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Article

11 Citations

8,313 Views

10 Pages

Structure-Based Drug Design of Small Molecule Peptide Deformylase Inhibitors to Treat Cancer

Jian Gao,
Tao Wang,
Shengzhi Qiu,
Yasheng Zhu,
Li Liang and
Youguang Zheng

Molecules2016, 21(4), 396;https://doi.org/10.3390/molecules21040396

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23 March 2016

Human peptide deformylase (HsPDF) is an important target for anticancer drug discovery. In view of the limited HsPDF, inhibitors were reported, and high-throughput virtual screening (HTVS) studies based on HsPDF for developing new PDF inhibitors rema...

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Article

2 Citations

3,336 Views

21 Pages

Prediction of Pharmacokinetics of IDP-73152 in Humans Using Physiologically-Based Pharmacokinetics

Myongjae Lee,
Yoo-Seong Jeong,
Min-Soo Kim,
Kyung-Mi An and
Suk-Jae Chung

Pharmaceutics2022, 14(6), 1157;https://doi.org/10.3390/pharmaceutics14061157

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28 May 2022

IDP-73152, a novel peptide deformylase inhibitor with an antibacterial effect against Gram-positive bacteria, is in phase I development. The objective of this study was to develop a physiologically-based pharmacokinetic model (PBPK) for IDP-73152 in...

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