article

Large Language Models (LLMs) have demonstrated exceptional performance in knowledge-based dialogue generation and text evaluation. Synthetic data serves as a cost-effective alternative for generating high-quality datasets. However, it often plagued by hallucinations, inconsistencies, and self-anthropomorphized responses. Concurrently, manual construction of knowledge-based dialogue datasets remains bottlenecked by prohibitive costs and inherent human subjectivity. To address these multifaceted challenges, we propose ACE (Automatic Construction of Knowledge-Grounded and Engaging Human–AI Conversation Dataset), a hybrid method using hierarchical prompt engineering. This approach mitigates hallucinations and self-personalization while maintaining response consistency. Furthermore, existing human and automated evaluation methods struggle to assess critical factors like factual accuracy and coherence. To overcome this, we introduce the Truthful Answer Score (TAS), a novel metric specifically designed for knowledge-based dialogue evaluation. Our experimental results demonstrate that the ACE dataset achieves higher quality than existing benchmarks, such as Wizard of Wikipedia (WoW) and FaithDial. Additionally, TAS aligns more closely with human judgment, offering a more reliable and scalable evaluation framework. Our findings demonstrate that leveraging LLMs through systematic prompting can substantially reduce reliance on human annotation while simultaneously elevating the quality and reliability of synthetic datasets. Full article

Non-contact monitoring of human vital signs using microwave radar has attracted increasing attention due to its capability to operate unobtrusively and through clothing or light obstacles. In vector network analyzer (VNA)-based radar systems, vital signs can be extracted from phase variations in the forward transmission coefficient $S_{21}$, whose sensitivity strongly depends on the electromagnetic performance of the antenna system. This work presents the design, optimization, fabrication, and experimental validation of a high-gain 12 GHz 4 × 4 microstrip patch antenna array specifically developed for phase-based vital signs monitoring. The antenna array was progressively optimized through coaxial feeding, slot-based impedance control, stepped transmission line matching, and mitered bends, achieving a simulated gain of 17.8 dBi, a measured gain of 17.06 dBi, a reflection coefficient of −26 dB at 12 GHz, and a total efficiency close to 74%. The antenna performance was experimentally validated in an anechoic chamber and subsequently integrated into a continuous-wave VNA-based radar system. Comparative measurements were conducted against a commercial biconical antenna, a single patch radiator, and an MIMO antenna under identical conditions. Results demonstrate that while respiration can be detected with moderate-gain antennas, reliable heartbeat detection requires high-gain, narrow-beam antennas to enhance phase sensitivity and suppress environmental clutter. The proposed array significantly improves pulse detectability in the (1–1.5) Hz band without relying on advanced signal processing. These findings highlight the critical role of antenna design in $S_{21}$-based biomedical radar systems and provide practical design guidelines for high-sensitivity non-contact vital signs monitoring. Full article

Given the increasing demand for rapid emergency management decision-making, which must be both timely and reliable, even slight delays can result in substantial human and economic losses. However, current systems and recent state-of-the-art work often use inflexible rule-based logic that cannot adapt to rapidly changing emergency conditions or dynamically optimise response allocation. As a result, our study presents the Calculation Logic Optimisation Framework (CLOF), a novel data-driven approach that enhances decision-making intelligently and strategically through learning-based predictive and multi-objective optimisation, utilising the 911 Emergency Calls data set, comprising more than half a million records from Montgomery County, Pennsylvania, USA. The CLOF examines patterns over space and time and uses optimised calculation logic to reduce response latency and increase decision reliability. The suggested framework outperforms the standard Decision Tree, Random Forest, Gradient Boosting, and XGBoost baselines, achieving 94.68% accuracy, a log-loss of 0.081, and a reliability score (R²) of 0.955. The mean response time error is reported to have been reduced by 19%, illustrating robustness to real-world uncertainty. The CLOF aims to deliver results that confirm the scalability, interpretability, and efficiency of modern EM frameworks, thereby improving safety, risk awareness, and operational quality in large-scale emergency networks. Full article

As social robots increasingly enter public environments, their acceptance depends not only on technical robustness but also on ethical integrity, accessibility, transparency, and consistent system behaviour across diverse users. This paper reports an in situ pilot deployment of an ARI social robot functioning as a university receptionist, designed and implemented in alignment with the SecuRoPS framework for secure, ethical, and reliable social robot deployment. Thirty-five students and staff interacted with the robot in a real public setting and provided structured feedback on safety, privacy, usability, accessibility, ethical transparency, and perceived reliability. The results indicate strong user confidence in physical safety, data protection, and regulatory compliance while revealing persistent challenges related to accessibility and interaction dynamics. These findings show that reliability in public-facing robotic systems extends beyond fault-free operation to include equitable and consistent user experience across contexts. Beyond reporting empirical outcomes, the study contributes in three key ways. First, it demonstrates a reproducible method for operationalising lifecycle governance frameworks in real-world deployments. Second, it provides new empirical insights into how trust, accessibility, and transparency are experienced by end users in public spaces. Third, it delivers a publicly available, open-source GitHubrepository containing reusable templates for ARI robot applications developed using the PAL Robotics ARI SDK (v23.12), lowering technical entry barriers and supporting reproducibility. By integrating empirical evaluation with practical system artefacts, this work advances research on reliable intelligent environments and provides actionable guidance for the responsible deployment of social robots in public spaces. Full article

Camera, lidar, and wearable-based gesture recognition technologies face practical limitations such as lighting sensitivity, occlusion, hardware cost, and user inconvenience. Wi-Fi channel state information (CSI) can be used as a contactless alternative to capture subtle signal variations caused by human motion. However, existing CSI-based methods are highly sensitive to domain shifts and often suffer notable performance degradation when applied to environments different from the training conditions. To address this issue, we propose a domain-robust touchless finger location sensing framework that operates reliably even in a single-link environment composed of commercial Wi-Fi devices. The proposed system applies preprocessing procedures to reduce noise and variability introduced by environmental factors and introduces a multi-domain segment combination strategy to increase the domain diversity during training. In addition, the dual-axis transformer learns temporal and spatial features independently, and the GNN-based integration module incorporates relationships among segments originating from different domains to produce more generalized representations. The proposed model is evaluated using CSI data collected from various users and days; experimental results show that the proposed method achieves an in-domain accuracy of 99.31% and outperforms the best baseline by approximately 4% and 3% in cross-user and cross-day evaluation settings, respectively, even in a single-link setting. Our work demonstrates a viable path for robust, calibration-free finger-level interaction using ubiquitous single-link Wi-Fi in real-world and constrained environments, providing a foundation for more reliable contactless interaction systems. Full article

Background: Whole-slide imaging and algorithmic advances have moved computational pathology from research to routine consideration. Despite notable successes, real-world deployment remains limited by generalization, validation gaps, and human-factor risks, which can be amplified in resource-constrained settings. Content/Scope: This narrative review and implementation perspective summarizes clinically proximate AI capabilities in cancer pathology, including lesion detection, metastasis triage, mitosis counting, immunomarker quantification, and prediction of selected molecular alterations from routine histology. We also summarize recurring failure modes, dataset leakage, stain/batch/site shifts, misleading explanation overlays, calibration errors, and automation bias, and distinguish applications supported by external retrospective validation, prospective reader-assistance or real-world studies, and regulatory-cleared use. We translate these evidence patterns into a practical checklist covering dataset design, external and temporal validation, robustness testing, calibration and uncertainty handling, explainability sanity checks, and workflow-safety design. Equity Focus: We propose a stepwise adoption pathway for low- and middle-income countries: prioritize narrow, high-impact use cases; match compute and storage requirements to local infrastructure; standardize pre-analytics; pool validation cohorts; and embed quality management, privacy protections, and audit trails. Conclusions: AI can already serve as a reliable second reader for selected tasks, reducing variance and freeing expert time. Safe, equitable deployment requires disciplined validation, calibrated uncertainty, and guardrails against human-factor failure. With pragmatic scoping and shared infrastructure, pathology programs can realize benefits while preserving trust and accountability. Full article

Precise identification of weeds at the maize seedling stage is pivotal for implementing Site-Specific Weed Management and minimizing herbicide environmental pollution. However, the performance of existing lightweight detectors is severely bottlenecked by unstructured field environments, characterized by the “green-on-green” spectral similarity between crops and weeds, diminutive seedling targets, and complex mutual occlusion of leaves. To address these challenges, this study proposes SLD-YOLO11, a topology-reconstructed lightweight detection model tailored for complex field environments. First, to mitigate the feature loss of tiny targets, a Lossless Downsampling Topology based on Space-to-Depth Convolution (SPD-Conv) is constructed, transforming spatial information into depth channels to preserve fine-grained features. Second, a Decomposed Large Kernel Attention (D-LKA) mechanism is designed to mimic the wide receptive field of human vision. By modeling long-range spatial dependencies with decomposed large-kernel attention, it enhances discrimination under severe occlusion by leveraging global structural context. Third, the DySample operator is introduced to replace static interpolation, enabling content-aware feature flow reconstruction. Experimental results demonstrate that SLD-YOLO11 achieves an mAP@0.5 of 97.4% on a self-collected maize field dataset, significantly outperforming YOLOv8n, YOLOv10n, YOLOv11n, and mainstream lightweight variants. Notably, the model achieves Zero Inter-class Misclassification between maize and weeds, establishing high safety standards for weeding operations. To further bridge the gap between visual perception and precision operations, a Visual Weed-Crop Competition Index (VWCI) is innovatively proposed. By integrating detection bounding boxes with species-specific morphological correction coefficients, the VWCI quantifies field weed pressure with low cost and high throughput. Regression analysis reveals a high consistency (R² = 0.70) between the automated VWCI and manual ground-truth coverage. This study not only provides a robust detector but also offers a reliable decision-making basis for real-time variable-rate spraying by intelligent weeding robots. Full article

Sound reproduction is the electro-mechanical re-creation of sound waves using analogue and digital audio equipment. Although sound reproduction implies that repeated acoustical events are close to identical, numerous fixed and variable conditions affect the acoustic result. To arrive at a better understanding of the magnitude of deviations in sound reproduction, amplitude deviation and phase distortion of a sound signal were measured at various reproduction stages and compared under a set of controlled acoustical conditions, one condition being the presence of a human subject in the acoustic test environment. Deviations in electroacoustic reproduction were smaller than ±0.2 dB amplitude and ±3 degrees phase shift when comparing trials recorded on the same day (Δt < 8 h, mean uncertainty $u$ = 1.58%). Deviations increased significantly with greater than two times the amplitude and three times the phase shift when comparing trials recorded on different days (Δt > 16 h, $u$ = 4.63%). Deviations further increased significantly with greater than 15 times the amplitude and the phase shift when a human subject was present in the acoustic environment ($u$ = 24.64%). For the first time, this study shows that the human body does not merely absorb but can also cause amplification of sound energy. The degree of attenuation or amplification per frequency shows complex variance depending on the type of reproduction and the subject, indicating a nonlinear dynamic interaction. The findings of this study may serve as a reference to update acoustical standards and improve accuracy and reliability of sound reproduction and its application in measurements, diagnostics and therapeutic methods. Full article